scholarly journals Encapsulation of Vitamins Using Nanoliposome: Recent Advances and Perspectives

2021 ◽  
Author(s):  
Masoud Aman Mohamadi ◽  
Parastou Farshi ◽  
Parisa Ahmadi ◽  
Azam Ahmadi ◽  
Mohammad Yousefi ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Bioactive Compounds ◽  
Food Processing ◽  
Encapsulation Efficiency ◽  
Direct Relationship ◽  
The Body ◽  
Polydispersity Index ◽  
Food Sources ◽  
Review Study

Nowadays the importance of vitamins is clear for everyone. However, many patients are suffering from insufficient intake of vitamins. Incomplete intake of different vitamins from food sources due to their destruction during food processing or decrease in their bioavailability when mixing with other food materials, are factors resulting in vitamin deficiency in the body. Therefore, various lipid based nanocarriers such as nanoliposomes were developed to increase the bioavailability of bioactive compounds. Since the function of nanoliposomes containing vitamins on the body has a direct relationship with the quality of produced nanoliposomes, this review study was planned to investigate the several aspects of liposomal characteristics such as size, polydispersity index, zeta potential, and encapsulation efficiency on the quality of synthesized vitamin-loaded nanoliposomes.

scholarly journals Formulation and evaluation of polymeric nanoparticles of an antihypetensive drug for gastroretention

2018 ◽  
Vol 8 (6) ◽  
pp. 82-86 ◽  
Author(s):  
Surendranath Betala ◽  
M Mohan Varma ◽  
K Abbulu
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Chlorinated Solvents ◽  
Entrapment Efficiency ◽  
The Body ◽  
Hydrophilic Polymers ◽  
Polydispersity Index ◽  
Average Particle ◽  
Loading Efficiency ◽  
Gastro Retentive

The aim of present study was to formulate and evaluate nanoparticles of carvedilol by using different hydrophilic polymers. Carvedilol was selected as a suitable drug for gastro- retentive nanoparticles due to its short half life, low bioavailability, high frequency of administration, and narrow absorption window in stomach and upper part of GIT. The nano-precipitation method was used to prepare nanoparticles so as to avoid both chlorinated solvents and surfactants to prevent their toxic effect on the body. Nanoparticles of  carvedilol were prepared by using hydrophilic polymers such as HPMC K100M, chitosan, and gelatin. The prepared formulations were then characterized for particle size, polydispersity index, zeta potential, loading efficiency, encapsulation efficiency and drug-excipient compatibility. The prepared nanoparticulate formulations of carvedilol  with different polymers in 1:1 ratio have shown particle size in the range of 250.12-743.07 nm, polydispersity index (PDI) in the range of 0.681-1.0, zeta potential in the range of -14.2 to +33.2 mV, loading efficiency in the range of 8.74-17.54%, and entrapment efficiency in the range of 55.7%-74.2%. Nanoparticulate formulation prepared with chitosan in 1:1 ratio showed satisfactory results i.e. average particle size 312.04 nm, polydispersity index 0.681, zeta potential 33.2 mV, loading efficiency 17.54%, and entrapment efficiency 73.4%. FTIR study concluded that no major interaction occurred between  the drug and polymers used in the present study. Keywords: Nanoparticles; gastro-retentive; nano-precipitation, polydispersity index, zeta potential; entrapment efficiency.

Formulation and Evaluation of Polymeric Nanoparticles of an Antiviral Drug for Gastroretention

2012 ◽  
Vol 4 (4) ◽  
pp. 1557-1562 ◽  
Author(s):  
Ankit Anand Kharia ◽  
A K Singhai ◽  
R Verma
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Average Particle Size ◽  
Chlorinated Solvents ◽  
Entrapment Efficiency ◽  
The Body ◽  
Hydrophilic Polymers ◽  
Polydispersity Index ◽  
Average Particle ◽  
Loading Efficiency

