Improving diagnostics of periodontal diseases in children with connective tissue dysplasia based on X-ray morphometric and densitometric data

2020 ◽  
Vol 25 (4) ◽  
pp. 266-275
Author(s):  
B. N. Davydov ◽  
D. A. Domenyuk ◽  
S. V. Dmitrienko ◽  
T. A. Kondratyeva ◽  
Yu. S. Harutyunyan
Keyword(s):  
Connective Tissue ◽  
Bone Tissue ◽  
Bone Structure ◽  
Periodontal Diseases ◽  
Healthy Children ◽  
Strong Positive Correlation ◽  
X Ray ◽  
Lower Jaw ◽  
Connective Tissue Dysplasia ◽  
Peripheral Skeleton

Relevance. Detection of maxillofacial pathomorphological changes in children with connective tissue dysplasia (CTD) allows identifying the nature and severity of disorders, as well as it serves the basis for selecting the best treatment options in view of the pathogenetic features. The purpose is to improve the diagnosis of periodontal diseases in children with CTD based on x-ray morphometric indices of the lower jaw and peripheral skeleton ultrasound osteodensitometry.Materials and methods. 92 children with varying CTD severity, and 43 healthy children, underwent cone-beam computed tomogram examination with a further analysis of their X-ray morphometric (quantitative, qualitative) values and the lower jaw optical density indices. Besides, the status of the peripheral skeleton bone tissue was also determined through quantitative ultrasonic densitometry.Results. Quantitative X-ray morphometric indices in healthy children and children with CTD revealed strong positive correlation with the Z-criterion of osteodensitometry, offering an objective reflection of the bone tissue status in the peripheral skeleton.Conclusion. CTD progression in children correlates with the bone structure destruction intensity in the maxillofacial area, an increase in chronic productive inflammation, a decrease in the bone density, bone tissue fibrous transformation, a decrease in the thickness of cortical, and fiber-dissociation in closing, plates, of the lower jaw, prevalence of mid- and fine-meshed bone pattern, disturbed spatial orientation and thinning of bone trabeculae, as well as the development of pathologies in the periodontium.

Cephalometric features of connective tissue dysplasia manifestation in children and adolescents

2020 ◽  
Vol 20 (3) ◽  
pp. 174-183 ◽  
Author(s):  
B. N. Davydov ◽  
D. A. Domenyuk ◽  
S. V. Dmitrienko ◽  
T. A. Kondratyeva ◽  
Yu. S. Harutyunyan
Keyword(s):  
Connective Tissue ◽  
Morphological Features ◽  
Short Branch ◽  
Lower Jaw ◽  
Carious Lesions ◽  
High Prevalence ◽  
Care Facilities ◽  
The Face ◽  
Connective Tissue Dysplasia ◽  
Brain Parts

Relevance. The high prevalence of dysplastic disorders involving connective tissue, and its negative effecton the development of dentoalveolar anomalies, carious and non-carious lesions of the teeth, periodontopathy, temporomandibular joint issues in the child population, lay the basis for improving diagnostics algorithms. Enhancing the already available standards is of greatest importance for children at the initial stages of diagnostics when evaluating the external signs of dysplastic disorders.Purpose – improving diagnostics algorithms for connective tissue dysplasia (CTD) in children in primary dental care facilities based on the evaluation of external phenotype signs and maxillofacial morphological features.Materials and methods. Depending on the external phenotype manifestations severity, as well as on laboratory, clinical and instrumental signs, the 92 children with CTD were divided into groups with mild, moderate and severe degrees of undifferentiated dysplasia. Gnathometric and biometric examinations of the maxillofacial area were performed through traditional methods, whereas the diagnosis was set following the generally accepted classifications. The diagnosis confirmation implied evaluation through cone beam computed imaging.Results. The nature and the intensity of morphofunctional disorders in the craniofacial structures (“small” stigmas) depend on the severity of connective tissue dysplastic disorders.Conclusions. The change direction vector in the facial and brain parts of cranium in children with CTD is aimed at increasing hypoplastic tendencies and dolichocephalia, proof to that being the following constitutional and morphological features: the prevalence of the vertical type of face skeleton growth over the horizontal and neutral ones; a convex face profile with a disproportionate general heights of the face skeleton; reduction of latitudinal with an increase in altitude facial parameters; a narrow short branch of the lower jaw; the upper jaw displaced downwards and forward; a decrease in the size of the apical basis of the lower dentition, the lower jaw body, as well as the height and width of the lower jaw branches. 

