scholarly journals PERBANDINGAN NILAI AGREGASI TROMBOSIT PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN KOMPLIKASI VASKULAR DAN TANPA KOMPLIKASI VASKULAR DI RSUP PROF. DR. R. D KANDOU MANADO

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Gratia Tangkuman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Platelet Aggregation ◽  
Platelet Function ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Significant Difference ◽  
The World ◽  
Diabetes Melitus

Abstract: Diabetes melitus is a main medical problem around the world. WHO estimated that in 2000 there were 171 milion people with diabetes around the world and in 2030 there will be 366 million people. In diabetic patients, there are dysfunctions of platelet function caused microangiopati, macroangiopati, and platelet reactivity. Dysfunction of platelet function are associated with vascular complications of diabetes melitus. This study used an observational analytic method using comparative hypothesis test. This study was conducted to 30 diabetic patients, 15 patients have vascular complications while the other 15 have no vascular complications. Those patients are registered in Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. The samples were processed in Prokita Laboratorium in Malalayang, Manado. Data analysis showed that there are significant difference between platelet aggregation value examined using ADP 5 µm agonist in diabetic patient with vascular complications and diabetic patients without vascular compications (p = 0.004). The same result were obtained from comparing the platelet agggregation value examined using ADP 10 µm agonist (p = 0.000). There are significant difference between platelet aggregation value in type 2 diabetes melitus patients with vascular complications and without complications. Keywords: Platelet aggregation, type 2 diabetes melitus, vascular complications.  Abstrak: : Diabetes Melitus menjadi masalah kesehatan di dunia. WHO memperkirakan ada 171 juta orang di dunia dengan diabetes pada tahun 2000 dan diproyeksikan meningkat menjadi 366 juta pada tahun 2030. Pada diabetes melitus terjadi disfungsi dari trombosit sehingga menyebabkan mikroangiopati, makrongiopati dan hiperaktivitas trombosit. Gangguan fungsi trombosit ini dihubungkan dengan berbagai komplikasi vaskuler. Penelitian ini menggunakan observasional analitik dengan menggunakan metode uji hipotesis komparatif. Subjek dalam penelitian ini berjumlah 30 orang, 15 orang pasien diabetes mellitus tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vaskular yang terdaftar di Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. Pembuatan sampel dilakukan di Laboratorium Prokita Malalayang Manado. Dari hasil analisis, didapatkan adanya perbedaan yang bermakna antara nilai agregasi trombosit yang diperiksa menggunakan agonis ADP 5 µm pada pasien dengan komplikasi vaskuler dan pasien diabetes tanpa komplikasi vaskuler (p = 0,004). Hasil yang sama juga didapatkan pada nilai agregasi trombosit yang diperiksa menggunakan agonis ADP 10 µm (p = 0,000). Kesimpulan dari penelitian ini didapatkan terdapat perbedaan signifikan antara nilai agregasi trombosit pada pasien diabetes mellitus tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vaskular. Kata Kunci: Agregasi trombosit, diabetes melitus tipe 2, komplikasi vaskular.

scholarly journals PERBANDINGAN JUMLAH TROMBOSIT PADA DIABETES MELITUS TIPE 2 DENGAN KOMPLIKASI VASKULAR DAN TANPA KOMPLIKASI VASKULAR DI RSUP PROF. DR. R. D. KANDOU

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Nina S Widiarto ◽  
Jimmy Posangi ◽  
Arthur Mongan ◽  
Maya Memah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Platelet Count ◽  
Vascular Complications ◽  
Vascular Complication ◽  
Cross Sectional ◽  
Whitney Test ◽  
Significant Difference ◽  
Diabetes Melitus

