Rationale for using nutrient complexes with vitamin and mineral compositions in rehabilitation schemes for patients who have undergone viral infections (literature review)

2021 ◽  
pp. 20-36
Author(s):  
Oksana A. Gizinger
Keyword(s):  
Folic Acid ◽  
Literature Review ◽  
Glycyrrhizic Acid ◽  
Viral Infections ◽  
Food Supplements ◽  
Biologically Active ◽  
Important Link ◽  
Mineral Compositions ◽  
Rehabilitation Measures

The results of the previous studies have shown that the use of nutrient complexes with vitamin and mineral compositions in rehabilitation schemes for patients who have undergone viral infections, including COVID-19, is an important link in rehabilitation measures and post COVID-19. The article pathogenetically substantiates the use of biologically active food supplements containing vitamins A, D3, E, C, B1, B2, B3, B5, B6, folic acid, zinc, vanadium, catechins, proanthocyanidins, flavonoids and glycyrrhizic acid.

Glycyrrhizic acid derivatives as new antiviral and immune modulate agents

2020 ◽  
Vol 16 ◽  
Author(s):  
Lidia Baltina ◽  
Rimma Kondratenko
Keyword(s):  
Influenza A ◽  
Glycyrrhizic Acid ◽  
Viral Infections ◽  
Biologically Active ◽  
New Drugs ◽  
Licorice Root ◽  
Primary Immune Response ◽  
Amino Sugars ◽  
Biological Studies ◽  
Influenza A H1n1

: A search of new drugs for the treatment of viral infections and immune deficiencies of various etiologies is still one of the most important tasks of medicinal chemistry, pharmacy and medicine due to the wide spread of a number socially dangerous viral infections. This review is devoted to the chemical modification of Glycyrrhizic acid, the main component of licorice root, which is currently a leading natural glycoside promising as a basis for creation of new antiviral agents. The review presents the results of studies conducted over the past 15 years to obtain a library of Glycyrrhizic acid derivatives for biological studies and search of lead compounds. The synthesis of new biologically active derivatives and analogues (conjugates with amino acids and dipeptides, amino sugars, licorice triterpene acids conjugates with amino sugars, saponins and mono glycosides, heterocyclic amides) was carried out , and their antiviral and immune modulate properties were studied. Potent inhibitors of HIV, SARS CoV, Epstein-Barr, influenza A/H1N1 viruses and stimulators of primary immune response were found among GL derivatives and analogues produced.

Innovative approaches to the correction of chronotrope status of pregnant and lactating women

2016 ◽  
pp. 37-40
Author(s):  
S.I. Zhuk ◽  
◽  
K.K. Bondarenko ◽  
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Active Form ◽  
Biologically Active ◽  
Lactating Women ◽  
Pathological Conditions ◽  
Prevention And Treatment ◽  
The Impact ◽  
High Bioavailability ◽  
Key Words Mthfr

Most recent studies show the impact of violations in the metabolism of folate and metin period in the pathogenesis of neural tube defects (NTD) of the fetus. Metafolin has a number of advantages, which primarily includes direct intake of substances in biologically active form and the optimum effect, even in the case when the patient homozygote and/or heterozygote genotype 677С T polymorphism in MTHFR. With the aim of prevention and treatment of various pathological conditions related to folate deficiency during pregnancy, it is advisable to apply vitamin-mineral complexes, containing metafolin - active form of folate with high bioavailability. Key words: MTHFR, metafolin, folic acid, pregnancy.

