scholarly journals Is There Any Relationship Between Maternal Vitamin D and Thyroid Function in Pregnancy With Maternal and Neonatal Outcomes? A Cross-sectional Study

2021 ◽  
Author(s):  
Salma Ahi ◽  
Iman Fereydooni²
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Thyroid Function ◽  
Significant Relationship ◽  
Maternal Age ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Relationship ◽  
In Pregnancy

Abstract Background: The aim of this study was to evaluate the prevalence of vitamin D deficiency in pregnant women to investigate the relationship between vitamin D level and thyroid function.Methods: In this cross-sectional descriptive study, a total number of 90 patients during the three trimesters of pregnancy were investigated, 30 pregnant women were studied in each trimester of pregnancy. We evaluated thyroid function test and thyroid auto-antibodies (TPO Ab, Tg Ab) also serum level of 25OHD, to determine the relationship between vitamin D level and autoimmune or non-autoimmune thyroid disease in pregnancy. Results: Pearson correlation in all subjects showed that vitamin D levels did not have a significant relationship with maternal age. Only in the third trimester, there was a significant difference in maternal age based on their vitamin D status. The mean age of patients with a sufficient level of vitamin D (29.29 ± 3.87) was higher than the moderate vitamin D deficient patient’s age (23.4 ± 1.51). There was no significant difference between the trimesters of pregnancy and vitamin D status (P>0.05). Also, there were no significant differences between serum levels of vitamin D within three trimesters. Regarding the pregnancy outcomes, two newborns were admitted to NICU, Meconium Aspiration in one case, and IUFD in another case leads to pregnancy termination. These four cases were related to maternal history of hypothyroidism. Conclusion: There was no significant relationship between vitamin D and pregnancy trimester. The serum level of vitamin D had no particular effect on the outcome of pregnancy and the thyroid gland function.

scholarly journals Interactions between Vitamin D Status, Calcium Intake and Parathyroid Hormone Concentrations in Healthy White-Skinned Pregnant Women at Northern Latitude

Nutrients ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 916 ◽  
Author(s):  
Andrea Hemmingway ◽  
Karen O’Callaghan ◽  
Áine Hennessy ◽  
George Hull ◽  
Kevin Cashman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Pregnant Women ◽  
Calcium Intake ◽  
Geometric Mean ◽  
Vitamin D Status ◽  
Metabolic System ◽  
Cross Sectional ◽  
The Mean ◽  
In Pregnancy

Adverse effects of low vitamin D status and calcium intakes in pregnancy may be mediated through functional effects on the calcium metabolic system. Little explored in pregnancy, we aimed to examine the relative importance of serum 25-hydroxyvitamin D (25(OH)D) and calcium intake on parathyroid hormone (PTH) concentrations in healthy white-skinned pregnant women. This cross-sectional analysis included 142 participants (14 ± 2 weeks’ gestation) at baseline of a vitamin D intervention trial at 51.9 °N. Serum 25(OH)D, PTH, and albumin-corrected calcium were quantified biochemically. Total vitamin D and calcium intakes (diet and supplements) were estimated using a validated food frequency questionnaire. The mean ± SD vitamin D intake was 10.7 ± 5.2 μg/day. With a mean ± SD serum 25(OH)D of 54.9 ± 22.6 nmol/L, 44% of women were <50 nmol/L and 13% <30 nmol/L. Calcium intakes (mean ± SD) were 1182 ± 488 mg/day and 23% of participants consumed <800 mg/day. The mean ± SD serum albumin-adjusted calcium was 2.2 ± 0.1 mmol/L and geometric mean (95% CI) PTH was 9.2 (8.4, 10.2) pg/mL. PTH was inversely correlated with serum 25(OH)D (r = −0.311, p < 0.001), but not with calcium intake or serum calcium (r = −0.087 and 0.057, respectively, both p > 0.05). Analysis of variance showed that while serum 25(OH)D (dichotomised at 50 nmol/L) had a significant effect on PTH (p = 0.025), calcium intake (<800, 800–1000, ≥1000 mg/day) had no effect (p = 0.822). There was no 25(OH)D-calcium intake interaction effect on PTH (p = 0.941). In this group of white-skinned women with largely sufficient calcium intakes, serum 25(OH)D was important for maintaining normal PTH concentration.

scholarly journals VITAMIN D;

2019 ◽  
Vol 26 (04) ◽  
Author(s):  
Tanveer Hussain Shah ◽  
Tahir Saeed Siddiqui ◽  
Ahmad Zeb
Keyword(s):  
Vitamin D ◽  
Daily Intake ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Age Group ◽  
Vitamin D Status ◽  
School Students ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Significant Difference

