scholarly journals UPAYA PENINGKATAN PENGETAHUAN MASYARAKAT MELALUI KEGIATAN PENYULUHAN KESEHATAN MENGENAI MENGENALI OBESITAS & POTENSI PENYAKIT SERTA UPAYA PENGENDALIANNYA

2021 ◽  
Vol 1 (1) ◽  
pp. 21
Author(s):  
Chrisyen Damanik ◽  
Sumiati Sinaga ◽  
Siti Mukaromah
Keyword(s):  
Normal Status

Obesitas adalah suatu penyakit serius yang dapat mengakibatkan masalah emosional dan sosial. Seorang dikatakan overweight bila berat badannya 10% sampai dengan 20% berat badan normal, sedangkan seseorang disebut obesitas apabila kelebihan berat badan mencapai lebih 20% dari berat normal. status kesehatan mayoritas masyakat RT 33 sebagian besar dalam kondisi kesehatan baik, namun terdapat beberapa dari masyarakat RT 09 yang menderita penyakit yang diantaranya Hipertensi, Berat Badan Berlebih sampai dengan Obesitas, Asam Urat, Gastritis, ISPA, Dislipedmia, gangguan jantung, stroke dan DM. Masyarkat RT 33 dengan tingkat Pendidikan yang rata-rata Pendidikan dalam kategori Atas dan memiliki penghasilan menengah atas, Masyarakat RT 33 memiliki pola kebiasaan hidup sehat yang dapat ditunjukkan melalui perilaku kebiasaan melaksanakan kegiatan olahraga rutin seperti senam sehat maupun jalan santai, dan masyakat memiliki kebiasaan menggunakan sarana layanan kesehatan seperti praktek dokter, klinik maupun rumah sakit yang memfasilitasi masyarakat dalam mengatasi dan mencegah setiap penyakit yang berkembang di masyarakat. Kegiatan yang dilaksanakan meliputi Penjajakan, Perneriksaan Kesehatan, Konseling & Penyuluhan Kesehatan rnengenali Obesitas & Potensi Penyakit Serta Upaya Pengendaliannya ditujukan pada warga RT 33 Kelurahan Air Putih Kota Samarinda. Sebanyak kurang lebih 26 peserta yang dilaksanakan pada tanggal 14 sampai 16 November 2019. Kegiatan pengabdian kepada masyarakat mendapatkan respon yang antusias dari warga masyarakat RT 33 Kelurahan Air Putih. Hasil Pemeriksaan kesehatan terdapat 15 orang masyarakat mengalami Berat Badan Berlebih, 6 diantaranya mendekat obesitas bahkan obesitas, 13 peserta mengalami peningkatan kadar kolesterol, dan terdapat 3 diantaranya warga mengalai berat badan berlebih dan terkena penyakit jantung dan DM

A Longitudinal Posthumous Study of Letter Writing in a Late Elderly Case

2015 ◽  
Vol 20 (1) ◽  
pp. 22-33
Author(s):  
Angel Ball ◽  
Jean Neils-Strunjas ◽  
Kate Krival
Keyword(s):  
Longitudinal Study ◽  
Elderly Woman ◽  
Semantic Content ◽  
Cognitive Status ◽  
Letter Writing ◽  
Linguistic Performance ◽  
Errors Analysis ◽  
Normal Status

This study is a posthumous longitudinal study of consecutive letters written by an elderly woman from age 89 to 93. Findings reveal a consistent linguistic performance during the first 3 years, supporting “normal” status for late elderly writing. She produced clearly written cursive form, intact semantic content, and minimal spelling and stroke errors. A decline in writing was observed in the last 6–9 months of the study and an analysis revealed production of clausal fragmentation, decreasing semantic clarity, and a higher frequency of spelling, semantic, and stroke errors. Analysis of writing samples can be a valuable tool in documenting a change in cognitive status differentiated from normal late aging.

