scholarly journals Adherence to a Mediterranean Diet and Thyroid Function in Obesity: A Cross-Sectional Apulian Survey

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3173
Author(s):  
Roberta Zupo ◽  
Fabio Castellana ◽  
Francesco Panza ◽  
Luisa Lampignano ◽  
Isanna Murro ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Mediterranean Diet ◽  
Thyroid Function ◽  
Serum Levels ◽  
Overweight And Obesity ◽  
Free T4 ◽  
Cross Sectional ◽  
Free T3 ◽  
Obese Subjects ◽  
The Relationship

Much research suggests that Mediterranean eating habits and lifestyle contribute to counteract the risk of chronic diseases while promoting longevity, but little information is available on the effects of the Mediterranean diet (Med-Diet) on thyroid function, particularly among overweight/obese subjects. Nevertheless, consistent data reported a slight increase in serum levels of the thyroid-stimulating hormone (TSH) and a higher rate of conversion of thyroxine (T4) to triiodothyronine (T3) in obesity. This cross-sectional study was aimed at investigating the relationship between adherence to the Med-Diet and circulating thyroid hormones in a cohort of overweight/obese subjects from Apulia (Southern Italy). Methods: We studied 324 consecutive outpatient subjects (228 women and 96 men, age range 14–72 years) taking no drug therapy and showing normal levels of thyroid hormones, but complicated by overweight and obesity (body mass index (BMI) ≥ 25 Kg/m2). The PREDIMED (PREvención con DIeta MEDiterránea) questionnaire was cross-sectionally administered to assess the adherence to the Med-Diet, and hormonal, metabolic, and routine laboratory parameters were collected. Results: Higher adherence to Med-Diet was found to be inversely related to free T3 (p < 0.01) and T4 (p < 0.01) serum levels. Considering each item in the PREDIMED questionnaire, people consuming at least four spoonfuls of extra-virgin olive oil (EVOO) per day, as well as those consuming at least two servings of vegetables per day, had lower free T3 levels (p 0.033 and p 0.021, respectively). Furthermore, consuming at least four spoonfuls of EVOO per day was found to be associated to lower free T4 serum concentrations (p 0.011). Multinomial logistic regression models, performed on tertiles of thyroid hormones to further investigate the relationship with Med-Diet, corroborated the significance only for free T4. Conclusion: Increased adherence to the Med-Diet was independently associated to a slightly reduced thyroid function, but still within the reference range for free T3 and T4 serum levels. This first finding in this field opens up a research line on any underlying biological interplay.

Relationship Among Adherence to The Mediterranean Diet and Anthropometric and Metabolic Parameters in Subjects with Obesity

2020 ◽  
Vol 20 ◽  
Author(s):  
Luisa Lampignano ◽  
Roberta Zupo ◽  
Rossella Donghia ◽  
Vito Guerra ◽  
Fabio Castellana ◽  
...  
Keyword(s):  
Mediterranean Diet ◽  
Hdl Cholesterol ◽  
Fat Distribution ◽  
Serum Levels ◽  
Overweight And Obesity ◽  
Height Ratio ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Waist To Height Ratio ◽  
The Mediterranean

Background: There is moderate-to-high evidence that the Mediterranean diet prevents increases in body weight and waist circumference in non-obese individuals but less is known about its effects in subjects with overweight and obesity. The present study was focused on exploring the cross-sectional association among the adherence to Mediterranean diet and the most commonly used variables of metabolic and cardiovascular risk factors in a cohort of overweight subjects from a typical Mediterranean region, Apulia, in Southern Italy. Methods:: The study was performed in a cohort of 1214 individuals, all with overweight or obesity but no other clinical condition. We investigated the association among adherence to Mediterranean diet, assessed with the PREDIMED score, and anthropometric parameters [namely body mass index (BMI), WC, waist to height ratio (WHtR) and neck circumference (NC)], fasting serum levels of glucose, insulin, uric acid and lipids (triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol), and blood pressure and insulin resistance, measured by HOMA-IR. Results:: The waist to height ratio was negatively associated to a PREDIMED score ≥7 (p<0.04), whereas HDL cholesterol was positively associated to a PREDIMED score ≥7 (p<0.04) Conclusion: This study suggests that body fat distribution and HDL-cholesterol are the parameters most strongly influenced by MedDiet in Apulian subjects.

scholarly journals Thyroid Function as a Predictive Tool for The Prognosis of Traumatic Patients Admitted in Surgery ICUs