The aim of present study was to formulate and evaluate nanoparticles of acyclovir by using different hydrophilic polymers. Acyclovir was selected as a suitable drug for gastro-retentive nanoparticles due to its short half life, low bioavailability, high frequency of administration, and narrow absorption window in stomach and upper part of GIT. The nano-precipitation method was used to prepare nanoparticles so as to avoid both chlorinated solvents and surfactants to prevent their toxic effect on the body. Nanoparticles of acyclovir were prepared by using hydrophilic polymers such as bovine serum albumin, chitosan, and gelatin. The prepared formulations were then characterized for particle size, polydispersity index, zeta potential, loading efficiency, encapsulation efficiency and drug-excipient compatibility. The prepared nanoparticulate formulations of acyclovir with different polymers in 1:1 ratio have shown particle size in the range of 250.12-743.07 nm, polydispersity index (PDI) in the range of 0.681-1.0, zeta potential in the range of -14.2 to +33.2 mV, loading efficiency in the range of 8.74-17.54%, and entrapment efficiency in the range of 55.7%-74.2%. Nanoparticulate formulation prepared with chitosan in 1:1 ratio showed satisfactory results i.e. average particle size 312.04 nm, polydispersity index 0.681, zeta potential 33.2 mV, loading efficiency 17.54%, and entrapment efficiency 73.4%. FTIR study concluded that no major interaction occurred between the drug and polymers used in the present study.  

scholarly journals The Study of African Leave (Vernonia amygdalina) in for Improving the Quality of Local Duck Meats of West Sumatera

2019 ◽  
Vol 20 (1) ◽  
pp. 55-59
Author(s):  
Zasmeli Suhaemi ◽  
Zulkarnaini Zulkarnaini ◽  
Afrijon Afrijon ◽  
PN Jefri
Keyword(s):  
Body Weight ◽  
Cholesterol Content ◽  
The Body ◽  
Blood Cholesterol ◽  
Food Sources ◽  
Meat Production ◽  
Feed Conversion ◽  
Weight Growth ◽  
Randomized Design

This research purpose to observe the response of local duck, especially male duck that given African Leaf Flour (ALF) in the diet, toward body weight and blood cholesterol content. The treatment for this research will be given by differentiate the ALF level in five levels (0%, 0.5%, 1.0%, 1.5%, and 2.0%) with four times replication. This research used Completely Randomized Design. This treatment is obsessed to 80 male ducks which are rearing from the age of 4 until 10 weeks. The result showed that the increasing of ALF level in diets, will highly significant increase the body weight growth (BWG) of duck, as the increasing value of BWG is 23.59% (P<0,01), and its similarly with the Feed Conversion Ratio (FCR). The blood cholesterol content is decreasing to 7.41% for 1.5% the ALF level given (P<0,01), while the content of cholesterol-HDL and LDL has not significantly (P>0,05). However, the content of cholesterol-HDL in blood tend to increase along with the increasing of the ALF level given. Utilization of ALF level until 2.0% could increase the quality of local duck meat, because its produce higher meat production and improve the content of cholesterol for creating healthy animal food sources.

scholarly journals Poly-ε-Caprolactone Microsphere Polymers Containing Usnic Acid: Acute Toxicity and Anti-Inflammatory Activity

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Jéssica A. P. Barbosa ◽  
Eryvelton S. Franco ◽  
Camilla V. N. S. Silva ◽  
Tatiane O. Bezerra ◽  
Marllon A. N. Santana ◽  
...  
Keyword(s):  
Particle Size ◽  
Acute Toxicity ◽  
Zeta Potential ◽  
Encapsulation Efficiency ◽  
Usnic Acid ◽  
Polydispersity Index ◽  
Inflammatory Activity ◽  
Promising Alternative ◽  
Anti Inflammatory ◽  
Low Solubility