Abstract: Diabetes mellitus (DM) is a degenerative disease which has increased from year to year. Type 2 diabetes has the highest number of cases. There is a change in platelet count in type 2 diabetes. The change in platelet count can lead to vascular complications in DM. This was a descriptive analytic study with a cross sectional design by using the medical record data of type 2 diabetic patients in the outpatient department of Prof. DR. R. D. Kandou Hospital, Manado. Subjects who met the inclusion criteria were 72 patients; 36 patients with vascular complications and 36 patients without vascular complications. Data were analyzed by using the Mann-Whitney test to determine the ratio of the platelet count in patient with type 2 diabetes patient with and without vascular complication, with α = 0.05. The Mann-Whitney test showed that there was no significant difference in platelet count among patients with type 2 diabetes, with and without vascular complication (P = 0.051). Conclusion: There was no significant difference in the platelet count of type 2 diabetes patients with and without vascular complication.Keywords: type 2 diabetes mellitus, vascular complication, platelet countAbstrak: Diabetes Melitus (DM) merupakan salah satu penyakit degeneratif yang semakin meningkat jumlahnya dari tahun ke tahun. Jenis DM yang paling banyak kasusnya ialah DM tipe 2. Pada DM tipe 2 terjadi perubahan jumlah trombosit, yang dapat menyebabkan terjadinya komplikasi vaskular pada DM. Penelitian ini bersifat deskriptif analitik dengan rancang penelitian cross sectional dengan menggunakan data rekam medik pasien DM tipe 2 yang rawat jalan di RSUP Prof. DR. R. D. Kandou Manado. Subjek penelitian yang memenuhi kriteria inklusi berjumlah 72 pasien; 36 pasien dengan komplikasi vaskular dan 36 pasien tanpa komplikasi vaskular. Hasil penelitian diuji menggunakan uji Mann-Whitney untuk mengetahui perbandingan jumlah trombosit pada pasien DM tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vascular, α = 0,05. Uji Mann-Whitney menunjukkan bahwa perbedaan jumlah trombosit tidak bermakna antara pasien DM tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vaskular (p=0,051). Simpulan: Tidak terdapat perbedaan bermakna antara jumlah trombosit pada pada DM tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vaskular.Kata kunci: DM tipe 2, komplikasi vaskular, jumlah trombosit

scholarly journals May C-peptide index be a new marker to predict proteinuria in anemic patients with type 2 diabetes mellitus?

2020 ◽  
Vol 54 (1) ◽  
pp. 1-5
Author(s):  
Bilal Katipoglu ◽  
Mustafa Comoglu ◽  
Ihsan Ates ◽  
Nisbet Yilmaz ◽  
Dilek Berker
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Oral Antidiabetic Agent ◽  
C Peptide ◽  
Significant Difference ◽  
Reliable Marker

AbstractObjective. C-peptide is a reliable marker of beta cell reserve and is associated with diabetic complications. Furthermore, HbA1c level is associated with micro- and macro-vascular complications in diabetic patients. HbA1c measurement of diabetic patients with anemia may be misleading because HbA1c is calculated in percent by taking reference to hemoglobin measurements. We hypothesized that there may be a relationship between C-peptide index (CPI) and proteinuria in anemic patients with type 2 diabetes mellitus (T2DM). Therefore, the aim of the present study was to investigate the association between C-peptide levels and CPI in anemic patients with T2DM and proteinuria.Methods. The patients over 18 years of age with T2DM whose C-peptide levels were analyzed in Endocrinology and Internal medicine clinics between 2014 and 2018 with normal kidney functions (GFR>60 ml/min) and who do not use any insulin secretagogue oral antidiabetic agent (i.e. sulfonylurea) were enrolled into the study.Results. Hemoglobin levels were present in 342 patients with T2DM. Among these 342 cases, 258 (75.4%) were non-anemic whereas 84 (24.6%) were anemic. The median DM duration of the anemic group was statistically significantly higher in T2DM (p=0.003). There was no statistically significant difference found in proteinuria prevalence between non-anemic and anemic patient groups (p=0.690 and p=0.748, respectively). Anemic T2DM cases were corrected according to the age, gender, and duration of DM. C-peptide and CPI levels were not statistically significant to predict proteinuria (p=0.449 and p=0.465, respectively).Conclusion. The present study sheds light to the association between C-peptide, CPI, and anemic diabetic nephropathy in T2DM patients and indicates that further prospective studies are needed to clarify this issue.

scholarly journals Relationship between homocysteine and non-dipper pattern in patients with type 2 diabetes mellitus

2012 ◽  
Vol 56 (5) ◽  
pp. 285-290 ◽  
Author(s):  
Serdal Korkmaz ◽  
Abdulkerim Yilmaz ◽  
Gürsel Yildiz ◽  
Fatih Kiliçli ◽  
Serhat Içağasioğlu
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Control Group ◽  
Diabetic Patients ◽  
Nocturnal Blood Pressure ◽  
Type 2 Dm ◽  
Significant Difference

