Catecholamines influence myocardial 123I MIBG uptake in neuroblastoma patients

2013 ◽  
Vol 52 (06) ◽  
pp. 228-234 ◽  
Author(s):  
R. L. F. van der Palen ◽  
A. M. C. Mavinkurve-Groothuis ◽  
L. Bellersen ◽  
H. W. M. van Laarhoven ◽  
L. Kapusta ◽  
...  
Keyword(s):  
Ventricular Dysfunction ◽  
Inverse Correlation ◽  
Specific Reference ◽  
Vanillylmandelic Acid ◽  
Mibg Uptake ◽  
Urinary Catecholamine ◽  
Significant Inverse Correlation ◽  
Urine Metabolites ◽  
Patient Category ◽  
The Relationship

SummaryAim: Cardiac 123I metaiodobenzylguanidine (MIBG) imaging can be influenced by several factors. We evaluated the relationship between catecholamine measurements and cardiac 123I MIBG uptake in neuroblastoma patients. Patients, methods: 30 neuroblastoma patients were retrospectively assessed on cardiac 123I MIBG uptake and urinary catecholamine dopamine and metabolites, homovanillic acid (HVA) and vanillylmandelic acid (VMA). Cardiac 123I MIBG uptake was quantified by heart-to-mediastinum (H/M) ratios, which were calculated into standard deviation scores (SDS) using age-specific reference values. Results: In 17 (57%) and 12 patients (40%) H/M ratio measurements were below –1.0 and –2.0 SDS at diagnosis. A significant inverse correlation between the average of urine metabolites HVA and VMA, and H/M ratio SDS was observed (r -.39, p = 0.04). Furthermore, there was a significant correlation between the urinary catecholamine metabolite HVA and H/M ratio SDS (r -.40, p = 0.04). Conclusion: Routine calculation of H/M ratios in 123I MIBG scintigrams of neuroblastoma patients is not helpful because it will not identify cardiac ventricular dysfunction in this patient category. A low H/M ratio on 123I MIBG scintigraphy is explained by increased cathecholamine levels secreted by neuroblastoma tumours.

scholarly journals Effect of Trochlear Dysplasia on Commonly Used Radiographic Parameters to Assess Patellar Instability

2020 ◽  
Vol 8 (7) ◽  
pp. 232596712093876
Author(s):  
J. Lee Pace ◽  
Chris Cheng ◽  
Sheeba M. Joseph ◽  
Matthew J. Solomito
Keyword(s):  
Risk Factors ◽  
Patellar Instability ◽  
Trochlear Dysplasia ◽  
Inverse Correlation ◽  
Trochlear Groove ◽  
Modified Technique ◽  
Significant Inverse Correlation ◽  
Patellar Tilt ◽  
Level Of Evidence ◽  
The Relationship

Background: Trochlear dysplasia (TD) is an important anatomic risk factor for patellar instability (PI). Several imaging-based risk factors for PI have been established, but it is unclear what effect TD has on these measurements, and the Dejour method of categorizing TD has been shown to be unreliable. The lateral trochlear inclination (LTI) is a quantifiable measurement of proximal trochlear morphology. Recently, a modified technique for measuring LTI referencing the posterior condylar angle has demonstrated near-perfect reliability and may serve as a new standard for quantifying TD. Purpose/Hypothesis: The purpose of this study was to evaluate how TD, expressed in terms of LTI, affects historically used measures of PI, including the sulcus angle (SA), tibial tuberosity to trochlear groove (TT-TG) distance, lateral patellar inclination (LPI), and Caton-Deschamps (CD) ratio. We hypothesized that lower LTI (ie, more dysplastic trochlea) will correlate with higher SA and TT-TG distances, increased patellar tilt, and more patella alta. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Patients aged 9 to 18 years treated for PI between January 2014 and August 2017 were queried. On magnetic resonance imaging (MRI), LTI, SA, LPI, and the TT-TG measured at the most proximal (pTT-TG) and distal (dTT-TG) aspects of the fully formed trochlear groove were measured on axial images. CD ratio was measured using sagittal MRI as well as lateral radiographs. All measurements were performed by 2 independent observers. Patients were included if there was a diagnosis of PI that was confirmed with a chart review and if there were appropriate imaging studies to analyze. Results: A total of 65 patients met inclusion criteria for this study. Average pTT-TG distance (15.7 ± 4.5 mm) was not significantly different from dTT-TG distance (15.7 ± 4.2 mm) ( P = .94). LTI had a weak but significant inverse correlation with pTT-TG ( r = –0.40; β = –0.15 mm; P < .001) and SA ( r = –0.43; β = –0.478°; P < .001). There was a moderate and significant inverse correlation of LTI with dTT-TG ( r = –0.593; β = –0.21 mm; P < .001) and with LPI ( r = –0.69; β = –0.54°; P < .001). There was a weak but significant correlation between LTI and the MRI-based CD ratio ( r = 0.279; β = 0.149; P = .005). Radiograph-based CD ratio did not show a significant correlation with LTI ( r = –0.189; P = .135). Conclusion: Smaller (ie, more dysplastic) LTI values correlated significantly with larger TT-TG, SA, LPI, and MRI-based CD ratio measurements. The relationship between SA and LTI is intuitive, but the relationship between LTI and the other analyzed variables suggests that they are dependent variables to TD and may not be consistent independent risk factors for PI. Together, these suggest that TD alters the radiographic interpretation of TT-TG and patellar tilt. The correlation between TD and patellar height is unclear and warrants further investigation.

