scholarly journals Hubungan tekanan intraocular dengan diabetes retinopati proliferatif

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Felix Martua ◽  
Laya Rares ◽  
Yamin Tongku
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Intraocular Pressure ◽  
Proliferative Diabetic Retinopathy ◽  
Vital Sign ◽  
Vision Loss ◽  
Severe Form ◽  
Common Complication ◽  
Dummy Variable ◽  
Period Data

Abstrak: Diabetes Mellitus (DM) adalah penyakit tidak menular yang diderita lebih dari 170 juta orang di seluruh dunia, salah satu komplikasi dari DM adalah diabetes retinopati dimana salah satu bentuknya adalah proliferatif (PDR). Jika PDR tidak ditangani dengan cepat maka akan menimbulkan penurunan tajam penglihatan dan disertai peningkatan tekanan intraokular (TIO). Penelitian ini dilakukan untuk menemukan hubungan antara PDR dengan peningkatan TIO. Penelitian dilakukan dengan metode analitik retrospektif, dengan menggunakan data rekam medik dari pasien yang berobat di Poliklinik Mata RSUP Prof. R.D. Kandou Manado periode Januari 2015-September 2016. Data yang diambil antara lain status tekanan intraocular dan tanda vital pasien sebelum menerima tindakan terapi. Dari 24 data rekam medik pasien yang memenuhi kriteria didapat 15 pasien jenis kelamin perempuan (62,5%) dan 9 pasien jenis kelamin laki-laki (37,5%). Rentang usia paling banyak terkena PDR adalah 55-64 tahun sebanyak 10 orang (41,7%). Hasil analisis menggunakan metode analisis regresi dengan variabel dummy terdapat tingkat hubungan sebesar 29,7% yang berarti PDR sedikit berpengaruh pada TIO, dengan p=0,03 yang menunjukkan hubungan yang kurang signifikan antara PDR dan TIO (p<0,05). Simpulan: didapat hubungan yang kurang signifikan antara PDR dan TIO.Kata kunci: diabetes retinopati proliferatif, tekanan intraokular Abstract: Diabetes Mellitus (DM) is an uninfectious disease that affect more than 170 million persons worldwide. Diabetic retinopathy is one of the most common complication on people with diabetes, and Proliferative Diabetic Retinopathy (PDR) is the most severe form of diabetic retinopathy. PDR will cause vision loss if not treated quickly and causing elevation of intraocular pressure (IOP). PDR and its association with elevation of IOP is the main focus of this study. This study was an analytic-retrospective, using the data from medical record of patients that visits Polyclinic of Opthalmology in Prof. R.D. Kandou Hospital from January 2015 until September 2016 period. Data used for this study is IOP, vision status, and vital sign, and the IOP was measured before patient taking any medication. From 24 samples were used for this study, 15 of them is females (62,5%), based on age span, most patients with PDR are between 55-64 y.o. by 10 people (41,7%). Analytic result using dummy variable shows PDR has little effect to IOP, by 29,7% and shows little signifancy (p=0,03; p<0,05). Conclusion: PDR has little significant correlation to IOP. Keywords: proliferative diabetic retinopathy, intraocular pressure

scholarly journals Survival Time of Visual Gains after Diabetic Vitrectomy and Its Relationship with Ischemic Heart Disease

2020 ◽  
Vol 17 (1) ◽  
pp. 310
Author(s):  
Abdah Khairiah Che Md Noor ◽  
Evelyn Li Min Tai ◽  
Yee Cheng Kueh ◽  
Ab Hamid Siti-Azrin ◽  
Zamri Noordin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Survival Time ◽  
Proliferative Diabetic Retinopathy ◽  
Vision Loss ◽  
Ischemic Heart ◽  
Vitrectomy Surgery

Vitrectomy surgery in proliferative diabetic retinopathy improves the vision-related quality of life. However, there is lack of data on the duration of maintenance of visual gains post vitrectomy. This study thus aimed to determine the survival time of visual gains and the prognostic factors of vision loss after vitrectomy surgery for complications of proliferative diabetic retinopathy. A retrospective cohort study was conducted in an ophthalmology clinic in Malaysia. We included 134 patients with type 2 diabetes mellitus on follow-up after vitrectomy for proliferative diabetic retinopathy. Visual acuity was measured using the log of minimum angle of resolution (LogMar). A gain of ≥0.3 LogMar sustained on two subsequent visits was considered evidence of visual improvement post vitrectomy. Subjects were considered to have vision loss when their post-operative visual acuity subsequently dropped by ≥0.3 LogMar. Kaplan–Meier analysis was used to determine the survival time of visual gains. Cox Proportional Hazard regression was used to determine the prognostic factors of vision loss. The median age of patients was 56.00 years (IQR ± 10.00). The median duration of diabetes mellitus was 14.00 years (IQR ± 10.00). Approximately 50% of patients with initial improvement post vitrectomy subsequently experienced vision loss. The survival time, i.e., the median time from surgery until the number of patients with vision loss formed half of the original cohort, was 14.63 months (95% CI: 9.95, 19.32). Ischemic heart disease was a significant prognostic factor of vision loss. Patients with underlying ischemic heart disease (adjusted HR: 1.97, 95% CI: 1.18, 3.33) had a higher risk of vision loss post vitrectomy, after adjusting for other factors. Approximately half the patients with initial visual gains post vitrectomy maintained their vision for at least one year. Ischemic heart disease was a poor prognostic factor for preservation of visual gains post vitrectomy.