Usnic acid (UA) has been studied by its pharmacological properties; however, it presents moderate toxicity, low solubility, and absorption by biological membranes. The aim of this study was to develop poly-ε-caprolactone microsphere polymers containing UA (UA-micro) and evaluate their acute toxicity and anti-inflammatory activity. The microspheres were prepared by multiple emulsion technique (water/oil/water) and characterized by the encapsulation efficiency, particle size, polydispersity index, and zeta potential. The acute toxicity of UA and UA-micro (25–50 mg/kg; p.o.) was evaluated in mice. The anti-inflammatory activity of UA and UA-micro was evaluated by subcutaneous air pouch and carrageenan-induced paw edema in rat, with measurement of inflammatory cytokines and MPO levels. The UA presented encapsulation efficiency of 97.72%, particle size of 13.54 micrometers, polydispersity index of 2.36, and zeta potential of 44.5 ± 2.95 mV. The UA-micro presented lower acute toxicity (LD50 value up to 2000 mg/kg; p.o.) when compared to UA. UA-micro and UA (25 mg/kg) significantly reduced paw volume and decreased MPO levels, whereas only UA-micro (50 mg/kg) reduced significantly IL-1β, TNF-α, and NO levels in inflammatory exudate. These results suggest that controlled release systems, as microspheres, can be a promising alternative to reduce the toxicity of UA, making it a viable compound for inflammation therapy.

scholarly journals Nanoformulation Development to Improve the Biopharmaceutical Properties of Fisetin Using Design of Experiment Approach

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3031
Author(s):  
Wan-Yi Liu ◽  
Chia-Chen Lin ◽  
Yun-Shan Hsieh ◽  
Yu-Tse Wu
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Oral Delivery ◽  
Encapsulation Efficiency ◽  
Average Particle Size ◽  
Amorphous State ◽  
Polydispersity Index ◽  
Morphological Observation ◽  
Average Particle ◽  
Biopharmaceutical Properties

This study aimed to design an effective nanoparticle-based carrier for the oral delivery of fisetin (FST) with improved biopharmaceutical properties. FST-loaded nanoparticles were prepared with polyvinyl alcohol (PVA) and poly(lactic-co-glycolic acid) (PLGA) by the interfacial deposition method. A central composite design of two independent variables, the concentration of PVA and the amount of PLGA, was applied for the optimization of the preparative parameter. The responses, including average particle size, polydispersity index, encapsulation efficiency, and zeta potential, were assessed. The optimized formulation possessed a mean particle size of 187.9 nm, the polydispersity index of 0.121, encapsulation efficiency of 79.3%, and zeta potential of −29.2 mV. The morphological observation demonstrated a globular shape for particles. Differential scanning calorimetry and powder X-ray diffraction studies confirmed that the encapsulated FST was presented as the amorphous state. The dissolution test indicated a 3.06-fold increase for the accumulating concentrations, and the everted gut sac test showed a 4.9-fold gain for permeability at the duodenum region. In conclusion, the optimized FST-loaded nanoparticle formulation in this work can be developed as an efficient oral delivery system of FST to improve its biopharmaceutic properties.

scholarly journals Cyclodextrin Based Biocompatible Nanosystems for Improving Drug Delivery

2021 ◽  
Vol 16 (2) ◽  
Author(s):  
Lokesh Adhikari ◽  
Nitin Kumar ◽  
Abhijit Saha ◽  
Mona Semalty ◽  
Ajay Semalty
Keyword(s):  
Drug Delivery ◽  
Zeta Potential ◽  
Encapsulation Efficiency ◽  
Polydispersity Index ◽  
Average Particle ◽  
Drug Solubility ◽  
Colloidal Solutions ◽  
Molecular Chemistry ◽  
In Vitro Permeation

Cyclodextrins (CDs) have a hollow bucket like conformations with hydrophobic interior and hydrophilic outer surfaces. These structures are well known in macro-molecular chemistry for their unique ability to form inclusion complexes with different organic molecules. These host-guest complexes were presented in papers for decades for improving solubility, permeability, stability and masking toxic effects of drugs. In the present study, we have designed the nanoparticles of βCD and HPβCD, using Pluronic F108 as cosurfactants for improvement in drug delivery using herbal hydrophobic drug curcumin as a model. And formulated nanosystems evaluated for average particle sizing, polydispersity index, zeta potential, ATR-FTIR, per cent encapsulation efficiency, in-vitro permeation and drug solubility. Both the systems produced colloidal solutions of particles size below 384.2nm with polydispersity index below 0.682, the zeta potential of -58.5 and -8.81, per cent encapsulation efficiency up to 13.5% and an increase in permeation and solubility up to 10 and 7 folds. Observed results of the present studies suggest that biocompatible, non-toxic nanosystems can be developed with different cyclodextrins to improve drug delivery

scholarly journals Polyethylene Glycol-Stabilized Zein Nanoparticles Containing Gallic Acid

