scholarly journals The Association of Thyroid Hormones With β-HCG in Patients With Hydatidiform Mole

2020 ◽  
Vol 9 (4) ◽  
pp. 140-143
Author(s):  
Hamid Reza Samimagham ◽  
Shirin Mehraban ◽  
Marzieh Nikparvar ◽  
Mohsen Arabi ◽  
Elham Boushehri ◽  
...  
Keyword(s):  
Serum Level ◽  
Thyroid Hormones ◽  
Significant Relationship ◽  
Gestational Hypertension ◽  
Hydatidiform Mole ◽  
Serum Levels ◽  
Subclinical Hyperthyroidism ◽  
Free T4 ◽  
Β Hcg ◽  
The Relationship

Background: A hydatidiform mole or molar pregnancy is the most prevalent gestational trophoblastic disease (GTD). About 55%-60% of women with trophoblastic diseases have overt hyperthyroidism at the time of diagnosis, which may have severe manifestations. This study examined the relationship between gestational hypertension and the level of thyroid hormones with beta human chorionic gonadotropin (β-HCG) in patients with a hydatidiform mole. Materials and Methods: This cross-sectional study enrolled 65 patients with a hydatidiform mole admitted to Khalij-e Fars hospital, Bandar Abbas, Iran. Patients were divided into three groups of clinical hyperthyroidism, subclinical hyperthyroidism, and healthy. The serum levels of thyroid-stimulating hormone (TSH), T4, T3, and β-HCG were checked in all subjects, and the relationship between gestational hypertension and the level of thyroid hormones with β-HCG in patients with a hydatidiform mole was examined. Results: The mean age of patients was 29.93 ± 9.04 years, and their mean gestational age was 11.09 ± 4.2 weeks. In this study, 12.3% of the patients had subclinical hyperthyroidism, 41.5% had clinical hyperthyroidism, and 46.2% were healthy. A significant relationship was found between the serum level of β-HCG and thyroid function in patients with clinical and subclinical hyperthyroidism compared to the healthy group (P= 0.001). No significant relationship was found between systolic/ diastolic blood pressure and the serum level of β-HCG. Conclusion: A significant relationship was observed between the serum levels of β-HCG and TSH, free T3, and free T4 in patients with a hydatidiform mole and thyrotoxicosis. Thus, early diagnosis of hyperthyroidism can help treat these patients more quickly.

Evaluating the Relationship Between Serum Level of Interleukin-6 and Rheumatoid Arthritis Severity and Disease Activity

2020 ◽  
Vol 16 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Elham Rajaei ◽  
Karim Mowla ◽  
Qodratollah Hayati ◽  
Ali Ghorbani ◽  
Mehrdad Dargahi-Malamir ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Level ◽  
Interleukin 6 ◽  
Significant Relationship ◽  
Serum Levels ◽  
P Value ◽  
Das28 Score ◽  
Cross Sectional ◽  
Das 28 ◽  
The Relationship

Aim: The aim of this study was to evaluate the relationship between Interleukin-6 (IL-6) serum level and the severity and activity of Rheumatoid Arthritis (RA). Methods: In this cross-sectional study, 120 RA patients referred to the rheumatology clinic, the patients were diagnosed by rheumatologists according to ACR / EULAR 2010 criteria. Based on DAS28 score the patients were divided into 4 groups: Remission, Mild, Moderate and Severe. Each group contained 30 patients. Serum levels of Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), anti-Cyclic Citrullinated Peptide (anti-CCP) and Rheumatoid Factor (RF) and serum levels of IL-6, were measured. The relationship between these factors was measured and compared to the relationship between IL-6 and these factors, and the activity of the disease was evaluated based on DAS-28. Results: This study showed that the serum level of IL-6 has a significant relationship with RA activity according to DAS-28 (P value <0.001). There is also a significant relationship between the ESR level, the number of painful joints, and the number of swollen joints, and the severity of the disease based on VAS. Conclusion: Generally the findings of this study indicate that serum level of IL-6 plays an important role in the severity and activity of RA disease and can be considered as a determining factor in evaluating the severity of RA in RA patients and it is a good guide for a step up or down of treatment.

scholarly journals Adherence to a Mediterranean Diet and Thyroid Function in Obesity: A Cross-Sectional Apulian Survey

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3173
Author(s):  
Roberta Zupo ◽  
Fabio Castellana ◽  
Francesco Panza ◽  
Luisa Lampignano ◽  
Isanna Murro ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Mediterranean Diet ◽  
Thyroid Function ◽  
Serum Levels ◽  
Overweight And Obesity ◽  
Free T4 ◽  
Cross Sectional ◽  
Free T3 ◽  
Obese Subjects ◽  
The Relationship

