Residual activity after radioembolization of liver tumours with 90Y resin microspheres

SummaryThe actual number of resin microspheres is approximately 30-60 times higher than glass microspheres per 3 GBq vial. Thus, radioembolization (RE) with resin microspheres exerts an embolization effect besides the radiation effect. This embolization effect can occasionally cause early back flow of the microspheres before application of the entire calculated dose. To avoid these adverse side effects, RE has to be terminated at an earlier time point. Measurement of the residual activity in the delivery box, which includes the v-vial, tube and catheter, to calculate the achieved target dose is often challenging. The aim of the current study was to establish a post-RE measurement method comparable to the glass microspheres method without unnecessary radiation exposure to the staff and risk of contamination. Methods: Two different measurements were performed. First, total radioactivity in the shipping vial was measured in an ion chamber and then it was put in the delivery box and the radiation was measured from a 30 cm distance from the centre of the box with a dosimeter. The required radioactivity was then transferred to the v-vial, and the shipping vial was measured again. After that, the v-vial was measured from the same distance from the centre of the box with dosimeter. Results: Altogether 62 times the shipping vial with different activities were measured with a significant positive correlation between the amount of the activity measured in the iron chamber and the radiation dose, measured with dosimeter (r2 = 0.98; p < 0.001). There was also a strong positive correlation between these measurements of the v-vial (r2 = 0.98; p < 0.001). Conclusion: With measurement of the residual activity in the delivery box using a dosimeter the percentage of the whole injected activity can be easily calculated. This facilitates the calculation of the actual, achieved target and non-target dose in those cases, where therapy had to be stopped because of eminent flow reversal or obstruction.

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The Strong Positive Correlation between Factor VII Clotting Activity Using Bovine Thromboplastin and the Activated Factor VII Level

Thrombosis and Haemostasis ◽

10.1055/s-0038-1653792 ◽

1995 ◽

Vol 73 (03) ◽

pp. 429-434 ◽

Cited By ~ 19

Author(s):

Kazuomi Kario ◽

Takefumi Matsuo ◽

Reiko Asada ◽

Toshiyuki Sakata ◽

Hisao Kato ◽

...

Keyword(s):

Risk Factor ◽

Bovine Brain ◽

Factor Vii ◽

Rabbit Brain ◽

Strong Positive Correlation ◽

Chromogenic Substrate ◽

Moderate Correlation ◽

Positive Correlation ◽

Activated Factor Vii

SummaryWe compared factor VII clotting activity (FVIIc) assays using different thromboplastins to determine which is the most sensitive for activated FVII (FVIIa) or for FVII antigen (FVIIag). FVIIc levels were measured using thromboplastins derived from bovine brain (FVIIc Bov), human placenta (FVIIc Hum), and rabbit brain (FVIIc Rab). FVIIa levels were measured by fluorogenic assays using human soluble tissue factor (rsTF) or bovine rsTF. We also measured FVII activity by an amidolytic assay (FVIIc:am Hum) using human thromboplastin and a chromogenic substrate for thrombin. FVIIag levels were determined by ELISA. In the FVIIa assay, the reaction time obtained from using bovine rsTF was shorter than that with human rsTF, suggesting that the interaction of plasma FVIIa with bovine rsTF was stronger than with human rsTF. The plasma FVIIa levels measured using human rsTF and bovine rsTF were almost the same (r=0.947, p<0.0001). Among the three FVIIc assays, FVIIc Bov had the strongest positive correlation with the plasma FVIIa level (r=0.886, p<0.000l), but had no correlation with FVIIag. An increase of 1 ng/ml in the plasma FVIIa level yielded a 27.9% increase of FVIIc Bov. Plasma FVIIc Hum and FVIIc:am Hum showed moderate correlations with both FVIIa (r=0.520, p<0.02 and r=0.569, p<0.01, respectively) and FVIIag (r=0.438, p<0.05 and r=0.468, p<0.05, respectively). FVIIc Rab had the lowest correlation with FVIIa (r=0.367, p<0.1), but had a moderate correlation with FVIIag (r=0.436, p<0.05). After in vitro cold activation, FVIIc Bov levels increased the most and FVIIc:am levels showed the least change. These findings indicate that consideration of the thromboplastin used for assay is necessary when assessing the clinical significance of FVII activity as a cardiovascular risk factor.

