scholarly journals Immunogenicity after Second ChAdOx1 nCoV-19 (AZD1222) Vaccination According to the Individual Reactogenicity, Health Status and Lifestyle

Vaccines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1473
Author(s):  
Hyunji Choi ◽  
Sun-Min Lee ◽  
Seungjin Lim ◽  
Kyung-Hwa Shin ◽  
Taeyun Kim ◽  
...  

The immune-acquired responses after vaccination vary depending on the type of vaccine and the individual. The purpose of this study was to investigate the relationship between the acquisition of immunity and the side effects, health status, and lifestyle after completion of the second dose of AZD1222. Blood samples were collected after a second dose of AZD1222. The Euroimmun Anti-SARS-CoV-2 ELISA (IgG) for anti-S1 antibody, the cPASS SARS-CoV-2 neutralizing antibody detection kit for the surrogate virus neutralization test, and the T-spot Discovery SARS-CoV-2 kit were used to identify cellular immunogenicity. Patient experience of adverse effects was investigated using questionnaires. Information on health status and lifestyle were collected from the most recent health checkup data. Generally, females experience more reactogenicity in both intensity and duration. The rash of the first shot and chills of the second shot were associated with humoral immunity. However, comprehensive adverse effects had no correlation with humoral and cellular immunity. The T-spot-positive group had a higher creatinine level, which reflects muscle mass, than the T-spot-negative group. Males presented a higher level of T-spot assays. Body mass index and age were negatively correlated with the T-spot assay and anti-S1 antibody, respectively. Immune acquisition after the second AZD1222 shot was not associated with reactogenicity. However, individuals’ sex, age, and BMI were found to be associated with immunogenicity after vaccination.

2020 ◽  
Vol 9 (2) ◽  
pp. 72-89
Author(s):  
Philippe Sarnin ◽  
Christine Durif-Bruckert ◽  
Sabrina Rouat

The purpose of this paper is to report, from a qualitative study, the individual and organizational factors andprocesses that lead an employee to build a unique relationship to is health. We discuss these processes in relationto the construction of health among a sample of 34 „workers” selected in diverse contexts, considering health asa dynamic and co-constructed object. From biographical interviews and records of interactions between workersand professionals who support them, we analyze we analyze the transactions made between work and health.These transactions, which are defined in dynamic and combined processes (psychological, cognitive, interactiveand organizational), contribute to define the orientation of the relationship to work, the professional route, anddetermine the evolution of more objective health status and how it can be seen, lived and managed individually.This article examines three different contexts: small business employees, employees of a large firm, and job seekers.These three contexts are related with different types of strategies implemented by individuals on their healthin relation to their position in the world of work.


Homeopathy ◽  
2021 ◽  
Vol 110 (01) ◽  
pp. 067-069
Author(s):  
Fernanda Maria Simões da Costa Fujino ◽  
Ana Amélia Campos Claro Olandim ◽  
Vagner Doja Barnabé ◽  
Jennifer Anne Coggan ◽  
Nilson Roberti Benites

AbstractCOVID-19 (coronavirus disease 2019) may present variable symptoms among infected individuals, with chronic disease patients appearing as the group most susceptible to present severe pulmonary infection, while having a higher risk of developing complications from the disease. This study demonstrates the relationship between the manifestation of COVID-19 and the presence of chronic miasmatic disease, based on the works of Samuel Hahnemann. The reaction of the individual who previously presented chronic miasmatic disease, when in contact with the stimulus of the epidemic disease, depends on the type of response that the organism was generating in the face of the pre-existing situation: if it is an intense reaction and greater than that which the stimulus of COVID-19 can generate, this individual will not develop the severe form of the epidemic disease; if the reaction is less than that generated by COVID-19, more intense symptoms may appear. Understanding that the presence of a chronic miasmatic disease interferes with the manifestation of COVID-19, which may have repercussions on other organs, can change how one must act on the treatment, as this can alter the individual's health status.