2022 ◽  
Vol 60 (2) ◽  
Author(s):  
Heliton Augusto Wiggers ◽  
Margani Taise Fin ◽  
Najeh Maissar Khalil ◽  
Rubiana Mara Mainardes
Keyword(s):  
Antioxidant Activity ◽  
Polyethylene Glycol ◽  
Zeta Potential ◽  
Gallic Acid ◽  
Encapsulation Efficiency ◽  
Drug Carrier ◽  
Drug Loading ◽  
Polydispersity Index ◽  
Food Simulants ◽  
Mean Size

Research background. Gallic acid is a polyphenol presenting antioxidant and antitumor activities, however its use as a nutraceutical or drug is hindered by its low bioavailability. Zein is a natural protein found in corn and has been applied as nanoparticle for drug carrier. In this study, zein nanoparticles were obtained and stabilized with polyethylene glycol (PEG) as gallic acid carriers. Experimental approach. Nanoparticles were obtained by the liquid-liquid method and characterized in terms of mean size, polydispersity index, zeta potential, morphology, solid-state interactions, and encapsulation efficiency/drug loading. The stability of nanoparticles was evaluated in simulated gastrointestinal fluids and food simulants, and the antioxidant activity was determined by the scavenging of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Results and conclusions. Zein nanoparticles containing gallic acid were obtained and stabilized only in the presence of PEG. The optimal conditions originated nanoparticles with mean size <200 nm, low polydispersity index (<0.25) and negative zeta potential (20 mV). The gallic acid encapsulation efficiency was about 40 %, drug loading about 5 %, and the compound was encapsulated in an amorphous state. FTIR did not identify chemical interactions after gallic acid nanoencapsulation. Zein nanoparticles were more susceptible to release the gallic acid in gastric than intestinal simulated medium, however more than 50 % of drug content was protected from premature release. In food simulants, the gallic acid release from nanoparticles was prolonged and sustained. Moreover, the nanoencapsulation did not reduce the antioxidant activity of gallic acid. Novelty and scientific contribution. The results show the importance of PEG on the formation and properties of zein nanoparticles obtained by the liquid-liquid dispersion method. This study indicates PEG-stabilized zein nanoparticles are potential carriers for gallic acid delivery by the oral route to take advantage of its antioxidant properties and be applied both in the pharmaceutical and food industry.

scholarly journals STUDY ON CHANGES IN CHEMICAL COMPOSITIONS AND BIOACTIVE COMPOUNDS IN POUTERIA CAMPECCHIANA FRUIT DURING STORAGE

2019 ◽  
Vol 57 (3B) ◽  
pp. 17
Author(s):  
Tran Xuan Hien ◽  
Huynh Lien Huong ◽  
Nguyen Trung Thanh
Keyword(s):  
Antioxidant Activity ◽  
Bioactive Compounds ◽  
Food Processing ◽  
Nutritional Value ◽  
Room Temperature ◽  
Storage Time ◽  
Mekong Delta ◽  
Chemical Compositions ◽  
Tannin Content

ABSTRACT - QMFS 2019               Pouteria campecchiana, a fruit cultivated in many provinces of the Mekong Delta, is typically eaten fresh and has many benefits to human health. Therefore, quality control during storage of this fruit is very important for fresh consumption and food processing. This study was conducted to investigate the effects of postharvest maturity on the quality of the fruit stored at room temperature, mainly on its chemical composition and bioactive compounds content. The results showed that storage time greatly affected amounts of carotenoids, tannin, phenolic and flavonoids: Highest content of carotenoids, polyphenols, flavonoids were obtained at day 10th of storage while tannin content gradually declined. The greatest antioxidant activity of fruit extracts was also obtained after 10 days storage. It was recommended that highest nutritional value of Pouteria campecchiana can be achieved from 8 to 10 days after harvest.