Exploring siRNA Umpired Nanogels: A Tale of Barrier Combating Carrier

2020 ◽  
Vol 26 (27) ◽  
pp. 3234-3250
Author(s):  
Sushil K. Kashaw ◽  
Prashant Sahu ◽  
Vaibhav Rajoriya ◽  
Pradeep Jana ◽  
Varsha Kashaw ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Engineering ◽  
Viral Infections ◽  
Slow Release ◽  
Molecular Level ◽  
Release Kinetics ◽  
Biologically Active ◽  
Release Process ◽  
Rapid Release ◽  
Wide Range

Potential short interfering RNAs (siRNA) modulating gene expression have emerged as a novel therapeutic arsenal against a wide range of maladies and disorders containing cancer, viral infections, bacterial ailments and metabolic snags at the molecular level. Nanogel, in the current medicinal era, displayed a comprehensive range of significant drug delivery prospects. Biodegradation, swelling and de-swelling tendency, pHsensitive drug release and thermo-sensitivity are some of the renowned associated benefits of nanogel drug delivery system. Global researches have also showed that nanogel system significantly targets and delivers the biomolecules including DNAs, siRNA, protein, peptides and other biologically active molecules. Biomolecules delivery via nanogel system explored a wide range of pharmaceutical, biomedical engineering and agro-medicinal application. The siRNAs and DNAs delivery plays a vivacious role by addressing the hitches allied with chronic and contemporary therapeutic like generic possession and low constancy. They also incite release kinetics approach from slow-release while mingling to rapid release at the targets will be beneficial as interference RNAs delivery carriers. Therefore, in this research, we focused on the latest improvements in the delivery of siRNA loaded nanogels by enhancing the absorption, stability, sensitivity and combating the hindrances in cellular trafficking and release process.

Is Intake of Flavonoid-Based Food Supplements During Pregnancy Safe for the Developing Child? A Literature Review

2016 ◽  
Vol 18 (2) ◽  
pp. 196-231 ◽  
Author(s):  
Marta Barenys ◽  
Stefan Masjosthusmann ◽  
Ellen Fritsche
Keyword(s):  
Literature Review ◽  
Food Supplements

scholarly journals New pharmacological means of radiation protection (literature review)

2019 ◽  
Author(s):  
Nataliya Uzlenkova
Keyword(s):  
Bone Marrow ◽  
Ionizing Radiation ◽  
Literature Review ◽  
Radiation Exposure ◽  
Progenitor Cells ◽  
Radiation Protection ◽  
Acute Radiation ◽  
Biologically Active ◽  
Pharmacological Agents ◽  
Methodological Approaches

The review systematized the current data on new classes of pharmacological compounds and biologically active substances in the field of radiation protection in Ukraine, as well as abroad. Methodological approaches and the importance of using appropriate animal models in the development of new pharmacological drugs for radiation protection are described, specifically in the cases when it is impossible to conduct full clinical trials on patients. Current views on the division of pharmacological agents into radioprotectors, radiomitigators, and therapeutic radiation protection agents are examined. The changes in the hematopoietic tissue, gastrointestinal tract and neurovascular system that occur after acute radiation exposure are also described. Particular attention is paid to pharmacological agents that can protect against acute exposure to ionizing radiation by limiting the risk of radiation mortality from the hematological and gastrointestinal forms of radiation syndrome. Results of the effectiveness of tolerant antioxidants with a wide spectrum of biological activity as promising agents for the prevention of acute and delayed radiation-induced pathology, in particular, in lung tissue, are presented. Possible molecular mechanisms of the radioprotective effect of pharmacological compounds on experimental models of total and local radiation exposure are discussed. The effectiveness of the therapeutic use of growth factors and recombinant cytokines in acute bone marrow suppression аfter accidental radiation exposure is shown. The possibilities of cell therapy with myeloid progenitor cells mobilized by tocopherol succinate hematopoietic/progenitor cells and bone marrow mesenchymal stromal cells in acute radiation injuries are shown. Special attention is paid to the importance of improving such methodological approaches and regulatory requirements when introducing into practice new radiation protection facilities in Ukraine. Key words: radiation protection, ionizing radiation, pharmacological agents, acute radiation syndrome. For citation: Uzlenkova NE. New pharmacological means of radiation protection (literature review). Journal of the National Academy of Medical Sciences of Ukraine. 2019;25(3) :268–77

scholarly journals Relevance of folic acid fortification of foods in the nutrition of women and children

