scholarly journals Hubungan Kadar Vitamin D dan Kadar C-Reactive Protein dengan Klinis Pasien Coronavirus Disease 2019

e-CliniC ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 370
Author(s):  
Catrien Berhandus ◽  
Jeffrey A. Ongkowijaya ◽  
Karel Pandelaki
Keyword(s):  
Vitamin D ◽  
Significant Relationship ◽  
Vitamin D Insufficiency ◽  
Clinical Severity ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Cross Sectional Design ◽  
The Relationship ◽  
Positive Effect

Abstract: COVID-19 patients could experience many respiratory symptoms accompanied with increased inflammatory markers, such as C-reactive protein (CRP). Vitamin D is known to have a positive effect on immune system by decreasing inflammatory process. This study was aimed to evaluate the relationship between vitamin D and CRP concentration and clinical severity, and the correlation between vitamin D concentration and CRP concentration in COVID-19 patients. This was an observational and analytical study with a cross-sectional design conducted at Prof. dr. R. D. Kandou hospital. A total of 40 subjects with COVID-19 were included. Clinical severity was classified into moderate and severe. All subjects underwent vitamin D and CRP concentration examination. The results showed that there was a significant relationship between vitamin D level and clinical severity of patients with COVID-19 (p=0.0001). There was a significant relationship between CRP level and clinical severity of patients with COVID-19 (p=0.0001). Moreover, there was a negative correlation between vitamin D concentration and CRP concentration (r=-0.49, p=0.001). In conclusion, vitamin D insufficiency or deficiency is related to CRP increament and clinical severity of patients with COVID-19.Keywords: coronavirus disease 2019, vitamin D, C-reactive protein (CRP), clinical severityAbstrak: Penderita COVID-19 mengalami berbagai gejala pernapasan disertai dengan pening-katan beberapa penanda inflamasi, salah satunya C-reactive protein (CRP). Vitamin D diketahui memiliki efek positif terhadap sistem imun tubuh dengan cara meredam proses inflamasi berlebihan. Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara kadar vitamin D dan kadar CRP dengan klinis COVID-19, dan korelasi antara kadar vitamin D dengan kadar CRP. Jenis penelitian ini ialah studi analitik observasional dengan desain potong lintang yang dilakukan di RSUP Prof. dr. R. D. Kandou. Total sampel sebanyak 40 pasien dengan diagnosis COVID-19. Gejala klinis pasien dibagi menjadi sedang dan berat. Pemeriksaan kadar vitamin D dan kadar CRP dilakukan pada seluruh sampel. Hasil penelitian mendapatkan hubungan bermakna antara kadar vitamin D dengan klinis pasien COVID-19 (p=0,0001), dan antara kadar CRP dengan klinis pasien COVID-19 (p=0,0001). Terdapat korelasi negatif antara kadar vitamin D dengan kadar CRP (r=-0,49, p=0,001). Simpulan penelitian ini ialah insufisiensi atau defisiensi vitamin D berhubungan dengan peningkatan CRP dan klinis pasien COVID-19.Kata kunci: coronavirus disease 2019, vitamin D, C-reactive protein (CRP), gejala klinis

scholarly journals The Relationship between Vitamin D and Coronary Artery Ectasia in Subjects with a Normal C-Reactive Protein Level

2017 ◽  
Vol 47 (2) ◽  
pp. 231 ◽  
Author(s):  
Goksel Cagirci ◽  
Selcuk Kucukseymen ◽  
Isa Oner Yuksel ◽  
Nermin Bayar ◽  
Erkan Koklu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Coronary Artery ◽  
Protein Level ◽  
Coronary Artery Ectasia ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

scholarly journals High Sensitivity CReactive Protein (hsCRP) Level on Premature Rupture of Membrane (PROM) at Term Pregnancy

2017 ◽  
pp. 12-15
Author(s):  
Meily Manoppo ◽  
Hermie MM Tendean ◽  
Joice MM Sondakh
Keyword(s):  
High Sensitivity ◽  
C Reactive Protein ◽  
Term Pregnancy ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
Hs Crp ◽  
Cross Sectional Design ◽  
Parametric Statistical Test

