Cyclodextrin Based Biocompatible Nanosystems for Improving Drug Delivery
Cyclodextrins (CDs) have a hollow bucket like conformations with hydrophobic interior and hydrophilic outer surfaces. These structures are well known in macro-molecular chemistry for their unique ability to form inclusion complexes with different organic molecules. These host-guest complexes were presented in papers for decades for improving solubility, permeability, stability and masking toxic effects of drugs. In the present study, we have designed the nanoparticles of βCD and HPβCD, using Pluronic F108 as cosurfactants for improvement in drug delivery using herbal hydrophobic drug curcumin as a model. And formulated nanosystems evaluated for average particle sizing, polydispersity index, zeta potential, ATR-FTIR, per cent encapsulation efficiency, in-vitro permeation and drug solubility. Both the systems produced colloidal solutions of particles size below 384.2nm with polydispersity index below 0.682, the zeta potential of -58.5 and -8.81, per cent encapsulation efficiency up to 13.5% and an increase in permeation and solubility up to 10 and 7 folds. Observed results of the present studies suggest that biocompatible, non-toxic nanosystems can be developed with different cyclodextrins to improve drug delivery