Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats

A design of new nanocomposites of bacterial cellulose (BC) and betulin diphosphate (BDP) pre-impregnated into the surface of zinc oxide nanoparticles (ZnO NPs) for the production of wound dressings is proposed. The sizes of crystalline BC and ZnO NPs (5–25%) corresponded to 5–6 nm and 10–18 nm, respectively (powder X-ray diffractometry (PXRD), Fourier-infrared (FTIR), ultraviolet (UV), atomic absorption (AAS) and photoluminescence (PL) spectroscopies). The biological activity of the wound dressings “BC-ZnO NPs-BDP” was investigated in rats using a burn wound model. Morpho-histological studies have shown that more intensive healing was observed during treatment with hydrophilic nanocomposites than the oleophilic standard (ZnO NPs-BDP oleogel; p < 0.001). Treatment by both hydrophilic and lipophilic agents led to increases in antioxidant enzyme activity (superoxide dismutase (SOD), catalase) in erythrocytes and decreases in the malondialdehyde (MDA) concentration by 7, 10 and 21 days (p < 0.001). The microcirculation index was restored on the 3rd day after burn under treatment with BC-ZnO NPs-BDP wound dressings. The results of effective wound healing with BC-ZnO NPs-BDP nanocomposites can be explained by the synergistic effect of all nanocomposite components, which regulate oxygenation and microcirculation, reducing hypoxia and oxidative stress in a burn wound.

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Evaluation of therapeutic effect of omega-6 linoleic acid and thymoquinone enriched extracts from Nigella sativa oil in the mitigation of lipidemic oxidative stress in rats

Nutrition ◽

10.1016/j.nut.2015.12.003 ◽

2016 ◽

Vol 32 (6) ◽

pp. 649-655 ◽

Cited By ~ 11

Author(s):

Shafeeque Ahmad ◽

Zafarul H. Beg

Keyword(s):

Oxidative Stress ◽

Linoleic Acid ◽

Therapeutic Effect ◽

Nigella Sativa ◽

Nigella Sativa Oil ◽

Omega 6

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Dietary Supplementation of Genistein Attenuates Inflammatory Responses and Oxidative Stress during Cutaneous Wound Healing in Diabetic Mice

Journal of Agricultural Science ◽

10.5539/jas.v7n2p80 ◽

2015 ◽

Vol 7 (2) ◽

Cited By ~ 1

Author(s):

Hyeyoon Eo ◽

Ji-Young Ann ◽

Yunsook Lim

Keyword(s):

Oxidative Stress ◽

Wound Healing ◽

Inflammatory Responses ◽

Dietary Supplementation ◽

Cutaneous Wound Healing ◽

Diabetic Mice ◽

Cutaneous Wound ◽

And Oxidative Stress

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The protective effect of Nigella sativa extract on lung inflammation and oxidative stress induced by lipopolysaccharide in rats

Journal of Ethnopharmacology ◽

10.1016/j.jep.2020.112653 ◽

2020 ◽

Vol 253 ◽

pp. 112653 ◽

Cited By ~ 6

Author(s):

Amin Mokhtari-Zaer ◽

Fatemeh Norouzi ◽

Vahid Reza Askari ◽

Mohammad Reza Khazdair ◽

Nama Mohammadian Roshan ◽

...

Keyword(s):

Oxidative Stress ◽

Protective Effect ◽

Lung Inflammation ◽

Nigella Sativa ◽

And Oxidative Stress

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The effect of Aloe Vera leaf gel in promoting wound healing and as antibacterial

The Iraqi Journal of Veterinary Medicine ◽

10.30539/iraqijvm.v32i2.738 ◽

2008 ◽

Vol 32 (2) ◽

pp. 46-59

Author(s):

Ali Aziz Al-Khayyat

Keyword(s):

Pseudomonas Aeruginosa ◽

Wound Healing ◽

Pathogenic Bacteria ◽

Nigella Sativa ◽

Aloe Vera ◽

Self Control ◽

Control Group ◽

Nigella Sativa Oil ◽

Normal Wound Healing ◽

Significant Difference

This study was carried out to explore the effect of Aloe Vera leafgel in promoting wound healing and to investigate theantibacterial effect against some pathogenic bacteria in comparisonwith Nigella sativa oil. Standard dilutions of Aloe Vera leaf gel weremade from ten to one hundred percent and its antibacterial effecthad been examined in seeded agar method against Staphylococcusaureus and Pseudomonas aeruginosa both were previously identifiedby laboratory and biochemical methods, Nigella Sativa oil which isknown to be one of the important medicinal plant was used forcomparison . Statistical analysis showed a significant difference(P<0.05) between AVG and Nigella Sativa oil.The effect of Aloe Vera leaf gel against Staph .aureus was morepotent than against Pseudomonas aeruginosa. There was aproportional relation between different concentrations of AVGwith the values of inhibition zones diameters of the bacteria.Results showed that Aloe Vera was more potent than Nigella sativaagainst both bacteria.The Minimum Inhibitory Concentration (MIC) was sixtymg/ml and the Minimum Bactericidal Concentration (MBC) waseighty mg/ml for Staph .aureus.In order to investigate the effect of Aloe Vera gel on woundhealing, twenty-four local male rabbits were used. They weredivided into four equal groups and each animal was wounded inboth sides of the back region by making a one by two centimetersquare standard longitudinal incision with surgical scalpel. Thefirst group was a control group (wounded without treatment); thisgroup was employed to observe the normal wound healing. Thesecond group was treated with crude Aloe Vera leaf gel twice dailyfor 10 days. While the third group was wounded and infected withthe pathogenic bacteria Staphylococcus vaureus without treatment,in order to observe the natural body defense against pathogenicmicroorganisms. The last group was infected with the samebacteria but treated with crude Aloe Vera leaf gel to observe theantibacterial effect. The wounds in the left side in second andfourth group were left as self-control.

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