OBJECTIVE: The rate of reduction of nocturnal blood pressure (NBP) is lesser than normal in patients with type 2 diabetes mellitus (type 2 DM). Hyperhomocysteinemia (HHC) disrupts vascular structure and function, no matter the underlying causes. The risk of development of vascular disease is greater in diabetic patients with hyperhomocysteinemia than in patients with normal homocystein levels. The aim of the study was to investigate whether there are differences of homocystein levels in dipper and non-dippers patients with type 2 DM. SUBJECTS AND METHODS: We compared 50 patients (33 females, 17 males) with type 2 DM and 35 healthy individuals (18 females, 17 males ) in a control group. Ambulatory blood pressure monitoring (ABPM) was performed and homocysteine levels were measured in all patients. RESULTS: We found that the percentage of non-dipper pattern was 72% in patients with type 2 DM and 57% in control group. In diabetic and control individuals, homocystein levels were higher in non-dipper (respectively 13.4 ± 8.1 µmol/L and 11.8 ± 5 µmol/L) than in dipper subjects (respectively, 11.8 ± 5.8 µmol/L and 10.1 ± 4.2 µmol/L), but there was no significant difference between the two groups (respectively, p = 0.545, p = 0.294). CONCLUSION: In both groups, homocystein levels were higher in non-dipper than in dipper participants, but there was no significant difference between the groups. High homocystein levels and the non-dipper pattern increases cardiovascular risk. Therefore, the relationship between nocturnal blood pressure changes and homocystein levels should be investigated in a larger study.

scholarly journals Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

2017 ◽  
Vol 2 (2) ◽  
pp. 26-34
Author(s):  
Hridaya Parajuli ◽  
Jyotsna Shakya ◽  
Bashu Dev Pardhe ◽  
Puspa Raj Khanal ◽  
Narayan Prasad Parajuli ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type Ii ◽  
Significant Difference

Background: Hyperuricemia is associated with type 2 diabetes, which is a metabolic disorder of multiple etiologies resulting from defects in insulin action. The present study wascarried out to look for any association between uric acid and Type II Diabetes Mellitus and also status of triacylglycerol level among those patients.Methods: The blood samples were collected 100 diabetic and 100 non-diabetic individuals in the department of biochemistry and then analyzed for estimation of blood glucose, Uric Acid and Triacylglycerol level.Results: The average level of serum uric acid in diabetic patients was higher (5.706±1.617) in comparison to non diabetic subjects (4.322±0.784) with statistically significant difference (p≤0.05). For female the result indicate there was a positive correlation between (FBS and triglycerides) and (triglycerides and uric acids) which was statistically significant (r =-0.465, n = 41, p = 0.002) and(r =-0.370, n = 41, p = 0.017) respectively.Conclusions: This study documents that hyperuricemia is associated with type 2 diabetes mellitus. Furthermore, the serum triacylglycerol and serum uric acid is also found to be associated risk factors for diabetic complications. Hence, timely diagnosis and management of diabetes is vital to control the complications related to diabetes.Ann. Clin. Chem. Lab. Med. 2016:2(1); 26-34

scholarly journals HUBUNGAN JUMLAH TROMBOSIT DAN NILAI AGREGASI TROMBOSIT PADA PASIEN DIABETES MELITUS TIPE 2 RSUP PROF. DR. R. D. KANDOU MANADO

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Maya F. Memah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Platelet Count ◽  
Platelet Aggregation ◽  
Pearson Correlation ◽  
Correlation Test ◽  
Pearson Correlation Test ◽  
Diabetes Melitus