scholarly journals Dynamics of the mandible bone tissue condition after the dental implantation and shockwave therapy

Morphologia ◽  
2021 ◽  
Vol 15 (3) ◽  
pp. 175-179
Author(s):  
I.V. Chelpanova ◽  
O.Z. Masna-Chala ◽  
A.M. Yashchenko ◽  
Z.Z. Masna ◽  
Kh.I. Rudnytska
Keyword(s):  
Shock Wave ◽  
Bone Density ◽  
Bone Tissue ◽  
Bone Structure ◽  
Traumatic Injury ◽  
The Body ◽  
Maximum Pressure ◽  
Shock Wave Therapy ◽  
X Ray ◽  
Dental Implantation

Background. The problem of restoration the integrity of the dentition after tooth loss remains one of the most problematic dental issues. Мodern dental technologies open a promising direction in its solution, in particular - the method of dental implantation. Objective. The aim of our work was to study the changes that occur in the bone tissue of the mandible after implantation of titanium foam and to determine the effect of shock wave therapy (SWT) on its structure restoration. Methods. The study was performed on 15 adult rabbits aged 6-7 months, weighing 2.5-3 kg. The animals from the experimental groups were implanted with titanium pin, 3 mm long. The pin was implanted under combined anesthesia bilaterally into the body of the mandible. One day after the operation, the animals received SWT 500 pulses with a frequency of 5 Hz and a maximum pressure at the wavefront of 1.2 Bar per implantation site using the device Storz Medical Master Plus MP 100. The animals were removed from the experiment on 15-th day, after which the mandible was disarticulated and radiographically performed. The obtained results were statistically significant. The differences at p<0.05 were considered significant. Results. The results showed that the bone tissue of the jaws during implantation undergoes traumatic injury, the results of which, two weeks after surgery on radiographs we can clearly see a violation of the bone tissue structure and a significant increase in its density. Using the SWT method, we obtained a positive dynamics of bone density after titanium pin implantation and slight Rh-changes in bone structure compared with normal. Conclusion. Аfter implantation with titanium pin the bone density of the rabbit lower jaw body is significantly reduced, X-ray shows the heterogeneity of bone structure, areas of sclerosis are expressed. Shock wave therapy helps to restore the quality of bone tissue, this is confirmed by the fact that the density indicators are close to the norm and X-ray shows some separate small areas of restructuring of bone tissue heterogeneity, mainly due to merging the pattern of the bone trabeculae of the bone cancellous part.

scholarly journals Assessment of heart rate variability and tone of the autonomic nervous system in puberty-aged children with undifferentiated connective tissue dysplasia

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
O V Sidorovich ◽  
S Y U Elizarova ◽  
A V Khizhnyak ◽  
N A Kuznetsova ◽  
E E Prosova
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Connective Tissue ◽  
Control Group ◽  
Healthy Children ◽  
Autonomic Nervous ◽  
Connective Tissue Dysplasia ◽  
End Of Puberty