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Microsatellite Variation and Recombination Rate in the Human Genome

Genetics ◽

10.1093/genetics/156.3.1285 ◽

2000 ◽

Vol 156 (3) ◽

pp. 1285-1298 ◽

Cited By ~ 3

Author(s):

Bret A Payseur ◽

Michael W Nachman

Keyword(s):

Recombination Rate ◽

Microsatellite Polymorphism ◽

Published Data ◽

Strong Positive Correlation ◽

Background Selection ◽

Recombination Rates ◽

Microsatellite Variation ◽

Positive Correlation ◽

Genome Recombination ◽

Neutral Mutations

Abstract Background (purifying) selection on deleterious mutations is expected to remove linked neutral mutations from a population, resulting in a positive correlation between recombination rate and levels of neutral genetic variation, even for markers with high mutation rates. We tested this prediction of the background selection model by comparing recombination rate and levels of microsatellite polymorphism in humans. Published data for 28 unrelated Europeans were used to estimate microsatellite polymorphism (number of alleles, heterozygosity, and variance in allele size) for loci throughout the genome. Recombination rates were estimated from comparisons of genetic and physical maps. First, we analyzed 61 loci from chromosome 22, using the complete sequence of this chromosome to provide exact physical locations. These 61 microsatellites showed no correlation between levels of variation and recombination rate. We then used radiation-hybrid and cytogenetic maps to calculate recombination rates throughout the genome. Recombination rates varied by more than one order of magnitude, and most chromosomes showed significant suppression of recombination near the centromere. Genome-wide analyses provided no evidence for a strong positive correlation between recombination rate and polymorphism, although analyses of loci with at least 20 repeats suggested a weak positive correlation. Comparisons of microsatellites in lowest-recombination and highest-recombination regions also revealed no difference in levels of polymorphism. Together, these results indicate that background selection is not a major determinant of microsatellite variation in humans.

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Changes in Antioxidative, Oxidoreductive and Detoxification Enzymes during Development of Aphids and Temperature Increase

Antioxidants ◽

10.3390/antiox10081181 ◽

2021 ◽

Vol 10 (8) ◽

pp. 1181

Author(s):

Roma Durak ◽

Jan Dampc ◽

Monika Kula-Maximenko ◽

Mateusz Mołoń ◽

Tomasz Durak

Keyword(s):

Antioxidant Enzymes ◽

Enzymatic Activity ◽

Antioxidant Enzyme ◽

Temperature Increase ◽

Enzyme System ◽

Life Cycles ◽

Detoxification Enzymes ◽

Strong Positive Correlation ◽

Positive Correlation ◽

Antioxidant Enzyme System

Temperature, being the main factor that has an influence on insects, causes changes in their development, reproduction, winter survival, life cycles, migration timing, and population dynamics. The effects of stress caused by a temperature increase on insects may depend on many factors, such as the frequency, amplitude, duration of the stress, sex, or the developmental stage of the insect. The aim of the study was to determine the differences in the enzymatic activity of nymphs and adult aphids Aphis pomi, Macrosiphum rosae and Cinara cupressi, and changes in their response to a temperature increase from 20 to 28 °C. The activity of enzymatic markers (superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), β-glucosidase, polyphenol oxidase (PPO) and peroxidase (POD)) in aphid tissues was analysed for three constant temperatures. The results of our research showed that the enzymatic activity of aphids (measured as the activity of antioxidant, detoxifying and oxidoreductive enzymes) was mainly determined by the type of morph. We observed a strong positive correlation between the activity of the detoxifying and oxidoreductive enzymes and aphids’ development, and a negative correlation between the activity of the antioxidant enzymes and aphids’ development. Moreover, the study showed that an increase in temperature caused changes in enzyme activity (especially SOD, CAT and β-glucosidase), which was highest at 28 °C, in both nymphs and adults. Additionally, a strong positive correlation between metabolic activity (heat flow measured by microcalorimeter) and longevity was observed, which confirmed the relationship between these characteristics of aphids. The antioxidant enzyme system is more efficient in aphid nymphs, and during aphid development the activity of antioxidant enzymes decreases. The antioxidant enzyme system in aphids appears to deliver effective protection for nymphs and adults under stressful conditions, such as high temperatures.