Objective: To compare the level of high sensitivity C-Reactive Protein (hs-CRP) on patients with premature rupture of membranes (PROM) at term pregnancy. Methods: The study was cross-sectional design. The data collection included age, parity, gestational age, birth weight, and APGAR score on 28 pregnant women at term pregnancy consisting of 14 subjects of Premature Rupture of Membrane (PROM) less than 12 hours and the remaining one was equal or more than 12 hours. We took blood samples from the subjects for the examination of hs-CRP level. Data were analyzed using non-parametric statistical test and processed using Statistical Package for Social Sciences (SPSS) version 20. Results: The mean hs-CRP level on PROM <12-hour and 12-hour group was 12.9 and 17.8 mg/l. There was not significant difference on hs-CRP level between both of group at term pregnancy (p=0.734). Conclusion: The level of hs-CRP does not have association with the incidence of PROM. [Indones J Obstet Gynecol 2017; 5-1: 12-15] Keywords: high sensitivity C-Reactive Protein, premature ruptures of membranes, term pregnancy

scholarly journals Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus

2020 ◽  
Vol 77 (6) ◽  
pp. 582-589
Author(s):  
Marijana Petrovic ◽  
Tamara Dragovic ◽  
Stanko Petrovic ◽  
Katarina Obrencevic ◽  
Nemanja Rancic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Hemoglobin A1c ◽  
Vitamin D Insufficiency ◽  
C Reactive Protein ◽  
Urine Protein ◽  
Reactive Protein ◽  
Type 2 Dm ◽  
Calcium Phosphorus

Background/Aim. Vitamin D insufficiency/deficiency is often present in patients with type-2 diabetes mellitus (DM) and could present a risk factor for rapid progression of diabetic nephropathy and for higher incidence of cardiovascular events. The aim of this study was to examine the influence of vitamin D supplementation on proteinuria, cholesterol, triglycerides, C-reactive protein (CRP) and hemoglobin A1c in patients with type-2 DM and vitamin D insufficiency/ deficiency. Methods. This prospective, cohort study included 90 patients with type-2 DM and vitamin D insufficiency/ deficiency divided into 3 equal groups: with normal proteinura, with microproteinuria and with macroproteinuria. Therapy included six months of supplementation with cholecalciferol drops: first two months with 20,000 IU twice weekly, than if level of vitamin D was below normal the same dose was given next four months. If the level of vitamin D was normal 5,000 IU was given twice weekly. At the begining and at the end of the study the levels of urea, creatinine, fasting blood glucose, calcium, phosphorus, cholesterol, triglycerides, CRP, hemoglobin A1c, intact parathyroid hormone, 24-hour urine protein and creatinine clearance were determined. Levels of calcium, phosphorus and vitamin D were also checked 2 months after beginning of therapy due to possible correction of cholecalciferol dose. Results. The lowest level of vitamin D before therapy was found in patients with macroproteinuria, while at the end of the study the significantly higher level of vitamin D was found in all three groups. After 6 months of therapy a significant decrease of 24-hour urine protein, cholesterol, triglycerides, hemoglobin A1c in all three groups, and CRP in patients with normal proteinuria and microproteinuria were found. Significantly negative correlation between vitamin D and 24-hour urine protein, cholesterol and CRP was found in patients with macroproteinuria. Also, significantly negative correlation was found between vitamin D and hemoglobin A1c, in patients with normal proteinuria, vitamin D and CRP in patients with microproteinuria. Conclusion. A preventive use of high-dose cholecalciferol supplementation in patients with type-2 DM (with or without proteinuria) decreases cholesterol, triglycerides, proteinuria, CRP and hemoglobin A1c.

scholarly journals Hubungan antara Kebiasaan Merokok dengan Angka Kejadian Lesi yang Diduga Stomatitis Nikotina pada Masyarakat Desa Ongkaw Dua

e-CliniC ◽  
2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Miranda A. Tambunan ◽  
Pieter L. Suling ◽  
Christy N. Mintjelungan
Keyword(s):  
Significant Relationship ◽  
Analytical Study ◽  
Smoking Habit ◽  
Smoking Habits ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
The Relationship ◽  
Heavy Smokers