Much research suggests that Mediterranean eating habits and lifestyle contribute to counteract the risk of chronic diseases while promoting longevity, but little information is available on the effects of the Mediterranean diet (Med-Diet) on thyroid function, particularly among overweight/obese subjects. Nevertheless, consistent data reported a slight increase in serum levels of the thyroid-stimulating hormone (TSH) and a higher rate of conversion of thyroxine (T4) to triiodothyronine (T3) in obesity. This cross-sectional study was aimed at investigating the relationship between adherence to the Med-Diet and circulating thyroid hormones in a cohort of overweight/obese subjects from Apulia (Southern Italy). Methods: We studied 324 consecutive outpatient subjects (228 women and 96 men, age range 14–72 years) taking no drug therapy and showing normal levels of thyroid hormones, but complicated by overweight and obesity (body mass index (BMI) ≥ 25 Kg/m2). The PREDIMED (PREvención con DIeta MEDiterránea) questionnaire was cross-sectionally administered to assess the adherence to the Med-Diet, and hormonal, metabolic, and routine laboratory parameters were collected. Results: Higher adherence to Med-Diet was found to be inversely related to free T3 (p < 0.01) and T4 (p < 0.01) serum levels. Considering each item in the PREDIMED questionnaire, people consuming at least four spoonfuls of extra-virgin olive oil (EVOO) per day, as well as those consuming at least two servings of vegetables per day, had lower free T3 levels (p 0.033 and p 0.021, respectively). Furthermore, consuming at least four spoonfuls of EVOO per day was found to be associated to lower free T4 serum concentrations (p 0.011). Multinomial logistic regression models, performed on tertiles of thyroid hormones to further investigate the relationship with Med-Diet, corroborated the significance only for free T4. Conclusion: Increased adherence to the Med-Diet was independently associated to a slightly reduced thyroid function, but still within the reference range for free T3 and T4 serum levels. This first finding in this field opens up a research line on any underlying biological interplay.

scholarly journals The Association with Subclinical Thyroid Dysfunction and Uric Acid

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Yuling Xing ◽  
Linlin Yang ◽  
Jing Liu ◽  
Huijuan Ma
Keyword(s):  
Uric Acid ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Meta Analysis ◽  
Serum Levels ◽  
Subclinical Hyperthyroidism ◽  
Funnel Plot ◽  
Different Types ◽  
Standardized Mean Difference ◽  
The Relationship

The relationship between subclinical thyroid dysfunction and uric acid was not well established. This study aimed to determine if subclinical thyroid dysfunction is associated with hyperuricemia risk and to evaluate the levels of uric acid in patients with different forms of subclinical thyroid dysfunction. A systematic search was conducted in 4 databases to obtain relevant studies on subclinical thyroid dysfunction (subclinical hyperthyroidism and subclinical hypothyroidism) and uric acid. The standardized mean difference (SMD) or odds ratio (OR) and 95% confidence interval (95% CI) were used for evaluation, and the sensitivity analysis was conducted. Publication bias was estimated by funnel plot, Egger’s test, and Begg’s test. A total of 73 studies were included in this meta-analysis. The results demonstrated that serum levels of uric acid in patients with subclinical hypothyroidism were significantly higher than those of controls and patients with subclinical hyperthyroidism. Patients with subclinical thyroid dysfunction had a higher prevalence of hyperuricemia compared with normal clinical thyroid function. Subclinical thyroid dysfunction was associated with the prevalence of hyperuricemia. Different types of subclinical thyroid dysfunction had varied effects on serum levels of uric acid.

scholarly journals Thyroid Function as a Predictive Tool for The Prognosis of Traumatic Patients Admitted in Surgery ICUs

2017 ◽  
Vol 5 (3) ◽  
pp. 14
Author(s):  
Ramin Azhough ◽  
Reza Movassaghi ◽  
Ali Farbod
Keyword(s):  
Thyroid Hormones ◽  
Critically Ill ◽  
Thyroid Function ◽  
Critically Ill Patients ◽  
Analytical Study ◽  
Serum Levels ◽  
Predictive Tool ◽  
Duration Of Hospitalization ◽  
Patient Prognosis ◽  
The Relationship

