scholarly journals The Effect of Zanthium Extracts on Germination in Relation to Interior and Exterior Factors

2004 ◽  
pp. 65-69
Author(s):  
István Dávid
Keyword(s):  
Inhibitory Effect ◽  
Actual Condition ◽  
Initial Growth ◽  
Row Crops ◽  
Retarding Effect ◽  
Significant Inhibitory Effect ◽  
Fast Spreading ◽  
The Difference ◽  
Soil Influence ◽  
Mediator Agent

In Hungary, the cocklebur species significantly endanger row crops (i.e. corn, sunflower, sugar beet). Their fast spreading is caused by many reasons: long-lasting emergence, reduced sensitivity to many kinds of herbicides, vigorous competitional ability, allelopathy, fast initial growth and changes in climate. The means of allelopathy is used by many species of plants in the competition with one another, as well as by the cockleburs. But the efficiency of this is influenced by many factors. Species with allelopathical effect could show different behaviour under different conditions: they can produce compounds with retarding and stimulating effects in different quantities or compositions. The actual condition of the acceptor plant and the mediator agent (i.e. soil) influence the final effect.In this experiment influence of phenology and rainfall was studied on allelopathy of cockleburs in May, July and September. A stronger inhibition was observed on growth of cress before rain in July than in May, but this retarding effect disappeared after rainfall. However, the samples collected in September have significant inhibitory effect after rain. Inhibition of sugarbeet’s germination was stronger in May than in July, and the difference increased after rain.

scholarly journals Allelopathic effects of water extracts of pieces of wooly cupgrass (Eriochloa villosa) on the seedlings of field crops

2017 ◽  
pp. 167-170
Author(s):  
Arnold Szilágyi ◽  
László Radócz
Keyword(s):  
Plant Species ◽  
Initial Growth ◽  
Row Crops ◽  
Water Extracts ◽  
Field Crops ◽  
Fast Spreading ◽  
Woolly Cupgrass ◽  
Allelopathic Effects ◽  
Eriochloa Villosa

In Hungary, the woolly cupgrass (Eriochloa villosa [Thunb.] Kunth) endanger row crops (i.e. corn, sunflower). Its fast spreading based on some reason viz. long-lasting emergence, reduced sensitivity to many kinds of herbicides, vigorous competitional ability and fast initial growth. Allelopathy, ability of many plant species to produce one or more biochemicals wgich is used tocompete with each others. In this experiment we examined, whether the woolly cupgrass possesses allelopathy, and if so, how influences on the development of cultured crops like maize, sunflower and lettuce.

scholarly journals Antioxidative enzymes of Cucumis sativus seeds are modulated by Leucaena leucocephala extracts

2017 ◽  
Vol 39 (3) ◽  
pp. 373 ◽  
Author(s):  
Vandjore De Mattos Ribeiro ◽  
Ariane Spiassi ◽  
Thaís Regina Marcon ◽  
Gislaine Piccolo de Lima ◽  
Jaqueline Malagutti Corsato ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inhibitory Effect ◽  
Germination Percentage ◽  
Early Growth ◽  
Initial Growth ◽  
Leaf Extracts ◽  
Enzymes Activity ◽  
Significant Inhibitory Effect ◽  
Growth Changes ◽  
Peroxidase Enzymes

 This study aimed to analyze oxidative stress produced in cucumber seeds and seedlings when exposed to aqueous extract from dried leaves of leucaena, as well as its effect on the germination behavior, early growth and the antioxidant enzymes activity. It was evaluated the percentage, the speed index, the average time, the frequency and germination synchronization, the root length and shoot, as well as the catalase and peroxidase enzymes activity. There was no significant inhibitory effect of the leaf extracts on the germination percentage. However, there was delay in the seeds germination, as the extract proportion increased. A stimulatory effect of the extract compared to the shoot length was observed, however the root growth was significantly reduced. The catalase activities had a peak at 24 hours after soaking the seeds, however, the activities were reduced in seedlings. The peroxidase activity was low in the seeds and increased in the seedlings at 168 hours after immersion. The results suggest that there was oxidative stress due to allelochemicals present in the leaves extracts from leucaena, verified by germination and initial growth changes, causing alterations in the plants rootlets. 