Abstract: Nicotine stomatitis could be found among heavy smokers. This study was aimed to determine the relationship between smoking habits and the incidence of lesions suspected as nicotine stomatitis among villagers of Ongkaw Dua. This was an analytical study with a cross sectional design. Population consisted of 183 smokers aged >15 years at Desa Ongkaw Dua and the subjects were 65 smokers. The chi-square showed a p-value of 0.592 for the relationship between the duration of smoking and the occurence of lesion supspected as nicotine stomatitis. Moreover, the chi-square showed a p-value of 0.005 for the relationship between the number of cigarettes consumed per day and the occurence of lesion suspected as nicotine stomatitis. In conclusion, there was no relationship between the duration of smoking and the occurence of lesion suspected as nicotine stomatitis, but there was a significant relationship between the number of cigarettes consumed per day and the occurence of lesion suspected as nicotine stomatitis.Keywords: smoking habit, nicotine stomatitis Abstrak: Stomatitis nikotina dapat dijumpai pada perokok berat. Penelitian ini bertujuan untuk mengetahui hubungan antara kebiasaan merokok dengan angka kejadian lesi yang diduga stomatitis nikotina pada masyarakat desa Ongkaw Dua. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Populasi penelitian ini yaitu 183 perokok berusia >15 tahun di Desa Ongkaw Dua dan yang menjadi subyek penelitian berjumlah 65 orang. Hasil uji chi-square terhadap hubungan lama merokok dengan angka kejadian lesi yang diduga stomatitis nikotina mendapatkan p=0,592. Hasil uji chi-square terhadap hubungan antara jumlah rokok yang dihisap setiap hari dengan angka kejadian lesi yang diduga stomatitis nikotina mendapatkan p=0,005. Simpulan penelitian ini ialah tidak terdapat hubungan antara lamanya merokok dengan angka kejadian lesi yang diduga stomatitis nikotina, tetapi terdapat hubungan bermakna antara jumlah rokok yang dihisap setiap hari dengan angka kejadian lesi yang diduga stomatitis nikotina.Kata kunci: kebiasaan merokok, stomatitis nikotina

scholarly journals Kadar High Sensitivity C-Reactive Protein Berkaitan dengan Lingkar Pinggang pada Lansia

2021 ◽  
Vol 8 (1) ◽  
pp. 21
Author(s):  
Deny Yudi Fitranti ◽  
Bunga Syifarahmi ◽  
Martha Ardiaria ◽  
Nurmasari Widyastuti
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
International Physical Activity Questionnaire ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Consecutive Sampling ◽  
Hs Crp ◽  
Activity Questionnaire

<p>Proses penuaan mempengaruhi peningkatan distribusi lemak abdominal dengan indikator lingkar pinggang (LP) dan rasio lingkar pinggang panggul (RLPP). Penimbunan lemak abdominal menyebabkan disfungsi jaringan adiposa sehingga mempengaruhi biomarker proinflamasi yaitu kadar serum <em>high-sensitivity C-reactive Protein</em> (hs-CRP). Penelitian bertujuan untuk mengetahui hubungan LP dan RLPP dengan kadar hs-CRP lansia wanita. Rancangan penelitian <em>cross sectional</em> pada 53 subjek dipilih secara <em>consecutive sampling</em>. Antropometri yang diukur adalah LP dan RLPP. Pengukuran kadar serum hs-CRP dianalisis dengan metode <em>enyme-linked immunosorbent assay</em> (ELISA). Wawancara yang dilakukan yaitu data diri, asupan, aktivitas fisik, dan riwayat konsumsi obat. Data asupan diperoleh dengan metode <em>food recall</em> 3x24 jam. Aktivitas fisik diperoleh menggunakan <em>International Physical Activity Questionnaire</em> (IPAQ). Analisis data digunakan uji korelasi <em>Spearman</em>. Hasil penelitian menunjukkan bahwa persentase LP pada lansia wanita yang berisiko sebesar 90,6%, RLPP yang berisiko sebesar 98,1%, dan kadar hs-CRP tinggi sebesar 30,2%. Terdapat hubungan positif antara LP dengan kadar serum hs-CRP (r=0,417 ; p=0,002). Dalam penelitian ini RLPP, aktivitas fisik, asupan energi, karbohidrat, protein, lemak, serat, vitamin A, vitamin C, vitamin D,vitamin E, dan selenium tidak berkorelasi dengan kadar hs-CRP. Simpulan penelitian ini adalah LP berkorelasi positif dengan kadar serum hs-CRP, namun RLPP tidak berkorelasi dengan kadar serum hs-CRP</p>

scholarly journals Gambaran kadar C-reactive protein (CRP) serum pada perokok aktif usia >40 tahun

