On the possibilities of digitalization of the design of specialized food products

2021 ◽  
pp. 599-602
Author(s):  
V.P. Karagodin
Keyword(s):  
Clinical Trials ◽  
Food Products ◽  
Foreseeable Future ◽  
Russian Market ◽  
New Approaches ◽  
Current State ◽  
Individual Consumption

The main problem of the Russian market of specialized food products (SFP) is the lack of reliably confirmed data on their efficacy. Most likely, due to the duration and high cost of clinical trials, this situation will continue in the foreseeable future. However, it seems that the current state of science makes it possible to propose new approaches to confirming the SFP effectiveness, including at the level of individual consumption.

Analytical measurements in food examination

2020 ◽  
pp. 38-41
Author(s):  
Sergey Khurshudyan ◽  
E. Lazareva ◽  
Anastasia Ryabova ◽  
Yu. Mikhaylova
Keyword(s):  
Continuous Improvement ◽  
Historical Context ◽  
Food Products ◽  
Quality And Safety ◽  
Analytical Instruments ◽  
New Approaches ◽  
Analytical Measurements ◽  
Product Identification ◽  
Food Market ◽  
Domestic Food

The process of formation and continuous improvement of methods for assessing the quality and safety of food products using analytical instruments to expose the increasingly sophisticated falsification of food products in the domestic food market can be traced in the historical context. In this article, you can learn about new approaches to product identification.

Analysis of the Market, Regulatory Landscape, and Current State of Clinical Trials Pertaining to Digital Health

2018 ◽  
Vol 5 (1) ◽  
pp. 21-34
Author(s):  
Cheyenne E. Allenby ◽  
Eric S. Babiash ◽  
Patrick N. Blank ◽  
Marco D. Carpenter ◽  
Isabelle G. Lee ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Digital Health ◽  
Current State ◽  
Regulatory Landscape

scholarly journals Novel immune checkpoints beyond PD-1 in advanced melanoma

2021 ◽  
Author(s):  
Nina Zila ◽  
Christoph Hoeller ◽  
Verena Paulitschke
Keyword(s):  
Clinical Trials ◽  
Checkpoint Inhibitors ◽  
Short Review ◽  
Therapy Resistance ◽  
Advanced Melanoma ◽  
Immune Checkpoints ◽  
Malignant Diseases ◽  
Foreseeable Future ◽  
Cell Responses ◽  
Therapeutic Landscape

SummaryIn malignant diseases, targeting of immune checkpoints successfully changed the therapeutic landscape and helped to unleash anti-tumor T cell responses, resulting in durable clinical outcomes, but only in up to 50% of patients. The success of these therapies and the need to overcome intrinsic and acquired therapy resistance stimulated research to identify new pathways and targets. Numerous clinical trials are currently evaluating novel checkpoint inhibitors or recently developed strategies like modulating the tumor microenvironment, mostly in combination with approved therapies. This short review briefly discusses promising therapeutic targets, currently still under investigation, with the chance to realize clinical application in the foreseeable future.

scholarly journals Conceptual Framework to Support Clinical Trial Optimization and End-to-End Enrollment Workflow

2019 ◽  
pp. 1-10 ◽  
Author(s):  
Neha M. Jain ◽  
Alison Culley ◽  
Teresa Knoop ◽  
Christine Micheel ◽  
Travis Osterman ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Knowledge Representation ◽  
Conceptual Framework ◽  
Trial Design ◽  
Clinical Trial Design ◽  
Prospective Clinical Trial ◽  
Future Trends ◽  
Current State ◽  
Evaluation Strategies

In this work, we present a conceptual framework to support clinical trial optimization and enrollment workflows and review the current state, limitations, and future trends in this space. This framework includes knowledge representation of clinical trials, clinical trial optimization, clinical trial design, enrollment workflows for prospective clinical trial matching, waitlist management, and, finally, evaluation strategies for assessing improvement.

scholarly journals The United States’ Regulatory Environment Is Evolving to Accommodate a Coming Boom in Gene Therapy Research

2019 ◽  
Vol 24 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Daniel Eisenman
Keyword(s):  
United States ◽  
Gene Therapy ◽  
Clinical Trials ◽  
The United States ◽  
Regulatory Environment ◽  
Evidence Based ◽  
Regulatory Structure ◽  
Regulatory Changes ◽  
Current State ◽  
Therapy Field