2021 ◽  
Vol 11 (7) ◽  
pp. 627
Author(s):  
Jeanne Perrot ◽  
Jean-François Hamel ◽  
Antoine Lamer ◽  
Mathieu Levaillant

Mostly studied at the individual level, the analysis of immigrants’ health status at a populational level may provide a different perspective to investigate, including social determinants as part of the explanation of the relationship between them and health status in France. We analyzed freely accessible databases curated by French public bodies. The dependent variables were death rate and mean age at death. Immigrant rate and covariates associated with either of the outcomes were explored in univariate and multivariate models. Linear models were used to explain the mean age at death, whereas tobit models were used to explain the death rate. The immigrant rate varied markedly from one department to another, as did healthcare accessibility, population’s age profile, and economic covariates. Considering univariate models, almost all the studied covariates were significantly associated with comes. The immigrant rate was associated with a lower death rate and a lower age at death. In multivariate models, the immigrant rate was no longer associated with age at death but was still negatively associated with the death rate. In France, the departments with a higher proportion of immigrants were those with a lower death rate, possibly because immigrants are attracted to economically thriving areas.


2018 ◽  
Vol 1 (1) ◽  
pp. 296-302
Author(s):  
Sri Supriyantini ◽  
Khirzun Nufus

Untuk meraih gelar sarjana di perguruan tinggi, mahasiswa diwajibkan untuk menyelesaikan tugas akhir skripsi. Umumnya mahasiswa diberikan waktu untuk penyusunan skripsi selama 1 semester atau kuranglebih 6 bulan. Namun banyak mahasiswa yang memerlukan waktu lebih dari enam bulan untuk mengerjakan skripsi[5]. Hal ini berakibat pada masa studi mahasiswa yang menjadi lebih lama dari yang seharusnya. Salah satu faktor yang menyebabkan keterlambatan mahasiswa dalam menyusun skripsi adalah prokrastinasi akademik. Prokrastinasi akademik ini terkait dengan self efficacy yang dimiliki mahasiswa. Penelitian ini merupakan penelitian korelasional yang bertujuan untuk mengetahui hubungan antara self efficacy dengan prokrastinasi akademik pada mahasiswa Universitas Sumatera Utara yang sedang menyusun skripsi. Menurut Steel (2007) prokrastinasi adalah menunda dengan sengaja kegiatan yang diinginkan walaupun individu mengetahui bahwa perilaku penundaan tersebut dapat menghasilkan dampak buruk. Prokrastinasi akademik merupakan prokrastinasi yang terjadi pada bidang akademik. Prokrastinasi yang dilakukan berkaitan dengan menunda untuk memulai dan menyelesaikan skripsi. Prokrastinasi akademik berkaitan dengan keyakinan dari dalam diri mahasiswa akan kemampuan yang dimiliki untuk mengerjakan tugas (dalam hal ini adalah penyusunan skripsi). Keyakinan seseorang akan kemampuannya oleh Bandura (2001) disebut sebagai self efficacy. Sampel penelitian ini adalah 307 mahasiswa USU yang sedang menyusun skripsi. Data diambil dengan menggunakan skala self efficacy yang disusun berdasarkan dimensi- dimensi self efficacy [1] dan skala prokrastinasi akademik berdasarkan aspek-aspek prokrastinasi akademik [6]. Hasil analisa data menunjukkan adanya hubungan negatif antara self efficacy dengan prokrastinasi akademik pada mahasisa USU yang sedang menyusun skripsi (r = -0.335, p = 0.000).   To get a bachelor's degree in college, students are required to complete the thesis final assignments. Generally, students are given time for the preparation of a thesis for 1 semester or approximately 6 months. But many students need more than six months to work on a thesis [5]. This results in the study period of students becoming longer than they should. One of the factors that causes student delays in preparing a thesis is academic procrastination. Academic procrastination is related to student self-efficacy. This research was a correlational study that aimed to determine the relationship between self-efficacy and academic procrastination in University of Sumatera Utara students who were preparing a thesis. According to Steel (2007) procrastination is to deliberately delay the desired activity even though the individual knows that the delaying behavior can produce adverse effects. Academic procrastination is procrastination that occurs in the academic field. Procrastination is carried out in connection with delaying starting and completing a thesis. Academic procrastination is related to the confidence in the student's ability to do the task (in this case the preparation of the thesis). A person's belief in his ability by Bandura (2001) is referred as self-efficacy. The sample of this study was 307 USU students who were preparing a thesis. Data were taken using the scale of self-efficacy which was compiled based on the dimensions of self-efficacy [1] and the scale of academic procrastination based on aspects of academic procrastination [6]. The results of data analysis showed a negative relationship between self-efficacy and academic procrastination of USU's students who were preparing a thesis (r = -0.335, p = 0.000).


