scholarly journals The Effectiveness of Topical Drugs with a Personalized Approach in the Treatment of Chronic Dermatoses

2021 ◽  
Vol 17 (35) ◽  
pp. 6-10
Author(s):  
P.E. Konnov ◽  
◽  
A.A. Arsenieva
Keyword(s):  
Atopic Dermatitis ◽  
Topical Drugs ◽  
External Agents ◽  
Highly Effective ◽  
Personalized Approach ◽  
Effective Drugs

At the present time, dermatologists’ arsenal has been significantly enriched with new highly effective drugs able to improve significantly the treatment of chronic immune-dependent dermatoses, in particular – atopic dermatitis and microbial eczema. The article discusses topical external agents for the treatment of patients with chronic dermatoses.

scholarly journals The Keratinocyte as a Crucial Cell in the Predisposition, Onset, Progression, Therapy and Study of the Atopic Dermatitis

2021 ◽  
Vol 22 (19) ◽  
pp. 10661
Author(s):  
Pamela Gallegos-Alcalá ◽  
Mariela Jiménez ◽  
Daniel Cervantes-García ◽  
Eva Salinas
Keyword(s):  
Atopic Dermatitis ◽  
Complex Disease ◽  
Skin Diseases ◽  
Current Knowledge ◽  
Immune Dysregulation ◽  
Chronic Inflammatory Disease ◽  
Skin Microbiota ◽  
External Agents ◽  
Chronic Skin ◽  
Inflammatory Molecules

The keratinocyte (KC) is the main functional and structural component of the epidermis, the most external layer of the skin that is highly specialized in defense against external agents, prevention of leakage of body fluids and retention of internal water within the cells. Altered epidermal barrier and aberrant KC differentiation are involved in the pathophysiology of several skin diseases, such as atopic dermatitis (AD). AD is a chronic inflammatory disease characterized by cutaneous and systemic immune dysregulation and skin microbiota dysbiosis. Nevertheless, the pathological mechanisms of this complex disease remain largely unknown. In this review, we summarize current knowledge about the participation of the KC in different aspects of the AD. We provide an overview of the genetic predisposing and environmental factors, inflammatory molecules and signaling pathways of the KC that participate in the physiopathology of the AD. We also analyze the link among the KC, the microbiota and the inflammatory response underlying acute and chronic skin AD lesions.

Antipruritic therapy issues on background of skin xerosis

2021 ◽  
pp. 37-41
Author(s):  
L. S. Kruglova ◽  
E. V. Tipaeva
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Practice ◽  
Drug Therapy ◽  
Skin Diseases ◽  
Transepidermal Water Loss ◽  
Topical Drugs ◽  
Antipruritic Therapy ◽  
Therapeutic Measures ◽  
Relationship Of ◽  
The Relationship

The relationship of xerosis with various skin diseases is very multifaceted, at the same time, xerosis can be the cause of the onset or aggravation of itching. Modern recommendations for the external treatment of chronic dermatoses, accompanied by xerosis and itching, imply two directions: direct therapeutic measures during an exacerbation and the use of dermatocosmetics adapted to certain symptoms.Material and methods. We observed 26 patients (mean age 38.7 ± 1.9 years with atopic dermatitis, eczema, psoriasis or pruritus, where xerosis was present in the clinical picture and pruritus was noted. All patients used topical drugs in accordance with the nosology, in as an adjuvant therapy – Neotanin Comfort Plus cream.Research results. In atopic dermatitis, the corneometry index increased by an average of 21%, with eczema – by 20%, with psoriasis – by 22%, with skin itching – by 12%. Transepidermal water loss decreased in atopic dermatitis by 19.8%, with eczema – by 22.8%, with psoriasis – by 21.8%, with pruritus – by 18.4% The value of the total BRS index decreased by more than two times.Conclusion. The use of Neotanin Comfort Plus cream in combination with topical drug therapy (GCS, multicomponent drugs) is highly effective and safe in patients with atopic dermatitis, eczema, psoriasis or pruritus, which makes it possible to recommend it for use in wide clinical practice.