Background: Present study was designed by keeping in view the importance of vitamin D in adolescents’ age group. Objectives: To explore the cases of low vitamin D status (<50 nmol/l) with respect to age & sex factors in school students. Study Design: Observation cross-sectional study. Setting: Department of Biochemistry faculty of Health Sciences, Hazara University Mansehra, Ayub Medical College and Teaching Hospital Abbottabad. Period: June 2014 to June 2015. Subject & Methods: We recorded daily intake of vitamin D of each individual and  measured serum 25 hydrxoy vitamin D in a school based cross sectional sample of adolescents girls (n=93) and boys (n=96) students. Results: Results of this study reflected that, out of total boys and girls students, 16% and 39% of the sample  respectively showed low serum vitamin D status(<50 nmol/l). Number of cases had low vitamin D level increased with age in girls and decreased with age in boys. Serum vitamin D concentration was decreased with increase in age of girls and found significantly low (p=0.0087) in higher age group (>13-≤16).  No significant difference (p=0.29) was noted regarding daily intake of vitamin D between lower & higher age. Conclusion: It is concluded that, age and sex might be contributory factors in the occurrence of low vitamin D status.

Evaluating the Relationship Between Serum Level of Interleukin-6 and Rheumatoid Arthritis Severity and Disease Activity

2020 ◽  
Vol 16 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Elham Rajaei ◽  
Karim Mowla ◽  
Qodratollah Hayati ◽  
Ali Ghorbani ◽  
Mehrdad Dargahi-Malamir ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Level ◽  
Interleukin 6 ◽  
Significant Relationship ◽  
Serum Levels ◽  
P Value ◽  
Das28 Score ◽  
Cross Sectional ◽  
Das 28 ◽  
The Relationship

Aim: The aim of this study was to evaluate the relationship between Interleukin-6 (IL-6) serum level and the severity and activity of Rheumatoid Arthritis (RA). Methods: In this cross-sectional study, 120 RA patients referred to the rheumatology clinic, the patients were diagnosed by rheumatologists according to ACR / EULAR 2010 criteria. Based on DAS28 score the patients were divided into 4 groups: Remission, Mild, Moderate and Severe. Each group contained 30 patients. Serum levels of Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), anti-Cyclic Citrullinated Peptide (anti-CCP) and Rheumatoid Factor (RF) and serum levels of IL-6, were measured. The relationship between these factors was measured and compared to the relationship between IL-6 and these factors, and the activity of the disease was evaluated based on DAS-28. Results: This study showed that the serum level of IL-6 has a significant relationship with RA activity according to DAS-28 (P value <0.001). There is also a significant relationship between the ESR level, the number of painful joints, and the number of swollen joints, and the severity of the disease based on VAS. Conclusion: Generally the findings of this study indicate that serum level of IL-6 plays an important role in the severity and activity of RA disease and can be considered as a determining factor in evaluating the severity of RA in RA patients and it is a good guide for a step up or down of treatment.

An Investigation of the Relationship Between Attitudes Towards Caring for Dying Patients and Compassion

2021 ◽  
pp. 003022282110048
Author(s):  
Senay Karadag Arli
Keyword(s):  
Significant Relationship ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Self Compassion ◽  
Dying Patients ◽  
Significant Difference ◽  
Volunteer Participation ◽  
The Relationship ◽  
Compassion Scale

The study aims to investigate the relationship between nurses’ attitudes towards caring for dying patients and compassion levels. This cross-sectional study was conducted with the volunteer participation of 130 nurses working in various clinics in a hospital located in eastern Turkey between March and June 2019. Data were collected through the Socio-demographic Form, the Frommelt Attitude toward Care of Dying Scale (FATCOD), and the Self-Compassion Scale (SCS). A statistically significant difference was found between nurses’ education level and compassion level (p < 0.01). A significant difference was found between the units where they were working and attitude towards caring for dying patients (p < 0.01). A positive, statistically significant relationship was found between the FATCOD total score and SCS total score (p < 0.01). A significant relationship between the compassion level and attitude toward caring for dying patients is an important finding for nurses, who encounter death frequently.

scholarly journals The correlation between serum level of brain natriuretic peptide and amount of left to right shunt

2019 ◽  
Vol 11 (1) ◽  
pp. 68-71
Author(s):  
Ahmad Jamei Khosroshahi ◽  
Akbar Molaei ◽  
Mahmoud Samadi ◽  
Elnaz Eskandartash
Keyword(s):  
Serum Level ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Significant Relationship ◽  
Septal Defect ◽  
Ductus Arteriosus ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Physical Examinations ◽  
The Relationship

