scholarly journals Discovery and Further Studies on Giant Viruses at the IHU Mediterranee Infection That Modified the Perception of the Virosphere

Viruses ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 312 ◽  
Author(s):  
Clara Rolland ◽  
Julien Andreani ◽  
Amina Louazani ◽  
Sarah Aherfi ◽  
Rania Francis ◽  
...  

The history of giant viruses began in 2003 with the identification of Acanthamoeba polyphaga mimivirus. Since then, giant viruses of amoeba enlightened an unknown part of the viral world, and every discovery and characterization of a new giant virus modifies our perception of the virosphere. This notably includes their exceptional virion sizes from 200 nm to 2 µm and their genomic complexity with length, number of genes, and functions such as translational components never seen before. Even more surprising, Mimivirus possesses a unique mobilome composed of virophages, transpovirons, and a defense system against virophages named Mimivirus virophage resistance element (MIMIVIRE). From the discovery and isolation of new giant viruses to their possible roles in humans, this review shows the active contribution of the University Hospital Institute (IHU) Mediterranee Infection to the growing knowledge of the giant viruses’ field.

2018 ◽  
Vol 5 (2) ◽  
pp. 75-79
Author(s):  
Dianiris Rodríguez ◽  
Teresita Rey ◽  
Mariela Ramírez ◽  
Daniela Cabrera

Abstract: Objective: To describe the clinical and sociodemographic characteristics of patients with temporomandibular joint (TMJ) dysfunction at the University Hospital of Maracaibo. Methods: A retrospective study was conducted by assessing the clinical history of patients with TMJ dysfunction who underwent orthopedic treatment in the Oral Surgery Unit of the Dentistry Service of the University Hospital of Maracaibo. Information was collected on socio-demographic characteristics (age, gender, origin, and occupation) and clinical findings related to the presence, location, area, beginning, frequency, cause, and duration of pain, and signs present during mandibular dynamics; additionally, a structural and functional diagnosis was made. The data were processed and analyzed using SPSS v.9. Results: 221 patients were included, with only 10% of the disorders observed in males. Regarding occupation, 39.1% worked at home and 28.3% were students. 97.2% of patients presented pain, and of these, pain was localized in 75%. During mandibular movement with maximum opening, 47.4% showed some difficulty, which was more significant in males. TMJ noises were noted in 74.9%, more often in females. In addition, the previous partial displacement of a disk with recapture presented an incidence of 66.4%. Conclusion: The prevalence of TMJ dysfunction was higher in female patients and in adulthood. Noises were present with a high frequency, as was limited mandibular movement.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
F. Cyr Doscoph Afle ◽  
Alidéhou Jerrold Agbankpe ◽  
Roch Christian Johnson ◽  
Olivia Houngbégnon ◽  
Sègbè Christophe Houssou ◽  
...  

2019 ◽  
Vol 128 (10) ◽  
pp. 693-698
Author(s):  
Sabine Dillenberger ◽  
Detlef K. Bartsch ◽  
Elisabeth Maurer ◽  
Peter Herbert Kann

Abstract Purpose It is assumed that primary hyperparathyroidism (pHPT) in Multiple Endocrine Neoplasia (MEN) and lithium-associated pHPT (LIHPT) are associated with multiple gland disease (MGD), persistence and recurrence. The studies purpose was to determine frequencies, clinical presentation and outcome of sporadic pHPT (spHPT), LIHPT and pHPT in MEN. Additional main outcome measures were the rates of MGD and persistence/recurrence. Methods Retrospective analysis of medical records of 682 patients with pHPT who had attended the University Hospital of Marburg between 01–01–2004 and 30–06–2013. All patients were sent a questionnaire asking about their history of lithium medication. Results Out of 682 patients, 557 underwent primary surgery (532 spHPT, 5 LIHPT, 20 MEN), 38 redo-surgery (31 spHPT, 7 MEN), 55 were in follow-up due to previous surgery (16 spHPT, 1 LIHPT, 38 MEN) and 37 were not operated (33 spHPT, 1 LIHPT, 3 MEN). Primary surgeries were successful in 97.4%, revealed singular adenomas in 92.4%, double adenomas in 2.9% and MGD in 3.4% of the cases. Rates of MGD in MEN1 (82.35%) were significantly higher than in spHPT (3.8%), while there was no significant difference between LIHPT (20%) and spHPT. Rates of persistence/recurrence did not significantly differ due to type of surgery (bilateral/unilateral) or type of HPT (spHPT/LIHPT/MEN). Conclusions History of lithium medication is rare among pHPT patients. While MGD is common in MEN1, rates of MGD, persistence or recurrence in LIHPT were not significantly higher than in spHPT.


Traditio ◽  
1953 ◽  
Vol 9 ◽  
pp. 430-434 ◽  
Author(s):  
Alfons Nehring

Treatises de modis significandi are known to have been a favorite genre of scholastic literature. One of them, by Martinus de Dacia, has lately been made the subject of a thorough study by Father Heinrich Roos, S.J., and will be briefly discussed in these pages. The text of this treatise, and commentaries on it, are found in a fairly large number of manuscripts, of which Fr. Roos presents a list, and which he endeavors to determine in their mutual relation in order to lay the groundwork for a future edition, apparently — as much as any one not himself familiar with the manuscripts can judge — with thoroughness and reliablity (chs. I, II). In some of the manuscripts and in certain other sources the treatise is ascribed to one Martinus de Dacia (Denmark). Very convincingly Fr. Roos demonstrates (ch. III) that this bit of information is correct and that the author was identical with a high-ranking Danish cleric of that name, who at one time was the chancellor of King Eric VI Menved. It is likely that Martinus composed his treatise while he was a professor in the Liberal Arts Faculty of the University of Paris, probably around 1250. The treatise seems to have enjoyed a great reputation, which would be accounted for if Fr. Roos is right in assuming that Martinus set the model for the entire type. In the last two chapters (IV, V) Fr. Roos describes the character and basic ideas of the tractate against the background of the development of scholarship and higher education during the Middle Ages. This historical outline is very interesting and instructive indeed. Nevertheless it provokes criticism regarding two interrelated points, namely, the characterization of scholastic grammar and its position in the history of linguistic studies.


