scholarly journals Serum levels of non-enzymatic antioxidants in female dementia patients with respect to the degree of cognitive impairment

2021 ◽  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Assessment ◽  
Longitudinal Research ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Protective Role ◽  
Enzymatic Antioxidants ◽  
Cross Sectional ◽  
Severe Cognitive Impairment ◽  
Dementia Patients

The aim of this study was to investigate the correlation between the severity of cognitive impairment in Alzheimer’s disease (AD) and vascular dementia (VD) and the serum antioxidant status of uric acid (UA), albumin (ALB) and bilirubin (BIL) in female patients. The cross-sectional study included 90 subjects, aged ≥65, divided into three groups: 30 patients with AD, 30 patients with VD and 30 control subjects. For cognitive assessment, all participants underwent the Montreal Cognitive Assessment (MoCA). Serum concentrations of ALB, UA and BIL were determined spectrophotometrically. The AD patients had a significant decrease of UA and increase of serum BIL. Upon stratification according to the degree of cognitive impairment, lower UA concentrations were found in patients with severe cognitive impairment, whereas increased BIL was found in patients with moderate cognitive impairment. Patients with VD were characterized by hypoalbuminemia and upon stratification this finding was evident among patients with severe cognitive impairment. The MoCA score correlated positively with BIL in AD patients. The obtained data supports the protective role of serum antioxidants in the pathogenesis of dementia. Further on, we suggest further longitudinal research to confirm the combined use of these parameters as potential biomarkers in AD and VD.

scholarly journals Relation of Secondhand Smoking to Mild Cognitive Impairment in Older Inpatients

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Giuseppe Orsitto ◽  
Vincenzo Turi ◽  
Amedeo Venezia ◽  
Francesco Fulvio ◽  
Cosimo Manca
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Older Patients ◽  
Cross Sectional Study ◽  
Smoking History ◽  
Cross Sectional ◽  
Secondhand Smoking ◽  
Dementia Patients ◽  
Older Inpatients ◽  
Never Smokers

Up to now, controversy still exists regarding the role of secondhand smoking (SHS) in developing cognitive impairment. This study aimed to evaluate the prevalence of SHS in hospitalized older patients with cognitive deficit, particularly in those with mild cognitive impairment (MCI). Smoking history was classified into four groups: never smokers, former-active smokers/no SHS, active smokers, and secondhand smokers, and cognitive function into three levels: normal cognition (C), MCI, and dementia. A total of 933 older subjects with diagnoses of MCI (n=98), dementia (n=124), or C (n=711) were enrolled in this cross-sectional study. As expected, patients with dementia had significantly higher frequency of former-active smokers than cognitively normal. Moreover, patients with MCI showed a significantly higher frequency of active and secondhand smokers than patients with dementia or C. A smoking history is very frequent in older patients with dementia. Patients with MCI had even higher rate of exposure to active or secondhand smoking.

scholarly journals HUBUNGAN ANTARA JUMLAH LIMFOSIT TCD4+ DENGAN GANGGUAN FUNGSI KOGNITIF PADA PASIEN TERINFEKSI HIV

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Rilia Datan Sampepajung ◽  
Audry Devisanty Wuysang ◽  
Abdul Muis
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
T Lymphocyte ◽  
Cognitive Assessment ◽  
Cross Sectional Study ◽  
Montreal Cognitive Assessment ◽  
Hiv Patients ◽  
Cross Sectional ◽  
Immunodeficiency Virus

