STUDY OF SERUM GHRELIN IN THYROID PATIENTS

2021 ◽  
pp. 140-142
Author(s):  
G.G. Kaushik ◽  
Kavita Sharma
Keyword(s):  
Thyroid Hormone ◽  
Healthy Subjects ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Ghrelin Level ◽  
Cross Sectional ◽  
Group Iii ◽  
Medical College ◽  
Group I ◽  
Serum Ghrelin

Background: Hypothyroidism is a common endocrine disorder resulting from deciency of thyroid hormone. Hyperthyroidism is a set of disorders that involve excess synthesis and secretion of thyroid hormone by the thyroid gland. Ghrelin is octanoylated peptide containing a 28 amino acid act as an energy balance regulator & play an important role in metabolic process .The aim of the study was to establish possible relationship between them. Materials and methods: The present study is a cross sectional study, was conducted in the Department of Biochemistry, J.L.N. Medical college and associated group of Hospitals, Ajmer (Raj.). 65 hypothyroid subjects (group-II) and 65 hyperthyroid subjects (group-III) attending Medical OPD of J.L.N. Hospitals were included and 130 age-sex matched euthyroid controls (group-I) were selected. Results: In hypothyroid subjects, mean serum Ghrelin levels were found to be signicantly higher in comparison to healthy subjects (p<0.0001). In hyperthyroid subjects, mean serum Ghrelin levels were found to be signicantly lower in comparison to healthy subjects (p<0.0001). Conclusion: The overall ndings of the present study thus conrm that serum Ghrelin level is signicantly higher in Hypothyroid subjects and the level is signicantly lower in the Hyperthyroid subjects, thus we have found positive association between serum TSH level and Ghrelin level. However, further experimental and observational studies are needed to illustrate the role of Ghrelin in Hypothyroidism and Hyperthyroidism.

scholarly journals Association of Age with Thyroid Hormone Status and Ischaemic Heart Disease (IHD)

2012 ◽  
Vol 2 (2) ◽  
pp. 80-84
Author(s):  
Nasreen Sultana Lovely ◽  
Rokeya Begum ◽  
Qazi Shamima Akhter ◽  
Salma Akhter ◽  
Nilufar Yasmin Mili ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Healthy Subjects ◽  
Meta Analysis ◽  
Age Groups ◽  
Cross Sectional Study ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Cardiology Department

Background: Aging is associated with increased prevalence of thyroid function abnormalities including hypothyroidism. A meta-analysis showed an increased prevalence and incidence of cardiovascular mortality only in a relatively younger population. Objective: To compare the thyroid function status in IHD patients of different age groups. Methods: This cross sectional   study was carried out on 31 IHD subjects aged 35-59 years (Group B1) and 19 IHD subjects aged 60-85 years (Group B2) in the Department of Physiology, Dhaka Medical College, Dhaka from July 2009 to June 2010. For comparison 24 healthy subjects aged 35-59 years   (Group A1) and 26 with age 60-85 years (Group A2) were studied. The IHD subjects were   selected from coronary care unit of cardiology department and OPD of Dhaka Medical College Hospital, Dhaka. Serum FT3, FT4 and TSH of all subjects were measured by radioimmunoassay. Statistical analysis was done by unpaired Student’s ‘t’ test. Results: The mean ± SD of FT3 and FT4 were significantly lower and TSH was significantly higher in   Group B1 IHD patients than that of Group A1 healthy subjects, but no difference was found between Group A2 and Group B2 and between Group B1 and Group B2.Conclusion: Thyroid   hormone levels are significantly lower in younger IHD population (age 35-59 years) than the   age-matched normal controls. DOI: http://dx.doi.org/10.3329/jemc.v2i2.12842 J Enam Med Col 2012; 2(2): 80-84

scholarly journals Study of Thyroid Hormone Status in Ischemic Heart Disease (IHD)

1970 ◽  
Vol 6 (1) ◽  
pp. 27-31
Author(s):  
Nasreen Sultana Lovely ◽  
Rokeya Begum ◽  
Qazi Shamima Akhter ◽  
Most. Sabinus Sultana ◽  
Salina Akhtar
Keyword(s):  
Thyroid Hormone ◽  
Healthy Subjects ◽  
Elevated Serum ◽  
Cross Sectional Study ◽  
Chi Square ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Chi Square Test ◽  
Group B

