Anti-obesity Activity Tin Leaf Extract (Ficus carica Linn)  on the Rats given High Fat Diets

Obesity is a health problem in the community because it can cause a risk of degenerative diseases such as type 2 diabetes mellitus, high blood pressure, heart disease, cancer, and atherosclerosis. Unhealthy lifestyles such as lack of physical activity by exercising, a diet high in carbohydrates and fats, can cause fat deposits in the body, especially in the abdomen. The use of chemical drugs such as Orlistat as a weight loss or to help reduce the risk of regaining lost weight, is less effective because it requires a long consumption time and the presence of side effects. Tin leaf content (Ficus carica Linn) is flavonoids, alkaloids, tannins and steroids, tin leaf extract has IC50 150mg/L antioxidant activity. This study was to determine the anti-obesity activity of tin leaf extract in male Sprague-Dawley rats given a high fat diet. 30 Sprague-Dawley rats were classified into 6 groups. The results obtained, in the group dose of 100 mg / kg obtained an average body weight of 381.8 grams, the test group 200 mg / kg obtained an average body weight of 414.5 grams, in the test group 400 mg / kg obtained 387 grams. The conclusion of this study is that the activity of Tin leaf extract (Ficus carica Linn) can be used as an anti-obesity.

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BODY WEIGHT PROFILEAND MORTALITY RATEOF MALE SPRAGUE DAWLEY RATS DURING THE FORMATION OF FIBROSARCOMA INDUCED BY BENZO(A)PYRENE

Indonesia Medicus Veterinus ◽

10.19087/imv.2021.10.1.1 ◽

2021 ◽

Vol 10 (1) ◽

pp. 1-11

Author(s):

Palagan Senopati Sewoyo ◽

Anak Agung Ayu Mirah Adi ◽

Ida Bagus Oka Winaya

Keyword(s):

Body Weight ◽

Mortality Rate ◽

The Body ◽

Sprague Dawley ◽

Patients With Cancer ◽

Sprague Dawley Rats ◽

Polycyclic Aromatic ◽

The Mean ◽

Average Body ◽

Average Body Weight

Benzo(a)pyrene (BaP) is one of several examples of polycyclic aromatic hydrocarbons that come from incomplete combustion of organic materials.BaP compound is used in research to induce fibrosarcoma.In general, patients with cancer will experience a reduction in body weight. This study aims to determine the body weight profile, the time it takes to cause fibrosarcoma, and the mortality rate of male Sprague Dawley rats after injection with BaP. In this study, 18 rats were used with two treatments.Rats in treatment 0 (P0) were not treated, while rats in treatment I (PI) were injected with BaP 0.3% in 0.1 mL oleum olivarumten times given gradually at two-day intervals via subcutaneous. There were six and 12 rats, respectively, P0 and PI. BaP solution is prepared by dissolving in oleum olivarum, mixing, and stirring until homogeneous. The rats were weighed at the beginning of the study and then carried out routinely once a weekfor 19 weeks of research. At the beginning of the study, the average body weight of rats at P0 and PI were 121.43 ± 7.04 g and 131.49 ± 16.31 g, respectively. The mean body weight of the rats at P0 and PI from the first week to the 19th were178.53 ± 29.97 g and 159.20 ± 14.24 g, respectively. The time taken to inducefibrosarcoma was 85.5 ± 17.6 days. The mortality rate in treatment P0 was 0% and PI treatment was 8.33%.From the results of this study, it can be concluded that giving BaP significantly reduces the body weight profile of rats and has a mortality rate of 8.33%.

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Sineol dalam Minyak Kayu Putih sebagai Pelangsing Aromaterapi

Jurnal Jamu Indonesia ◽

10.29244/jji.v1i3.20 ◽

2016 ◽

Vol 1 (3) ◽

pp. 12-17

Author(s):

Irmanida Batubara ◽

Irma Herawati Suparto ◽

Fiqa Annisa Rakhmatika

Keyword(s):

Body Weight ◽

Essential Oil ◽

Gas Chromatograph ◽

Sprague Dawley ◽

High Cholesterol ◽

Control Groups ◽

Sprague Dawley Rats ◽

Average Body ◽

Average Body Weight

Cajuput is one of plants containing essential oil with cineole as a major component. This aim of study is to separate cineole in cajuput oil and to analyze its potency as slimming aromatherapy through in vivo assay. The essential oil was fractionated by column chromatography resulting 23 fraction (F1-F23). Cajuput oil, cineole, and F9 were analyzed by gas chromatograph-mass spectrometer, and the slimming aromatherapy potency was studied on white adult male Sprague-Dawley rats. Inhalation result of cineole showed that the average body weight of rats after 5 weeks treatment period was lower than that of the normal and the control groups which consumed high cholesterol feed. In conclusion, cineole is a compound that is potential in slimming aromatherapy.