scholarly journals Test Anxiety and Academic Self-Concept of Students

2016 ◽  
Vol 3 (4) ◽  
Author(s):  
Gagandeep Kaur ◽  
Senthil Kumaran J
Keyword(s):  
Test Anxiety ◽  
Random Sampling ◽  
Inverse Correlation ◽  
Self Concept ◽  
Categorical Variables ◽  
Stratified Random Sampling ◽  
Significant Inverse Correlation ◽  
School Consultation ◽  
Relationship Of ◽  
The Relationship

The study aimed at exploring the relationship of Academic self-concept and Test Anxiety of students and to find out the differences in these two variables with respect to some selected categorical variables. The objectives included (i) to find out the differences in Test anxiety and Academic Self-concept with respect to gender, stream of study and academic self-appraisal; and (2) to find out the relationship between Test anxiety and Academic Self-concept. For this purpose, 200 students studying various streams from a university were selected through stratified random sampling keeping gender and stream of study as strata. Academic Self Concept Scale by Liu, Wang &Parkins (2005) and Fried-Ben Test anxiety Scale (FTAS) by Friedman &Bendas Jacob (1997) were utilized to collect data. The data analysis revealed significant differences in test anxiety and academic self-concept of students with respect to their gender, course of study and academic self-appraisal. Also, significant inverse correlation was found between test anxiety and academic self-concept. Thus the study aligned with the existing literature. Implications and suggestions are posed as how the findings can be utilized for school consultation and in which direction the further research can be executed.

High Levels of Plasma Protein C in Nephrotic Syndrome

1985 ◽  
Vol 53 (01) ◽  
pp. 005-007 ◽  
Author(s):  
I Pabinger-Fasching ◽  
K Lechner ◽  
H Niessner ◽  
P Schmidt ◽  
E Balzar ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Plasma Protein ◽  
Protein C ◽  
Inverse Correlation ◽  
Elevated Plasma ◽  
Significant Inverse Correlation ◽  
At Iii ◽  
Thrombotic Tendency ◽  
Protein C Activity

SummaryIn patients with severe nephrotic syndrome determinations of plasma protein C : Ag levels (8 patients: 5 adults, 3 children) and protein C activity (3 out of 8 patients) revealed significantly elevated plasma protein C concentrations. Furthermore we observed a significant inverse correlation of protein C : Ag to AT III : Ag levels. No protein C : Ag could be detected in the urine of two patients studied. We conclude from our data, that changes of plasma protein C do not contribute to the high thrombotic tendency in nephrotic syndrome.

scholarly journals The relationship between CD204 M2-polarized tumour-associated macrophages (TAMs), tumour-infiltrating lymphocytes (TILs), and microglial activation in glioblastoma microenvironment: a novel immune checkpoint receptor target

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Maher Kurdi ◽  
Badrah Alghamdi ◽  
Nadeem Shafique Butt ◽  
Saleh Baeesa
Keyword(s):  
Microglial Activation ◽  
Inverse Correlation ◽  
Idh1 Mutation ◽  
High Expression ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes ◽  
The Relationship ◽  
Low Expression