Abstract   Within the framework of the research into pathological conditions and syndromes associated with undifferentiated connective tissue dysplasia (UCTD), an emphasis needs to be placed on the changes in heart rhythm. In puberty, the severity of neurovegetative disorders caused by the presence of UCTD might increase manifold. The features of heart rate variability (HRV) in pubertal children against the background of UCTD have been studied insufficiently and require more detailed analysis. This study aims to assess heart rate variability and tone of the autonomic nervous system (ANS) in puberty-aged children with UCTD. Two groups of children were examined, with methods including electrocardiography and cardiointervalography. The main group consisted of 36 puberty-aged children with UCTD, the control group consisted of 30 healthy children. ANS tone was assessed based on the HRV. In the control group of children aged 11, the value of variation range (VR) was 0.18±0.4, mode amplitude (MA) 35.2±2.4, stress index (IN) 72.8±4.3, which corresponds to the state of vegetative balance. As the puberty progresses, the state of eutonia is replaced by the activation of the sympathetic division of the ANS, which becomes most pronounced at the age of 13 years. In the control group of children aged 13, the value of VR was 0.08±0.02, MA 61.7±2.1, SI 210.6±8.6, which corresponds to moderate sympathicotonia. By the end of puberty, in healthy children, the severity of sympathetic activation begins to decrease, and at the age of 15 years, vegetative balance is again observed. However, this pattern is violated in children with UCTD. Upon entering puberty, moderate activation of the sympathetic division of the ANS is already observed in children with UCTD. At the age of 11 years in this group, the value of VR is 0.06±0.02, MA 72.4±3.1, SI 211.2±8.6. At the age of 13, pronounced sympathicotonia is observed, which is confirmed by the values of VR - 0.04±0.01, MA 80.2±4.3 and SI 34.3±14.7. By the end of puberty in children with UCTD, in contrast to the control group, the analyzed parameters indicate not an equilibrium of the ANS, but the predominance of parasympathetic activation. The research provides an insight into heart rate variability in puberty-aged children with UCTD. It was established that healthy children enter puberty in a state of equilibrium of the autonomic nervous system, which in the middle of puberty is replaced by moderate sympathicotonia, and then returns to its original values. Children with the presence of UCTD enter puberty with moderately pronounced sympathicotonia, which gradually increases to pronounced values and is replaced by moderate vagotonia. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Meyer dysplasia in children’s connective-tissue disorders phenotype (the results of observation in the Municipal Children’s Polyclinic №2, Stavropol city)

2019 ◽  
Vol 26 (2) ◽  
pp. 32-36
Author(s):  
A. A Vorotnikov ◽  
D. Yu Zakota ◽  
G. A Saneeva ◽  
G. A Airapetov
Keyword(s):  
Connective Tissue ◽  
Detailed Examination ◽  
Diagnostic Methods ◽  
Connective Tissue Disorders ◽  
Hip Joints ◽  
Small Children ◽  
X Ray ◽  
Ultrasonic Examination ◽  
Clinical Presentations ◽  
Connective Tissue Dysplasia

Aim. The research of the prevalence, nosological structure, clinical presentations, and pathogenetic features of different forms of coxal epiphyseal pathology including Meyer dysplasia in small children based on the results of clinical and instrumental observation on outpatient orthopedic admission. Material and methods. In 12,000 children from 0 to 5 years, an orthopedic examination was conducted with an assessment of external dysmorphogenetic signs of connective tissue dysplasia, an ultrasonic examination of hip joints, an in-depth X-ray examination. The step-by-step examination algorithm was structured and detailed according to the presence and severity of the coxal region pathology, children’s age. Conclusion. The combination of dysplastic phenotype with joints formation inhibition in children aged 1 year is a predictor of Mayer’s dysplasia and must be the reason for a detailed examination of the hip joints with use of visual diagnostic methods.

scholarly journals Estimation of the proportionality of the physical development of children of the Khanty-Mansiysk autonomous district – Yugra with non-differentiated connective tissue displasion

2021 ◽  
Vol 12 (4) ◽  
pp. 27-33
Author(s):  
I. A. Shevnin ◽  
N. A. Ilyushchenko ◽  
O. N. Ragozin ◽  
O. V. Ragozin ◽  
N. V. Ermakova
Keyword(s):  
Connective Tissue ◽  
Average Length ◽  
Physical Development ◽  
The Body ◽  
Lower Limbs ◽  
Childhood And Adolescence ◽  
Healthy Children ◽  
The North ◽  
Connective Tissue Dysplasia ◽  
The Impact