2017 ◽  
Vol 5 (3) ◽  
pp. 14
Author(s):  
Ramin Azhough ◽  
Reza Movassaghi ◽  
Ali Farbod
Keyword(s):  
Thyroid Hormones ◽  
Critically Ill ◽  
Thyroid Function ◽  
Critically Ill Patients ◽  
Analytical Study ◽  
Serum Levels ◽  
Predictive Tool ◽  
Duration Of Hospitalization ◽  
Patient Prognosis ◽  
The Relationship

Background: APACHE Score is an important criterion for determining the patient prognosis, especially in critically ill patients. According to significantly changes in the serum levels of thyroidal hormones in patients, especially in critically ill patients, the aim of the present study was to evaluate the relationship between thyroid function and APACHE 4 score in the prognosis of the traumatic patients admitted in surgery ICU. Method & Material: In a descriptive-analytical study, 90 patients with multiple trauma were studied. Thyroid hormones and APACHE 4 Score were evaluated on 1st, 5th and10th days of admission for each patient. Their clinical features and duration of hospitalization, either in trauma unit or ICU, elation between thyroidal hormones and APACHE 4 Score, duration of hospitalization, and survival of patients were evaluated. Results: This study included 90 patients. A statistically significant relation was detected between thyroid hormones (TT3) and APACHE 4 Score and duration of hospitalization. Conclusion: TT3 might be utilized as a prognostic factor in the traumatic patients admitted to ICU. 

scholarly journals The relationship between thyroid function and ovarian reserve: a prospective cross-sectional study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Roya Kabodmehri ◽  
Seyedeh Hajar Sharami ◽  
Ziba Zahiri Sorouri ◽  
Nasrin Ghanami Gashti ◽  
Forozan Milani ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Ovarian Function ◽  
Serum Levels ◽  
Thyroid Stimulating Hormone ◽  
Roc Curve Analysis ◽  
Free T4 ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Relationship ◽  
Stimulating Hormone

Abstract Background Thyroid dysfunction can affect fertility and miscarriage risk by affecting the process of follicular growth, embryo development, implantation, and placental formation. It has been suggested that thyroid disorders are associated with ovarian reserve by affecting the follicular process. The aim of the present study was to investigate the relationship between thyroid hormone levels and ovarian reserve. Methods Three hundred fourteen women with infertility due to various etiologies were enrolled in this study (172 individuals with Anti-Mullerian hormone (AMH) level ≥ 1.1 ng/ml and 142 individuals with AMH < 1.1 ng/ml). Serum levels of follicle-stimulating hormone (FSH), estradiol (E2) on day 2–4 of menstrual cycles, AMH, Thyroid-stimulating hormone (TSH), and thyroxine (free T4) were evaluated. Results In participants with age over 35 years, median TSH level in women with AMH < 1.1 ng/ml was significantly higher than those with AMH ≥1.1 ng/ml (P-value =0.037). There was no significant difference in body mass index (BMI) in patients with age older than 35 years and younger than 35 years sub-groups based on AMH level (P-value = 0.102, and P-value = 0.909 respectively). With one unit increase in TSH level, the odds of having AMH < 1.1 ng/ml increases by 1.25 times or by 25% (P-value =0.017). Receiver operator characteristic (ROC) curve analysis showed a TSH cut-off point of 1.465 mIU/L in participants over 35 years in identifying decreased AMH level. Conclusion Our study supports the relationship between TSH level and ovarian reserve so that with an increase in TSH from a certain level is associated with a decrease in ovarian function.

scholarly journals Thyroid status in patients undergoing maintenance haemodialysis: a South Indian cohort study

2019 ◽  
Vol 6 (5) ◽  
pp. 1531
Author(s):  
Bhaskaran S. ◽  
Sakthidasan S. ◽  
Lalitha Shanmugam ◽  
Suthakaran C.
Keyword(s):  
Thyroid Hormones ◽  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Status ◽  
Tertiary Referral Hospital ◽  
Free T4 ◽  
Cross Sectional ◽  
Maintenance Haemodialysis ◽  
South Indian ◽  
The Status