scholarly journals Diabetic Retinopathy. Morphofunctional State of the Retina in Pancreas Recipients

2021 ◽  
Vol 18 (3) ◽  
pp. 459-469
Author(s):  
I. V. Vorobyeva ◽  
L. K. Moshetova ◽  
A. V. Pinchuk ◽  
E. V. Bulava ◽  
K. E. Lazareva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Pancreas Transplantation ◽  
Patient Management ◽  
Molecular Mechanisms ◽  
Vision Loss ◽  
Retinal Damage ◽  
Common Complication ◽  
Immunological Markers

Diabetes mellitus (DM) is one of the most common and rapidly progressing diseases worldwide. Diabetic retinopathy (DR) is a common complication of diabetes and the main cause of vision loss in middle-aged and elderly people. The development and progression of DR is closely related to the duration of diabetes, hyperglycemia, and arterial hypertension. There is growing evidence that inflammation is one of the key links in the pathogenesis of diabetic retinal damage, but the exact molecular mechanisms remain to be known. Pancreas transplantation (PT) is currently the only effective treatment for diabetes that restores normal physiological glucose metabolism. Due to the limited number of PT surgeries associated with the severity of intra- and postoperative complications and the acute issue of organ donation, studies on the assessment of DR after PT are few and contradictory. There is a need for further studies of the DR state after PT with the study of the influence of risk factors, determination of the level of immunological markers and the use of modern instrumental research methods to create effective patient management regimens in the postoperative period.

scholarly journals Modern optimizing techniques of surgical treatment of proliferative diabetic retinopathy

2019 ◽  
Vol 100 (4) ◽  
pp. 611-615
Author(s):  
V S Stebnev ◽  
S D Stebnev ◽  
I V Malov ◽  
V M Malov ◽  
E B Eroshevskaya
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Intraocular Pressure ◽  
Proliferative Diabetic Retinopathy ◽  
Digital Imaging ◽  
Three Dimensional ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Postoperative Control ◽  
Insulin Dependent

Aim. To evaluate the clinical efficacy of microinvasive vitrectomy and three-dimensional digital imaging in patients with proliferative diabetic retinopathy. Methods. The clinical treatment results were studied in 62 patients (62 eyes) with proliferative diabetic retinopathy complicated by tractional retinal detachment who underwent vitreoretinal surgery with the use of microinvasive techniques and three-dimensional digital imaging. There were 38 (61%) women, 24 (39%) men, mean age 57±5.2 years. The duration of diabetes mellitus was 6 to 13 years (an average of 11.7 years). Of the 62 patients, 11 had insulin-dependent diabetes mellitus, and 51 had non-insulin-dependent diabetes. Results. Final anatomical result (the elimination of the zones of proliferation and adhesion of the retina) was reached in 59/62 (95.1%) of the eyes: in 54/62 (87%) eyes after the first intervention, in 8/62 eyes after additional surgical intervention. The maximum corrected visual acuity increased in 55/62 (88.7%) eyes from 0.01±0.12 to 0.22±0.11 (p <0.05); in 3/62 (4.8%) eyes remained the same; 4/62 (6.5%) eyes had visual impairment. Complications were diagnosed in 14 (22.6%) of the eyes: retinal tears (10), hemophthalmus (2), subchoroid hemorrhage (1), detachment of the choroid (1). Postoperative control of intraocular pressure demonstrated the following: 36 (58.1%) eyes had normal intraocular pressure (11–22 mm Hg), 20 (32.3%) — increased intraocular pressure (≥22 mm Hg), 6 (9.7%) — reduced intraocular pressure (≤10 mm Hg). In the postoperative period (up to 1 month after surgery) additional surgical interventions were performed on 8/62 (12.9%) eyes. Conclusion. In patients with proliferative diabetic retinopathy, the use of microinvasive vitreoretinal technologies and digital imaging system provide high anatomical (95.1% of patients) and functional results (88.7% of patients).

scholarly journals Visual Cortex Transcranial Direct Current Stimulation for Proliferative Diabetic Retinopathy Patients: A Double-Blinded Randomized Exploratory Trial