Abstract Background Tumour associated macrophages (TAMs) and tumour infiltrating lymphocytes (TILs) are considered dominant cells in glioblastoma microenvironment. Aim The purpose of this study was to assess the expression of CD204+ M2-polarized TAMs in glioblastomas and their relationship with CD4+TILs, Iba+microglia, and IDH1 mutation. We also exploreed the prognostic value of these markers on the recurrence-free interval (RFI). Methods The expressions of CD204+TAMs, CD4+TILs, and Iba1+microglia were quantitively assessed in 45 glioblastomas using immunohistochemistry. Kaplan–Meier analysis and Cox hazards were used to examine the relationship between these factors. Results CD204+TAMs were highly expressed in 32 tumours (71%) and the remaining 13 tumours (29%) had reduced expression. CD4+TILs were highly expressed in 10 cases (22%) and 35 cases (77.8%) had low expression. There was an inverse correlation between CD204+TAMs and CD4+TILs, in which 85% of tumours had a high expression of CD204+TAMs and a low expression of CD4+TILs. Nevertheless, there was no significant difference in IDH1 mutation status between the two groups (p = 0.779). There was a significant difference in Iba1+microglial activation between IDH1mutant and IDH1wildtype groups (p = 0.031). For cases with a high expression of CD204+TAMs and a low expression of CD4+TILs, there was a significant difference in RFI after treatment with chemoradiotherapy or radiotherapy (p = 0.030). Conclusion Glioblastoma with a dense CD204+TAMs and few CD4+TILs is associated with IDH1wildtype. These findings suggest that TAMs masks tumour cell and suppress T-cell tumoricidal functions via immunomodulatory mechanisms. Blockade of the CD204-TAM receptor may prevent this mechanism and allow the evolution of TILs.

scholarly journals The Dependence of Renal 68Ga[Ga]-DOTATOC Uptake on Kidney Function and Its Relevance for Peptide Receptor Radionuclide Therapy with 177Lu[Lu]-DOTATOC

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1216
Author(s):  
Falk Gühne ◽  
Alexander Heinzig ◽  
Philipp Seifert ◽  
Robert Drescher ◽  
Martin Freesmeyer
Keyword(s):  
Kidney Function ◽  
Specific Binding ◽  
Correlation Coefficients ◽  
Inverse Correlation ◽  
Peptide Receptor Radionuclide Therapy ◽  
Tracer Uptake ◽  
Significant Inverse Correlation ◽  
Peptide Receptor ◽  
Pet Ct ◽  
Induced Changes

Background: In addition to its SSTR-specific binding in tumors and healthy tissues, DOTATOC analogues accumulate in kidney parenchyma. Renal tracer uptake might be a surrogate of kidney function or dysfunction. This study aimed to evaluate if kidney function can be estimated from 68Ga[Ga]-DOTATOC uptake in PET/CT and its impact on the nephrotoxicity of 177Lu[Lu]-DOTATOC PRRT. Methods: Two cohorts of patients (A: 128 diagnostic patients; B: 32 PRRT patients) were evaluated retrospectively. SUV values of the kidneys, physiologically SSTR-expressing organs and in background compartments were assessed. Kidney function was calculated as eGFR by CKD-EPI creatinine equation. Pearson’s correlation coefficients and treatment-induced changes of uptake and kidney function were assessed and compared. Results: Kidney function and renal DOTATOC uptake showed a significant inverse correlation (R2 = 0.037; p = 0.029). Evaluated models of PET/CT measurements were not able to predict kidney function sufficiently. The uptake of other organs did not depend on eGFR. While the renal uptake increased after PRRT (p < 0.001), the kidney function did not change significantly (p = 0.382). Neither low pre-therapeutic eGFR nor high pre-therapeutic kidney uptake were risk factors of PRRT-induced deterioration in kidney function. Conclusion: The relevance of kidney function for renal 68Ga[Ga]-DOTATOC uptake is limited. The nephrotoxicity of 177Lu[Lu]-DOTATOC PRRT might be low and cannot be reliably predicted by pre-therapeutic measurements.