Introduction: A dramatic increase in the number of clinical trials involving gene-modified cell therapy and gene therapy is taking place. The field is on the verge of a boom, and the regulatory environment is evolving to accommodate the growth. Discussion: This commentary summarizes the current state of the field, including an overview of the growth. The United States (US) regulatory structure for gene therapy will be summarized, and the evolution of the oversight structure will be explained. Conclusion: The gene therapy field has recently produced its first FDA-approved therapeutics and has a pipeline of other investigational products in the final stages of clinical trials before they can be evaluated by the FDA as safe and effective therapeutics. As research continues to evolve, so must the oversight structure. Biosafety professionals and IBCs have always played key roles in contributing to the safe, evidence-based advancement of gene therapy research. With the recent regulatory changes and current surge in gene therapy research, the importance of those roles has increased dramatically.

RUSSIAN MARKET OF PROFESSIONAL MOBILE RADIO AND CRITICAL COMMUNICATIONS: CURRENT STATE, PROBLEMS, PROSPECTS

2021 ◽  
Author(s):  
О.А. ШОРИН ◽  
Р.Ю. КАСПАРИ
Keyword(s):  
Information Transmission ◽  
Communication Networks ◽  
Communication Technology ◽  
Mobile Radio ◽  
Radio Communication ◽  
Russian Market ◽  
Critical Information ◽  
Current State ◽  
Telecommunications Market

Рассмотрены характеристики и аудитория сетей профессиональной радиосвязи и критических коммуникаций. Проведен анализ используемых в России технологий профессиональной радиосвязи и перспектив развития данного сегмента телекоммуникационного рынка, произведена оценка его объемов в пятилетней перспективе. Показано, что внедряемая технология широкополосной профессиональной связи МАКВИЛ не только решает назревшие проблемы, связанные с модернизацией морально и физически устаревших систем ведомственной и корпоративной транкинговой связи, но и открывает новые возможности роста рынка услуг передачи критически важной информации. The characteristics and audience of professional mobile radio and critical communication networks are reviewed. The analysis of professional mobile radio technologies used in Russia and the prospects for the development of this segment of the telecommunications market is carried out, as well as its volume is estimated in the five-year perspective. It is shown that McWiLL broadband professional radio communication technology not only solves the urgent problems associated with the modernization of morally and physically obsolete systems of departmental and corporate trunking communications, but also opens up new opportunities for the growth of the market for critical information transmission services.

Free radical peroxidation and natural antioxidants

2021 ◽  
pp. 36-44
Author(s):  
Oksana Anatolievna Gizinger ◽  
V. A. Dadali
Keyword(s):  
Free Radical ◽  
Antioxidant Status ◽  
Natural Antioxidants ◽  
Food Products ◽  
Nutritional Deficiency ◽  
The Body ◽  
Current State

Modern food products provide no more than 5-6% of the body's need for micronutrients, many of which are antioxidants. The current state of the problem of nutritional deficiency predetermines a chronic long-term deficiency of antioxidants in the diet. Providing the body with balanced polyvalent antioxidant complexes and normalizing its antioxidant status is the basis of health and active longevity.

scholarly journals Status Quo and Trends of Intra-Arterial Therapy for Brain Tumors: A Bibliometric and Clinical Trials Analysis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1885
Author(s):  
Julian S. Rechberger ◽  
Frederic Thiele ◽  
David J. Daniels
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Brain Tumors ◽  
Phase 1 ◽  
Citation Count ◽  
Tumor Therapy ◽  
The United States ◽  
Blood Brain Barrier Disruption ◽  
Current State ◽  
Brain Barrier Disruption

Intra-arterial drug delivery circumvents the first-pass effect and is believed to increase both efficacy and tolerability of primary and metastatic brain tumor therapy. The aim of this update is to report on pertinent articles and clinical trials to better understand the research landscape to date and future directions. Elsevier’s Scopus and ClinicalTrials.gov databases were reviewed in August 2021 for all possible articles and clinical trials of intra-arterial drug injection as a treatment strategy for brain tumors. Entries were screened against predefined selection criteria and various parameters were summarized. Twenty clinical trials and 271 articles satisfied all inclusion criteria. In terms of articles, 201 (74%) were primarily clinical and 70 (26%) were basic science, published in a total of 120 different journals. Median values were: publication year, 1986 (range, 1962–2021); citation count, 15 (range, 0–607); number of authors, 5 (range, 1–18). Pertaining to clinical trials, 9 (45%) were phase 1 trials, with median expected start and completion years in 2011 (range, 1998–2019) and 2022 (range, 2008–2025), respectively. Only one (5%) trial has reported results to date. Glioma was the most common tumor indication reported in both articles (68%) and trials (75%). There were 215 (79%) articles investigating chemotherapy, while 13 (65%) trials evaluated targeted therapy. Transient blood–brain barrier disruption was the commonest strategy for articles (27%) and trials (60%) to optimize intra-arterial therapy. Articles and trials predominately originated in the United States (50% and 90%, respectively). In this bibliometric and clinical trials analysis, we discuss the current state and trends of intra-arterial therapy for brain tumors. Most articles were clinical, and traditional anti-cancer agents and drug delivery strategies were commonly studied. This was reflected in clinical trials, of which only a single study had reported outcomes. We anticipate future efforts to involve novel therapeutic and procedural strategies based on recent advances in the field.