Background: Hypothyroidism is common throughout the world and the prevalence of hypothyroidism is high in India. Ailment of thyroid function has been documented to occur at a higher rate in patients with chronic kidney disease (CKD), including those undergoing dialysis than in general population.Methods: A prospective cross-sectional observational clinical study in real time was carried out to assess the thyroid status in eighty-nine adult patients undergoing a 4 h three times weekly haemodialysis schedule in a rural tertiary referral hospital in South India. The status of the thyroid was monitored via Free T3 Free T4 and Thyroid Stimulating Hormone levels.Results: Subclinical hypothyroidism was common in patients undergoing haemodialysis. Although there was a negative correlation between the levels of thyroid hormones and other variables, it was clinically insignificant.Conclusions: The present study showed that abnormalities in thyroid function are high in patients undergoing haemodialysis and that there were no clinically significant correlation between the levels of thyroid hormones and clinical or biochemical characteristics.

scholarly journals Effect of acute and chronic liver diseases on the thyroid function in children

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gihan M. Bebars ◽  
Madeha A. Sayed ◽  
Lamia Hamdy ◽  
Reem A. Abdel Aziz
Keyword(s):  
Thyroid Hormones ◽  
Acute Hepatitis ◽  
Thyroid Function ◽  
Liver Diseases ◽  
Complete Blood Count ◽  
Serum Levels ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Positive Correlation ◽  
Free T3

Abstract Background Thyroid hormones modulate hepatic function through regulation of basal metabolic rate in addition; the liver metabolizes the thyroid hormones and regulates their endocrine effects. Objectives To assess thyroid functions in children with acute and chronic liver diseases. Methods 85 studied children were divided into 4 groups; group 1 (20 children) with acute hepatitis (AH), group 2 (20 children) chronic liver disease1 (CLD1; relatively preserved liver functions including Child-Pugh stage A), group 3 (20 children) chronic liver disease2 (CLD2; includes Child-Pugh stage B or C), group 4 (25 children) controls. All groups were subjected to detailed history, physical examination, Complete blood count, liver, renal function tests, viral markers, and thyroid functions (FT3, FT4, TSH). Results Free T3 levels were lower in children with AH, CLD1 and CLD2. There was significant increase in TSH serum levels in CLD2.In acute hepatitis a negative correlation between serum free T4 and AST (r = -0.991), positive correlation between serum TSH and AST, VLDL, and cholesterol levels (r= 0.503, 0.533 and 0.498). A positive correlation between free T3 levels and prothrombin concentration (r= 0.991). Negative correlations between free T3 levels and PT, serum bilirubin and LDL serum levels in children with CLD2 (r= -0.992) (r= -0.902) and (r= -0.946) Conclusion Acute and chronic liver diseases affect thyroid function in children and is correlated with the disease severity.

scholarly journals Association between Normal Thyroid Hormones and Diabetic Retinopathy in Patients with Type 2 Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Jian Zou ◽  
Zeping Li ◽  
Feng Tian ◽  
Yi Zhang ◽  
Chao Xu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Thyroid Hormones ◽  
Thyroid Function ◽  
Shaanxi Province ◽  
Free Triiodothyronine ◽  
Cross Sectional ◽  
Normal Thyroid ◽  
The Relationship

The relationship between normal thyroid function and type 2 diabetes mellitus (T2DM) has been a particular focus for concern. The present study determined the relationship between thyroid hormone levels and the prevalence of diabetic retinopathy (DR) in T2DM patients. A cross-sectional study (n = 633) was performed in Xi’an, Shaanxi Province, China. Subjects were evaluated for anthropometric measurements, thyroid function, and diabetic retinopathy. Logistic regression models were used to assess the relationships between thyroid hormones and DR. Of 633 patients, 243 (38.4%) patients suffered from DR. The prevalence of DR showed a significantly decreasing trend across the quartiles based on free triiodothyronine (FT3) (FT3 quartile 1 group [FT3-Q1] <4.35 pmol/L, FT3 quartile 2 group [FT3-Q2] 4.35–4.70 pmol/L, FT3 quartile 3 group [FT3-Q3] 4.70–5.08 pmol/L, and FT3 quartile 4 group [FT3-Q4] ≥5.08 pmol/L) (56.7%, 42.5%, 33.1%, 23.8%, P<0.001). In comparison with all participants categorized in FT3-Q1, the multivariable adjusted odds ratios (95% confidence interval) of DR in FT3-Q2, FT3-Q3, and FT3-Q4 were 0.587 (0.340–1.012), 0.458 (0.258–0.813), and 0.368 (0.201–0.673), (P=0.055, P=0.008, P=0.001), respectively. FT3 levels within the normal range are negatively associated with DR in euthyroid patients with type 2 diabetes. Further studies should be aimed at clarifying the relationship between thyroid hormones and T2DM.

