scholarly journals Hubungan Nilai Carcinoembryonic Antigen dengan Kejadian Metastasis Karsinoma Kolorektal di RSUP Prof. Dr. R. D. Kandou Manado

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Fahrizal Maradjabessy ◽  
Laurens Kalesaran ◽  
Ferry Kalitouw ◽  
Heber Sapan
Keyword(s):  
Colorectal Cancer ◽  
Statistical Analysis ◽  
Tumor Marker ◽  
Carcinoembryonic Antigen ◽  
Correlation Coefficient ◽  
Preoperative Diagnosis ◽  
Inclusion Criteria ◽  
Point Biserial Correlation ◽  
Study Population ◽  
The Mean

Abstract: Carcinoembryonic antigen (CEA) is a tumor marker which has been used worldwide as an indicator of recurrency after treatment and prognosis but not for preoperative diagnosis. This study was aimed to obtain the correlation between CEA level and the metastasis of colorectal cancer. This was an analytical correlational study. Population and samples were patients with colorectal cancer that fulfilled the inclusion criteria at Prof. Dr. R. D. Kandou Hospital Manado from January 2015 through December 2016. Data were analyzed with point-biserial correlation coefficient. There were 55 patients with colorectal cancer in this study. The incidence of colorectal cancer was higher in 2016 (37 patients). Most of them were males (63.3%), had colorectal cancer in the rectum (47.3%), and CEA level above normal (98.1%). As many as 36 patients with CEA level above normal had no metastasis. Of 18 patients with metastasis, the most were in liver, followed by lungs and bones. There were 9 patients with CEA level >1000 μg/dl; all had metastasis. The statistical analysis showed a rpb of 0.634 (P < 0.01). The mean level of CEA in patients with metastasis (541.82 μg) was much higher than of them without metastasis (60.19 μg). Conclusion: There was a strong and significant correlation between CEA level and metastasis.Keywords: colorectal cancer, carcinoembryonic antigen (CEA), metastasisAbstrak: Carcinoembryonic antigen (CEA) merupakan salah satu tumor marker yang sudah banyak digunakan secara luas. Saat ini pemeriksaan CEA diangggap berguna untuk indikator faktor rekurensi setelah diterapi dan prognostik, namun kemampuan diagnostik CEA preoperasi masih sangat kurang. Penelitian ini bertujuan untuk mengetahui hubungan antara CEA dengan kejadian metastasis karsinoma kolorektal. Jenis penelitian ialah analitik korelatif. Populasi dan sampel ialah semua pasien karsinoma kolorektal yang memenuhi kriteria inklusi di RSUP Prof. Dr. R. D. Kandou Manado mulai bulan Januari 2015 sampai Desember 2016. Analisis data menggunakan analisis koefisien korelasi point biserial. Hasil penelitian mendapatkan 55 pasien karsinoma kolorektal dengan insiden terbanyak pada tahun 2016 (37 pasien). Terbanyak ditemukan ialah letak karsinoma kolerektal pada daerah rektum (47,3%), jenis kelamin laki-laki (63,3%), dan kadar CEA di atas normal (98,1%). Sebanyak 36 pasien dengan nilai CEA di atas normal tanpa metastasis dan 18 pasien dengan metastasis terbanyak di hati, kemudian paru, dan tulang. Terdapat 9 pasien dengan nilai CEA >1000 μg/dl; kesemuanya mengalami metastasis. Uji statistik mendapatkan rpb = 0,634 dengan P < 0,01. Nilai rerata CEA pada pasien dengan metastasis jauh lebih tinggi (541,82 μg) dibandingkan dengan nilai rerata pada pasien tanpa metastasis (60,19 μg). Simpulan: Terdapat hubungan yang kuat dan bermakna antara CEA dengan metastasis.Kata kunci: karsinoma kolorektal, carcinoembryonic antigen (CEA), metastasis

Novel Stimuli for Obtaining Nasalance Measures from Young Children

1996 ◽  
Vol 33 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Thomas Watterson ◽  
Julie Hinton ◽  
Stephen Mcfarlane
Keyword(s):  
At Risk ◽  
Statistical Analysis ◽  
Young Children ◽  
Correlation Coefficient ◽  
Communication Disorders ◽  
Velopharyngeal Insufficiency ◽  
Children At Risk ◽  
Significant Difference ◽  
History Of ◽  
The Mean