2020 ◽  
Author(s):  
Yiying Yang ◽  
Xiaoxia Zuo ◽  
Huali Zhang ◽  
Hui Luo ◽  
Sijia Liu

Abstract Background: To explore the relationship between anti-MDA5 antibody and clinical manifestations of dermatomyositis(DM) and to explain the correlation of prognosis as well. Methods: Retrospective analysis was performed at the Department of Rheumatology and Immunology in Xiangya Hospital, Central South University from April 2017 to February 2019. The clinical data were collected from 109 patients with DM, and then the patients were divided into anti-MDA5 antibody positive group and negative group according to the results of antibody detection, after which statistical analysis was carried out with SPSS 23.0 software.Results: Among the 109 DM patients, the ratio of male to female is 1:2.3, with 58 positive anti-MDA5 antibody and 51 negative anti-MDA5 antibody. There is no difference in gender and age between the two groups, and patients with positive anti-MDA5 have a shorter course. The incidence of clinical symptoms, including Gottron sign, skin ulcer, joint pain, joint swelling, nail erythema, dyspnea, and cough in patients with anti-MDA5-positive DM is significantly higher than those in the anti-MDA5-negative group. Anti-MDA5 antibodies are inversely associated with tumorigenesis. Patients with anti-MDA5-positive DM have less elevation of muscle enzymes and are prone to ILD and RPILD, while patients with anti-MDA5-positive DM have a high mortality rate and poor prognosis.Conclusion: Combined with RP-ILD, the prognosis of DM is poor. When patients have these clinical manifestations and positive MDA5, they must actively undergo lung imaging examination and be alert to RP-ILD.


2022 ◽  
Vol 9 (1) ◽  
pp. 36-37
Author(s):  
Howard Stuart

This abstract serves to introduce a 10 minute video in which I will discuss issues pertaining to the structure of the healthcare system in Quebec. At the same time I will review the concept of community within and around that system. The relationship and interplay between the two will be explored in the hope that the viewer might find resonance and meaning, and perhaps a springboard to further reflection and conversation. Many perceive a need for change in both the organizational systems as well as in the existing cultures within healthcare institutions, both in and outside of Quebec. Yet we often feel powerless to act. I will touch upon ideas on how we can make a difference using our individual influence to bring about the changes we seek. The concepts under discussion are abstract. In the hope of creating a greater degree of tangibility, I will offer a metaphor – namely the long-term detrimental effects brought about by the disruption, and in many cases destruction, of vibrant North American communities, caused by the building of highways straight through their hearts. I will suggest that though there may have been benefits to the society as a whole arising from the building of those highways, the adverse effects extended well beyond the individual communities involved. With this metaphor in mind, I will present the argument that the current structure of healthcare in Quebec, brought into effect in 2015, has resulted in over-bureaucratization and “decommunitization”, with a consequent diminution in the presence and role of culture, ultimately representing a loss for the community at large. Unintended deleterious societal effects arising from social system restructuring, are a phenomenon not unique to healthcare, nor to Quebec. It may take years for these consequences to become manifest, by which time they may prove difficult to reverse.