scholarly journals Thyroid Function Test in Patients with Chronic Kidney Disease

2021 ◽  
pp. 150-158
Author(s):  
V. Abhinaya ◽  
S. Magesh Kumar
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Thyroid Hormones ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Thyroid Function Test ◽  
Free T4 ◽  
Cross Sectional ◽  
Male Predominance ◽  
Low T3

Background: Kidneys have a significant role in the metabolism, degradation and excretion of thyroid hormones. Both thyroid hormones and kidney functions have a multifaceted mutual interdependence. Objectives: To find out the possible association between the severity of chronic kidney disease and thyroid dysfunction; To estimate the correlation between thyroid dysfunction and various stages of chronic kidney disease. Materials and Methods: A prospective Cross-sectional study was done on 50 patients with Chronic kidney disease who were not on dialysis and fulfilled all the inclusion criteria at Saveetha medical college over a period of 6 months. Free T3, Free T4 and TSH levels were estimated for those patients. Results: Results of this study showed that majority of subjects included in our study were in the age group of 50-60 years with Male predominance. Out of 50 patients included in our study, 8 patients(16%) were found to hypothyroidism; 5 patients (10%) were having subclinical hypothyroidism; 20 patients (40%) were having low T3 syndrome and 17 patients (34%) were having normal functioning thyroid gland. Staging of CKD was done in relation to the glomerular filtration rate .Most of the patients(n=20) were in Stage 5 of Chronic kidney disease out of which 18 patients were having thyroid disorders. Conclusion: There is a positive correlation between the severity of CKD and thyroid dysfunction. Hence a routine thyroid function status should be evaluated in each and every patient of CKD to reduce the morbidity and mortality rate of CKD patients as well as reduce the social burden and health expenditure.

scholarly journals The Association of Thyroid Hormones With β-HCG in Patients With Hydatidiform Mole

2020 ◽  
Vol 9 (4) ◽  
pp. 140-143
Author(s):  
Hamid Reza Samimagham ◽  
Shirin Mehraban ◽  
Marzieh Nikparvar ◽  
Mohsen Arabi ◽  
Elham Boushehri ◽  
...  
Keyword(s):  
Serum Level ◽  
Thyroid Hormones ◽  
Significant Relationship ◽  
Gestational Hypertension ◽  
Hydatidiform Mole ◽  
Serum Levels ◽  
Subclinical Hyperthyroidism ◽  
Free T4 ◽  
Β Hcg ◽  
The Relationship

Background: A hydatidiform mole or molar pregnancy is the most prevalent gestational trophoblastic disease (GTD). About 55%-60% of women with trophoblastic diseases have overt hyperthyroidism at the time of diagnosis, which may have severe manifestations. This study examined the relationship between gestational hypertension and the level of thyroid hormones with beta human chorionic gonadotropin (β-HCG) in patients with a hydatidiform mole. Materials and Methods: This cross-sectional study enrolled 65 patients with a hydatidiform mole admitted to Khalij-e Fars hospital, Bandar Abbas, Iran. Patients were divided into three groups of clinical hyperthyroidism, subclinical hyperthyroidism, and healthy. The serum levels of thyroid-stimulating hormone (TSH), T4, T3, and β-HCG were checked in all subjects, and the relationship between gestational hypertension and the level of thyroid hormones with β-HCG in patients with a hydatidiform mole was examined. Results: The mean age of patients was 29.93 ± 9.04 years, and their mean gestational age was 11.09 ± 4.2 weeks. In this study, 12.3% of the patients had subclinical hyperthyroidism, 41.5% had clinical hyperthyroidism, and 46.2% were healthy. A significant relationship was found between the serum level of β-HCG and thyroid function in patients with clinical and subclinical hyperthyroidism compared to the healthy group (P= 0.001). No significant relationship was found between systolic/ diastolic blood pressure and the serum level of β-HCG. Conclusion: A significant relationship was observed between the serum levels of β-HCG and TSH, free T3, and free T4 in patients with a hydatidiform mole and thyrotoxicosis. Thus, early diagnosis of hyperthyroidism can help treat these patients more quickly.

scholarly journals Association Between Thyroid Hormones and Lipids Stratified by Race and Sex