Construct Validity for Self-Acceptance and Fear of Negative Evaluation

2001 ◽  
Vol 89 (2) ◽  
pp. 386-386 ◽  
Author(s):  
Mark W. Durm ◽  
Patricia E. Glaze
Keyword(s):  
Construct Validity ◽  
Inverse Correlation ◽  
The Self ◽  
Negative Evaluation ◽  
Fear Of Negative Evaluation ◽  
Significant Inverse Correlation ◽  
Acceptance Scale ◽  
Self Acceptance

For 55 students (13 men, 42 women) there was a significant inverse correlation for scores on the Self-acceptance Scale and scores on the Fear of Negative Evaluation Scale, thereby giving credence to the construct validity of both scales, that is, the more one accepts oneself, the less negative evaluation there is of oneself.

Prospects for Cooperation Between Russia and Syria in Various Scenarios of Military Conflict Development

2021 ◽  
pp. 50-55
Author(s):  
Alheder Haled
Keyword(s):  
Growth Rate ◽  
Inverse Correlation ◽  
Foreign Economic Policy ◽  
Military Conflict ◽  
Political Situation ◽  
Gdp Growth Rate ◽  
Initial Stage ◽  
Military Conflicts ◽  
The Military ◽  
The Relationship

The paper is devoted to determining the prospects for cooperation between Russia and the Syrian Arab Republic in various scenarios of military conflicts. In order to identify the relationship between the success of the country's foreign economic policy and the military conflicts waged on its territory, a study was conducted of such indicators of Syria as: the growth rate of the peace index and the GDP growth rate. A strong inverse correlation is revealed, which means that the level of political situation and peace in the state determines the efficiency of the economy. In view of this, various scenarios of the development of the military conflict in Syria have been studied: at the initial stage, at the stage of active hostilities, at the present stage of overcoming the crisis. The last stage involves four different scenarios for the development of a military conflict, including a local nature and a protracted nature with the involvement of other countries of the world. Options for developing cooperation between Russia and Syria have been identified for each scenario. Taking into account the assessment of the international political situation, the two most likely scenarios for further military events in Syria are identified, and the prospects for cooperation between Russia and Syria in these conditions are outlined.

scholarly journals Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D2(300,000 IU)

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
A. Sankaralingam ◽  
R. Roplekar ◽  
C. Turner ◽  
R. N. Dalton ◽  
G. Hampson
Keyword(s):  
Vitamin D ◽  
Bone Health ◽  
Inverse Correlation ◽  
Loading Dose ◽  
Multilinear Regression ◽  
Significant Inverse Correlation ◽  
Blood Samples ◽  
Multilinear Regression Analysis ◽  
Wnt Inhibitors ◽  
Dickkopf 1

Background. Vitamin D is important for bone health, although high loading doses have been associated with an increase in fracture risk. The mechanisms remain uncertain.Aim. We hypothesize that supraphysiological concentrations of 1,25 (OH)2vitamin D may inhibit formation by increasing the production of Wnt inhibitors: sclerostin andDKK1.Subjects and Methods. We measured serum sclerostin andDKK1in 34 patients (21 F, 13 M) aged mean (SD) 61.3 (15.6) years with vitamin D deficiency/insufficiency treated with a loading dose of vitamin D2(300,000 IU) intramuscularly. Blood samples were taken at baseline and serially up to 3 months.Results. Serum 1,25 (OH)2vitamin D increased markedly at 3 months (mean (SD) baseline 116 (63), 3 months : 229 (142) pmol/L,P<0.001). There was a significant correlation between sclerostin andDKK1at baseline (r=0.504, P=0.002) and at 3 months (r=0.42, P=0.013). A significant inverse correlation was observed between sclerostin and eGFR at 3 months (r=-0.494, P=0.007). Sclerostin increased significantly at 3 months (P=0.033). In a multilinear regression analysis with % change in sclerostin andDKK1as dependent variable, a positive significant association was observed with % change in 1,25 (OH)2vitamin D (P=0.038), independent of changes in PTH and following correction for confounders such as age, gender, BMI, BMD and eGFR.Conclusions. Supraphysiological concentration in 1,25 (OH)2vitamin D achieved following a loading dose of vitamin D increases sclerostin and may inhibit Wnt signalling. This may have detrimental effects on bone.

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