Background. Assessment of the physical development of children in individual regions of the Russian Federation does not lose its relevance and requires constant updating, in this regard, it is important to study it in children adapting to the climatic and geographical conditions of the North, as well as the effect of undifferentiated connective tissue dysplasia on it. Aim. Aim of the study is to study the gender and age characteristics of the proportionality of physical development in children with undifferentiated connective tissue dysplasia living in the Khanty-Mansiysk Autonomous Okrug Yugra. Materials and methods. The analysis of physical development of 528 children of the second childhood and adolescence, living in the Khanty-Mansi Autonomous Okrug Yugra, was carried out. The study group consisted of 342 children (248 boys and 94 girls) with a diagnostically significant number of undifferentiated connective tissue dysplasia symptoms (from 6 to 18 stigmas). The comparison group included 186 children (111 boys and 75 girls) who did not score a significant threshold of phene signs (from 0 to 5 stigmas). Physical development was assessed according to the Quetelet II weight-height index, chest-weight indices: Pignet, Vervek, and Brugsch, as well as proportionality indices: sternum, shoulder width, pelvic width, torso shape, arm and leg length indices, cranial and facial indices, interorbital-circular index. Results. Children without undifferentiated connective tissue dysplasia during the second childhood have a tendency to malnutrition, and are characterized by a weak physique with a tendency to narrow chest. In adolescence, the tendency towards weakness of the physique persists, while height-weight ratios deviate towards normotrophy. Children with undifferentiated connective tissue dysplasia during the second childhood and adolescence have a rectangular or trapezoidal body with an average length, as well as long upper and lower limbs relative to the length of the body. Conclusion. The impact of the socio-ecological factors of the North neutralizes the differences in the rates of physical development in healthy children and persons with disorders caused by congenital disorders of organogenesis of the undifferentiated connective tissue dysplasia type.

scholarly journals CLINICAL-LABORATORY MARKERS OF FIBRILOGENESIS DISORDERS IN THE SEVERITY OF PYELONEPHRITIS IN CHILDREN

2018 ◽  
Vol 2 ◽  
pp. 30-38
Author(s):  
Natalia Lukyanenko ◽  
Mariana Iskiv
Keyword(s):  
Connective Tissue ◽  
Acute Pyelonephritis ◽  
Clinical Laboratory ◽  
Joint Hypermobility ◽  
Chronic Pyelonephritis ◽  
Control Group ◽  
Healthy Children ◽  
Laboratory Markers ◽  
Frequent Relapses ◽  
Connective Tissue Dysplasia

Aim of the research: to establish the role of undifferentiated connective tissue dysplasia, as a manifestation of violation of fibrillogenesis, in the severity of the course of pyelonephritis in children. 154 children with pyelonephritis from 3 to 18 years were examined. As a result of catamnestic surveillance, they were divided into 2 groups: I – 92 persons, children with chronic pyelonephritis in which were diagnosed 3 or more episodes of relapse of pyelonephritis during the year, and II – 56 children with acute pyelonephritis, in which during the year no relapses were noted. The control group were 65 somatically healthy children of the same age (III - health-control). All children had a routine comprehensive clinical and laboratory examination and clinical and laboratory markers of a fibrillogenic disorder were established. In children with chronic pyelonephritis, the frequency of all analyzed complaints was significantly higher than in children with acute pyelonephritis without relapses: frequent headaches – 56.52 % versus 25.0 %, appetite loss – 28.26 % vs. 19.64 %, frequent abdominal pain – 52.17 % vr. 32.14 %, increased fatigue – 41.30 % vr. 28.57 %. In children with chronic pyelonephritis, phenotypic signs of undifferentiated connective tissue dysplasia (UCTD) were significantly more marked, such as joint hypermobility (in 52.0 % of children versus 5.4 %), asthenic body structure (59.0 % vs. 26.78 %), visual disturbance (84.8 % vs. 32.14 %), chest deformity (42.4 % vs. 8.9 %), scoliosis (52.17 % vs 10.7 %), arachnodactyly and predisposition to bleeding were observed only in children of the 1st group (22.5 % and 4.34 % respectively). In practically all children with chronic pyelonephritis, the values of free and bound oxyproline fractions in blood plasma were significantly increased (47.14±0.03 μmol/l and 40.08±0.03 μmol/l, respectively), according to arithmetic meanings, reliably differing from the data of children with acute pyelonephritis (17.65±0.01 μmol/l and 17.22±0.02 μmol/l), in which these oxyproline fractions were elevated only in 12.0 % and 16.0 % of the subjects. In 97.0 % of children with chronic pyelonephritis, the level of oxyproline in urine was elevated and significantly exceeded the level of excretion of oxyproline in urine in children with acute pyelonephritis. The presence of UCTD in a child plays an important role in the process of chronic pyelonephritis, and children with its manifestations have a heavier course of disease with frequent relapses, therefore, the presence of signs UCTD is prognostically unsuccessful, which dictates the need for the appointment of metabolic therapy in the first episodes of the disease in children, if they have clinical and laboratory manifestations of UCTD.