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A283-A283
Author(s):  
Musa Shakoor ◽  
Zahid Ahmad
Keyword(s):  
Thyroid Hormones ◽  
Total Cholesterol ◽  
Correlation Coefficient ◽  
Thyroid Function ◽  
Black Males ◽  
Thyroid Dysfunction ◽  
Thyroid Function Tests ◽  
Free T4 ◽  
Black Females ◽  
The Relationship

Abstract It has been well-established that thyroid hormones play a role in cholesterol and lipoprotein metabolism. However, there is limited data assessing the variability in the association between thyroid hormones and lipids across sex and race. We hypothesized that thyroid dysfunction is associated with changes in lipids and lipoproteins with no substantial variability in this association between races and sex. The electronic medical record of a large county hospital in Dallas, TX was queried to obtain data on all patients who had lipid panels and thyroid function tests checked on the same day from 1/1/2013 to 1/1/2018. The results were stratified into hypothyroid (TSH greater than 4.5 mcIU/L and Free T4 less than 0.8 ng/dL), hyperthyroid (TSH less than 0.5 mcIU/L and Free T4 greater than 1.8 ng/dL) and normal (TSH between 0.5 and 4.5 mcIU/L, Free T4 between 0.8 and 1.8 ng/dL). Results consistent with subclinical thyroid disease were excluded from further analysis. There were 25,290 unique results for thyroid hormones and lipid panels checked on the same day. The results were further stratified by race and sex, and the relationship between thyroid function and lipids was assessed. The correlation coefficient (r) was compared between sexes within each race for the following variables: TSH vs HDL-C, TSH vs LDL-C, TSH vs Total Cholesterol, TSH vs triglycerides, FT4 vs HDL-C, FT4 vs LDL-C, FT4 vs Total Cholesterol, and FT4 vs triglycerides. Among black males with hypothyroidism, there was a notably stronger correlation when compared to black females in the relationship between TSH vs LDL-C, and TSH vs Total Cholesterol. Specifically, the correlation coefficient of TSH vs LDL-C among Black males with hypothyroidism was 0.582, compared to 0.133 among Black females with hypothyroidism (P=0.0053). Furthermore, the correlation coefficient of TSH vs Total Cholesterol among Black males was 0.567 compared to 0.184 among Black females (P=0.016). In contrast, no difference in any of the relationships between thyroid and lipids was demonstrated between sexes amongst Whites, Asians, and Hispanics. Overall, we found differences in Black patients compared to patients of other races with regards to the association between thyroid and lipids. Specifically, it was found that Black males with hypothyroidism had a stronger positive correlation in TSH vs LDL-C and TSH vs Total Cholesterol than Black females. This type of difference between sexes was not found amongst any other race. These findings suggest that thyroid dysfunction is associated with changes in lipids, and the way these changes manifest may vary depending on the race and sex. This further highlights the importance of checking lipid panels in patients with thyroid dysfunction. Further research is needed to more clearly characterize the variation that is seen in thyroid and lipid function amongst races.

scholarly journals The Influence of Age and Sex on Tests of Thyroid Function

1985 ◽  
Vol 22 (5) ◽  
pp. 502-505 ◽  
Author(s):  
J A Franklyn ◽  
D B Ramsden ◽  
M C Sheppard
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Thyroid Function ◽  
Normal Subjects ◽  
Thyroid Stimulating Hormone ◽  
Free T4 ◽  
Reverse T3 ◽  
Free Thyroid Hormones ◽  
Free T3 ◽  
Age And Sex

Serum concentrations of total thyroid hormones, thyroid hormone binding proteins, free thyroid hormones and thyroid stimulating hormone (TSH) were measured in a large group of healthy normal subjects ( n = 218) to determine the influence of age and sex on tests of thyroid function. No effect of age on measurements of total thyroxine (T4), total triiodothyronine (T3) or reverse T3 was evident. Concentrations of free T4, free T3 and TSH were similarly unaffected, suggesting that increasing age alone does not significantly influence thyroid hormone measurements. There was, however, a rise in thyroxine-binding globulin (TBG) concentration with increasing age and a fall in thyroxine-binding prealbumin (TBPA). An influence of sex on tests of thyroid function was clearly evident. Levels of total T4, total T3, free T4 and the T4: TBG ratio were lower in women between 16 and 49 years than in men, despite an increase in TBG. Lower levels of free T3 were confined to the group of women aged 16–29 years. TSH values were unaffected by sex. These results suggest that sex hormone status in the pre-menopausal female subject may result in an increase in TBG concentration, and in addition may have an opposing effect on circulating thyroid hormone concentrations.

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