Potential antidiarrheal agents: 1-(11-Cyano-6,11-dihydrodibenzo[b,e]thiepin-11-yl-alkyl)- and 1-(10-cyano-10,11-dihydrodibenzo[b,f]thiepin-10-yl-alkyl)-4-substituted piperidines

1985 ◽  
Vol 50 (5) ◽  
pp. 1089-1096 ◽  
Author(s):  
Karel Šindelář ◽  
Jan Metyš ◽  
Miroslav Protiva
Keyword(s):  
Inhibitory Effect ◽  
Substitution Reactions ◽  
Significant Inhibitory Effect

Substitution reactions of 11-(2-bromoethyl)- and 11-(3-bromopropyl)-6,11-dihydrodibenzo[b,e]thiepin-11-carbonitrile and further of 10-(2-bromoethyl)- and 10-(3-bromopropyl)-10,11-dihydrodibenzo[b,f]thiepin-10-carbonitrile with ethyl 4-phenylpiperidine-4-carboxylate, 4-phenylpiperidin-4-ol, 4-(2-tolyl)piperidin-4-ol, 4-(4-fluorophenyl)piperidin-4-ol, 4-(2-oxobenzimidazolin-1-yl)-piperidine and 1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one afforded the tricyclic piperidinoalkyl nitriles IV-XIII which are cyclic analogues of the antidiarrheal agents diphenoxylate (I) and loperamide (III). Out of the compounds prepared only IV and XI showed a significant inhibitory effect towards diarrhea elicited by intravenously administered serotonin in mice.

scholarly journals A novel BRD4 inhibitor suppresses osteoclastogenesis and ovariectomized osteoporosis by blocking RANKL-mediated MAPK and NF-κB pathways

2021 ◽  
Vol 12 (7) ◽  
Author(s):  
Ying Liu ◽  
Wenjie Liu ◽  
Ziqiang Yu ◽  
Yan Zhang ◽  
Yinghua Li ◽  
...  
Keyword(s):  
Bone Loss ◽  
Osteoporosis Treatment ◽  
Inhibitory Effect ◽  
Specific Gene ◽  
Actin Ring ◽  
Treatment Target ◽  
Significant Inhibitory Effect ◽  
Promising Treatment

AbstractBromodomain-containing protein 4 (BRD4) has emerged as a promising treatment target for bone-related disorders. (+)-JQ1, a thienotriazolodiazepine compound, has been shown to inhibit pro-osteoclastic activity in a BRD4-dependent approach and impede bone loss caused by ovariectomy (OVX) in vivo. However, clinical trials of (+)-JQ1 are limited because of its poor druggability. In this study, we synthesized a new (+)-JQ1 derivative differing in structure and chirality. One such derivative, (+)-ND, exhibited higher solubility and excellent inhibitory activity against BRD4 compared with its analogue (+)-JQ1. Interestingly, (-)-JQ1 and (-)-ND exhibited low anti-proliferative activity and had no significant inhibitory effect on RANKL-induced osteoclastogenesis as compared with (+)-JQ1 and (+)-ND, suggesting the importance of chirality in the biological activity of compounds. Among these compounds, (+)-ND displayed the most prominent inhibitory effect on RANKL-induced osteoclastogenesis. Moreover, (+)-ND could inhibit osteoclast-specific gene expression, F‐actin ring generation, and bone resorption in vitro and prevent bone loss in OVX mice. Collectively, these findings indicated that (+)-ND represses RANKL‐stimulated osteoclastogenesis and averts OVX-triggered osteoporosis by suppressing MAPK and NF-κB signalling cascades, suggesting that it may be a prospective candidate for osteoporosis treatment.

scholarly journals Synthesis and Evaluation of Biological Activity of New Arylphosphoramidates

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Amal Thebti ◽  
M. A. K. Sanhoury ◽  
H-I. Ouzari ◽  
T. Barhoumi-slimi
Keyword(s):  
Biological Activity ◽  
Ir Spectroscopy ◽  
Acetylcholinesterase Activity ◽  
Inhibitory Effect ◽  
Bacterial Strains ◽  
Significant Inhibitory Effect ◽  
Subsequent Addition

The synthesis of new substituted arylphosphoramidates is performed in two steps through phosphorylation of the corresponding alcohols followed by aminolysis. The formation of the desired phosphoramidates depends on the subsequent addition of the two alcohols with the amine being added at the last step. The products were obtained in 58–95% yields. They were characterized mainly by multinuclear (1H, 13C, 31P, and 19F) NMR and IR spectroscopy. In addition, the antimicrobial and antiacetylcholinesterase activities were evaluated. The results showed acetylcholinesterase activity by some compounds, whilst no significant inhibitory effect against the tested bacterial strains has been recorded.