scholarly journals Development and optimization of quercetin-loaded PLGA nanoparticles by experimental design

2015 ◽  
Vol 88 (2) ◽  
pp. 214-223 ◽  
Author(s):  
Lucia Ruxandra Tefas ◽  
Ioan Tomuță ◽  
Marcela Achim ◽  
Laurian Vlase
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Encapsulation Efficiency ◽  
Polymeric Nanoparticles ◽  
Entrapment Efficiency ◽  
Negative Influence ◽  
Plga Nanoparticles ◽  
Polydispersity Index ◽  
Negative Effect ◽  
Experimental Values

Background and aims: Quercetin is a flavonoid with good antioxidant activity, and exhibits various important pharmacological effects. The aim of the present work was to study the influence of formulation factors on the physicochemical properties of quercetin-loaded polymeric nanoparticles in order to optimize the formulation.Materials and methods: The nanoparticles were prepared by the nanoprecipitation method. A 3-factor, 3-level Box-Behnken design was employed in this study considering poly(D,L-lactic-co-glycolic) acid (PLGA) concentration, polyvinyl alcohol (PVA) concentration and the stirring speed as independent variables. The responses were particle size, polydispersity index, zeta potential and encapsulation efficiency.Results: The PLGA concentration seemed to be the most important factor influencing quercetin-nanoparticle characteristics. Increasing PLGA concentration led to an increase in particle size, as well as encapsulation efficiency. On the other hand, it exhibited a negative influence on the polydispersity index and zeta potential. The PVA concentration and the stirring speed had only a slight influence on particle size and polydispersity index. However, PVA concentration had an important negative effect on the encapsulation efficiency. Based on the results obtained, an optimized formulation was prepared, and the experimental values were comparable to the predicted ones.Conclusions: The overall results indicated that PLGA concentration was the main factor influencing particle size, while entrapment efficiency was predominantly affected by the PVA concentration.

scholarly journals The Effect of Foot Orthosis on the Vertical Component of the Ground Reaction Force While Walking: A Review Study

2021 ◽  
Vol 22 (1) ◽  
pp. 10-27
Author(s):  
Seyed Mohammad Mousavi Nodoshan ◽  
◽  
Ali Reza Taheri ◽  
Keyword(s):  
Ground Reaction Force ◽  
Controlled Trial ◽  
Reaction Force ◽  
Control Level ◽  
Vertical Component ◽  
Internal Validity ◽  
The Body ◽  
Review Study ◽  
Foot Orthosis

Objective Everyone is required to walk and stand for long time in daily activities, especially in the workplace. As a result, the Ground Reaction Force (GRF) on the components and joints is so great that they sometimes reach several times the weight of the body. These forces can have devastating effects on the feet and ankles. Various studies have suggested different methods and factors for reducing the GRF while walking. The purpose of this study was to identify the different causes of factors and methods affecting the GRF according to the current study. Materials & Methods This review study was conducted by searching the databases of ProQuest, PabMed, Web of Science, and MBS from 1995 to 2019. The keywords included 'Ground Reaction Force', foot orthosis', 'walking', 'long term standing impact force'. After reviewing the abstract and title of each study by the authors, the criteria for selecting the article were considered. At the control level of each article, based on the main design of the search, from 1 to 5 were scored as randomized control trial, prospective controlled trial (Cohort), case-control, pre/post, observational clinical consensus, respectively. The quality of the articles was evaluated and scored using the Down and Black tool. Results Out of 82 articles, 21 articles were selected for analysis based on the criteria. Reporting scores, external validity, and internal validity varied between 4-8, 3-1, 5-2, 6-3, 7-4, respectively. From the studies performed on the molding insoles and the change in the loading rate of the maximum vertical GRF, there is a contradiction in proving it. Investigating the effect of foot orthoses in terms of material may lead to a further reduction in plantar. Conclusion Determining the effect of different components on GRF in the sole of the foot will help us better understand the factors involved in quality of life. The four domains of gender, post, material, and molding had different effects. Due to the lack of articles related to the study of the effect of gender and the creation of posts in the insole on the GRF can not be decisive.

Sign in / Sign up

Export Citation Format

Share Document