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Hendrika N. C. Dewi ◽  
Michaela E. Paruntu ◽  
Murniati Tiho
Keyword(s):  
Inflammatory Marker ◽  
Systemic Disease ◽  
Toxic Chemical ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Positive Serum ◽  
Cross Sectional Design ◽  
Serum Crp ◽  
Descriptive Method

Abstract: Cigarette are the most cause of death around the world. Smoking cigarrete is harmful to the organs because it contains many toxic chemical that can stimulate inflammatory process. Smoking cigarrete is a risk factors for heart disease and chronic pulmonary disease (COPD). C-reactive protein (CRP) are a non spesific inflammatory marker that can elevated in both local and systemic disease. Beside biomarker, CRP also use as prognostic marker for inflammation. The purpose of this study was to identify the level of serum CRP of smokers aged >40 years old. Twenty eight smokers were eligible to this criteria and participated in this study. Cross-sectional design with a descriptive method was employed in this study. Sampels were analysed in laboratory for serum CRP levels. The results showed that 23 subjects (82%) had normal (negatif) serum CRP level and five subjects (18%) had positive serum CRP level. It can be concluded that serum CRP level of >40 years old smokers in Kolombo village, west Bitung two were mostly in normal level.Keywords: c-reactive protein (crp), active smoker, at age >40 years oldAbstrak: Rokok menjadi salah satu penyebab kematian terbesar di dunia. Merokok membahayakan hampir semua organ tubuh karena mengandung berbagai bahan kimia berbahaya yang dapat merangsang proses peradangan dan merupakan faktor utama penyakit jantung dan penyakit paru obstruktif kronik (PPOK). C-Reactive Protein (CRP) merupakan petanda inflamasi non-spesifik yang meningkat pada penyakit lokal maupun sistemik. Selain biomarker CRP juga dijadikan sebagai penanda prognostik untuk inflamasi. Tujuan dari penelitian ini untuk mengetahui kadar CRP serum pada perokok berusia >40 tahun. Dua puluh delapan perokok memenuhi syarat untuk kriteria ini dan berpartisipasi dalam penelitian ini. Penelitian ini menggunakan desain cross-sectional dengan metode deskriptif. Kadar CRP serum sampel dianalisis di laboratorium. Hasil penelitian menunjukkan bahwa 23 subyek (82%) memiliki kadar CRP serum normal (negatif) dan lima subjek (18%) memiliki kadar CRP serum positif. Dapat disimpulkan bahwa kadar CRP serum perokok berusia >40 tahun di desa Kolombo, Bitung barat dua kebanyakan dalam kadar normal.Kata kunci: c-reactive protein (crp), perokok aktif, usia >40 tahun.

scholarly journals Pengetahuan dan Perilaku Ibu Rumah Tangga dalam Pengelolaan Sampah Plastik

2013 ◽  
Vol 7 (12) ◽  
pp. 562 ◽  
Author(s):  
Ririn Setyowati ◽  
Surahma Asti Mulasari
Keyword(s):  
Significant Relationship ◽  
Simple Random Sampling ◽  
Statistical Test ◽  
Plastic Waste ◽  
Bivariate Analysis ◽  
Chi Square ◽  
Cross Sectional ◽  
Level Of Knowledge ◽  
Cross Sectional Design ◽  
The Relationship

