Methods in Year 50: Preserving the Past and Preparing for the Future

2011 ◽  
Vol 50 (01) ◽  
pp. 1-6 ◽  
Author(s):  
D. Aronsky ◽  
T. Y. Leong ◽  
A. T. McCray ◽  
R. Haux
Keyword(s):  
Medical Informatics ◽  
Strategic Decisions ◽  
Major Focus ◽  
Editorial Policies ◽  
The Past ◽  
Processing Data ◽  
Online Access ◽  
Aims And Scope ◽  
Online Methods ◽  
Sixth Decade

Summary Background: Founded in 1962 and, therefore, the oldest international journal in medical informatics, Methods of Information in Medicine will publish its 50th volume in 2011. At the start of the journal’s sixth decade, a discussion on the journal’s profile seems appropriate. Objectives: To report on the new opportunities for online access to Methods publications as well as on the recent strategic decisions regarding the journal‘s aims and editorial policies. Methods: Describing and analyzing the journal’s aims and scope. Reflecting on recent publications and on the journal’s development during the last decade. Results: From 2011 forward all articles of Methods from 1962 until the present can be accessed online. Methods of Information in Medicine stresses the basic methodology and scientific fundamentals of processing data, information and knowledge in medicine and health care. Although the journal‘s major focus is on publications in medical informatics, it has never been restricted to publications only in this discipline. For example, articles in medical biometry, in or close to biomedical engineering, and, later, articles in bioinformatics continue to be a part of this journal. Conclusions: There is a continuous and, as it seems, ever growing overlap in the research methodology and application areas of the mentioned disciplines. As there is a continuing and even growing need for such a publication forum, Methods of Information in Medicine will keep its broad scope. As an organizational consequence, the journal’s number of associate editors has increased accordingly.

Fluorescent potentiometric dyes for membrane-potential imaging

1994 ◽  
Vol 52 ◽  
pp. 166-167
Author(s):  
Leslie M. Loew
Keyword(s):  
Membrane Potential ◽  
Single Cells ◽  
Quantitative Imaging ◽  
Optical Recording ◽  
Biological Processes ◽  
Major Focus ◽  
The Past ◽  
Excitable Systems ◽  
Major Application ◽  
The Impact

A major application of potentiometric dyes has been the multisite optical recording of electrical activity in excitable systems. After being championed by L.B. Cohen and his colleagues for the past 20 years, the impact of this technology is rapidly being felt and is spreading to an increasing number of neuroscience laboratories. A second class of experiments involves using dyes to image membrane potential distributions in single cells by digital imaging microscopy - a major focus of this lab. These studies usually do not require the temporal resolution of multisite optical recording, being primarily focussed on slow cell biological processes, and therefore can achieve much higher spatial resolution. We have developed 2 methods for quantitative imaging of membrane potential. One method uses dual wavelength imaging of membrane-staining dyes and the other uses quantitative 3D imaging of a fluorescent lipophilic cation; the dyes used in each case were synthesized for this purpose in this laboratory.

scholarly journals Benefit-risk of Patients' Online Access to their Medical Records: Consensus Exercise of an International Expert Group

2018 ◽  
Vol 27 (01) ◽  
pp. 156-162 ◽  
Author(s):  
Harshana Liyanage ◽  
Siaw-Teng Liaw ◽  
Emmanouela Konstantara ◽  
Freda Mold ◽  
Richard Schreiber ◽  
...  
Keyword(s):  
Health Care ◽  
Medical Informatics ◽  
Medical Records ◽  
Panel Discussion ◽  
Care Quality ◽  
Care Providers ◽  
Consensus Statements ◽  
Online Access ◽  
The Impact

Background: Patients' access to their computerised medical records (CMRs) is a legal right in many countries. However, little is reported about the benefit-risk associated with patients' online access to their CMRs. Objective: To conduct a consensus exercise to assess the impact of patients' online access to their CMRs on the quality of care as defined in six domains by the Institute of Medicine (IoM), now the National Academy of Medicine (NAM). Method: A five-round Delphi study was conducted. Round One explored experts' (n = 37) viewpoints on providing patients with access to their CMRs. Round Two rated the appropriateness of statements arising from Round One (n = 16). The third round was an online panel discussion of findings (n = 13) with the members of both the International Medical Informatics Association and the European Federation of Medical Informatics Primary Health Care Informatics Working Groups. Two additional rounds, a survey of the revised consensus statements and an online workshop, were carried out to further refine consensus statements. Results: Thirty-seven responses from Round One were used as a basis to initially develop 15 statements which were categorised using IoM's domains of care quality. The experts agreed that providing patients online access to their CMRs for bookings, results, and prescriptions increased efficiency and improved the quality of medical records. Experts also anticipated that patients would proactively use their online access to share data with different health care providers, including emergencies. However, experts differed on whether access to limited or summary data was more useful to patients than accessing their complete records. They thought online access would change recording practice, but they were unclear about the benefit-risk of high and onerous levels of security. The 5-round process, finally, produced 16 consensus statements. Conclusion: Patients' online access to their CMRs should be part of all CMR systems. It improves the process of health care, but further evidence is required about outcomes. Online access improves efficiency of bookings and other services. However, there is scope to improve many of the processes of care it purports to support, particularly the provision of a more effective interface and the protection of the vulnerable.