Actual recommendations for multicomponent drug use in dermatology

2019 ◽  
Vol 2 (26) ◽  
pp. 67-72
Author(s):  
L. S. Kruglova ◽  
D. V. Fyodorov ◽  
A. G. Stenko ◽  
N. V. Gryazeva ◽  
A. B. Yakovlev
Keyword(s):  
Atopic Dermatitis ◽  
Drug Use ◽  
Years Of Experience ◽  
Combination Drug ◽  
Drug Of Choice ◽  
Effective Components ◽  
Antimycotic Activity ◽  
Highly Effective ◽  
Therapeutic Measures ◽  
Inflammatory Component

Many years of experience in using fixed combinations of topical glucocorticosteroids in dermatology today seem to be justified not only theoretically (the pathogenesis of immuno-inflammatory and infectious dermatoses), but also from the perspective of optimizing therapeutic measures in this category of patients. From this position, the innovative combination drug Tetraderm® can be regarded as the drug of choice for dermatoses of combined etiology. The composition of the drug includes highly effective components that allow you to affect the inflammatory component, infection and trophic tissue in the lesions. The components of the drug show a favorable profile of antibacterial and antimycotic activity. Highly potent corticosteroid can effectively stop inflammation. The drug has prospects for use in various dermatoses of combined etiology (atopic dermatitis, eczema), in clinical situations when mycoses or pyoderma have signs of eczematization of the process, rashes in large folds, cystic dermatoses and diskeratoses.

scholarly journals Genetic technologies for medicine: the demands of society and business

2019 ◽  
Vol 89 (5) ◽  
pp. 470-474
Author(s):  
D. V. Morozov ◽  
R. A. Ivanov ◽  
P. M. Gershovich ◽  
N. E. Pestova ◽  
M. V. Petrova
Keyword(s):  
New Technologies ◽  
Academic Science ◽  
Successful Implementation ◽  
Car T ◽  
Genetic Technologies ◽  
Personalized Approach ◽  
Favorable Conditions ◽  
Gene Diagnostics ◽  
Effective Drugs ◽  
Diagnostics And Therapy

Genetic technologies play a key role in the development of new approaches to the diagnostics and therapy of diseases. Russian scientists who have already successfully developed effective drugs based on monoclonal antibodies are elaborating new products in the field of CAR-T-therapy and recombinant adeno-associated viruses-based gene therapy. In addition, implementation of gene diagnostics into practice allows increased efficiency of medical care through a personalized approach to the treatment of diseases. Successful implementation of new technologies and novel diagnostic and treatment methods is impossible without the cooperation of academic science and business. Companies that create favorable conditions for the cooperation with academic science and attracting specialists of various profiles are bringing the mass adoption of genetic technologies, and therefore, enabling victory over many previously incurable, socially significant diseases.

scholarly journals Methods to monitor the therapy oral anticoagulants: the current problems.

2018 ◽  
Vol 96 (2) ◽  
pp. 101-105
Author(s):  
J. Antovic ◽  
Tat'yana B. Kondratieva
Keyword(s):  
Atrial Fibrillation ◽  
Venous Thrombosis ◽  
Gold Standard ◽  
Laboratory Tests ◽  
Oral Anticoagulants ◽  
Coagulation Assays ◽  
Urgent Surgery ◽  
Routine Monitoring ◽  
Highly Effective ◽  
Effective Drugs

Oral anticoagulants antivitamin-K (ОАС - AVК) are highly effective drugs that prevent the development of venous thrombosis, stroke in atrial fibrillation. Routine monitoring is not recommended for DOAC. If measurements are necessary LC-MS/MS is the gold standard. The classical coagulation assays, PT-INR and aPTT, have no or very limited utility. The absence of the ability of simple laboratory tests in emergent or urgent surgery or procedures still remains unresolved.

scholarly journals Atopic Dermatitis-Like Skin Lesions Reduced by Topical Application and Intraperitoneal Injection of Hirsutenone in NC/Nga Mice

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Mi Sook Jeong ◽  
Sun Eun Choi ◽  
Ji Young Kim ◽  
Jung Shim Kim ◽  
Eun Joo Kim ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Lesions ◽  
Clinical Applications ◽  
Inflammatory Factors ◽  
Inflammatory Skin Disease ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy ◽  
Cox 2 ◽  
Effective Drugs

Atopic dermatitis (AD) is a common inflammatory skin disease. The increasing prevalence and severity of AD have prompted the developments of safer, more effective drugs. Although topical corticosteroids have been used as first line therapy for AD, their potential side effects limit their clinical applications. To investigate the effect of hirsutenone (HIR), a diarylheptanoid compound, on AD-like skin lesions and other factors related to immune response is the aim of this paper Th2-related cytokines (IL-4, IL-5, IL-13), eosinophil, IgE inflammatory factors (COX-2, iNOS) levels were reduced in blood, lymphocytes, and tissue after HIR treatment. These results suggest that HIR might be an effective treatment for AD.

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