EVALUASI KUALITAS PERAIRAN DALAM PEMBENIHAN IKAN KERAPU TIKUS (Cromileptis altivelis) Di HATCHERY PERAIRAN TANJUNG RIAU BATAM

2018 ◽  
Vol 5 (2) ◽  
Author(s):  
Ratu Siti Aliah
Keyword(s):  
Water Quality ◽  
Water Supply ◽  
Good Condition ◽  
Brood Stock ◽  
Water Storage Tank ◽  
Water Quality Status ◽  
Set Up ◽  
Normal Status ◽  
Tank Water ◽  
Quality Status

An evaluation of the water quality at the hatchery of Tanjung Riau was conducted to understand the water quality status at the several place of the hatchery unit such as brood stock tanks, larva rearing tank, water storage tank, fi ngerling tank as well as the source of the water supply. The water quality status of Tanjung Riau generally is in a good condition to support the hatchery activities, but for turbidity and salinity were in the exceed and below the normal status and its infl uence on the spawning activity. To overcome the problem on the spawning of the brood stock, the improving of water supply with higher salinity and low turbidity should be set up to ensure the succeeded of the spawning.Key words : Water quality, grouper brood stock, hatchery,Tanjung Riau Batam

scholarly journals Clinical approach to coma patients: tips and tricks

2021 ◽  
Keyword(s):  
Clinical Evidence ◽  
Primary Treatment ◽  
Clinical Approach ◽  
Loss Of Consciousness ◽  
Tips And Tricks ◽  
Secondary Complications ◽  
Reticular Activating System ◽  
Four Levels ◽  
Unconscious Patients ◽  
Normal Status

The reticular activating system (RAS) is responsible for wakefulness. The RAS projects activation to either side of the hemisphere. The dysfunction of the RAS or insufficiency of its activation results in impairment of consciousness. Physicians classify levels of awareness into four levels, from normal status to most severe unconsciousness, these being alert, drowsy, stupor, and coma, respectively. While the causes of unconsciousness are varied, physicians generally divide them into structural and metabolic etiologies upon the dominant approach. Surgical management is the primary treatment for the structural coma, while the metabolic coma requires predominantly medical treatment. The diagnosis and management of unconscious patients require extensive clinical assessment, consisting of a careful approach to history-taking and general medical and neurological examinations. Following immediate resuscitation by the ABCDE approach and proper management protocols, physicians should look for causes of loss of consciousness through clinical evidence and investigations. Appropriate management will help to avoid secondary complications related to the impairment of consciousness. The prognostication of a coma is also varied and primarily depends on its etiology. The algorithm for prognostication in a coma is helpful for poor outcome determinants.

scholarly journals CRISPR-mediated modification of DNA methylation pattern in the new era of cancer therapy

Epigenomics ◽  
2020 ◽  
Vol 12 (20) ◽  
pp. 1845-1859
Author(s):  
Faezeh Maroufi ◽  
Amirhosein Maali ◽  
Meghdad Abdollahpour-Alitappeh ◽  
Mohammad Hossein Ahmadi ◽  
Mehdi Azad
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Cancer Progression ◽  
Methylation Pattern ◽  
Epigenetic Therapy ◽  
Special Importance ◽  
New Era ◽  
Major Mechanism ◽  
Aberrant Dna Methylation ◽  
Normal Status

In the last 2 decades, a wide variety of studies have been conducted on epigenetics and its role in various cancers. A major mechanism of epigenetic regulation is DNA methylation, including aberrant DNA methylation variations such as hypermethylation and hypomethylation in the promoters of critical genes, which are commonly detected in tumors and mark the early stages of cancer development. Therefore, epigenetic therapy has been of special importance in the last decade for cancer treatment. In epigenetic therapy, all efforts are made to modulate gene expression to the normal status. Importantly, recent studies have shown that epigenetic therapy is focusing on the new gene editing technology, CRISPR-Cas9. This tool was found to be able to effectively modulate gene expression and alter almost any sequence in the genome of cells, resulting in events such as a change in acetylation, methylation, or histone modifications. Of note, the CRISPR-Cas9 system can be used for the treatment of cancers caused by epigenetic alterations. The CRISPR-Cas9 system has greater advantages than other available methods, including potent activity, easy design and high velocity as well as the ability to target any DNA or RNA site. In this review, we described epigenetic modulators, which can be used in the CRISPR-Cas9 system, as well as their functions in gene expression alterations that lead to cancer initiation and progression. In addition, we surveyed various species of CRISPR-dead Cas9 (dCas9) systems, a mutant version of Cas9 with no endonuclease activity. Such systems are applicable in epigenetic therapy for gene expression modulation through chemical group editing on nucleosomes and chromatin remodeling, which finally return the cell to the normal status and prevent cancer progression.