  CORRELATION BETWEEN QUANTITY OF CD4+ T LYMPHOCYTE AND COGNITIVE IMPAIRMENT IN PATIENTS WITH HIV INFECTIONABSTRACTIntroduction: CD4+T lymphocyte is a T-lymphocyte that has CD4 glycoprotein on its surface. The quantity of CD4+ T lymphocyte is associated with cognitive function impairment.Aim: To determine the correlation between the quantity of CD4+ T lymphocyte with the cognitive function impairment in patients infected by human immunodeficiency virus (HIV).Methods: This is a cross-sectional  study on HIV patients at Wahidin Sudirohusodo Hospital, Makassar  from October to December 2018. Cognitive function was assessed using Montreal Cognitive Assessment of Indonesian version (MoCA-Ina) and all infected HIV patients’ CD4+ T lymphocyte was counted through blood laboratory examination. The data processing used SPSS program.Results: There were 40 subjects with male majority (70%). Most subjects (75%) had low count of CD4+ T lymphocytes (<200cel/µL) and most of them (72.5%) had cognitive function impairment.Discussion: The CD4+T lymphocyte was associated significantly with executive and memory impairment in patients with HIV.Keywords: CD4+ T lymphocyte, cognitive impairment, HIVABSTRAKPendahuluan: Limfosit TCD4+ adalah limfosit T yang memiliki glikoprotein CD4 pada permukaan selnya. Jumlah limfosit TCD4+ telah diketahui berhubungan dengan gangguan fungsi kognitif.Tujuan: Mengetahui hubungan antara jumlah limfosit TCD4+  dengan gangguan fungsi kognitif pada pasien terinfeksi human immunodeficiency virus (HIV).Metode: Penelitian observasional dengan rancangan potong lintang terhadap pasien yang terinfeksi HIV di RSUP Dr. Wahidin Sudirohusodo, Makassar pada bulan Oktober-Desember 2018. Subjek dinilai fungsi kognitif menggunakan Montreal Cognitive Assessment versi Indonesia (MoCA-Ina) dan penghitungan jumlah limfosit TCD4+. Pengolahan data menggunakan program SPSS.Hasil: Terdapat 40 subjek yang mayoritas (70%) laki-laki. Terdapat 75% subjek memiliki kadar limfosit TCD4+ yang rendah (<200sel/µL) yang sebagian besarnya (72,5%) mengalami gangguan fungsi kognitif.Diskusi: Jumlah limfosit TCD4+ memiliki hubungan yang signifikan dengan komponen eksekutif dan memori dari fungsi kognitif pada pasien yang terinfeksi HIV.Kata kunci: Gangguan kognitif, HIV, limfosit TCD4+  

scholarly journals SKRINING COGNITIVE IMPAIRMENT PADA PASIEN HIPERTENSI DI BANDUNG

2019 ◽  
Vol 5 (2) ◽  
pp. 114-120
Author(s):  
Irma Darmawati ◽  
Heni Purnama ◽  
Linlin Lindayani
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Cognitive Assessment ◽  
Cross Sectional Study ◽  
Montreal Cognitive Assessment ◽  
Sectional Study ◽  
Cross Sectional

Hipertensi merupakan salah satu faktor resiko tertinggi untuk gangguan fungsi kognitif. Studi sebelumnya melaporkan bahwa terjadi peningkatan white matter lession pada pasien hipertensi. Akan tetapi, penelitian tentang deteksi dini gangguan fungsi kognitif pada pasien hipertensi di Indonesia masih terbatas. Tujuan dari penelitian ini adalah mengidentifikasi gangguan fungsi kognitif pada pasien dengan hipertensi. Jenis penelitian yanga akan digunakan adalah cross-sectional study. Peserta dalam penelitian adalah seseorang berusia lebih dari 18 tahun yang didiagnosa hipertensi, tidak ada riwayat penyakit yang berhubungan dengan fungsi kognitif seperti stroke, epilepsy atau riwayat bedah otak. Fungsi Kognitif diukur dengan menggunakan The Montreal Cognitive Assessment (MoCA). Sebanyak 120 pasien dengan hipertensi berhasil direkrut dalam penelitian ini. Sebanyak 68.9% mengalami gangguan fungsi kognitif dengan nilai rata-rata paling rendah adalah dalam kemampuan mengingat angka, huruf, pengurangan, dan orientasi. Deteksi dini gangguan kognitif pada pasien hipertensi harus dilakukan secara rutin di klinik ataupun pusat pelayanan kesehatan primer lainnnya.

scholarly journals Patients with mild cognitive impairment diagnosed at dementia clinic display decreased maximum occlusal force: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hiroyuki Suzuki ◽  
Junichi Furuya ◽  
Rena Hidaka ◽  
Saki Miyajima ◽  
Chiaki Matsubara ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Oral Health ◽  
Cognitive Function ◽  
Cognitive Assessment ◽  
Odds Ratio ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Occlusal Force