Pencemaran lingkungan akibat sampah plastik semakin mengkhawatirkan apabila tidak ada usaha untuk mengatasinya. Masyarakat yang kurang pengetahuan dan berperilaku buruk dalam pengelolaan sampah plastik dapat menimbulkan gangguan kesehatan dan lingkungan. Penelitian ini bertujuan mengetahui hubungan antara tingkat pengetahuan ibu rumah tangga dengan perilaku mengelola sampah plastik. Penelitian dilakukan di Dusun Kedesen, Desa Kradenan, Kecamatan Kaliwungu, Kabupaten Semarang Tahun 2012. Penelitian ini menggunakan rancangan studi cross sectional, dengan sampel berjumlah 74 orang yang diambil secara secara acak sederhana. Pengumpulan data dilakukan dengan wawancara terstruktur menggunakan kuesioner. Data dianalisis menggunakan analisis univariat dan analisis bivariat dengan uji statistik Kai Kuadrat (X2). Penelitian menemukan sekitar 56,8% responden berpengetahuan tidak baik dan sekitar 60,8% responden berperilaku tidak baik. Analisis bivariat menunjukan hubungan yang sangat signifikan antara tingkat pengetahuan ibu rumah tangga dengan perilaku mengelola sampah plastik. Ada hubungan yang sangat signifikan antara tingkat pengetahuan ibu rumah tangga dengan perilaku mengelola sampah plastik di Dusun Kedesen, Desa Kradenan, Kecamatan Kaliwungu, Kabupaten Semarang tahun 2012.Pollution caused by plastic increase worrying if there is no attempt to resolve it. Lack of knowledge and poor people’s behavior in the management of plastic waste can cause environmental and health problems. Management of plastic waste can be started from each household who produce plastic waste. The purpose of this study to determine the relationship between the level of housewife’s knowledge with the behavior to manage of plastic waste at Kedesen, Kradenan Village, District Kaliwungu, Semarang in 2012. The study was analytic survey with cross-sectional design. Sample was 74 respondents with simple random sampling. Research tool used was a questionnaire. Analyzed used univariate and bivariate analysis with statistical test Chi Square(X2). The results showed 74 respondents obtained from 42 respondents (56.8%) are not well knowledgeable, 32 respondents (43.2%) both knowledgeable. There were 45 respondents (60.8%) did not have good behavior, while 29 respondents (39.2%) had good behavior. Bivariate analysis showed that there was a significant relationship between the level of knowledge with behavior of housewives in managing plastic waste at the hamlet Kedesen. Statistical results showed the value (p = 0.000) smaller than alpha (a = 0.05). There was a significant relationship between the level of knowledge with behavior of housewife in managing plastic waste at Kedesen Hamlet, Village Kradenan, Kaliwungudistrict, Semarang regency in 2012.

scholarly journals Vitamin D status affects the relationship between lipid profile and high-sensitivity C-reactive protein

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Dan Jin ◽  
Dao-Min Zhu ◽  
Hong-Lin Hu ◽  
Meng-Nan Yao ◽  
Wan-Jun Yin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Lipid Profile ◽  
High Sensitivity ◽  
Vitamin D Status ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

scholarly journals The Relationship between Knowledge and Medication Compliance Behavior among Patients with Tuberculosis

2020 ◽  
Vol 2 (2) ◽  
pp. 1
Author(s):  
Jufri Hidayat ◽  
Mei-Chen Lee ◽  
Ming-Der Lee ◽  
Chen-Hsiu Chen
Keyword(s):  
Significant Relationship ◽  
Medication Compliance ◽  
Total Sample ◽  
Categorical Variables ◽  
Adherence To Treatment ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Compliance Behavior ◽  
Cross Sectional Design ◽  
The Relationship

Tuberculosis (TB) remains the highest priority among infectious diseases in the world today with increasing morbidity and mortality every year. Adherence to treatment plays an important role in the success of therapy among TB patients. This study aims to explore the relationship between demographic characteristics, knowledge, and medication compliance behavior among patients with tuberculosis in Indonesia. This study was descriptive correlational and cross-sectional design with the total sample was 150 tuberculosis confirmed in Medan Pulmonary Hospital, Indonesia. In this study found that there is a significant relationship between ethnicity and medication adherence (continues variable) with p = 0.01. Meanwhile when medication compliance behavior was treated as categorical variables, a significant relationship was found between medication compliance behavior and medical history (p = 0.03), smoking (p = 0.005), and alcohol (p = 0.03) among tuberculosis patients in Indonesia. In the multivariate analysis, multiple linear regression was performed which surprisingly shows that education was significantly associated with knowledge of TB (p = 0,02), and ethnicity (0.04).

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