Abstract: Patients with type 2 diabetes mellitus (T2DM) are characterized by an acceleration of thrombopoiesis, an increase of platelet turnover, and a decrease of platelet survival time. These conditions affect the platelet count that manifest as an increase of the proportion of large and reactive platelets which are more thrombogenic. This study aimed to obtain the correlation between the platelet count and the platelet aggregation value in T2DM patients. This was an observational analytical study using the Pearson correlation test. Subjects were 30 T2DM outpatients at Endocrine-Metablolic Clinic of Prof. Dr. R.D. Kandou Hospital Manado. Blood samples of all patients were examined for platelet count and platelet aggregation value. The results showed that most of the subjects were ≥50 tahun (86.7%). Mean thrombocyte count was within normal level. Platelet aggregation values of the ADP 10 µm showed hypoaggregation, meanwhile of the ADP 5 µm showed normoaggregation The Pearson correlation test showed that there was no significant correlation between the platelet count and the platelet aggregation value, either using 10µm ADP (P = 0.22) or using 5µm ADP (P = 0.08). Conclusion:Keywords: platelet count, platelet aggregation, T2DMThere was no significant correlation between the platelet count and the platelet aggregation values in patients with type-2 diabetes mellitus at Endocrine-Metabolic Clinic of Prof. Dr. R.D. Kandou Hospital Manado.   Abstrak: Pada pasien diabetes melitus tipe 2 (DMT2) terjadi percepatan trombopoiesis, peningkatan pergantian trombosit, dan penurunan waktu hidup trombosit. Hal-hal tersebut dapat memengaruhi jumlah trombosit, yang menyebabkan terjadinya peningkatan trombosit berukuran lebih besar dan reaktif yang lebih bersifat trombogenik. Penelitian ini bertujuan  untuk mendapatkan hubungan antara jumlah trombosit dan nilai agregasi trombosit pada pasien DMT2. Penelitian ini bersifat observasional analitik dengan menggunakan uji korelasi Pearson. Subjek penelitian berjumlah 30 pasien DMT2 di Poliklinik Edokrin-Metabolik RSUP Prof. Dr. R. D. Kandou Manado. Sampel darah dilakukan pemeriksaan jumlah trombosit dan nilai agregasi trombosit. Hasil penelitian memperlihatkan bahwa subjek penelitian terbanyak pada usia tua ≥ 50 tahun (86,7%). Rerata jumlah trombosit masih dalam rentang normal, sedangkan nilai agregasi trombosit dengan ADP 10 µm menunjukkan hipoagregasi dan yang dengan ADP 5 µm menunjukkan normoagregasi. Hasil uji korelasi Pearson menunjukkan tidak terdapat hubungan bermakna antara jumlah trombosit dan nilai agregasi trombosit baik dengan ADP 10 µm (P = 0,22) maupun ADP 5 µm (P = 0,08). Simpulan: Pada pasien DMT2 di Poliklinik Edokrin-Metabolik RSUP Prof. Dr. R. D. Kandou Manado tidak terdapat hubungan bermakna antara  jumlah trombosit dan nilai agregasi trombosit.  Kata kunci: jumlah trombosit, sgregasi trombosit, DMT2

scholarly journals Gender based variation of lipid abnormalities in type-2 diabetes mellitus patients

2021 ◽  
Vol 9 (10) ◽  
pp. 3068
Author(s):  
Arpita Jaidev ◽  
Hitesh Shah ◽  
Liggy Andrews ◽  
Bhavisha N. Vagheda
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Density Lipoprotein ◽  
Diabetic Patients ◽  
Male And Female ◽  
Significant Difference

Background: Dyslipidemia has a varying pattern among the male and female patients of type 2 diabetes mellitus (DM).Methods: This study was conducted in the out-patient department (OPD) of department of medicine at GMERS, Patan, Gujarat from July 2020 to December 2020 for a period of six months. Fasting blood sugar, hemoglobin A1c (FBS, HbA1c) lipid profile triacylglycerol-triglyceride, total cholesterol, low density lipoprotein cholesterol and high-density lipoprotein cholesterol (TG, TC, LDL-C, and HDLC) were measured. Statistical analyses were performed with the SPSS software program.Results: A total number of 200 type 2 DM patients (100 males and 100 females) attending to GMERS OPD were recruited in this study. Blood sugar was higher than normal in both male and female (FBS=142.44±36.21, 146.40±41.49 respectively). TG level was also higher in two groups of study subjects with female level slightly more than male (164.99±67.1and 138.21±70 respectively) with no significant difference between the groups (p>0.05).Total cholesterol and LDL-C level was within normal physiological level in both groups, where-as these levels were higher in female in comparison to male (TC=198.07±40.82 and 169.5±36.13 respectively, LDLC=118±34 and 99±27, respectively), showing significant difference between the groups (p=0.014). HDL-C was not below normal in both male (41±5.4) and female (43.99±4.31); however, HDL-C was slightly higher in female than male and the difference was significant (p=0.0129).Conclusions: Dyslipidemia was noticed in a greater proportion of female diabetic patients than male diabetic patients.