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Sineol dalam Minyak Kayu Putih sebagai Pelangsing Aromaterapi

Jurnal Jamu Indonesia ◽

10.29244/jjidn.v1i3.30639 ◽

2016 ◽

Vol 1 (3) ◽

pp. 12-17

Author(s):

Irmanida Batubara ◽

Irma Herawati Suparto ◽

Fiqa Annisa Rakhmatika

Keyword(s):

Body Weight ◽

Essential Oil ◽

Gas Chromatograph ◽

Sprague Dawley ◽

High Cholesterol ◽

Control Groups ◽

Sprague Dawley Rats ◽

Average Body ◽

Average Body Weight

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Effect of fluoride on the proteomic profile of the hippocampus in rats

Zeitschrift für Naturforschung C ◽

10.1515/znc-2014-4158 ◽

2015 ◽

Vol 70 (5-6) ◽

pp. 151-157 ◽

Cited By ~ 3

Author(s):

Ye Pan ◽

Peng Lü ◽

Lijing Yin ◽

Keping Chen ◽

Yuanqing He

Keyword(s):

Body Weight ◽

Spectroscopic Analysis ◽

Physiological Saline ◽

Treated Group ◽

The Body ◽

Learning Ability ◽

Sprague Dawley ◽

Acid Biosynthesis ◽

Two Dimensional Gel Electrophoresis ◽

Sprague Dawley Rats

Abstract Two-dimensional gel electrophoresis (2-DE) was used to detect fluoride-induced alterations in the proteome of the rat hippocampus. Male Sprague-Dawley rats (n=30) were subjected to treatments three weeks after weaning. Animals of the first group were injected intraperitoneally (i.p.) with aqueous NaF (20 mg/kg/body weight/day), the second group, injected with physiological saline, served as the control. After 30 days, the body weight of the fluoride-treated rats was lower than that of the control, and F– levels in serum were higher than in the control. The hippocampus was subjected to proteomic analysis, and the fluoride-treated group was found to contain 19 up-regulated and eight down-regulated proteins. The proteins, identified by mass-spectroscopic analysis of their fragments obtained after digestion, were found to be involved in amino acid biosynthesis, the insulin signaling pathway and various other crucial functions. Our results also provide useful information on the mechanism of the reduction of the learning ability and memory induced by F.

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The regional centile table of the newborn’s body weight for the city of Kiev and the Kiev region

HEALTH OF WOMAN ◽

10.15574/hw.2018.130.30 ◽

2018 ◽

pp. 30-33

Author(s):

V.V. Bila ◽

◽

V.O. Golyanovsky ◽

V.M. Muravyov ◽

◽

...

Keyword(s):

Body Weight ◽

Fetal Growth ◽

Gestational Age ◽

The Body ◽

Biologically Active ◽

Perinatal Center ◽

Unbalanced Diet ◽

The City ◽

Average Body ◽

Average Body Weight

The objective: to develop a regional gestational percentiles table of body weight for newborns in Kiev and Kyiv’s oblast. Materials and methods. Data of the body weight of newborns were collected from Kyiv City Perinatal Center from January 2016 by January 2017. The total number included 5244 live births in the period of gestation 40+0–40+6 weeks of gestation. The standard deviation of the body weight, expressed as the percentage of the average body weight of all newborns, as well as the percentil calculator developed by Hadlock et al, supported by the WHO (2008), was used to generate the percentages and curves of the body weight. Materials and methods. A newborn body weight percentile table was constructed, depending on the gestational age. Differences were observed between the current average body weight of newborns for Kyiv and current WHO links. Conclusion. We found a rise in the average body weight of newborns, which we associate with excessive, unbalanced diet and the prescribing of a complex of multivitamins and biologically active substances during pregnancy. This indicates the importance of using this table for differential diagnosis of normal fetal growth from intrauterine growth restriction and small for fetal gestational age within the region of Kyiv and oblast. Key words: delayed fetal growth, percentile table of the city of Kiev, average body weight of newborns, percentile schedule.

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The application of [D-Tle6,ProNHEt9]mGnRH (Lecirelin) with the dopaminergic inhibitor metoclopramide to stimulate ovulation in African catfish (Clarias gariepinus)

Czech Journal of Animal Science ◽

10.17221/4313-cjas ◽

2011 ◽

Vol 49 (No. 7) ◽

pp. 297-306 ◽

Cited By ~ 5

Author(s):

E. Brzuska ◽

J. Kouřil ◽

J. Adamek ◽

Z. Stupka ◽

V. Bekh

Keyword(s):