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Vitamin D Status Among Children aged 2 months to 13 years-a Hospital Based Study

Birat Journal of Health Sciences ◽

10.3126/bjhs.v3i1.19766 ◽

2018 ◽

Vol 3 (1) ◽

pp. 381-384

Author(s):

Hem Sagar Rimal ◽

Shripad J Walavalkar

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Urban Area ◽

Serum Calcium ◽

Winter Season ◽

College Teaching ◽

Vitamin D Insufficiency ◽

P Value ◽

Strong Positive Correlation ◽

Positive Correlation

Introduction: Vitamin D is an important micronutrient having crucial role in calcium and phosphate homeostasis but there is emerging evidence to suggest its role in prevention of infectious, inflammatory and neoplastic diseases. The vitamin D insufficiency/deficiency is a widely recognized problem among children in developed as well as developing countries.Objective: To find out the prevalence of vitamin D deficiency/insufficiency among children aged 2 months to 13 yrs and its correlation with serum calcium, phosphate and demographic factors.Methodology: Prospective, cross sectional, hospital based study conducted at Birat Medical College Teaching Hospital for a period of one year among children presented to pediatric OPD in whom pediatrician had a suspicion of Vitamin D Insufficiency /Deficiency. Venous blood Samples were taken for the estimation of 25(OH) Vitamin D, Calcium and Phosphate. Statistical analysis was done using SPSS software version 16. Results Among 174 children aged 2 months to 13 years, the prevalence of vitamin D insufficiency at the cutoff of <30ng/ml was 82.75% where as no cases of vitamin D deficiency was noted at cut off level of < 10 ng/ml. Children residing in urban area, samples taken in the winter season had higher prevalence of vitamin D insufficiency (p value <0.05). Serum calcium and phosphate level were found positively correlated with Vitamin D level (p<.05). However the relationship was very strong between Vitamin D and Calcium (r=0.402, p-value <0.001) and weak positive correlation was noted with phosphate(r=0.155, p value <0.05).Conclusion: There is very high prevalence of Vitamin D insufficiency among children. The vitamin D insufficiency was significantly higher in winter season as compared to summer. Children living in the urban area are more prone to Vitamin D insufficiency. Moderately strong positive correlation was observed between Vitamin D level and calcium but weak correlation existed with phosphate. BJHS 2018;3(1)5 : 381-384

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Spatial Variation of the Relationship between PM2.5Concentrations and Meteorological Parameters in China

BioMed Research International ◽

10.1155/2015/684618 ◽

2015 ◽

Vol 2015 ◽

pp. 1-15 ◽

Cited By ~ 10

Author(s):

Gang Lin ◽

Jingying Fu ◽

Dong Jiang ◽

Jianhua Wang ◽

Qiao Wang ◽

...

Keyword(s):

Negative Correlation ◽

Meteorological Parameters ◽

Semiarid Region ◽

Strong Positive Correlation ◽

Annual Average ◽

Strong Negative Correlation ◽

Positive Correlation ◽

Humid Region ◽

The Relationship ◽

Warm Temperate

Epidemiological studies around the world have reported that fine particulate matter (PM2.5) is closely associated with human health. The distribution of PM2.5concentrations is influenced by multiple geographic and socioeconomic factors. Using a remote-sensing-derived PM2.5dataset, this paper explores the relationship between PM2.5concentrations and meteorological parameters and their spatial variance in China for the period 2001–2010. The spatial variations of the relationships between the annual average PM2.5, the annual average precipitation (AAP), and the annual average temperature (AAT) were evaluated using the Geographically Weighted Regression (GWR) model. The results indicated that PM2.5had a strong and stable correlation with meteorological parameters. In particular, PM2.5had a negative correlation with precipitation and a positive correlation with temperature. In addition, the relationship between the variables changed over space, and the strong negative correlation between PM2.5and the AAP mainly appeared in the warm temperate semihumid region and northern subtropical humid region in 2001 and 2010, with some localized differences. The strong positive correlation between the PM2.5and the AAT mainly occurred in the mid-temperate semiarid region, the humid, semihumid, and semiarid warm temperate regions, and the northern subtropical humid region in 2001 and 2010.

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Relationship amongst ResearchGate altmetric indicators and Scopus bibliometric indicators

New Library World ◽

10.1108/nlw-03-2015-0017 ◽

2015 ◽

Vol 116 (9/10) ◽

pp. 564-577 ◽

Cited By ~ 10

Author(s):

RISHABH SHRIVASTAVA ◽

Preeti Mahajan

Keyword(s):