scholarly journals The Use of Rentgenological Methods of Diagnostics in Surgical Treatment of Atrophy of the Alveolar Process of the Upper Jaw and Part of the Lower Jaw in Women of Postmenopausal Age

2018 ◽  
Vol 24 (2) ◽  
Author(s):  
Yurii I Solodzhuk ◽  
Mykola M Rozhko ◽  
Oleksanr G Denysenko ◽  
Iryna R Yarmoshuk
Keyword(s):  
Surgical Treatment ◽  
Bone Tissue ◽  
Bone Tissue Regeneration ◽  
Animal Origin ◽  
Alveolar Process ◽  
X Ray ◽  
Lower Jaw ◽  
Digital Format ◽  
Before And After ◽  
Upper Jaw

The objective of the study is to evaluate the condition of the alveolar part of the upper jaw and the part of the mandible according to X-ray studies in postmenopausal women before and after surgical treatment of the atrophy of jaw bone tissue using osteoplastic material and an ossein-hydroxyapatite compound. Materials and methods: There were observed 24 women in the postmenopausal period, aged from 51 to 58 years, with atrophy of the alveolar process of the upper jaw and the part of the lower jaw who were surgically treated. Results of the study. On the basis of the obtained results of the X-ray examination, we can assume that the developed by us technique of surgical treatment of atrophy of the alveolar process of the upper jaw and the part of the lower jaw by the use of bone material of animal origin in combination with the ossein-hydroxyapatite compound allows us to intensify bone tissue regeneration processes, which further will contribute to the increase of the volume of bone tissue. Conclusions. The use of modern X-ray methods, in particular orthopantomography and cone-beam computerized tomography in the diagnosis and surgical treatment of atrophy of the alveolar process of the upper jaw and the part of the lower jaw, are highly informative, and also provide the possibility of work with a roentgenographic image in a digital format that allows a more detailed assessment of the area of surgical intervention before and after the treatment.

scholarly journals BONE CHANGES IN JAWS AS A RESULT OF PRIMARY HYPERPARATHYROIDISM

2020 ◽  
Vol 23 (2) ◽  
pp. 80-84
Author(s):  
I. V. Kotova ◽  
M. E. Beloshitsky ◽  
V. G. Ignatuk
Keyword(s):  
Primary Hyperparathyroidism ◽  
Bone Structure ◽  
Cortical Layer ◽  
Coarse Grained ◽  
Facial Bones ◽  
Jaw Cysts ◽  
X Ray ◽  
Lower Jaw ◽  
Bone Changes ◽  
Upper Jaw

An analysis of bone changes in the jaws caused by primary hyperparathyroidism (PHPT) was performed based on the research and our own studies. Presented are the modern principles for the diagnosis of PHPT in patients undergoing treatment in maxillofacial clinics with recurrent epulids and jaw cysts. Variously expressed tumor jaw lesions were observed in 23 of 751 patients. 19 of them have the lower jaw, and 4 have the upper jaw tumors. Tumorous masses in 15 patients were caused by parathyroid adenoma, in 7 – by hyperplasia, in 1 – by cancer. The only clinical manifestation of hyperparathyroidism in 5 patients was a tumor-like mass of the upper jaw, in 1 – the lower one. Changes in the bone structure of jaws were found in PHPT patients who underwent orthopantomography, x-ray or computed tomography of the skull. In 26 of them, grainy and coarse-grained bone reconstruction was determined, in 9 – diffuse rarefaction of facial bones, in 10 – focal osteoclasia, in 21 – resorption of the closing plates of the dental alveoli, in 19 – subperiosteal resorption of the cortical layer of lower jaw. It was found that almost impossible to differentiate osteoblastoclastoma and hyperparathyroid osteodystrophy on a pathomorphological basis. In case of detected PHPT, first of all, the operation is performed on the parathyroid glands, and then the treatment strategy for jaw epulids is determined.