Background: APACHE Score is an important criterion for determining the patient prognosis, especially in critically ill patients. According to significantly changes in the serum levels of thyroidal hormones in patients, especially in critically ill patients, the aim of the present study was to evaluate the relationship between thyroid function and APACHE 4 score in the prognosis of the traumatic patients admitted in surgery ICU. Method & Material: In a descriptive-analytical study, 90 patients with multiple trauma were studied. Thyroid hormones and APACHE 4 Score were evaluated on 1st, 5th and10th days of admission for each patient. Their clinical features and duration of hospitalization, either in trauma unit or ICU, elation between thyroidal hormones and APACHE 4 Score, duration of hospitalization, and survival of patients were evaluated. Results: This study included 90 patients. A statistically significant relation was detected between thyroid hormones (TT3) and APACHE 4 Score and duration of hospitalization. Conclusion: TT3 might be utilized as a prognostic factor in the traumatic patients admitted to ICU. 

scholarly journals A Case of Rapid Transformation from Hydatidiform Mole to Invasive Mole: The Importance of β-hCG (Human Chorionic Gonadotropin) Serum Levels in Follow-Up Evaluation

2021 ◽  
Vol 22 ◽  
Author(s):  
Ali Budi Harsono ◽  
Yudi Mulyana Hidayat ◽  
Gatot Nyarumenteng Adhipurnawan Winarno ◽  
Aisyah Shofiatun Nisa ◽  
Firas Farisi Alkaff
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Hydatidiform Mole ◽  
Serum Levels ◽  
Β Hcg ◽  
Invasive Mole ◽  
Rapid Transformation

scholarly journals Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Pavel Borsky ◽  
Zdenek Fiala ◽  
Ctirad Andrys ◽  
Martin Beranek ◽  
Kvetoslava Hamakova ◽  
...  
Keyword(s):  
Disease Severity ◽  
Significant Relationship ◽  
Psoriasis Vulgaris ◽  
Serum Levels ◽  
Intracellular Proteins ◽  
Elisa Technique ◽  
Commercial Kits ◽  
Destructive Processes ◽  
Chronic Autoimmune Disease ◽  
The Relationship

Background. Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic patients. Alarmins, also known as danger signals, are intracellular proteins, which are released to an extracellular space after infection or damage. They are the markers of cell destructive processes. Objective. The aim of the present study was to evaluate the suitability of selected alarmins (HMGB1, IL-33, S100A7, and S100A12) as potential biomarkers of severity of psoriasis and to explore possible relationships between these proteins for the purpose of better understanding their roles in the immunopathology of psoriasis. Methods. The serum levels of selected alarmins were measured in 63 psoriatic patients and 95 control individuals. The levels were assessed by the ELISA technique using commercial kits. The data were statistically processed with MedCalc version 19.0.5. Results. In psoriatic patients, we found significantly increased levels of HMGB1 (p<0.05), IL-33 (p<0.01), S100A7 (p<0.0001), and S100A12 (p<0.0001). In addition, we found a significant relationship between HMGB1 and S100A7 (Spearman’s rho=0.276, p<0.05) in the patients and significant relationship between HMGB1 and IL-33 in the controls (Spearman’s rho=0.416, p<0.05). We did not find any relationship between observed alarmins and the disease severity. Conclusions. The alarmins HMGB1, IL-33, S100A7, and S100A12 were significantly elevated in the serum of patients, which states the hypothesis that they play specific roles in the immunopathology of psoriasis. However, we have not yet found a relationship between observed alarmins and the disease severity. The discovery of the relationship between HMGB1 and S100A7 is a novelty that should be studied in the future to further clarify its role and importance.

scholarly journals Free triiodothyronine (T3) is negatively associated with fasting ghrelin serum levels in a population sample of euthyroid subjects

2021 ◽  
Author(s):  
D. A. Wittekind ◽  
J. Kratzsch ◽  
R. Mergl ◽  
R. Baber ◽  
V. Witte ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Thyroid Hormones ◽  
Population Sample ◽  
Serum Levels ◽  
Total Serum ◽  
Free Triiodothyronine ◽  
Negatively Associated ◽  
Total Ghrelin ◽  
Serum Ghrelin ◽  
The Relationship