Author(s):  
Brynne D. Ovalle ◽  
Rahul Chakraborty

This article has two purposes: (a) to examine the relationship between intercultural power relations and the widespread practice of accent discrimination and (b) to underscore the ramifications of accent discrimination both for the individual and for global society as a whole. First, authors review social theory regarding language and group identity construction, and then go on to integrate more current studies linking accent bias to sociocultural variables. Authors discuss three examples of intercultural accent discrimination in order to illustrate how this link manifests itself in the broader context of international relations (i.e., how accent discrimination is generated in situations of unequal power) and, using a review of current research, assess the consequences of accent discrimination for the individual. Finally, the article highlights the impact that linguistic discrimination is having on linguistic diversity globally, partially using data from the United Nations Educational, Scientific and Cultural Organization (UNESCO) and partially by offering a potential context for interpreting the emergence of practices that seek to reduce or modify speaker accents.


Crisis ◽  
2016 ◽  
Vol 37 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Meshan Lehmann ◽  
Matthew R. Hilimire ◽  
Lawrence H. Yang ◽  
Bruce G. Link ◽  
Jordan E. DeVylder

Abstract. Background: Self-esteem is a major contributor to risk for repeated suicide attempts. Prior research has shown that awareness of stigma is associated with reduced self-esteem among people with mental illness. No prior studies have examined the association between self-esteem and stereotype awareness among individuals with past suicide attempts. Aims: To understand the relationship between stereotype awareness and self-esteem among young adults who have and have not attempted suicide. Method: Computerized surveys were administered to college students (N = 637). Linear regression analyses were used to test associations between self-esteem and stereotype awareness, attempt history, and their interaction. Results: There was a significant stereotype awareness by attempt interaction (β = –.74, p = .006) in the regression analysis. The interaction was explained by a stronger negative association between stereotype awareness and self-esteem among individuals with past suicide attempts (β = –.50, p = .013) compared with those without attempts (β = –.09, p = .037). Conclusion: Stigma is associated with lower self-esteem within this high-functioning sample of young adults with histories of suicide attempts. Alleviating the impact of stigma at the individual (clinical) or community (public health) levels may improve self-esteem among this high-risk population, which could potentially influence subsequent suicide risk.


Author(s):  
Emma Simone

Virginia Woolf and Being-in-the-world: A Heideggerian Study explores Woolf’s treatment of the relationship between self and world from a phenomenological-existential perspective. This study presents a timely and compelling interpretation of Virginia Woolf’s textual treatment of the relationship between self and world from the perspective of the philosophy of Martin Heidegger. Drawing on Woolf’s novels, essays, reviews, letters, diary entries, short stories, and memoirs, the book explores the political and the ontological, as the individual’s connection to the world comes to be defined by an involvement and engagement that is always already situated within a particular physical, societal, and historical context. Emma Simone argues that at the heart of what it means to be an individual making his or her way in the world, the perspectives of Woolf and Heidegger are founded upon certain shared concerns, including the sustained critique of Cartesian dualism, particularly the resultant binary oppositions of subject and object, and self and Other; the understanding that the individual is a temporal being; an emphasis upon intersubjective relations insofar as Being-in-the-world is defined by Being-with-Others; and a consistent emphasis upon average everydayness as both determinative and representative of the individual’s relationship to and with the world.


2016 ◽  
pp. 45-49
Author(s):  
P.N. Veropotvelyan ◽  
◽  
I.S. Tsehmistrenko ◽  
N.P. Veropotvelyan ◽  
N.S. Rusak ◽  
...  

Was to conduct a systematic review of data on the relationship between polymorphisms genes of detoxification system and development of preeclampsia (РЕ). Рresents the main genes of detoxification system (GSTPI, GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) and their functions. Of interest is the possibility of calculating the individual risk of PE based on the results about the presence of a combination of different polymorphisms in the genotype of the female. Question about early diagnosis of РЕ remains controversial and not fully understood. It is necessary to conduct further in-depth, extended study of this problem. Key words: preeclampsia, oxidative stress, genes of the detoxification system.


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