1999 ◽  
Vol 17 (No. 1) ◽  
pp. 35-39
Author(s):  
R. Uherova ◽  
M. Horkulicova ◽  
M. Mikusova
Keyword(s):  
Folic Acid ◽  
Essential Amino Acids ◽  
Biologically Active ◽  
Free Form ◽  
Biological Processes ◽  
Folic Acid Fortification ◽  
The Past ◽  
Hydrophilic Character ◽  
Women And Children ◽  
Growth And Reproduction

Folic acid and its biologically  active derivates  (folacin  or folates)  rank among  the B-group  vitamins  due to their  hydrophilic character. This acid occurs in nature either in the free form or it is bound to proteins or polysaccharides. Folic acid belongs to the group of vitamins which, in the past were not considered important because the relevance of the acid in biological  processes of the living cell has been discovered  by the scientific  research only in recent years. Folates play an important role as co-enzymes in the synthesis of RNA, DNA, proteins and of some essential amino acids. Therefore they are inevitable for the haematopoiesis, growth and reproduction  of cells. In this sense a widely oriented  research  named "Maternal Folate Status" is proceeding  in the U.S.A., Australia and France.

Biologically active casein peptides implicated in immunomodulation

1989 ◽  
Vol 56 (3) ◽  
pp. 357-362 ◽  
Author(s):  
D. Migliore-Samour ◽  
F. Floc'h ◽  
P. Jollès
Keyword(s):  
Synthetic Peptides ◽  
Viral Infections ◽  
Milk Proteins ◽  
Biologically Active ◽  
Passive Immunity ◽  
Maternal Milk ◽  
Enzymic Digestion ◽  
Immunomodulating Peptides

SummaryMaternal milk should not only be considered as a nutrient, but also as a protecting agent against aggressions from the neonate's new environment. Breastfeeding facilitates transmission of a passive immunity by multifunctional factors which have a direct effect on the neonate's resistance to bacterial and viral infections. Among these factors are the main milk proteins, the caseins: during enzymic digestion of human and bovine caseins, immunomodulating peptides are released. Corresponding synthetic peptides stimulated in vitro phagocytic activity of murine and of human macrophages and exerted in vivo a protective effect against Klebsiella pneumoniae infection of mice. These data suggest that casein peptides may exert a stimulating function on the immune system of the newborn.

scholarly journals Vitis vinifera L. Pruning Waste for Bud-Preparations as Source of Phenolic Compounds–Traditional and Innovative Extraction Techniques to Produce New Natural Products

Plants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2233
Author(s):  
Dario Donno ◽  
Federica Turrini ◽  
Raffaella Boggia ◽  
Maddalena Guido ◽  
Giovanni Gamba ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Vitis Vinifera ◽  
Extraction Methods ◽  
Food Supplements ◽  
Biologically Active ◽  
Vitis Vinifera L ◽  
Herbal Products ◽  
Sustainable Supply Chains ◽  
Phytochemical Composition ◽  
Chromatographic Fingerprints

Herbal products are now considered among the most important sources of phenolic compounds: the FINNOVER project aimed at the creation and development of sustainable supply chains to extract and use natural biologically active agents. Vitis vinifera is one of the most utilised herbal products derived from buds and sprouts as polyphenolic food supplements for its homeostatic and astringent properties. This research was aimed to describe the antioxidant capacity and the phytochemical composition of V. vinifera herbal products by the application of spectroscopic and chromatographic fingerprints considering phenolics as potential markers to significantly differentiate traditional preparations (macerates) from innovative extracts obtained by an ultrasound extraction from V. vinifera buds. Two different commercial products were also considered. Flavonols were the most abundant class in ultrasound extracts (45%), while phenolic acids were the most important class in traditional macerates (49%) and commercial bud-preparations (about 50%). This study may support the potential use of V. vinifera bud-products (starting from pruning byproducts) as food supplements to integrate human diet with good amounts of phenolics. Finally, the use of different extraction methods on the same plant material could be an important development to produce innovative herbal products with a phytochemical composition similar to traditional preparations.

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