Sample Size ◽

Correlation Coefficients ◽

Strong Positive Correlation ◽

Bibliometric Indicators ◽

Pearson’S Correlation ◽

Content Type ◽

Positive Correlation ◽

Pearson's Correlation ◽

Different Characteristics ◽

The Relationship

Purpose – The purpose of this paper is twofold. First, the study aims to investigate the relationship between the altmetric indicators from ResearchGate (RG) and the bibliometric indicators from the Scopus database. Second, the study seeks to examine the relationship amongst the RG altmetric indicators themselves. RG is a rich source of altmetric indicators such as Citations, RGScore, Impact Points, Profile Views, Publication Views, etc. Design/methodology/approach – For establishing whether RG metrics showed the same results as the established sources of metrics, Pearson’s correlation coefficients were calculated between the metrics provided by RG and the metrics obtained from Scopus. Pearson’s correlation coefficients were also calculated for the metrics provided by RG. The data were collected by visiting the profile pages of all the members who had an account in RG under the Department of Physics, Panjab University, Chandigarh (India). Findings – The study showed that most of the RG metrics showed strong positive correlation with the Scopus metrics, except for RGScore (RG) and Citations (Scopus), which showed moderate positive correlation. It was also found that the RG metrics showed moderate to strong positive correlation amongst each other. Research limitations/implications – The limitation of this study is that more and more scientists and researchers may join RG in the future, therefore the data may change. The study focuses on the members who had an account in RG under the Department of Physics, Panjab University, Chandigarh (India). Perhaps further studies can be conducted by increasing the sample size and by taking a different sample size having different characteristics. Originality/value – Being an emerging field, not much has been conducted in the area of altmetrics. Very few studies have been conducted on the reach of academic social networks like RG and their validity as sources of altmetric indicators like RGScore, Impact Points, etc. The findings offer insights to the question whether RG can be used as an alternative to traditional sources of bibliometric indicators, especially with reference to a rapidly developing country such as India.

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Radioembolization With Holmium-166 Polylactic Acid Microspheres: Distribution of Residual Activity in the Delivery Set and Outflow Dynamics During Planning and Treatment Procedures

Journal of Endovascular Therapy ◽

10.1177/1526602821996719 ◽

2021 ◽

pp. 152660282199671

Author(s):

Robert Drescher ◽

Philipp Seifert ◽

Falk Gühne ◽

René Aschenbach ◽

Christian Kühnel ◽

...

Keyword(s):

Residual Activity ◽

Injection Technique ◽

Flow Profile ◽

Dose Calibrator ◽

Transarterial Radioembolization ◽

Resin Microspheres ◽

Injection Methods ◽

Treatment Procedures ◽

Injection Cycle ◽

Treatment Activity

Purpose: To evaluate the microsphere outflow dynamics and residual Ho-166 activity during and after transarterial radioembolization planning and treatment procedures, and to assess the distribution and predilection sites of residual activity in the proprietary delivery set and the microcatheter. Materials and Methods: Fifteen planning and 12 therapeutic radioembolization procedures were performed with poly-l-lactic acid microspheres loaded with Ho-166. The amount and distribution of residual activity was assessed by dose calibrator measurements and SPECT imaging. The activity flow profile from the microcatheter was assessed dynamically. For planning procedures, different injection methods were evaluated in order to attempt to decrease the residual activity. Results: The median residual activities for planning and treatment procedures using standard injection methods were 31.2% (range 17.3%–44.1%) and 4.3% (range 3.5%–6.9%), respectively. Planning residual activities could be decreased significantly with 2 injection methods similar to treatment procedures, to 17.5% and 10.9%, respectively ( P = 0.002). Main predilection sites of residual microspheres were the 3-way stopcock and the outflow needle connector. During treatment procedures, more than 80% of the injected activity is transferred during the first 3 injection cycles. Conclusion: After treatment procedures with holmium-loaded microspheres, mean residual activity in the delivery set is reproducibly low and between reported values for glass and resin microspheres. The majority of microspheres is transferred to the patient during the second and third injection cycle. An estimated residual waste of 3% to 4% may be included in the treatment activity calculation. For planning procedures, a modified injection technique should be used to avoid high residual activities.

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Characterization of Black Carbon and Its Correlations with VOCs in the Northern Region of Hangzhou Bay in Shanghai, China

Atmosphere ◽

10.3390/atmos12070870 ◽

2021 ◽

Vol 12 (7) ◽

pp. 870

Author(s):

Fangfang Wang ◽

Jialuo Xu ◽

Yinzhi Huang ◽

Guangli Xiu

Keyword(s):