The use of novel stimuli for obtaining nasalance measures in young children was the focus of this study. The subjects were 20 children without a history of communication disorders and 20 children at risk for velopharyngeal insufficiency (VPI). Each subject recited three passages; the standard Zoo Passage, and two novel stimuli that were named the Turtle Passage and the Mouse Passage. Like the Zoo Passage, the Turtle Passage contained no normally nasal consonants. The Mouse Passage was about 11% nasal consonants, which is similar to the Rainbow Passage. Statistical analysis showed no significant difference between the mean nasalance for the Zoo Passage and the Turtle Passage for either the subjects without risk of VPI (15.4% vs 15.7%) or for those at risk (30.4% vs 28.8%). Nasalance measures for the Mouse Passage were significantly higher than for either the Zoo Passage or the Turtle Passage. Listeners rated the stimuli on a 5-point equal-appearing intervals scale. The correlation coefficient between listener judgments of hypernasality and nasalance was significant for the Zoo Passage (r = 0.70) and for the Turtle Passage (r = 0.51) but not significant for the Mouse Passage (r = 0.32). Using cut-off scores of 22% for nasalance and 2.25 for hypernasality, the sensitivity for the Zoo Passage was 0.72, and for the Turtle Passage, 0.83.

Lymphopenia is Associated with Severe Coronavirus Disease 2019 (COVID-19) Infections

2021 ◽  
Vol 15 (10) ◽  
pp. 2540-2542
Author(s):  
Maria Shireen ◽  
Sarah Shoaib Qureshi ◽  
Arsalan Nawaz ◽  
Wasim Amir ◽  
Mehrin Farooq ◽  
...  
Keyword(s):  
Observational Study ◽  
Viral Infection ◽  
Retrospective Observational Study ◽  
Shortness Of Breath ◽  
Inclusion Criteria ◽  
Corona Virus ◽  
Severe Group ◽  
Study Population ◽  
The Mean ◽  
Pro Forma

Background: Covid-19 is a very contagious and quickly spreading viral infection, caused by a corona virus SARS-COV-2 which was originally reported in China on December 5, 2019. It was confirmed as pandemic by WHO on March 11, 2020. This disease is yet under research. It has variable severity which includes no symptoms to pneumonia. This can cause death of the patient. Aim: To evaluate the association of Lymphopenia with severity of COVID 19 in COVID-19 patients Methods: It was a retrospective observational study conducted in COVID wards of Ghurki hospital Lahore. Record of 100 COVID-19 patients that were admitted between March and July 2021 fulfilling the inclusion criteria was included in the study. A pre-structured pro forma was filled to collect the data. Results: Out of 100 patients, 30 patients were included in Non-severe group while severe group had 70 patients. The mean age of study population was 52.5±10.38 with 60% male and 40% female. 70% patients in severe group had some co-existent comorbidity. The most commonly reported symptoms were fever and cough in both groups while shortness of breath was more commonly reported in severe group. Conclusion: Lymphopenia is associated with severe Coronavirus disease 2019 (COVID-19) infections. Lymphocytes count can be used to assess the severity of COVID 19. Keywords: Lymphocytes, Lymphopenia, Coronavirus disease 2019, COVID 19.

scholarly journals Effectiveness of Genicular Nerve Cooled Radiofrequency Ablation on Chronic Knee Osteoarthritis Pain

2019 ◽  
pp. 83-90
Author(s):  
Jonathan Carrier
Keyword(s):  
Statistical Analysis ◽  
Radiofrequency Ablation ◽  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Primary Outcome ◽  
Time Points ◽  
Chronic Knee Pain ◽  
Study Population ◽  
The Mean