Cholecystokinin octapeptide analogues suppress food intake via central CCK-A receptors in mice

1993 ◽  
Vol 265 (3) ◽  
pp. R481-R486 ◽  
Author(s):  
Y. Hirosue ◽  
A. Inui ◽  
A. Teranishi ◽  
M. Miura ◽  
M. Nakajima ◽  
...  
Keyword(s):  
Food Intake ◽  
Receptor Antagonist ◽  
Rank Order ◽  
Peripheral Circulation ◽  
Inhibitory Effect ◽  
Peripheral Tissues ◽  
Cholecystokinin Octapeptide ◽  
The Central Nervous System ◽  
The Difference ◽  
The Brain

To examine the mechanism of the satiety-producing effect of cholecystokinin (CCK) in the central nervous system, we compared the potency of intraperitoneally (ip) or intracerebroventricularly (icv) administered CCK-8 and its analogues on food intake in fasted mice. The icv administration of a small dose of CCK-8 (0.03 nmol/brain) or of Suc-(Thr28, Leu29, MePhe33)-CCK-7 (0.001 nmol/brain) suppressed food intake for 20 min, whereas CCK-8 (1 nmol/kg, which is equivalent to 0.03 nmol/brain) or Suc-(Thr28, Leu29, MePhe33)-CCK-7 (1 nmol/kg) had satiety effect after ip administration. Dose-response studies indicated the following rank order of potency: Suc-CCK-7 > or = Suc-(Thr28, Leu29, MePhe33)-CCK-7 > or = CCK-8 > or = (Nle28,31)-CCK-8 >> desulfated CCK-8 = CCK-4 = 0 in the case of ip administration and Suc-(Thr28, Leu29, MePhe33)-CCK-7 >> Suc-CCK-7 > or = CCK-8 > or = (Nle28,31)-CCK-8 >> desulfated CCK-8 = CCK-4 = 0 in the case of icv administration. The selective CCK-A receptor antagonist MK-329 reversed the inhibitory effect of the centrally as well as peripherally administered CCK-8, or of Suc-(Thr28, Leu29, MePhe33)-CCK-7, whereas the selective CCK-B receptor antagonist L-365260 did not. The icv administered CCK-8 did not appear in the peripheral circulation. These findings suggest the participation of CCK-A receptors in the brain in mediating the satiety effect of CCK and the difference in CCK-A receptors in the brain and peripheral tissues.

Pharmacological Modulation of Cutaneous Reactivity to Histamine: A Double-Blind Acute Comparative Study between Cetirizine, Terfenadine and Astemizole

1989 ◽  
Vol 17 (1) ◽  
pp. 24-27 ◽  
Author(s):  
L. Ghys ◽  
J.-P. Rihoux
Keyword(s):  
Comparative Study ◽  
Healthy Volunteers ◽  
Inhibitory Effect ◽  
Blind Study ◽  
Double Blind Study ◽  
Single Administration ◽  
Double Blind ◽  
Pharmacological Modulation ◽  
The Difference ◽  
Cutaneous Reactivity

In a double-blind study performed in 81 healthy volunteers, 10 mg cetirizine and 60 mg terfenadine given orally in a single administration significantly inhibited skin reactivity to histamine. Astemizole (10 mg) was completely ineffective. The inhibitory effect of cetirizine was potent and regular whereas 6/28 (21%) volunteers did not respond to terfenadine. The difference observed beween cetirizine and terfenadine might be due to differences in the metabolism of the two drugs after administration: terfenadine is rapidly and extensively metabolized whereas cetirizine is directly active without the need for biotransformation and, indeed is poorly metabolized.

scholarly journals A potential new fabric evaluation approach by capturing brain perception under fabric contact pressure

2018 ◽  
Vol 89 (16) ◽  
pp. 3312-3325 ◽  
Author(s):  
Jie Yuan ◽  
Weidong Yu ◽  
Kemin Chen ◽  
Zhongwei Zhang ◽  
Yi Li ◽  
...  
Keyword(s):  
Contact Pressure ◽  
Inhibitory Effect ◽  
High Temporal Resolution ◽  
Non Invasive ◽  
Evaluation Approach ◽  
Postcentral Gyrus ◽  
Comfort Perception ◽  
Peak Points ◽  
The Difference ◽  
Fabric Comfort