2021 ◽  
Vol 11 (2) ◽  
pp. 270
Author(s):  
Angelito Braulio F. de Venecia ◽  
Shane M. Fresnoza
Keyword(s):  
Diabetic Retinopathy ◽  
Visual Cortex ◽  
Proliferative Diabetic Retinopathy ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Vision Loss ◽  
Sham Stimulation ◽  
Direct Current Stimulation ◽  
Residual Vision ◽  
Cathodal Tdcs

Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes. PDR-related retinal hemorrhages often lead to severe vision loss. The main goals of management are to prevent visual impairment progression and improve residual vision. We explored the potential of transcranial direct current stimulation (tDCS) to enhance residual vision. tDCS applied to the primary visual cortex (V1) may improve visual input processing from PDR patients’ retinas. Eleven PDR patients received cathodal tDCS stimulation of V1 (1 mA for 10 min), and another eleven patients received sham stimulation (1 mA for 30 s). Visual acuity (logarithm of the minimum angle of resolution (LogMAR) scores) and number acuity (reaction times (RTs) and accuracy rates (ARs)) were measured before and immediately after stimulation. The LogMAR scores and the RTs of patients who received cathodal tDCS decreased significantly after stimulation. Cathodal tDCS has no significant effect on ARs. There were no significant changes in the LogMAR scores, RTs, and ARs of PDR patients who received sham stimulation. The results are compatible with our proposal that neuronal noise aggravates impaired visual function in PDR. The therapeutic effect indicates the potential of tDCS as a safe and effective vision rehabilitation tool for PDR patients.

scholarly journals Wide-field imaging in proliferative diabetic retinopathy

2019 ◽  
Vol 5 (S1) ◽  
Author(s):  
T. Y. Alvin Liu ◽  
J. Fernando Arevalo
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Vision Loss ◽  
Current Data ◽  
Panretinal Photocoagulation ◽  
Main Body ◽  
Wide Field ◽  
Fundus Imaging ◽  
Field Imaging ◽  
Wide Field Imaging

Abstract Background Diabetic retinopathy (DR) is one of the leading causes of vision loss worldwide. For decades, 7-field 30-degree fundus imaging has been the gold standard for DR classification. The aim of this review article is to discuss how the advent of ultra-wide-field (UWF) fundus imaging has changed the management of proliferative diabetic retinopathy (PDR). Main body Current data suggests that UWF imaging, as compared to conventional Early Treatment Diabetic Retinopathy Study (ETDRS) fields, detects additional and more extensive PDR pathologies. DR lesions, captured by UWF imaging outside of ETDRS fields, likely carry prognostication value. Conclusion UWF imaging represents a major advancement in the detection and management of DR. It remains unclear whether, when and how patients, with PDR changes only peripheral to standard ETDRS fields, should be treated. A larger, prospective, randomized clinical trial is also needed to compare the efficacy of UWF image-guided targeted laser photocoagulation with that of conventional panretinal photocoagulation.

scholarly journals Study of aerobic bacterial conjunctival flora in patients with diabetes mellitus

2013 ◽  
Vol 5 (1) ◽  
pp. 28-32 ◽  
Author(s):  
D Karimsab ◽  
SK Razak
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Bacterial Flora ◽  
Diabetic Patients ◽  
Coagulase Negative Staphylococci ◽  
Ocular Infections ◽  
Patients With Diabetes ◽  
Conjunctival Flora ◽  
Normal Bacterial Flora

Introduction: Normal bacterial flora may be altered by a variety of factors. Objective: To study the aerobic bacterial conjunctival flora in patients with diabetes mellitus and to find its clinical significance by comparing the results to the conjunctival flora of non-diabetic subjects. Materials and methods: A total of 75 diabetic patients were included as cases and 25 nondiabetics as controls to compare the results. Specimens for the study of conjunctival flora were taken by rubbing sterile cotton-tipped swabs to the inferior palbebral conjunctiva. The conjunctival culture report of the patients with diabetic mellitus was compared to that of nondiabetic subjects. Results: Positive conjunctival cultures were seen in a higher percentage of patients with diabetes (unilateral and bilateral positive conjunctival cultures 34.66 % and 58.66 % respectively) compared to that in non-diabetic controls (unilateral and bilateral positive conjunctival cultures 24 % and 16 % respectively). Diabetics showed a higher proportion of coagulase negative staphylococci (45.33 %), compared to the non-diabetic group (16 %). Among the diabetic patients, positive conjunctival cultures were detected more frequently in those with diabetic retinopathy compared to those without retinopathy. A higher proportions of bilateral positive conjunctival cultures were seen in cases with proliferative diabetic retinopathy (38.63 %) in comparison to patients with no retinopathy and different stages of non-proliferative diabetic retinopathy. Conclusion: The conjunctival floral pattern with increased bacteria in diabetics is a predominant cause of many diabetes-related ocular infections. The presence of diabetic retinopathy is an indicator for increased colonization of conjunctiva, and its severity correlates with the severity of diabetic retinopathy. Nepal J Ophthalmol 2013; 5(9):28-32 DOI: http://dx.doi.org/10.3126/nepjoph.v5i1.7818

scholarly journals Prevalence of Diabetic Retinopathy in Type 1 and Type 2 Diabetes Mellitus Patients in North-East Poland