Background: Outside of an invasive total knee arthroplasty, the available therapies for the treatment of pain secondary to knee osteoarthritis (OA) provide marginal and short-lived symptomatic relief. Genicular nerve radiofrequency ablation (RFA) serves as an alternative treatment modality for OA-associated knee pain and disability. Objectives: To quantify the effectiveness of cooled radiofrequency ablation (C-RFA) of the genicular nerves for chronic knee pain secondary to OA. Study Design: Retrospective chart review performed using Redcap, implementing current procedural terminology codes. Setting: An academic pain management center. Methods: Study population included patients treated with C-RFA from April 2015 through June 2017. Numeric Rating Scale (NRS) data were analyzed at 3 time points: 2 weeks, 4-6 weeks, and 7-33 weeks post-RFA (extended follow-up). Primary outcome for statistical analysis was NRS and the change in NRS from baseline at each of the 3 predetermined time points. Differences between the change in NRS and the number of diagnostic blocks performed (1 vs. 2) was evaluated. Correlation between the change in NRS and patient body mass index (BMI) was calculated. Results: Pre-RFA average NRS scores were available for 47 knees from 31 individuals, which were included in the analysis. The mean NRS score decreased by 50% at 2 weeks (n = 33; P < 0.001), 55% at 4-6 weeks (n = 18; P < 0.001), and 26% at 7-33 weeks (n = 18; P = 0.009). Eight patients (12 knees) provided specific data on the total duration of relief following RFA. The mean duration was 39 weeks or approximately 9 months. There were no statistically significant differences between groups receiving 1 versus 2 diagnostic blocks at 2 weeks or 4-6 weeks post- RFA. At 7-33 weeks, those who received 1 block had a decrease in NRS of –3.1, whereas those who received 2 blocks had an increase in NRS of +0.1 (P = 0.008). There was no correlation identified between BMI and change in NRS at any time point. Limitations: This study’s retrospective design inherently leads to a higher risk of selection bias. The sample size was relatively small as a high percentage of patients were lost to follow-up. The primary outcome measure for this study was the change in mean NRS pain score, and the mean of ordinal data with a nonnormal distribution lacks validity in statistical analysis. Conclusions: In this study population, C-RFA of the genicular nerves lead to 50% or greater pain relief at 2 weeks and 4-6 weeks postintervention. A 26% pain relief was achieved at 7-33 weeks, but this did not meet the established minimal clinically important difference cutoff. Two diagnostic genicular nerve blocks did not improve the rate of treatment success when compared to a single diagnostic block. BMI does not appear to correlate with outcomes. Key words: Genicular radiofrequency ablation, genicular RFA, cooled radiofrequency ablation, chronic knee pain, knee osteoarthritis

scholarly journals Evaluation of Sexual Life Problems among Menopausal Woman with post-menopausal Bleeding at Maternity Hospitals in Baghdad City

2021 ◽  
Vol 7 (3) ◽  
Keyword(s):  
Statistical Analysis ◽  
Sexual Life ◽  
Menopausal Woman ◽  
Inclusion Criteria ◽  
Life Problems ◽  
Menopausal Women ◽  
Maternity Hospitals ◽  
The Mean ◽  
Post Menopausal ◽  
Descriptive Statistical Analysis

Objective: To identify the sexual life problems among menopausal woman and to evaluate the levels of sexual life problems among menopausal woman. Methods: This study was conducted at maternity hospitals in Baghdad city to evaluate of sexual life problems among menopausal woman. This study was started in January 2021 to February 2021, The data regarding sexual life problems was achieved through the answering of women that attending maternity hospitals, the study consist of (200) women with menopausal age which were selected according to inclusion criteria (Women at menopausal age, Women with post-menopausal bleeding). The data are analyzed through the use of descriptive statistical analysis and inferential statistics. Results: most of women are showing unproblematic sexual life and only (23.5%) are showing problematic sexual life. presents the mean of scores for evaluation the items of sexual life among women at menopause age; the mean scores indicate unproblematic among most of the items except the items that are related to (suffering from reduced sexual activity; they had regular sexual relations; suffering from a lack of sexual desire; and they cannot give their husband's marital rights). Conclusion: Most of menopausal women are showing unproblematic sexual life and they have normal and joyful sexual life regardless they suffering from post-menopausal bleeding.

scholarly journals The role of NT-proBNP in the diagnosis of diastolic heart failure and its correlation with echocardiography

2021 ◽  
Vol 8 (3) ◽  
pp. 404
Author(s):  
Archana Toppo ◽  
Sanjay Varma ◽  
Aneesh Karwa ◽  
Rajeev Lochan Khare ◽  
Yogendra Malhotra
Keyword(s):  
Heart Failure ◽  
Statistical Analysis ◽  
Diastolic Dysfunction ◽  
Clinical Evaluation ◽  
Analytical Study ◽  
Diastolic Heart Failure ◽  
Current Investigation ◽  
Inclusion Criteria ◽  
The Mean

Background: The primary aim of the current investigation was to evaluate the role of NT-proBNP in the diagnosis of diastolic heart failure and its correlation with echocardiography.Methods: Hospital based observational and analytical study undertaken on a total of 65 patients of diastolic heart failure fulfilling clinical inclusion criteria. The enrolled patients had a mean age of 54.5 years with a female preponderance (33 females vs. 32 males). Patients underwent clinical evaluation and echocardiography examination. NT-proBNP estimation was done using autoanalyzer working on principle of electrochemiluminisense. Patients were divided into various grades of diastolic dysfunction on the basis of echocardiography. Statistical analysis was done to find the significance of levels of NT-proBNP and its correlation with the grading of diastolic heart failure.Results: There was a statistically significant higher level of serum NT-proBNP in patients with diastolic heart failure and the increasing levels were directly proportional to severity of diastolic dysfunction. The mean level of NT-proBNP increased from 361.08 pg/ml to 3570 pg/ml in increasing severity of diastolic dysfunction.Conclusions: Results suggested positive correlation of rising NT-proBNP levels with increasing severity of diastolic dysfunction. 