Introduction: Natriuretic peptides such as brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and pro-BNP are secreted in response to atrial and/or ventricular stretch. Left to right shunts such as ventricular septal defect (VSD), atrial septal defect (ASD), and patent ductus arteriosus (PDA), are treated medically or surgically. We aimed to evaluate whether the serum level of pro-BNP would be useful to measure the amount of the shunt. Methods: In this cross sectional study, 60 infants and children, in whom physical examinations approved heart murmur, and had undergone echocardiography by which VSD, ASD, or PDA had been proven, were included in the study. The relationship between serum BNP levels and severity of shunt (Qp/Qs) based on echocardiographic and hemodynamic evaluations, was studied. Results: There was a significant relationship between serum level of pro-BNP and the amount of the shunt in the patients with VSD, ASD, and PDA (P=0.01). A positive correlation was seen between pro-BNP serum level and Qp/Qs ratio. The mean ± SE serum level of pro-BNP in patients with Qp/Qs ratio of less than 1.5, equal to 1.5-2, and more than 2 was 30.83±2.4, 217.88±44.6, and 217.13±51.8, respectively showing a significant relationship (P=0.0001). The cut-off point of pro-BNP demonstrating a Qp/Qs ratio more than 1.5 was measured at the level of 40.36 pg/mL, with a sensitivity and specificity of 92% and 79%, respectively. Conclusion: Based on our study, the cut-off point of 40.36 pg/mL or more for pro-BNP, showing a Qp/Qs ratio more than 1.5, can be considered as an indication for interventional procedures.

scholarly journals HUBUNGAN KADAR VITAMIN D DALAM DARAH DENGAN KEJADIAN OBESITAS PADA SISWA SMA PEMBANGUNAN PADANG

2019 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
Sesmi Nanda Oktavia
Keyword(s):  
Vitamin D ◽  
Body Height ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Elisa Method ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
The Relationship

The obesity cases in the world, including Indonesia is increasing. This condition also occurs to senior high school (SMA) Pembangunan students in Padang. There are several factors affecting the obesity occurrence, one them is the level of vitamin D serum. The aims of this study was to identify the relationship between vitamin D levels in the blood and the obesity occurrence.This research used cross sectional study design from March to June 2017. The samples were 82 students from SMA Pembangunan in Padang conducted by using simple random sampling. The level of obesity was determined by measuring body height and weight. The z zscore BMI/age was calculated by using the WHO antro-plus program while the vitamin D level was measured by ELISA method. The statistical analysis used independent sample t-test.The result shows that there is significant difference of the average vitamin D level in the blood of students with obesity compared to normal students (p=0,025). There is also difference in proportion of obesity occurence between the respondents who lack Vitamin D compared to those with adequate level of vitamin D (p=0,020).Based on the research, it is concluded that there is significant relationship between the level of vitamin D in the blood and the occurrence of obesity. Suggestion further research on the effect of vitamin D on obesity needs to be conducted.

Serum vitamin D status does not correlate with the severity of obstructive sleep apnea in male adults: A controlled study design with minimized factors influencing serum vitamin D levels

2020 ◽  
Vol 90 (5-6) ◽  
pp. 470-476 ◽  
Author(s):  
Ozge Yagcioglu Yassa ◽  
Saime Fusun Domac ◽  
Gulay Kenangil
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Significant Relationship ◽  
Serum Vitamin ◽  
Controlled Study ◽  
Vitamin D Status ◽  
Anthropometric Measures ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference

Abstract. Observational studies performed in homogeneous groups to objectively investigate the cause and effect relationship between vitamin D deficiency and sleep disorders are scarce. In this study, it was aimed to analyze the relationship between the severity of OSAS and vitamin-D levels among the participants whose features affecting serum vit-D levels were minimised. Serum 25-OH vitamin-D levels in 121 OSAS Male patients diagnosed by polysomnography without any systemic disease or vitamin-D supplement that may effect the vitamin-D metabolism were measured. The study was conducted in winter (latitude: 41°). Anthropometric measures and biochemical tests were also performed. The distribution of vitamin-D levels was determined as severe deficiency, deficiency, insufficiency and sufficiency. Apnea-hypopne index (AHI) < 5 was considered as a control group. Patients were categorized into four groups according to AHI as control, mild, moderate and severe. The groups were similar in terms of age, BMI, lipid profile, serum calcium, anthropometric measures and smoking. There was no significant difference in the distribution of vitamin-D levels between the patient and control groups and also within OSAS subgroups (p = 0.57, p = 0.86, respectively). Odds ratio to have OSAS in patients with vitamin-D deficiency was found as 0.745 (95 %CI: 0.33–1.7). Multinominal regression analysis showed no significant relationship between the OSAS severity and the extent of vitamin-D status. Correlation analysis showed no significant relationship between vitamin-D and AHI (r = 0.017, p = 0.877). Vitamin-D status does not alter the severity of OSAS. Vitamin-D deficiency might be the result of lifestyle changes due to OSAS rather than a cause.