Global Warming ◽

Black Carbon ◽

Northern Region ◽

Hangzhou Bay ◽

Industrial Park ◽

Strong Positive Correlation ◽

Incomplete Combustion ◽

Positive Correlation ◽

Industrial Parks ◽

Haze Pollution

Ozone and PM2.5 (all particulate matter with diameter of 2.5 µm or smaller) are currently two disturbing environmental issues in most cities of China. Black carbon (BC), mainly from incomplete combustion, is one of the most important components of PM2.5 because it can absorb light and contribute to haze pollution and global warming. Meanwhile, volatile organic compounds (VOCs) have become a major air pollutant due to their association with haze, ozone (O3), global warming and human health by direct or indirect processes. In this study, one year-long observation campaign of BC, VOCs and other conventional air pollutants was conducted in the Northern Region of the Hangzhou Bay (NRHB) in Shanghai, China. The results indicated that higher concentration of BC mainly occurred in the autumn and winter, especially in December. In December, higher BC concentrations were found when the air mass came from northwest where there is an important local freeway, or southwest where some adjacent southwest chemical industrial parks are located. Different from the characteristics of BC in urban areas reported by previous studies, the diurnal variation of BC exhibited three peaks, two of which coincided with the morning and evening rush hours which are related to the heavy diesel traffic from a nearby freeway, and the third peak was often found late at night, around 2 am, which might be associated with abnormal emissions from an industrial park or marine traffic in the ocean waterway. BC had weakly negative correlation with O3 and NO, and a strongly positive correlation with PM2.5, SO2, NO2 and NOx, which implies that some incomplete combustion sources might occur in the nearby regions. With regard to VOCs, BC had a strong positive correlation with alkane, alkenes, alkynes, aromatic and non-sulfur VOCs, particularly with aromatic organic matter. Unlike the stronger correlation with aromatics in the morning rush hours, a stronger correlation between BC and alkenes and alkynes during the evening rush hour was observed. The relationships between BC and VOCs, particularly with some specific VOCs species related to the neighboring chemical industrial park, demonstrated that the contribution of the surrounding chemical industrial parks to BC should not be neglected.

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Leisure Functioning and Offender Rehabilitation

International Journal of Offender Therapy and Comparative Criminology ◽

10.1177/0306624x15600695 ◽

2016 ◽

Vol 61 (2) ◽

pp. 150-170 ◽

Cited By ~ 5

Author(s):

Alison J. Link ◽

D J Williams

Keyword(s):

Intrinsic Motivation ◽

Empirical Evidence ◽

Offender Rehabilitation ◽

Strong Positive Correlation ◽

Statistical Relationship ◽

Leisure Education ◽

Positive Correlation ◽

Independent Variables ◽

Rehabilitation Strategy

This study examined the statistical relationship between offender rehabilitation and leisure functioning of Oregon prisoners ( N = 281) soon to reenter society. The strong positive correlation between leisure functioning and rehabilitation is an important finding of the study. Perception of freedom and intrinsic motivation in leisure, as independent variables, were significantly related to rehabilitation even when controlling for the influence of demographic and important forensic variables. This study provides initial empirical evidence for the importance of leisure in offender rehabilitation and successful offender reentry. The role of leisure education programming as a supportive offender rehabilitation strategy is also discussed.

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Correlation between tumor necrosis factor-alpha and septic shock in children

Paediatrica Indonesiana ◽

10.14238/pi53.1.2013.1-5 ◽

2013 ◽

Vol 53 (1) ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

Khrisanti Dinata ◽

Ari L. Runtunuwu ◽

Jose M. Mandei ◽

Julius H. Lolombulan

Keyword(s):

Septic Shock ◽

Tumor Necrosis Factor ◽

Tumor Necrosis Factor Alpha ◽

Tumor Necrosis ◽

Strong Positive Correlation ◽

Necrosis Factor Alpha ◽

Cross Sectional ◽

Positive Correlation ◽

Factor Alpha ◽

Necrosis Factor

Background The crucial role cytokines play in the pathophysiologyof sepsis is widely accepted. Infection stimulates the productionof cytokines in various cell types. Tumor necrosis factor-alpha(TNF-a) is one of the most extensively investigated cytokines inexperimental and clinical sepsis. Tumor necrosis factor-alpha hasbeen shown to mediate lethality in experimental sepsis.Objective To evaluate for a possible correlation between TNF-alevel and septic shock in children.Methods This cross-sectional study was conducted in Manadofrom June to September 2011. A total of 40 patients with arecent diagnosis of sepsis or septic shock were included. Plasmaspecimens were collected from subjects for measurement ofTNF-a concentration. Logistic regression analysis was used toassess the correlation between TNF-a level and sepsis, as well asthe probability of shock in children with sepsis, with P<0.05 asstatistically significant.Results There was a strong positive correlation betweenTNF-a level and the probability of shock in children with sepsis(regression coefficient = 0. 78, P = 0.002).Conclusions There is a strong positive correlation betweenTNF-a level with the probability of shock in children with sepsis.Higher plasma level ofTNF-a is associated with higher probabilityof septic shock.

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