scholarly journals TCF7L2 Gene Polymorphism as a Risk for Type 2 Diabetes Mellitus and Diabetic Microvascular Complications

2021 ◽  
Author(s):  
Noran Talaat Aboelkhair ◽  
Heba Elsayed Kasem ◽  
Amera Anwar Abdelmoaty ◽  
Rawhia Hassan Eledel
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Diabetic Patients ◽  
Tcf7l2 Gene ◽  
Significant Difference ◽  
Patient Groups ◽  
Diabetic Microvascular Complications

Abstract Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic condition with various genetics and environmental influences that affects the capacity of the body to produce or use insulin resulting in hyperglycemia, which may lead to variable complications. It is one of the world’s rising health problems. There is emerging evidence that some genetic polymorphisms can impact the risk of evolving T2DM. We try to determine the relationship of (rs7903146) variant of the Transcription factor 7-like 2 (TCF7L2) gene with T2DM and its microvascular complications.Methods and Results: This case-control study included 180 subjects: 60 diabetic patients without complications, 60 diabetic patients with microvascular complications and 60 matched healthy controls. Genotypes of rs7903146 (C/T) SNP in the TCF7L2 gene were evaluated by real-time polymerase chain reaction via TaqMan allelic discrimination. Logistic regression was used to detect the most independent factor for development of diabetes and diabetic microvascular complications. Variant homozygous TT and heterozygous TC genotypes were significantly increased in diabetic without complications and diabetic with complications groups than controls (p=0.003, 0.001) respectively. The T allele was more represented in both patient groups than controls with no significant difference between patient groups. TT genotype as well as T allele was significantly associated with increased T2DM risk.Conclusion: The T allele of rs7903146 polymorphism of TCF7L2 confers susceptibility to development of T2DM. However, no significant association was found for diabetic complications.

scholarly journals To study association of Neutrophil- Lymphocyte ratio with vascular complications in Type-2 Diabetes

2021 ◽  
Vol 12 (8) ◽  
pp. 16-22
Author(s):  
Shilpa Tumkur Andane Gowda ◽  
Shahari Hegde Kusumakar ◽  
Raveendra Kodur Ramamurthy ◽  
Rohith Maraludevanapura Govindaiah
Keyword(s):  
Type 2 Diabetes ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Medical College ◽  
Increased Risk ◽  
Significant Difference

Background: Diabetes is a pro-thrombotic state associated with increased risk of atherosclerosis and inflammation. Neutrophil lymphocyte ratio (NLR) provides information about early and subclinical inflammation and thus may act as a prognostic marker for vascular complications in type 2 diabetes. Aims and Objective: To analyze the correlation between Neutrophil- Lymphocyte ratio in diabetics with and without vascular complications. Materials and Methods: A total of 111 patients admitted in Victoria hospital and Bowring & Lady Curzon hospital attached to Bangalore Medical College and Research Institute from NOV 2018 to MAY 2020 were studied. The data was collected according to the proforma in terms of history, clinical examination and the necessary investigations. NLR was observed in type 2 diabetic patients and was compared in those with complications and without complications. Results: The NLR was higher in diabetics with vascular complications compared to those without complications, 2.8 ± 0.7 fl versus 6.8 ± 3.1 fl (P< 0.001), respectively. In this study, Mean N (%), In No Vascular Complications was 61.7 ± 10.6 and with vascular complications was 79.9 ± 9.5. Mean L (%) in No Vascular Complications was 23.7 ± 5.8. Mean N (%), In No Vascular Complications was 61.7 ± 10.6 and with vascular complications was 79.9 ± 9.5. There was a significant difference in mean N (%) mean L (%) and NLR in comparison with respect to Complications. Conclusion: This study showed significantly higher NLR in diabetic patients with vascular complications. Hence, NLR can be used as a simple parameter to assess the vascular complications in diabetes.

scholarly journals Comparison Pai-1 Level in Type 2 Diabetes Mellitus with and Without Diabetic Foot Ulcer

2018 ◽  
Vol 1 (1) ◽  
pp. 1-5
Author(s):  
Alfi Dewi Sholat ◽  
Dairion Gatot ◽  
Savina Handayani ◽  
Andri Iskandar Mardia ◽  
Santi Syafril
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Diabetic Patients ◽  
Significant Difference ◽  
Pai 1