scholarly journals Evaluation of the Relationship Between Celiac Disease and Refractory Epilepsy in Patients Referred to Imam Khomeini Hospital of Urmia

2021 ◽  
pp. 1-15
Author(s):  
Hanieh Mollazadeh ◽  
◽  
Surena Nazarbaghi ◽  
Mohammad Reza Pashaei ◽  
◽  
...  
Keyword(s):  
Celiac Disease ◽  
Serum Level ◽  
Refractory Epilepsy ◽  
Serum Levels ◽  
Control Group ◽  
Cross Sectional ◽  
Statistical Population ◽  
Significant Difference ◽  
The Mean ◽  
The Relationship

Objective: Celiac disease can be associated with other diseases, including neurological disorders. In this study, the relationship between celiac disease and refractory epilepsy was evaluated in patients referred to Imam Khomeini Hospital of Urmia. Material & Methods: In this cross-sectional study, patients with refractory epilepsy referred to the neurology clinic of Imam Khomeini Hospital of Urmia, during the second half of 2019 and controlled epilepsy were studied as a control group. The statistical population of the present study included 50 patients with refractory seizures and 50 patients with controlled seizures. The mean age of patients was 32.96 ± 11.35 years. Five ml blood samples were taken from the patients, and a serum anti-tTG test was performed using the ELISA kit. Then, in patients with positive anti-tTG, a duodenal biopsy sample was prepared using an endoscopy. Results: This study showed that the mean serum level of anti-tTG in patients with refractory epilepsy was higher than in patients with controlled epilepsy. Anti-tTG test results were positive in five of fifty patients with refractory epilepsy, and it was positive in two of fifty patients with controlled epilepsy. There was no significant difference between the two groups in terms of serum levels anti-tTG (p=0.14). Also, there was no significant relationship between serum level anti-tTG, age and genus (p>0.05). Biopsy results in three patients in the refractory epilepsy group and one patient in the controlled epilepsy group was in favor of a definitive diagnosis of the celiac disease. Patients in whom the celiac disease was confirmed by endoscopy had higher anti-tTG levels (p=0.006). Conclusion: There was no significant difference between the celiac disease in the group with refractory epilepsy and controlled epilepsy.

scholarly journals The Relationship of Vitamin D Deficiency with Severity and Outcome of Acute Stroke

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Reza Ebrahimi Rad ◽  
Mohammadreza Zarbakhsh ◽  
Samira Sarabi
Keyword(s):  
Vitamin D ◽  
Acute Stroke ◽  
Vitamin D Deficiency ◽  
Clinical Severity ◽  
Stroke Severity ◽  
Cross Sectional ◽  
Nihss Score ◽  
Increased Risk ◽  
Significant Difference ◽  
The Relationship

Abstract Background: There are currently conflicting results regarding the link between vitamin D deficiency and increased risk for stroke and its poor prognosis. The present study aimed to assess the relationship between vitamin D deficiency and prognosis of acute stroke. Methods: This bi-center cross-sectional study was performed on 140 consecutive patients who referred to two general hospitals in Iran with the diagnosis of acute stroke. The levels of 25-hydroxy vitamin D were evaluated by Electrochemiluminescence (ECL) technique. Clinical severity of stroke on admission as well as on discharge time were evaluated using the National Institutes of Health Stroke Scale (NIHSS) or Modified Rankin (mRS) tools. Results: Mean serum level of vitamin D was 25.51 ± 18.87 ng/mL, ranging from 3.0 to 98.6 ng/ml. There was a significant difference between the two groups (with and without vitamin D deficiency) in terms of stroke severity and disability, as reflected by mRS (P=0.003) and NIHSS evaluation (14.24 ± 9.23 versus 9.73 ± 7.36, P=0.003). Also, regarding patients’ clinical condition, the mean NIHSS score in those with deficient and normal levels of vitamin D was 14.24 ± 9.23 and 9.73 ± 7.36, respectively with NIHSS score > 5 in 76.1% and 61.5%, respectively (P = 0.003). Conclusion: According to the results of study, vitamin D status can be related to the severity of stroke. However, considering the cross-sectional design of our study, it could not point out the causality between vitamin D deficiency and acute stroke and further studies are warranted. It is not possible to draw any conclusions in terms of causality. Further studies are required in order to assess the relationship between the serum vitamin D levels and stroke severity.

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