Abstract Purpose Ghrelin is an orexigenic peptide hormone secreted in times of stress and hunger. It is deeply involved in the regulation of metabolism and energy homeostasis, promoting energy intake and inhibiting energy expenditure on a metabolic level. In this regard, it has in many ways antagonistic effect on the thyroid hormones, which increase metabolism and thus energy expenditure. While there is reasonable evidence of a negative association between ghrelin and hormones of the hypothalamic-pituitary-thyroid (HPT-) axis from studies in patients with thyroid dysfunction and small intervention studies, large-scale studies in healthy subjects are lacking. Therefore, we studied the relationship between total ghrelin serum levels and serum levels of the thyroid hormones in a large sample of euthyroid subjects. Methods Total ghrelin, thyroid-stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) were determined after an overnight fast in 1666 subjects participating in a population-based cross-sectional study (‘LIFE’) including 10,000 adults. 1012 subjects were included in this analysis. Multiple linear regression analyses were performed. Results FT3 was negatively associated with serum ghrelin; total sample: β = − 0.0001, p < 0.001; men: β = − 0.0002, p = 0.013; women: β = − 0.0001, p = 0.010, adjusted for age, BMI, alcohol consumption, serum levels of TSH and fT4 and smoking status. No associations were found between ghrelin serum levels and serum levels of fT4 or TSH. Conclusion This is to date the largest study investigating the relationship between total serum ghrelin and thyroid hormones. The results point to a complex interaction and should initiate further research.

scholarly journals The correlation between serum level of brain natriuretic peptide and amount of left to right shunt

2019 ◽  
Vol 11 (1) ◽  
pp. 68-71
Author(s):  
Ahmad Jamei Khosroshahi ◽  
Akbar Molaei ◽  
Mahmoud Samadi ◽  
Elnaz Eskandartash
Keyword(s):  
Serum Level ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Significant Relationship ◽  
Septal Defect ◽  
Ductus Arteriosus ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Physical Examinations ◽  
The Relationship

Introduction: Natriuretic peptides such as brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and pro-BNP are secreted in response to atrial and/or ventricular stretch. Left to right shunts such as ventricular septal defect (VSD), atrial septal defect (ASD), and patent ductus arteriosus (PDA), are treated medically or surgically. We aimed to evaluate whether the serum level of pro-BNP would be useful to measure the amount of the shunt. Methods: In this cross sectional study, 60 infants and children, in whom physical examinations approved heart murmur, and had undergone echocardiography by which VSD, ASD, or PDA had been proven, were included in the study. The relationship between serum BNP levels and severity of shunt (Qp/Qs) based on echocardiographic and hemodynamic evaluations, was studied. Results: There was a significant relationship between serum level of pro-BNP and the amount of the shunt in the patients with VSD, ASD, and PDA (P=0.01). A positive correlation was seen between pro-BNP serum level and Qp/Qs ratio. The mean ± SE serum level of pro-BNP in patients with Qp/Qs ratio of less than 1.5, equal to 1.5-2, and more than 2 was 30.83±2.4, 217.88±44.6, and 217.13±51.8, respectively showing a significant relationship (P=0.0001). The cut-off point of pro-BNP demonstrating a Qp/Qs ratio more than 1.5 was measured at the level of 40.36 pg/mL, with a sensitivity and specificity of 92% and 79%, respectively. Conclusion: Based on our study, the cut-off point of 40.36 pg/mL or more for pro-BNP, showing a Qp/Qs ratio more than 1.5, can be considered as an indication for interventional procedures.

scholarly journals Is There Any Relationship Between Maternal Vitamin D and Thyroid Function in Pregnancy With Maternal and Neonatal Outcomes? A Cross-sectional Study

2021 ◽  
Author(s):  
Salma Ahi ◽  
Iman Fereydooni²
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Thyroid Function ◽  
Significant Relationship ◽  
Maternal Age ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Relationship ◽  
In Pregnancy

Abstract Background: The aim of this study was to evaluate the prevalence of vitamin D deficiency in pregnant women to investigate the relationship between vitamin D level and thyroid function.Methods: In this cross-sectional descriptive study, a total number of 90 patients during the three trimesters of pregnancy were investigated, 30 pregnant women were studied in each trimester of pregnancy. We evaluated thyroid function test and thyroid auto-antibodies (TPO Ab, Tg Ab) also serum level of 25OHD, to determine the relationship between vitamin D level and autoimmune or non-autoimmune thyroid disease in pregnancy. Results: Pearson correlation in all subjects showed that vitamin D levels did not have a significant relationship with maternal age. Only in the third trimester, there was a significant difference in maternal age based on their vitamin D status. The mean age of patients with a sufficient level of vitamin D (29.29 ± 3.87) was higher than the moderate vitamin D deficient patient’s age (23.4 ± 1.51). There was no significant difference between the trimesters of pregnancy and vitamin D status (P>0.05). Also, there were no significant differences between serum levels of vitamin D within three trimesters. Regarding the pregnancy outcomes, two newborns were admitted to NICU, Meconium Aspiration in one case, and IUFD in another case leads to pregnancy termination. These four cases were related to maternal history of hypothyroidism. Conclusion: There was no significant relationship between vitamin D and pregnancy trimester. The serum level of vitamin D had no particular effect on the outcome of pregnancy and the thyroid gland function.

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