CLINICAL AND DIAGNOSTICS CRITERIA OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA IN CHILDREN WITH DEVELOPMENTAL DYSPLASIA OF THE HIP

2021 ◽  
Vol 100 (5) ◽  
pp. 69-75
Author(s):  
A.V. Sertakova ◽  
◽  
M.Ch. Timaev ◽  
S.A. Rubashkin ◽  
M.M. Dokhov ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Musculoskeletal System ◽  
Heart Valves ◽  
Joint Hypermobility ◽  
Developmental Dysplasia ◽  
Control Group ◽  
Healthy Children ◽  
Clinical Markers ◽  
Connective Tissue Dysplasia ◽  
Dysplasia Of The Hip

Developmental dysplasia of the hip (DDH) is characterized by varying degrees of underdevelopment of the hip joint (HJ) and para-articular tissues with numerous variants of clinical and anatomical criteria. It is now considered one of the manifestations of undifferentiated connective tissue dysplasia (UCTD), which is confirmed by genetic testing. Undoubtedly, children with DDH also have other manifestations of UCTD, the clinical combination of which must be taken into account for the overall prognosis of the patient's quality of life, as well as the determination of control points in the treatment and prevention of the disease. Materials and methods of research: a singlestage observational screening study was carried out involving 785 children (578 girls and 207 boys) from 2 to 14 years old (7,5±1,5 years) with a radiographically confirmed diagnosis of DDH of various variants (torsion-valgus deformity, subluxation , dislocation in the vehicle). The control group consisted of 259 children (140 girls and 119 boys) without HJ pathology, who were examined at the Research Institute of Traumatology, Orthopedics and Neurosurgery for preparation for a kindergarten/school/sports section, comparable in age (6,5±1,3 years). The criteria for selecting UCTD was the Bayesian classifier modified by T.I. Kadurina and V.N. Gorbunova, including the 50 most common clinical markers. For analysis the clinical anamnestic method, instrumental data of somatic symptom disorder test was used. Results: after summing up the scores in children with DDH, grade I UCTD was diagnosed in 40,0% (314), grade II – in 36,1% (283) and grade III – in 23,9% (188). In most cases, symptoms of UCTD with an Ehlers-Danlos-like syndrome were noted, which are characterized by changes in the musculoskeletal system, skin, connective tissue elements of internal organs (hypermobility of the joints, stretchable skin, anatomical disorders of the heart valves, bile ducts, etc.) or signs of UCTD with an unclassifiable phenotype when there is a variety of stigmas. All children in this group have joint hypermobility, myotonic syndrome, and various types of posture disorders. In the control group with DDH, 27,4% (71) noted the burdened heredity in the pathology of the musculoskeletal system on the mother's or father's side. In the control group the signs of UCTD stigma were also diagnosed, however, the degree of their severity and occurrence were significantly lower (p<0,05). In these children, the most significant were changes in the organ of vision, nervous system, maxillofacial region, digestive tract and a decrease in immune function. Conclusion: manifestations of UCTD are significantly more common in children with DDH compared with healthy children; pathology of the musculoskeletal and cardiovascular systems prevails in the structure of UCTD stigmas. In the pathogenesis of DDH, a genetic predisposition is realized (45,5%, 357 children), hypermobility of joints, myatonic syndrome were observed in all children in the study group. Manifestations of UCTD were also found in the control group, however, the stigmas were of a visceral nature of lesions and impairments from the sense organs, which is not the subject of a pediatric orthopedist's study. Thus, the features of UCTD in children with DDH are considered as a predictor of the pathology severity.

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