Multiple Myeloma with IGH-Involving del(14q): Report of 34 Cases.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 991-991 ◽  
Author(s):  
Iwona Wlodarska ◽  
Fiona M. Ross ◽  
Lisa J. Russell ◽  
Helena Pospisilova ◽  
Laura Chiecchio ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Lymphocytic Leukaemia ◽  
Chromosomal Translocations ◽  
Fish Analysis ◽  
B Cell Malignancies ◽  
Poor Prognostic Factor ◽  
Igh Locus ◽  
Male Patients ◽  
Almost All ◽  
Normal Status

Abstract Chromosomal translocations involving the IGH locus on 14q32 are a hallmark of B-cell malignancies. These translocations are particularly frequent in non-hyperdiploid (NHD) multiple myeloma (MM), representing approximately 50% of myeloma cases. MM-associated primary t(14q32) target at least 7 partner genes including cyclins D (CCND1, −D3), MAF transcription factors (CMAF, MAF B and A) and MMSET/FGFR3. Some of the translocations are predictive of clinical outcome. Recently, we identified a novel interstitial del(14q) involving IGH and recurrent in chronic lymphocytic leukaemia and MM (Pospisilova et al, Leukemia, 2007). In spite of extensive studies, the mechanism(s) and molecular consequences of del(14q) remain unknown. We report here 34 cases of plasma cell (PC) malignancies with del(14q) involving IGH, as proven by FISH. Cases were collected in UK and Belgium. The estimated incidence of these aberrations in PC malignancies was 1.4%. There were 13 female and 21 male patients ranging in age from 49 to 86 years (average 68). Twenty seven patients had MM, one had SMM and 6 had MGUS. In almost all cases, the del(14q) was detected at diagnosis. Clinical data of the reported cases have been collected. The del(14q) were roughly mapped by FISH and grouped into 3 categories according to the proximal breakpoint: del(14)(q24.1q32.33) involving the ZFP36L1 region (11 cases); deletions proximal to ZFP36L1 (14 cases) and deletions distal to ZFP36L1 (7 cases). The size of del(14q) was not determined in 2 cases. Biallelic deletion of TRAF3/14q32.33 recurrently occurring in MM, was detected by FISH in 1 out of 9 analyzed cases. Additional FISH analysis showed that the del(14q) was predominantly associated with NHD tumors (62% vs 38% with hyperdiploid karyotypes) and frequently (60%) accompanied by del(13q), regarded as a poor prognostic factor. All reported cases were negative for t(4;14) and t(11;14); they also showed a normal status of CCND3, CMAF, MAFB and CMYC, when examined. A gain of 1q/CKS1B was found in 57% (8/14) of analyzed cases. The expression pattern of cyclin D1−D3 has been examined.

What the literature tells us about score sheet design

2016 ◽  
Vol 50 (6) ◽  
pp. 414-417 ◽  
Author(s):  
Philippe Bugnon ◽  
Maike Heimann ◽  
Michaela Thallmair
Keyword(s):  
Animal Welfare ◽  
Animal Health ◽  
Animal Experiments ◽  
Score Sheet ◽  
Essential Tool ◽  
And Behavior ◽  
Normal Status

Score sheets are an essential tool of animal welfare. They allow transparent assessments to be made of animal health and behavior during animal experiments and they define interventions when deviations from normal status are detected. As such, score sheets help to refine animal experiments as part of the 3R (replacement, reduction and refinement) concept. This mini review aims at summarizing the scarce literature available on score sheet design.

scholarly journals Magnesium Status in Hospitalized ICCU and non ICCU Patients With Special Reference to Waterborne Magnesium