scholarly journals Evaluation Of The Carcinoembryonic Antigen Test In Patients With Resected Colon Cancer

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S86-S87
Author(s):  
Y S Kamel ◽  
A Lotfy
Keyword(s):  
Colorectal Cancer ◽  
Carcinoembryonic Antigen ◽  
Residual Disease ◽  
Hepatic Metastases ◽  
Resected Specimen ◽  
Residual Tumour ◽  
Mean Values ◽  
Total Group ◽  
The Mean ◽  
Histological Confirmation

Abstract Introduction/Objective To determine the effectiveness of carcinoembryonic antigen (CEA) in patient with known residual disease after resection of colonic cancer Methods Serial carcinoembryonic antigen (CEA) levels were measured in 43 patients following incomplete excision of colorectal cancer. Twenty-seven patients received chemotherapy. The patients reported in this study were amongst those participating in a randomized trial of chemotherapy following palliative resection of colorectal cancer. All patients had a resection of colorectal cancer leaving behind macroscopic quantities of tumour, though of a small total residual bulk. The residual sites of tumour were recorded as: (a) local - where there was local extension of the tumour; (b) nodal - where there were clinically involved nodes remaining, with histological confirmation of involved nodes in the resected specimen; (c) hepatic - where small hepatic metastases were noted, individually not greater than 2 cm in diameter and in total representing less than 10% of the liver bulk; (d) peritoneal - where peritoneal tumour seedlings remained, with histological confirmation of at least one of the seedlings. Results Of the 43 patients studied after operation and prior to chemotherapy, the mean log CEA was 1.19 and only 3 patients exceeded 1.48, despite the fact that all patients were known to have residual tumour. Similarly, the mean log CEA at 3 months for the total group remained at 1.26 but 6 patients now had abnormal values. Thereafter the mean values of the total group exceeded the upper limit of normality and increasing numbers of patients showed elevated CEA values. About one half of the patients had levels of CEA well within the normal range during the first postoperative year despite the evidence of residual disease documented at operation. Conclusion The most appropriate application for a marker such as CEA may be as an assessment of the effect of chemotherapy in patients who have a definite, but objectively unmeasurable, tumour load.

scholarly journals Does clinical improvement of symptomatic degenerative lumbar disease impact obesity?

2017 ◽  
Vol 26 (6) ◽  
pp. 705-708 ◽  
Author(s):  
Jacob R. Joseph ◽  
Zishaan Farooqui ◽  
Brandon W. Smith ◽  
Elyne N. Kahn ◽  
Xilin Liu ◽  
...  
Keyword(s):  
Transforaminal Lumbar Interbody Fusion ◽  
Minimum Clinically Important Difference ◽  
Inclusion Criteria ◽  
Preoperative Body Mass Index ◽  
Vas Score ◽  
Substantial Clinical Benefit ◽  
Degenerative Lumbar Disease ◽  
Study Population ◽  
The Mean ◽  
Improved Function

OBJECTIVEObesity and low-back pain associated with degenerative spondylosis or spondylolisthesis are common comorbid conditions. Many patients report that the pain and disability associated with degenerative lumbar disease are key factors in their inability to lose weight. The aim of this retrospective study was to determine if there is an association between improved functional status and weight loss following a successful transforaminal lumbar interbody fusion (TLIF) procedure.METHODSA retrospective cohort study of patients who underwent single-level TLIF was performed. Inclusion criteria were preoperative body mass index (BMI) greater than 30 kg/m2, achievement of minimum clinically important difference in the Oswestry Disability Index (ODI, defined as improvement of 15 points), and minimum 1-year postoperative followup BMI. Preoperative and postoperative BMI, ODI, and visual analog scale (VAS) scores were compared. A subgroup analysis of patients who achieved substantial clinical benefit (SCB, defined as a net improvement of 18.8 points on the ODI) was also performed.RESULTSA total of 56 patients met the inclusion criteria. The mean age of the study population was 55.6 ± 13.7 years. The mean preoperative BMI was 34.8 ± 4.6 kg/m2, the mean preoperative ODI was 66.2 ± 10.1, and the mean preoperative VAS score was 7.1 ± 1.7. The mean change in ODI was −33.1 ± 13.5 (p < 0.01) and the mean change in the VAS score was −4.1 ± 2.1 (p < 0.01). The mean change in BMI was +0.15 ± 2.1 kg/m2 (range −4.2 to +6.5 kg/m2; p = 0.6). SCB was achieved in 46 patients on the ODI. The mean preoperative BMI for patients with SCB was 34.8 ± 4.8 kg/m2, and the mean postoperative BMI was 34.7 ± 5.0 kg/m2. The mean change in BMI was −0.03 ± 1.9 kg/m2 (p = 0.9).CONCLUSIONSDespite successful surgical intervention via TLIF with achievement of improved function and pain, obese patients did not have significant change in weight postoperatively.