scholarly journals Health Informatics: Building Capacity Worldwide. Editorial

2010 ◽  
Vol 19 (01) ◽  
pp. 06-07 ◽  
Author(s):  
C. A. Kulikowski ◽  
Antoine Geissbuhler
Keyword(s):  
Medical Informatics ◽  
Health Informatics ◽  
Main Theme ◽  
Building Capacity ◽  
Research Education ◽  
Main Research ◽  
The Past ◽  
Interdisciplinary Field ◽  
Wide Range ◽  
Workforce Capacity

Summary Objectives: To provide an editorial introduction to the 2010 IMIA Yearbook of Medical Informatics with an overview of its contents and contributors. Methods: A brief overview of the main theme, and an outline of the purposes, contents, format, and acknowledgment of contributions for the 2010 IMIA Yearbook. Results: This 2010 issue of the IMIA Yearbook highlights important developments in the building of workforce capacity in medical informatics worldwide, covering activities in research, education and practice in this interdisciplinary field. Progress towards educating and keeping professionals in the field up-to-date is complemented by outreach to the wide range of disciplines and biomedical and health specialties that are covered by this very broad field, identified from the recent literature, illustrated by selected papers published during the past 12 months.xs Conclusion: Reviews and Surveys of the main research sub-fields in biomedical informatics in the Yearbook provide an overview of progress and current challenges across the spectrum of the discipline.

scholarly journals Small but Smart: On the Diverse Role of Small Proteins in the Regulation of Cyanobacterial Metabolism

Life ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 322
Author(s):  
Fabian Brandenburg ◽  
Stephan Klähn
Keyword(s):  
Metabolic Pathways ◽  
Chemical Compounds ◽  
Industrial Processes ◽  
Biotechnological Applications ◽  
Major Focus ◽  
The Past ◽  
Metabolic Fluxes ◽  
Reactor Technology ◽  
Small Proteins

Over the past few decades, bioengineered cyanobacteria have become a major focus of research for the production of energy carriers and high value chemical compounds. Besides improvements in cultivation routines and reactor technology, the integral understanding of the regulation of metabolic fluxes is the key to designing production strains that are able to compete with established industrial processes. In cyanobacteria, many enzymes and metabolic pathways are regulated differently compared to other bacteria. For instance, while glutamine synthetase in proteobacteria is mainly regulated by covalent enzyme modifications, the same enzyme in cyanobacteria is controlled by the interaction with unique small proteins. Other prominent examples, such as the small protein CP12 which controls the Calvin–Benson cycle, indicate that the regulation of enzymes and/or pathways via the attachment of small proteins might be a widespread mechanism in cyanobacteria. Accordingly, this review highlights the diverse role of small proteins in the control of cyanobacterial metabolism, focusing on well-studied examples as well as those most recently described. Moreover, it will discuss their potential to implement metabolic engineering strategies in order to make cyanobacteria more definable for biotechnological applications.

scholarly journals Closing the Loops in Biomedical Informatics. Editorial

2009 ◽  
Vol 18 (01) ◽  
pp. 15-16
Author(s):  
Antoine Geissbuhler ◽  
C. A. Kulikowski
Keyword(s):  
Medical Informatics ◽  
Biomedical Research ◽  
Recent Literature ◽  
Biomedical Informatics ◽  
Research Progress ◽  
Editorial Introduction ◽  
Main Theme ◽  
Main Research ◽  
The Past

Summary Objectives To provide an editorial introduction to the 2009 IMIA Yearbook of Medical Informatics with an overview of its contents and contributors. Methods A brief overview of the main theme, and an outline of the purposes, contents, format, and acknowledgment of contributions for the 2009 IMIA Yearbook. Results This 2009 issue of the IMIA Yearbook highlights important, beneficial loops which, if closed, could lead to considerable advances in the field of biomedical informatics and, indirectly, in healthcare and biomedical research. Progress towards closing the loops and remaining gaps are identified from the recent literature, illustrated by selected papers published during the past 12 months. Conclusion Reviews and Surveys of the main research sub-fields in biomedical informatics in the Yearbook provide an overview of progress and current challenges across the spectrum of the discipline.