2019 ◽  
pp. 1-9
Author(s):  
Kirti R Surati ◽  
Ramavataram VSS Divvi ◽  
ShreeyasPrasad D Nilakhe ◽  
Drishty R Surati ◽  
Vipul Srivastav
Keyword(s):  
Healthy Subjects ◽  
Serum Magnesium ◽  
Clinical Information ◽  
Hospitalized Patients ◽  
Water Users ◽  
Significant Difference ◽  
Ethical Committee Approval ◽  
Kidney Liver ◽  
Normal Status ◽  
Magnesium Therapy

Introduction: Low serum magnesium levels in hospitalized patients including those with cardiovascular ailments have been reported by many studies. On the other hand, magnesium therapy is advocated but has not yet been conclusively proved. In our earlier study, an association between waterborne magnesium and hypomagnesaemia in healthy subjects was reported. The present study was aimed at the contribution of waterborne magnesium among filtered and non-filtered water users in hospitalized patients. Material and methods: The present study was carried out at SMIMER, Surat. Ethical committee approval was taken. On informed consent, subjects from ICCU and general ward of Medicine unit were selected. Demographic and clinical information was collected. Serum magnesium, cardiac profile and renal profile were analyzed. Patients with conditions such as kidney, liver, brain and other critical illness were excluded. The results were expressed as Mean and SD and appropriate statistical tools were applied to arrive at conclusions.  Results: Among total 557 subjects including 185 healthy subjects, 93 ICCU and 279 non-ICCU patients, the incidence of hypomagnesaemia (serum Mg < 1.7 mg/dl) was 18%, 36% and 42% was observed respectively. A significant difference (p < 0.01) in serum magnesium between filtered and non-filtered water users in healthy (1.77 ±0.36 vs 2.01 ±0.48), ICCU  (1.35 ±0.44 vs 1.72±0.55), and in non-ICCU patients (1.51 ±0.59 vs 1.77±0.51) was found. No significant difference was observed in other parameters. Conclusion: Significant hypomagnesaemia was observed among users of filtered water as compared to nonfiltered water users in all groups (ICCU, non-ICCU and healthy), strongly suggestive of contribution of waterborne magnesium in maintaining normal status in the population and inadequate levels may be correlated to a higher incidence of myocardial infarction as evident from the present study wherein a 42% prevalence of hypomagnesaemia in ICCU patients was found. 

scholarly journals How to Find Candidate Drug-targets for Antiepileptogenic Therapy?

2020 ◽  
Vol 18 (7) ◽  
pp. 624-635 ◽  
Author(s):  
Nian Yu ◽  
Xing-jian Lin ◽  
Qing Di
Keyword(s):  
Drug Targets ◽  
Neuronal Excitability ◽  
Experimental Models ◽  
Pathological Process ◽  
Spontaneous Seizures ◽  
Candidate Drug ◽  
Underlying Mechanisms ◽  
Drug Resistant Epilepsy ◽  
Brain Insults ◽  
Normal Status

Although over 25 antiepileptic drugs (AEDs) have become currently available for clinical use, the incidence of epilepsy worldwide and the proportions of drug-resistant epilepsy among them are not significantly reduced during the past decades. Traditional screens for AEDs have been mainly focused on their anti-ictogenic roles, and their efficacies primarily depend on suppressing neuronal excitability or enhancing inhibitory neuronal activity, almost without the influence on the epileptogenesis or with inconsistent results from different studies. Epileptogenesis refers to the pathological process of a brain from its normal status to the alterations with the continuous prone of unprovoked spontaneous seizures after brain insults, such as stroke, traumatic brain injury, CNS infectious, and autoimmune disorders, and even some specific inherited conditions. Recently growing experimental and clinical studies have discovered the underlying mechanisms for epileptogenesis, which are multi-aspect and multistep. These findings provide us a number of interesting sites for antiepileptogenic drugs (AEGDs). AEGDs have been evidenced as significantly roles of postponing or completely blocking the development of epilepsy in experimental models. The present review will introduce potential novel candidate drug-targets for AEGDs based on the published studies.

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