Abstract Background Previous research indicates that patients with mild cognitive impairment (MCI) are more likely to have poor oral health and impairments in oral functions, which may be due to few remaining teeth and impaired tongue and lip motor function. However, the oral health of those patients following comprehensive cognitive assessment by a dementia specialist has not been sufficiently investigated. Therefore, this study aimed to clarify the oral function of patients with MCI and the association between oral health and lower cognitive function. Methods This cross-sectional study included 96 participants (men: 35; women: 61; mean age: 73.3 ± 8.5 years) who visited a dementia clinic between December 2017 and January 2020. Participants’ cognitive function was assessed by a dementia specialist using neuropsychological and hematological tests and neuroimaging immediately after enrollment. The participants were divided into the healthy and MCI groups according to comprehensive cognitive assessment. Participants’ age, sex, body mass index, primary disease, education level, drinking habits, smoking habits, living environment, employment status, and exercise habits were evaluated. Moreover, oral outcomes, including the number of existing teeth, number of functional teeth (natural and prosthetic teeth which were occluded with antagonists), denture use, oral dryness, tongue and lip motor function, tongue pressure, occlusal force, masticatory ability, and swallowing ability were recorded. The Mann–Whitney U test, χ2, and Fisher’s exact tests were used for between-group comparisons. Furthermore, logistic regression analysis using MCI diagnosis as the target variable was performed. Results A comprehensive evaluation of the cognitive function of the study participants by the dementia specialist revealed that 48 participants (mean age: 69.8 ± 8.8 years) were healthy and 48 (mean age: 76.9 ± 6.7 years) had MCI. MCI participants were significantly older (p < 0.001) and had significantly fewer existing teeth (p = 0.031) and lower maximum occlusal force (p = 0.019) than healthy participants. Age (odds ratio: 1.126, p = 0.002) and maximum occlusal force (odds ratio: 0.978, p = 0.048) were significantly associated with lower cognitive function. Conclusions Patients with MCI had poorer oral health than healthy individuals. Decreased maximum occlusal force was independently associated with lower cognitive function, even when adjusted for age and sex.

Prevalence of Mild-Cognitive-Impairment and Depression among Elderly Clients in Selected Wards of Baraha Municipality: A Cross-Sectional Study

2020 ◽  
Vol 3 (1) ◽  
pp. 57-65
Author(s):  
Nirmala Pradhan ◽  
Baikuntha Raj Adhikari ◽  
Sami Lama ◽  
Sharmila Shrestha ◽  
Rambha Sigdel
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Assessment ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Demographic Variables ◽  
Geriatric Depression ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of

Introduction: Mild-Cognitive-Impairment (MCI) is an intermediate state between normal cognitive ageing and dementia. Identification of MCI is thought to be crucial to early intervention. Objectives: To assess Mild-Cognitive-Impairment and Depression among elderly clients and to find out the associations between Mild-Cognitive-Impairment and Depression and socio-demographic variables. Methods: A descriptive, cross-sectional study design was adopted. A total of 115 elderly clients who fulfilled the selection criteria were enrolled using purposive sampling technique. Montreal Cognitive Assessment (MoCA) and Geriatric Depression Scale were used with Interview technique. Those elderly clients were selected from the 2 wards of Baraha Municipality. Results: Majority of the subjects (68.7%) were from between 60-70 years. More of the elderly clients were females (54.8%). Maximum (81.7%) were illiterate. About 35.7% had the history of medical and psychiatric illness. From the total sample, 39.1% had issues with memory. In case of Montreal Cognitive Assessment (MoCA), 93.0% was screened with Mild-Cognitive-Impairment. And, 60.9%of the elderly clients were screened as Depression. With regard to the associations between mild cognitive impairment and selected demographic variables, significant associations were found with gender, education level, marital status and previous history of medical/ psychiatric history. The correlation between MoCA score and geriatric depression score showed a negative relationship. Conclusion: Many elderly people in a community have Mild-Cognitive-Impairment and Depression. This study added evidence on prevalence of Mild-Cognitive-Impairment and Depression among geriatric clients in a community-dwelling.

scholarly journals A Study of Selenium in Leprosy

2018 ◽  
Vol 6 (3) ◽  
pp. 485-487 ◽  
Author(s):  
Donna Partogi ◽  
Dina Arwina Dalimunthe ◽  
Cut Putri Hazlianda
Keyword(s):  
General Hospital ◽  
Sampling Method ◽  
Venous Blood ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Protective Role ◽  
Cross Sectional ◽  
Leprosy Patients ◽  
Low Selenium ◽  
Bacterial Index

INTRODUCTION: Leprosy is a chronic infection caused by Mycobacterium leprae. Selenium, on the other hand, is a substance, which is needed for its protective role against microorganism infection.AIM: This study aims to know the association between selenium serum levels with bacteriological index.METHODS: This is an analytical cross-sectional study model. Sampling was done with consecutive sampling method in Pirngadi General Hospital, Lau Simomo Leprosy Hospital and H. Adam Malik General Hospital. Samples were taken from patients’ venous blood serum then selenium levels were measured.RESULTS: This study found 30 leprosy patients consisted of 19 patients with paucibacillary (PB) leprosy and 11 patients with multibacillary (MB) leprosy. Selenium serum levels of patients with PB leprosy (mean = 97.16 µg/dL) were found to be significantly higher than MB leprosy (mean = 77.27 µg/dL) with p = 0.008 using t-test. The negative correlation between selenium serum levels with bacterial index in patients with leprosy was also found in this study using Spearman’s rho test (r = - 0.499, p = 0.005).CONCLUSIONS: Selenium serum levels of patients with PB leprosy are higher than patients with MB leprosy, and high bacteriological index in patients with leprosy were correlated with low selenium serum levels.