In type 2 diabetes mellitus, there are changes in hemostasis components, including overexpression of PAI-1. By these facts, the authors are interested in conducting the study of PAI-1 level in diabetic patients with and without foot ulcer. Methods: The sample of this research was collected cross-sectionally on 20 type 2 diabetic patients with foot ulcer and 20 without foot ulcer. Blood samples were taken to measure serum PAI-1 level, complete blood count and hemostasis screening test. Results: Statistical analysis showed there are significant differences in hemoglobin, trombosit, Fibrinogen and D-dimer levels in the ulcer and non-ulcer groups but no significant difference in PAI-1 level. Conclusions: No higher PAI – 1 level were found in diabetic foot ulcer group than those without diabetic foot ulcer. There was no significant difference between PAI-1 level and grade of diabetic foot ulcer.

scholarly journals Gambaran Indeks Eritrosit Rerata pada Laki-laki Dewasa dengan Diabetes Melitus Tipe 2

e-CliniC ◽  
2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Talitha D. Saraswati ◽  
Linda W. A. Rotty ◽  
Karel Pandelaki
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medical Records ◽  
Diabetic Patients ◽  
Adult Males ◽  
Important Indicator ◽  
Erythrocyte Indices ◽  
Diabetes Melitus

Abstract: Diabetes mellitus (DM) is a metabolic disease indicated by high level of blood sugar resulting from a defect in insulin secretion, insulin activity, or both. The prevalence of DM in Indonesia is 1.9%, making it the 7th leading cause of deaths worldwide. In diabetic patients it is common to find any disorder in several systems, inter alia disorder of erythrocytes. An important indicator in portraying the erythrocytes state is the average erythrocyte indices (MCV, MCH, and MCHC). This study was aimed to provide an overview of the average erythrocyte indices in young adult males with type 2 DM (T2DM) at the Endocrine Polyclinic of Prof. Dr. R. D. Kandou Hospital. This was a descriptive and retrospective study using medical records of diabetic patients at the Endocrine Policlinic from September 2018 to September 2019. The results obtained a total of 1.432 medical records consisting of 550 males and 882 females. However, only 22 samples met the inclusion criteria, with a majority of samples were 40 to 45 years old (50%). Generally, the erythrocyte indices were still in normal range. Albeit, a few samples showed a decrease in hemoglobin level, MCV, and MCH. In conclusion, there was no significant change in the erythrocyte indices among adult males with type 2 diabetes mellitus at the Endocrine Polyclinic of Prof. Dr. R. D. Kandou Hospital.Keywords: average erythrocyte indices, type 2 diabetes mellitus Abstrak: Diabetes melitus (DM) merupakan penyakit metabolik yang ditandai dengan tingginya kadar gula darah akibat defek sekresi insulin, kerja insulin, atau keduanya. Prevalensi DM di Indonesia sebesar 1,9% menjadikan DM sebagai penyebab kematian urutan ke tujuh di dunia. Pada pasien DM seringkali ditemukan gangguan pada berbagai sistem, salah satunya pada eritrosit. Indikator penting yang dapat mencerminkan keadaan eritrosit ialah indeks eritrosit rerata (MCV, MCH, dan MCHC). Penelitian ini bertujuan untuk mengetahui gambaran indeks eritrosit rerata pada pasien laki-laki dewasa penyandang DM tipe 2 di Poliklinik Endokrin RSUP Prof. Dr. R. D. Kandou. Jenis penelitian ialah deskriptif retrospektif menggunakan data rekam medik pasien di Poli Endokrin RSUP Prof. Dr. R. D. Kandou periode September 2018 hingga September 2019. Hasil penelitian mendapatkan 1.432 rekam medis, terdiri dari 550 laki-laki dan 882 perempuan, namun hanya 22 data yang memenuhi kriteria penelitian, dengan mayoritas berusia 40-45 tahun (50%). Secara umum nilai indeks eritrosit rerata masih dalam rentang normal, namun terdapat beberapa sampel dengan penurunan kadar hemoglobin, MCV, dan MCH. Simpulan penelitian ini ialah tidak terdapat gambaran bermakna pada indeks eritosit pasien laki-laki dewasa dengan DM tipe 2 di Poliklinik Endokrin RSUP Prof. Dr. R. D. KandouKata kunci: indeks eritrosit rerata, diabetes melitus tipe 2

Sign in / Sign up

Export Citation Format

Share Document