Gate Oxide Integrity as Affected by Hf Last Wafer Treatments and Passivating Techniques

1993 ◽  
Vol 303 ◽  
Author(s):  
R.C. Hawthorne ◽  
R.P.S. Thakur ◽  
K. Morinville ◽  
R. Kauffman
Keyword(s):  
Defect Density ◽  
Gate Oxide ◽  
Device Performance ◽  
Primary Process ◽  
Chemical Treatments ◽  
The Past ◽  
Performance Requirements ◽  
Wafer Cleaning ◽  
Processing Data ◽  
Wafer Surfaces

ABSTRACTAs device performance requirements increase, device features become smaller and films become thinner. The resultant sensitivity to defect density is such that controlling the condition of wafer surfaces prior to primary process steps becomes more and more critical. Wafer cleaning technologies of the past may not be optimum in providing needed device characteristics and reliability of tomorrow's semiconductors. In this paper, we compare the currently used RCA wafer clean chemistries to newer HF last, vapor dry technologies which use direct displacement of liquids to minimize contaminants. Subsequent passivation of these hydrophobic wafer surfaces is accomplished by various methods of oxidation including chemical treatments and RTP processing. Data collected from I-V, SIMS and DEFECT DENSITY testing will be included in the presentation.

scholarly journals Evidence for the Default Network's Role in Spontaneous Cognition

2010 ◽  
Vol 104 (1) ◽  
pp. 322-335 ◽  
Author(s):  
Jessica R. Andrews-Hanna ◽  
Jay S. Reidler ◽  
Christine Huang ◽  
Randy L. Buckner
Keyword(s):  
Cognitive Processes ◽  
Medial Temporal Lobe ◽  
External World ◽  
Brain Regions ◽  
Self Report ◽  
Default Network ◽  
Considerable Variability ◽  
Major Focus ◽  
The Past ◽  
Cortical Regions

A set of brain regions known as the default network increases its activity when focus on the external world is relaxed. During such moments, participants change their focus of external attention and engage in spontaneous cognitive processes including remembering the past and imagining the future. However, the functional contributions of the default network to shifts in external attention versus internal mentation have been difficult to disentangle because the two processes are correlated under typical circumstances. To address this issue, the present study manipulated factors that promote spontaneous cognition separately from those that change the scope of external attention. Results revealed that the default network increased its activity when spontaneous cognition was maximized but not when participants increased their attention to unpredictable foveal or peripheral stimuli. To examine the nature of participants' spontaneous thoughts, a second experiment used self-report questionnaires to quantify spontaneous thoughts during extended fixation epochs. Thoughts about one's personal past and future comprised a major focus of spontaneous cognition with considerable variability. Activity correlations between the medial temporal lobe and distributed cortical regions within the default network predicted a small, but significant, portion of the observed variability. Collectively, these results suggest that during passive states, activity within the default network reflects spontaneous, internally directed cognitive processes.

Introduction: Emerging Adulthood Theory and Research

2015 ◽  
Author(s):  
Jeffrey Jensen Arnett
Keyword(s):  
Emerging Adulthood ◽  
Final Section ◽  
Life Stage ◽  
Structural Factors ◽  
Risk And Resilience ◽  
The Past ◽  
Aims And Scope ◽  
Explosive Expansion ◽  
To Come

This chapter provides an introduction to the Oxford Handbook of Emerging Adulthood. It begins with an overview of the aims and scope of the handbook. Then it summarizes briefly the content of the chapters to come. The handbook is comprised of 35 chapters organized into 10 parts, with each part containing from two to six chapters. The chapters cover a broad range of areas, from structural factors (such as social class) to relationships (from family to friends) to risk and resilience. The final section of this introductory chapter presents suggestions for the future of the field. The explosive expansion of the field over the past 15 years is noted, and suggestions are made for the field to focus more on EAs who do not attend college, devote more research to international variations in EA, and examine the transition from EA to the next life stage.

scholarly journals On Contributing to the Progress of Medical Informatics as Publisher

2017 ◽  
Vol 26 (01) ◽  
pp. 9-15
Author(s):  
R. Haux ◽  
A. Geissbuhler ◽  
J. Holmes ◽  
M.-C. Jaulent ◽  
S. Koch ◽  
...  
Keyword(s):  
Medical Informatics ◽  
Chief Executive Officer ◽  
Health Informatics ◽  
Driving Force ◽  
Critical Role ◽  
Chief Executive ◽  
80Th Birthday ◽  
Clinical Informatics ◽  
Research And Practice ◽  
The Past

SummaryMay 1st, 2017, will mark Dieter Bergemann’s 80th birthday. As Chief Executive Officer and Owner of Schattauer Publishers from 1983 to 2016, the biomedical and health informatics community owes him a great debt of gratitude. The past and present editors of Methods of Information in Medicine, the IMIA Yearbook of Medical Informatics, and Applied Clinical Informatics want to honour and thank Dieter Bergemann by providing a brief biography that emphasizes his contributions, by reviewing his critical role as an exceptionally supportive publisher for Schattauer’s three biomedical and health informatics periodicals, and by sharing some personal anecdotes. Over the past 40 years, Dieter Bergemann has been an influential, if behind-the-scenes, driving force in biomedical and health informatics publications, helping to ensure success in the dissemination of our field’s research and practice.

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