Author(s):  
Ignace N. Yao ◽  
Jean Marc L. Dia ◽  
Michelle M. Menin ◽  
Mouhedeen A. Oyelade ◽  
Corneille T. Saki ◽  
...  

Background: Describe the epidemiological and diagnostic of spontaneous aspects of early miscarriage in the department of the Gynecology Obsteric of Treichville University Teaching Hospital of   Treichville in Abidjan.Methods: A cross-sectional study was performed from January 2016 to March 2017 on patients received for an early miscarriage (gestational age less than 14 weeks of amenorrhea).Results: We recorded 337 cases of miscarriage and it shows that miscarriage was frequently estimated at 58 percent. Our patients had a average age of 32.9 years, 60.4 percent of them with primary education and 48 percent are housewives. The patients were paucigestes in 46 percent and the majority of them were nulliparous (62 percent). 6 percent with history of high blood pressure; diabetes (3 percent) and 31 percent of patients were HIV positive. Patients had pelvic pain at the admission in (55 percent). A miscarriage appears before 10 weeks of amenorrhea (76.1 percent) of cases. Ultrasound showed ovular debris (47 percent) of patients and (55.4 percent) were chromosomal abnormalities on anatomy-pathological examination.Conclusions: Spontaneous abortions are common and pathological examination is essential for diagnosis.


Neurosurgery ◽  
2003 ◽  
Vol 53 (3) ◽  
pp. 731-742 ◽  
Author(s):  
Tor Ingebrigtsen ◽  
Bertil Romner ◽  
Tore Solberg ◽  
Øystein P. Nygaard

2013 ◽  
Vol 35 (2) ◽  
pp. 169 ◽  
Author(s):  
Carolina Cotrim Dal Pozzo ◽  
Paulo Armindo Seibert ◽  
Dirce Shizuko Fujisawa

Pulmonary atelectasis is described as a state of a given region of lung parenchyma collapsed and non-aerated. This study aimed to describe the characteristics and clinical outcome of children with atelectasis, assisted by physical therapy service. This is a case report whose information was collected from records of children hospitalized at the University Hospital of Londrina/HU, in 2009. Seventeen patients with pulmonary atelectasis were treated, aged from 11 days to 9 years old. At initial assessment, 8 (47%) children had no signs of difficulty breathing. The most used techniques were the re-expansion techniques used in all patients (100%), the clearance techniques were performed in 16 (94%) children, and the deflated techniques were used for only one child. The mean number of physical therapy sessions performed for the resolution of atelectasis was 4, ranging from 2 to 9. All 17 cases of atelectasis treated by physical therapy had rapid resolution. Outcome of children treated was satisfactory at short term with low number of physical therapy attendances.  


1993 ◽  
Vol 21 (02) ◽  
pp. 113-117 ◽  
Author(s):  
W. Zwölfer ◽  
W. Keznickl-Hillebrand ◽  
A. Spacek ◽  
M. Cartellieri ◽  
G. Grubhofer

In a retrospective study 17 patients with long-standing history of asthma bronchiale were treated with acupuncture at the outpatient unit of the Department of Anaesthesia and Intensive Care in the University Hospital of Vienna. The subjective effectiveness of the treatment was determined using a standard questionnaire, which was sent to the patients' homes half a year after starting acupuncture treatment. Over 70% of our patients reported a significant improvement of their ailments after ten weeks of treatment as well as half a year after starting acupuncture.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Ben Cheikh ◽  
S Bhiri ◽  
N ketaka ◽  
A Gara ◽  
S Khefacha ◽  
...  

Abstract Background Ventilator-Associated Pneumonia (VAP) continues to cause significant morbidity, mortality, and hospital costs, especially in the intensive care unit (ICU). This study aimed to determine incidence and factors associated with VAP in six ICUs of the University Hospital-Sahloul (Sousse, Tunisia) in 2018. Methods We conducted a prospective observational cohort study over a three months period in six ICUs of the University Hospital-Sahloul (Sousse, Tunisia) in 2018. All patients hospitalized with mechanical ventilation (MV) for more than 48 hours in the ICUs were included. Logistic regression with the stepwise method of Hosmer and Lemeshow was used to identify factors associated with VAP. Results Overall, 110 patients were enrolled. The mean age of patients was 44 ± 25 years. Of them, 66.4% were male. The median duration of MV was 5 days [2-16]. The incidence of VAP was 32% and the density incidence was 33/1000 ventilator days. The most common organism were Pseudomonas aeruginosa (n = 14). Of them, 12 were ceftazidime-resistant and thee were resistant to imipenem. Independent risk factors associated with VAP in ICU were history of antibiotic therapy during last 6 months (p = 0.007), tracheotomy (p < 0.001) and reintubation (p < 0.001). Conclusions VAP rates in our ICUs were very high. Antimicrobial stewardship programs involving pharmacists and physicians must be elaborated to optimize the antibiotic prescribing. Mechanical ventilation require more-effective interventions control in our hospital. Key messages Ventilator-Associated Pneumonia rates were very high. Independent risk factors associated with Ventilator-Associated Pneumonia were history of antibiotic therapy during last 6 months, tracheotomy and reintubation.


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