Cognitive Performance and Neuro-Metabolites in HIV using 3T Magnetic Resonance Spectroscopy: A Cross-Sectional Study from India

2020 ◽  
Vol 18 ◽  
Author(s):  
Kartik Gupta ◽  
Shivabalan ◽  
Virendra Kumar ◽  
Surabhi Vyas ◽  
RM Pandey ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Motor Skills ◽  
Cross Sectional Study ◽  
Resonance Spectroscopy ◽  
Sectional Study ◽  
Cross Sectional ◽  
Total N ◽  
Simple Motor

Background: Cognitive impairment in patients with human immunodeficiency virus (HIV) is associated with higher morbidity. The prevalence of and the metabolite changes in the brain associated with cognitive impairment in anti-retroviral therapy naïve patients with HIV is unknown. Objective: To estimate the prevalence of, and the neurometabolites associated with cognitive impairment in antiretroviral therapy (ART) naïve patients with HIV. Methods: We conducted a cross-sectional study among ART naïve patients with HIV aged 18-50 years in a tertiary care center in India. Cognition was tested using the Post Graduate Institute battery of brain dysfunction across five domains; memory, attentioninformation processing, abstraction executive, complex perceptual, and simple motor skills. We assessed the total N-acetyl aspartyl (tNAA), creatine (tCr) and glutamate + glutamine (Glx) using 3T magnetic resonance spectroscopy. Cognitive impairment was defined as an impairment in ≥2 domains. Results: Among 43 patients eligible for this study, the median age was 32 years (IQR 29, 40) and 30% were women. Median CD4 count and viral load were 317 cells/µL (IQR 157, 456) and 9.3 copies/ µL (IQR 1.4, 38), respectively. Impairment in at least one cognitive domain was present in 32 patients (74.4%). Impairment in simple motor skills and memory was present in 46.5% and 44% of patients, respectively. Cognitive impairment, defined by impairment in ≥2 domains, was found in 22 (51.2%) patients. There was a trend towards higher concentration of tNAA (7.3 vs. 7.0 mmol/kg), tGlx (9.1 vs. 8.2 mmol/kg), and tCr (5.5 vs. 5.2 mmol/kg) in the frontal lobe of patients with cognitive impairment vs. without cognitive impairment but it did not reach statistical significance (p>0.05 for all). There was no difference in the concentration of these metabolites in the two groups in the basal ganglia. Conclusions: There is a high prevalence of cognitive impairment in ART naïve patients with HIV. There is no difference in metabolites in patients with or without cognitive impairment. Further studies, with longitudinal follow-up, are required to understand the underlying pathophysiological mechanisms.

Depression and Cognitive Impairment in Patients on Hemodialysis: A cross-sectional study

2020 ◽  
Vol 5 (15) ◽  
pp. 185-192
Author(s):  
Nor Jannah Nasution Raduan ◽  
Mohd Razali Salleh ◽  
Ghazali Ahmad ◽  
Zaleha Ismail
Keyword(s):  
Cognitive Impairment ◽  
Publishing House ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Education Level ◽  
Sectional Study ◽  
Contributing Factors ◽  
Cross Sectional ◽  
Factors Associated ◽  
Low Education

Depression and cognitive impairment are the most common complications of patients on hemodialysis. The objective of this study is to identify contributing factors to depression and cognitive impairment in hemodialysis patients. This is a cross-sectional study involving 110 hemodialysis patients in Hospital Kuala Lumpur. The samples were recruited through universal sampling. Patients were assessed with the Beck Depression Inventory and Montreal Cognitive Assessment. This study found that 18.2% of patients had depression, and 48.2% had cognitive impairment. Factors associated with depression were unmarried status, low education level, and cognitive impairment. Factors associated with cognitive impairment were low education level, depression, and unemployment. Keywords: hemodialysis, depression, cognitive, ESRD eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v5i15.2468.

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