scholarly journals Evaluation of Financial Performance of Islamic Banks in Jordan (2001-2010) “A Comparative Study”

2017 ◽  
Vol 9 (9) ◽  
pp. 166
Author(s):  
Rana M. Airout ◽  
Rula M. Airout
Keyword(s):  
Statistical Analysis ◽  
Comparative Study ◽  
Financial Performance ◽  
Statistical Significance ◽  
Islamic Banks ◽  
Short Term ◽  
International Bank ◽  
Islamic Bank ◽  
Study Population ◽  
The Mean

The purpose of this research is to evaluate the financial performance of two of the oldest banks in Jordan, Jordan Islamic Bank and Arab Islamic International Bank. The study population consists of the Islamic banks operating in Jordan. The Islamic Bank of Jordan and the Arab Islamic Bank were selected to compare the two banks from different aspects of the study, based on the data of the two banks during the period from 2001 to 2010. This research intended to investigate the following hypotheses:1)         There are no statistically significant differences in the performance of the Islamic Bank of Jordan and the Arab Islamic International Bank through profit indicators.2)         There are no significant differences in the performance of the Islamic Bank of Jordan and the Arab Islamic International Bank through liquidity indicators.3)         There are no significant differences in the performance of the Islamic Bank of Jordan and the Arab Islamic International Bank through indicators of indebtedness.4)         There are no significant differences in the performance of the Islamic Bank of Jordan and the Arab Islamic International Bank through indicators of activity.Both descriptive and inferential statistical analysis and results were as follows: The study found that there are no significant differences between the performance of the Arab Islamic Bank and the Jordanian Islamic Bank in the field of profitability, and no statistically significant differences in the field of liquidity, except for the percentage of total deposits / assets where the mean of this ratio to the Islamic Bank of Jordan was (87.55%) compared with Arab Islamic Bank where it was (60.78%), we conclude from that the Jordan Islamic Bank has the ability to meet short-term liabilities when due through its short-term assets more than Arab Islamic Bank. And there are statistical significance differences in the area of indebtedness.

Effect of Opium Smoking on Concentrations of Carcinoembryonic Antigen and Tissue Polypeptide Antigen

2004 ◽  
Vol 19 (4) ◽  
pp. 305-309
Author(s):  
F. Naghibalhossaini ◽  
J. Ay ◽  
J. Alavi ◽  
S. Oveisi ◽  
R. Chahardooli
Keyword(s):  
Carcinoembryonic Antigen ◽  
Elevated Serum ◽  
Control Group ◽  
Tissue Polypeptide Antigen ◽  
Study Population ◽  
Serum Cea ◽  
The Mean ◽  
Smoking Control ◽  
Urine And Serum ◽  
Serum And Urine

Previous studies have related opium and its pyrolysates to the risk of developing certain cancers. The aim of this work was to evaluate the clinical usefulness of determining carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) levels in habitual opium smokers. Serum CEA concentrations were measured in 128 opium smokers and in 44 controls of cigarette only smokers and 47 normal non-smokers by an EIA-based assay. TPA levels were also determined in serum and urine of a subgroup in the study population. The results indicated that serum CEA concentrations are higher in opium smokers than in healthy tobacco smokers (p=0.004) and non-smokers (p=0.001). The amount of opium used correlated with the serum CEA level (r=0.276, p<0.0001). The mean urine and serum TPA levels of the opium-addicted population were also higher than that of the non-smoking control group, but the differences were not statistically significant. We conclude that opium smoking is associated with elevated serum CEA levels. Therefore, for management of opium users with neoplastic diseases, increased levels of serum CEA should be viewed with caution to avoid misdiagnosis.

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