scholarly journals Vegetable growing in Azerbaijan in modern conditions

2020 ◽  
pp. 65-68
Author(s):  
H. G. Huseynov ◽  
I. G. Jafarov ◽  
Mink Vermeer ◽  
F. B. Musaev
Keyword(s):  
Vegetable Production ◽  
Agricultural Producers ◽  
Russian Market ◽  
Foreign Companies ◽  
Current State ◽  
Vegetable Seed ◽  
Traditional Sector ◽  
Production Area ◽  
The Republic ◽  
Further Development

Relevance. Vegetable growing is a traditional sector of agriculture in Azerbaijan. The republic has all the conditions for its development, both natural and socio-economic. Materials and methods. The aim of the research was to analyze the current state of vegetable growing in the republic, to identify the strengths and weaknesses of the industry, to determine the terms of support for producers from the state and branch science. Results. The gross harvest of vegetables has been steadily growing in the last decades, and by 2019 amounted to 1715 thousand tons. The yield of vegetables also increased during this period from 14, 7 to 21.9 t / ha. In door production area is approximately 4800 ha. The production of greenhouse vegetables is focused on the Russian market. The bottleneck in the industry is vegetable seed production, a market with a capacity of almost 20 million euros is occupied by foreign companies. At the same time, the agricultural producers get state support in the form of subsidies and soft loans and a full tax exemption. Industry science is also developing: the Research Institute of Vegetable Production has been reconstructed and fully equipped, special training organized for vegetable growers in the Azerbaijan State Agrarian University. Further development of the industry continues through the intensification and biologization of production, expanding the range and improving product quality. 

Nanoceuticals as an Emerging Field: Current Status and Future Prospective

2021 ◽  
Vol 17 ◽  
Author(s):  
Reetu Malik ◽  
Jyoti Rathi ◽  
Deeksha Manchanda ◽  
Manish Makhija ◽  
Deepshikha Kushwaha ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Biological Activities ◽  
Food Products ◽  
The Body ◽  
Current Status ◽  
Target Cells ◽  
Food Ingredients ◽  
Novel Foods ◽  
Quality Of Food

Background: The safety and quality of food has been a matter of great discussion throughout the centuries and the application of nanotechnology in the field of nutraceuticals i.e. nanoceuticals has improved the variety and protection of food products in many ways. Objective: Improving the quality and safety of the food products with a view to improve public health and the invasion of nanotechnological advancements in the area of nutrition has resulted in the expansion of novel foods with improved oral bioavailability as well as thermal stability. The main objective of this review is to summarize available literature on nanoceuticals including patents and clinical trials. Method: The review was extracted from the searches performed at PubMed, Google Patents and Google Scholars, etc. Data from these searches was collected and evaluated for getting the information about the available literature on the nanoceuticals. Along with this, some reported patents have also been included in this review in order to conclude the future of nanoceuticals. Result: The literature so obtained was studied thoroughly as per the requirement of the objective of this review. The details of nanoceuticals including major applications, regulatory aspects, some reported patents and clinical trials are compiled here in this review. Nanoceuticals like vitamins, antibiotics, bioactive peptides, probiotics etc., which are dispersed, absorbed or incorporated in nano diameter range sacs, having improved solubility, delivery properties, biological activities, protection against degradation and therefore having improved biological activities and delivery to the target cells and tissues in the body. Different regulations from various countries recommended that any food ingredients which results from the use of nanotechnologies must undergo safety risk assessment standards before entering into the market as nano-food. Conclusion: The idea of “nanoceuticals” is increasing enthusiasm and marketable dairy/food and food supplements. This article focuses on the history, applications, regulation aspects, patents, clinical trials and future prospects of nanoceuticals.

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