Body Weight ◽

Female Body ◽

Clarias Gariepinus ◽

The Body ◽

African Catfish ◽

Average Body ◽

Stimulation Of ◽

Average Body Weight ◽

Pituitary Homogenate

The results of reproduction were tested in females of the African catfish (Clarias gariepinus Burchell 1822) after stimulation of ovulation with carp pituitary (4 mg/kg body weight) or with Lecirelin (15 μg/kg) and metoclopramide (10 mg/kg). After administering the synthetic substance eggs were obtained from all females while in the group treated with pituitary homogenate 7 out of 8 hypophysed females spawned. The applied spawning agent did not significantly influence the weight of eggs expressed in grams, but in the case of females treated with carp pituitary homogenate a significantly higher weight of eggs expressed as the percentage of body weight of fish was recorded. The applied stimulators of ovulation did not affect any trait reflecting the quality of eggs. Females used as an experimental material belonged to two categories in respect of body weight: lighter females with average body weight of 2.63 ± 0.36 kg and heavier females with average body weight of 3.91 ± 0.48 kg. It was proved that the weight of eggs expressed either in grams or as a percentage of a female’s weight was significantly related to the body weight of a female (P ≤ 0.01 and P ≤ 0.05, respectively), as well as the percentage of fertilised eggs and the percentage of living embryos after 28 hours of incubation (P ≤ 0.05 and P ≤ 0.05, respectively). The interaction between the stimulator of ovulation and the female body weight was significant only for traits reflecting the weight of obtained eggs (P ≤ 0.05 and P ≤ 0.01).  

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Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

Endocrine Connections ◽

10.1530/ec-18-0535 ◽

2019 ◽

Vol 8 (3) ◽

pp. 203-216 ◽

Cited By ~ 3

Author(s):

Anna C Simcocks ◽

Kayte A Jenkin ◽

Lannie O’Keefe ◽

Chrishan S Samuel ◽

Michael L Mathai ◽

...

Keyword(s):

Body Weight ◽

G Protein ◽

High Fat Diet ◽

Chow Diet ◽

Sprague Dawley ◽

High Fat ◽

G Protein Coupled Receptor ◽

Diet Induced Obesity ◽

Sprague Dawley Rats ◽

G Protein Coupled

Atypical cannabinoid compounds O-1602 and O-1918 are ligands for the putative cannabinoid receptors G protein-coupled receptor 55 and G protein-coupled receptor 18. The role of O-1602 and O-1918 in attenuating obesity and obesity-related pathologies is unknown. Therefore, we aimed to determine the role that either compound had on body weight and body composition, renal and hepatic function in diet-induced obesity. Male Sprague–Dawley rats were fed a high-fat diet (40% digestible energy from lipids) or a standard chow diet for 10 weeks. In a separate cohort, male Sprague–Dawley rats were fed a high-fat diet for 9 weeks and then injected daily with 5 mg/kg O-1602, 1 mg/kg O-1918 or vehicle (0.9% saline/0.75% Tween 80) for a further 6 weeks. Our data demonstrated that high-fat feeding upregulates whole kidney G protein receptor 55 expression. In diet-induced obesity, we also demonstrated O-1602 reduces body weight, body fat and improves albuminuria. Despite this, treatment with O-1602 resulted in gross morphological changes in the liver and kidney. Treatment with O-1918 improved albuminuria, but did not alter body weight or fat composition. In addition, treatment with O-1918 also upregulated circulation of pro-inflammatory cytokines including IL-1α, IL-2, IL-17α, IL-18 and RANTES as well as plasma AST. Thus O-1602 and O-1918 appear not to be suitable treatments for obesity and related comorbidities, due to their effects on organ morphology and pro-inflammatory signaling in obesity.

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Effect of farm and birth season on calf body weight in the first week of life

Biotechnology in Animal Husbandry ◽

10.2298/bah2003297s ◽

2020 ◽

Vol 36 (3) ◽

pp. 297-307

Author(s):

Ljiljana Samolovac ◽

Milos Marinkovic ◽

Maja Petricevic ◽

Tamara Stamenic ◽

Ivan Cosic ◽

...

Keyword(s):

Body Weight ◽

Production Process ◽

The Body ◽

Season Of Birth ◽

Birth Season ◽

Technological Production ◽

Newborn Calves ◽

On Farm ◽

Average Body ◽

Average Body Weight

The body weight of calves in the earliest period of their life (age from 0 to 7 days) is under the greatest influence of the farm and the season of birth. The farm manifests its influence most often through the conditions of nutrition and housing and the organization of the technological production process, while the influence of the birth season is manifested through microclimatic and nutritional conditions, as well. The most common deficiencies related to the nutrition of newborn calves are related to: inadequate colostrum supply in terms of quality, quantity and time of colostrum intake, which is closely related to the organization of the technological production process on the farm. Dietary deficiencies affect the body weight of calves at birth and at 8 days of age. In a study conducted over a year (4 seasons), the colostrum diet of newborn calves of the HF breed on two farms (A and B) with a tied housing system was analyzed. Calves were fed colostrum on both farms at intervals, usually up to 2 hours, less often up to 4 hours after birth. The colostrum consumed came from the mother, most often, and less often from the other cow, while on one of the farms it was also used frozen. However, the amount of colostrum consumed was deficient, it was 1-2 l on farm A, and 2.5 to 3 l on farm B. The occurence of a deficient diet or other deficiencies in the diet of calves was indicated by the average body weight, measured at birth and at the age of 8 days. On farm A, a lower average body weight of calves (37.95 and 39.68 kg) was recorded than on farm B (40.00 and 41.80 kg) by age categories, respectively. The average body weight of calves was statistically significantly (p <0.01) influenced by the farm and the season of birth, as well as their mutual interaction, but the effect of the farm was more pronounced.

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