Background: Thyroid dysfunction especially hypothyroidism is cardiovascular risk factor because of its association with elevated serum total and LDL cholesterol. Objective: To assess the association of thyroid hormone levels with IHD. Methods: This cross-sectional study was carried out on 50 IHD subjects aged 35 to 85 years (Group B), in the Department of Physiology, Dhaka Medical College, Dhaka from of July 2009 to June 2010. For comparison 50 age, sex, and BMI matched apparently healthy subjects (Group-A) were also studied. The study subjects were selected from coronary care unit (CCU) of Cardiology Department & OPD of Dhaka Medical College Hospital, Dhaka. Serum FT3, FT4 and TSH were assessed by radio-immuno assay. Statistical analysis was done by student’s unpaired ‘t’ test and chi-square test as applicable. Result: The mean ±SD of serum FT3 and FT4 were significantly lower and serum TSH was significantly higher in IHD patients than that of healthy subjects (p<0.05). Conclusion: Hypothyroidism occurs in patients suffering from IHD. Key words: Thyroid hormone; IHD. DOI: http://dx.doi.org/10.3329/jbsp.v6i1.8080 J Bangladesh Soc Physiol. 2011 June; 6(1): 27-31

scholarly journals TO STUDY THE ONSET AND PROGRESSION OF AIRWAY ABNORMALITY IN TERMS OF ALTERATION IN PFT IN ASYMPTOMATIC SMOKERS.

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dr. Hitesh Kumar Solanki ◽  
Dr. Omnath P Yadav ◽  
Dr. Anita J Gojiya
Keyword(s):  
Lung Function ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Group I ◽  
Significant Difference ◽  
History Of ◽  
Young Smokers ◽  
The Mean ◽  
Group Ii

The study was conducted in department of physiology, B J Medical College, Ahmedabad from Mar. 2012 to Feb. 2013. This was a cross-sectional study to evaluate the effect of smoking on lung   function and serum lipids in asymptomatic smokers   and comparable non   smokers. The mean of the various spirometric parameters were calculated of the subjects for both the groups. The mean FVC in group I and group II was 2.60 ± 0.62 L and 4.10 ± 0.64L respectively. The mean FEV1 in group I was 1.91 ± 0.57L and     3.19 ± 0.77L in group II Group I had mean FEF25% - 75% and PEFR of 1.98 ± 0.67L/sec and 4.50 ± 1.57L/sec respectively. Group II had mean FEF25 – 75% of 4.22 ± 1.23L/sec and a mean PEFR of 7.22 ± 1.42L/sec. In young smokers and asymptomatic, still the spirometric values were significantly deranged as compared to controls. Even smokers with history of less pack years of smoking also had significant abnormalities of lung function. All he spirometric values in the two groups had statistically highly significant difference and were higher in non-smokers as compared to smokers. The spirometric values were reduced in smokers with history of smoking for as low as two pack years. Keywords: Progression, PFT, Asymptomatic & Smokers

scholarly journals Effect of maternal BMI on labor outcomes in primigravida pregnant women

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Eissa Khalifa ◽  
Alaa El-Sateh ◽  
Mohamed Zeeneldin ◽  
Ahmed M. Abdelghany ◽  
Mahmoud Hosni ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Active Phase ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Group Iii ◽  
Second Stage Of Labor ◽  
Group I ◽  
Increased Risk ◽  
Group Ii ◽  
Labor Outcomes

Abstract Background This study aims to detect the effects of increased BMI on labor outcomes in primigravida pregnant women. Methods A cross-sectional study involved 600 full-term singleton primigravida pregnant women who presented in the active phase of labor to the labor ward. They were divided according to BMI into three equals groups; women with normal BMI (group I), overweight women (group II), and women with class I obesity (group III). Results We found that high BMI was associated with a significantly increased risk of Caesarean section (C.S.) (13% in group I, 18% in group II and 40% in group III). Women with higher BMI and delivered vaginally had a significantly prolonged first and second stage of labor, consequently increased the need for oxytocin augmentation as well as the oxytocin dose. Regarding the maternal and fetal outcomes, there are significantly increased risks of postpartum sepsis, perineal tears, wound infection, as well as significantly increased birth weight and longer neonatal stay in the neonatal unit (NNU). Conclusion Obese primigravida pregnant women were at higher risk of suboptimal outcomes. Besides, prolonged first and second stages of labor and the incidence of C.S. have also been increased.

scholarly journals Effect of obesity on lung function test among adults

2020 ◽  
Vol 7 (12) ◽  
pp. 1795
Author(s):  
Dhairya Salvi ◽  
Dhanvi Moradia
Keyword(s):  
Vital Capacity ◽  
Lung Function Test ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Sectional Study ◽  
Cross Sectional ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Function Test