The problem of the transmission mechanism of textile perception and the barrier to express textile cognition directly are the two major issues in the field of textile evaluation. In this study, an advanced biomedical imaging technology, functional magnetic resonance imaging, which is non-invasive and has a high temporal resolution and spatial resolution, was utilized to describe the features of brain perception in the brain mask areas under increased fabric contact pressures, and thus it was attempted to provide a new approach to express fabric comfort perception. As a result, we found that when fabric contact pressure increased from 0.5 to 1.5 kPa, both maximum activation intensity T Z and activation proportion K of the peak points were transferred from the postcentral gyrus in the SI to the amygdala, and were negative activations. Therefore, we drew the conclusion that both a lower and a higher fabric contact pressure (about 1 kPa of proper comfort fabric pressure) would produce a brain signal inhibitory effect on the SI and amygdala. The difference was the fact that the inhibition role on the SI was more obvious under a lower pressure, while the inhibition role on the amygdala was more remarkable under a higher pressure, which meant that the SI, particularly the postcentral gyrus in the SI, was likely to play a significant role in surface tactile perception of fabrics, while the amygdala might be related to the fabric oppressing sensation.

scholarly journals Sustained density of neuroendocrine cells with aging precedes development of prostatic hyperplasia in spontaneously hypertensive rats

BMC Urology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yuki Kyoda ◽  
Koji Ichihara ◽  
Kohei Hashimoto ◽  
Ko Kobayashi ◽  
Fumimasa Fukuta ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Prostatic Hyperplasia ◽  
Neuroendocrine Cells ◽  
Initial Growth ◽  
Hypertensive Rats ◽  
Initial Development ◽  
Spontaneously Hypertensive ◽  
Significant Difference ◽  
The Difference ◽  
Wistar Kyoto

Abstract Background Neuroendocrine (NE) cells may have an impact on the development and initial growth of benign prostatic hyperplasia (BPH) according to previous human studies. Methods To explore the relationship of NE cells and BPH development, we compared the density of NE cells and also prostatic weight in spontaneously hypertensive rats (SHR), which develop by aging, and Wistar-Kyoto rats (WKY) as control. The total weights of the epithelium and stroma in the ventral lobes of 8-, 12, 16-, 28- and 56-week-old SHR and WKY were calculated using Image J software. NE cells in the ventral prostatic ducts (VPd) were quantified using immunohistochemical staining for serotonin. Results Although there was no significant difference in the estimated total weight of the epithelium and stroma in the ventral lobes adjusted by body weight (ES weight) between the two groups at 8, 12 and 16 weeks of age, ES weight was significantly greater in the SHR group than in the WKT group at 28 and 56 weeks. The density of NE cells in the VPd decreased with aging in the WKY group, whereas it was sustained until 16 weeks and then decreased with aging in the SHR group. The difference in the density between the two groups was most marked at 16 weeks of age. Conclusion In the natural history of BPH, NE cells may play an important role in the initial development of BPH because sustained density of NE cells in the VPd precedes the development of prostatic hyperplasia.

scholarly journals The Impact of China’s Low-Carbon Initiative on the Location Expansion of International SPA Enterprises

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Zhaoyang Zhao ◽  
Chong Ye
Keyword(s):  
Economic Development ◽  
Product Life Cycle ◽  
Large Scale ◽  
High Energy ◽  
Inhibitory Effect ◽  
Low Carbon ◽  
Suppression Effect ◽  
Carbon Neutrality ◽  
The Difference ◽  
The Impact

“Fast fashion” represents a short product life cycle, and international SPA enterprises are therefore criticised as representatives of high energy consumption, pollution, and emissions, which is contrary to China’s goal of achieving carbon neutrality. In the context of China’s shift to a low-carbon economic development model, how should SPA enterprises breakthrough in the face of China’s large-scale market advantage and domestic demand potential? Based on the statistics of 277 prefecture-level cities from 2010 to 2018, this article selects 5 leading international SPA enterprises and uses the difference-in-differences (DID) method to explore the impact of low-carbon initiative on the location expansion of international SPA enterprises. The results suggest that the quantity of location expansions of SPA enterprises in the pilot cities is significantly lower by approximately 0.418 units compared with the nonpilot cities, implying that the low-carbon initiative has a significant inhibitory effect on the location expansion of SPA enterprises. After a series of robustness tests, the conclusion is valid. The results of the heterogeneity test suggest that the suppression effect is mainly found in the subsample of central cities and cities with medium and low levels of economic development. This article proposes that SPA enterprises should reduce their carbon emissions and gradually explore a green and sustainable development path.

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