Medicina ◽  
2020 ◽  
Vol 56 (4) ◽  
pp. 164
Author(s):  
Wojciech Matuszewski ◽  
Angelika Baranowska-Jurkun ◽  
Magdalena M. Stefanowicz-Rutkowska ◽  
Robert Modzelewski ◽  
Janusz Pieczyński ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Lifestyle Changes ◽  
North East ◽  
Experimental Group

Background and Objectives: The global epidemic of diabetes, especially type 2 (DM2), is related to lifestyle changes, obesity, and the process of population aging. Diabetic retinopathy (DR) is the most serious complication of the eye caused by diabetes. The aim of this research was to assess the prevalence of diabetic retinopathy in type 1 and type 2 diabetes mellitus patients in north-east Poland. Materials and Methods: The eye fundus was assessed on the basis of two-field 50 degrees color fundus photographs that showed the optic nerve and macula in the center after the pupil was dilated with 1% tropicamide. Results: The experimental group included 315 (26%) patients with type 1 diabetes mellitus (DM1) and 894 (74%) patients with DM2. DM1 patients were diagnosed with DR in 32.58% of cases, with non-proliferative diabetic retinopathy (NPDR) in 24.44% of cases, proliferative diabetic retinopathy (PDR) in 1.59% of cases, diabetic macular edema (DME) in 5.40% of cases, and PDR with DME in 0.95% of cases. DR was found in DM2 patients in 23.04% of cases, NPDR in 17.11% of cases, PDR in 1.01% of cases, DME in 4.81% of cases, and PDR with DME in 0.11% of cases. Conclusions: The presented study is the first Polish study on the prevalence of diabetic retinopathy presenting a large group of patients, and its results could be extrapolated to the whole country. Diabetic retinopathy was found in 25.48% of patients in the whole experimental group. The above results place Poland within the European average, indicating the quality of diabetic care offered in Poland, based on the number of observed complications.

Effects of diabetes duration and HgA1C level on corneal endothelial morphology

2020 ◽  
pp. 112067212091481
Author(s):  
Salih Çolak ◽  
Burcu Kazanci ◽  
Dilek Ozçelik Soba ◽  
Yasemin Ozdamar Erol ◽  
Pelin Yilmazbas
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Endothelial Cell ◽  
Standard Deviation ◽  
Proliferative Diabetic Retinopathy ◽  
Coefficient Of Variation ◽  
Corneal Thickness ◽  
Healthy Individuals ◽  
Significant Difference ◽  
Corneal Endothelial Cell Density

Objective: The aim of this study is to investigate the effects of the HbA1c level and the duration of diabetes mellitus on the corneal endothelium morphology and to compare between healthy individuals and diabetes mellitus patients with non-proliferative diabetic retinopathy and proliferative diabetic retinopathy. Material and methods: Ninety patients who applied to the Health Sciences University Ulucanlar Eye Training and Research Hospital between January 2016 and January 2017 were included in this prospective randomized study. In the study, 45 diabetes mellitus patients and 45 healthy individuals were evaluated. The diabetes patients were compared in terms of HbA1c level, diabetes mellitus duration, corneal endothelial cell density, coefficient of variation, standard deviation, and hexagonality with healthy control group. Results: A statistically significant difference was found in the endothelial cell densitometer, coefficient of variation, and standard deviation measurements between the diabetes mellitus patients and the control (healthy) group. But, there was no statistically significant difference between 6A (hexagonality) and central corneal thickness measurements. There was a negative correlation between HbA1c levels and diabetes mellitus times and endothelial cell densitometer values in the patients with diabetes mellitus diagnosis and standard deviation values in the positive direction. There was a statistically significant difference between diabetes mellitus patients with the diagnosis of non-proliferative diabetic retinopathy and proliferative diabetic retinopathy in the endothelial cell densitometer and standard deviation values. But there was not any statistically significant difference between coefficient of variation, 6A, and central corneal thickness values. Conclusion: The endothelial cell densitometer in diabetes mellitus patients with retinopathy is lower than that in healthy individuals. There is a negative correlation between retinopathy severity and corneal endothelial cell density. Diabetes affects negatively not only vascular tissues but also avascular cornea.

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