Background: Obesity is a chronic disease characterized by excessive body fat that causes damage to the individual’s health and is associated with comorbidities such as diabetes and hypertension and vascular dysfunction. This cross-sectional study was carried out with the objective of evaluating the effect of obesity on lung function test in obese but otherwise healthy adults.Methods: It was a cross-sectional study carried out at tertiary care institute of Gujarat, India. It was conducted over a period of 5 months. A total of 240 adult healthy subjects of both sexes were selected randomly belonging to varying socio-economic status. The study subjects were divided into 3 categories (normal body mass index i.e. BMI, overweight, obese). BMI were calculated for the randomly selected subjects from each list till the desired number in each BMI group were attained. Four respiratory parameters viz. forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), forced expiratory volume in 3 seconds (FEV3), and maximum voluntary ventilation (MVV) were used to assess their lung functions.Results: Two hundred and forty subjects (each group having n=80). The mean age of group I, group II and group III were 27.45±6.37, 28.18±6.42 and 28.98±6.74 respectively. Lung volumes showed significant difference in relation to the BMI. FVC and FEV1 show significant decrease. Group III verses group I (p˂0.001 and p˂0.017 respectively) FEV3 showed significant difference between group I and group III and between group II and group III (p˂0.001). MVV was significantly lower in group III when compared to group I.Conclusions: There is decline in pulmonary function in obese as compared to normal weight adults. These findings suggest deleterious effects on ventilatory mechanics caused by obesity, due to probable lung compression (reduction in the expiratory reserve volume i.e. ERV), leading to a compensatory increase in the inspiratory reserve volume (IRV) in an attempt to maintain a constant vital capacity (VC).

scholarly journals Raised Vaginal Fluid Fibronectin Level Indicates Premature Rupture of Membrane

2012 ◽  
Vol 2 (2) ◽  
pp. 74-79
Author(s):  
Shamima Rahman ◽  
Samsad Jahan ◽  
Samira Humaira Habib ◽  
Nasrin Sultana ◽  
Mst Nigar Sultana ◽  
...  
Keyword(s):  
Normal Pregnancy ◽  
Clinical Situation ◽  
Cross Sectional Study ◽  
Clinical Event ◽  
Vaginal Fluid ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Medical College ◽  
Group I ◽  
The Common

Background: Premature rupture of membrane (PROM) is one of the common complications  of pregnancy that has major impact on fetal and neonatal outcome. It is the commonest  clinical event where a normal pregnancy becomes suddenly a high-risk one for mother and  fetus or neonate. Objective: The study was undertaken to investigate whether raised  fibronectin level in vaginal fluid may indicate premature rupture of membrane. Materials and  Methods: This cross sectional study was conducted in the department of Obstetrics and  Gynecology in Sir Salimullah Medical College & Mitford Hospital, Dhaka during the period  of January 2006 to December 2007. A total of 114 pregnant women with gestational age 28th  week up to 40th week were included. Sixty were PROM (Group I) and 54 were non-PROM  (Group II) subjects. Fibronectin in vaginal fluid was measured by an immunochemical  reaction by nephelometer. Statistical analysis was done by SPSS version 10.0. Results: The  PROM patients had significantly higher concentration of fibronectin (225.77 ± 115.18 ng/mL)  compared to that in non-PROM subjects (8.04 ± 16.17 ng/mL) (p < 0.001). Conclusion: It  can be concluded that in cases of unequivocal rupture or intactness of the membranes, the  result of the fibronectin test corresponds well with the clinical situation. So fibronectin is a  sensitive test for detection of amniotic fluid in the vagina. DOI: http://dx.doi.org/10.3329/jemc.v2i2.12841 J Enam Med Col 2012; 2(2): 74-79

scholarly journals High Sensitive C-Reactive Protein (hs-CRP) and Its Correlation with Angiographic Severity of Patient with Coronary Artery Disease (CAD)

1970 ◽  
Vol 19 (2) ◽  
pp. 91-97 ◽  
Author(s):  
MA Hasnat ◽  
AEMM Islam ◽  
AW Chowdhury ◽  
HILR Khan ◽  
MZ Hossain
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Group I ◽  
Extent Score ◽  
Hs Crp ◽  
Artery Disease ◽  
Vessel Score

Background: Association between the plasma hs-CRP levels and the severity of coronary stenosis in subjects remains controversial. This cross sectional study was performed in the Department of Cardiology, Dhaka Medical College during July 2008 to December 2009, to determine whether the concentrations of hs-CRP correlate with the coronary atherosclerotic disease assessed by coronary angiography. Methods: For this purpose, a total number of 90 consecutive patients having IHD admitted in the Dhaka Medical College Hospitals were enrolled in this study. Patients were divided into three groups according to their level of hs-CRP. Out of 90 cases, 22(24.4%) patients were in group I, in group II 33(36.7%) patients and rest 35(38.9%) were in group III according to their hs-CRP level. Severity of CAD was assessed by vessel score, stenosis score and extent score. Result: Significant positive correlation (r=0.7409; p<0.001 r=0.6648; p<0.001 and r=0.6386; p<0.001) was found between hs-CRP and vessel score, stenosis score and hs-CRP and extent score suggesting increasing level of hs-CRP strongly suggestive of extensive coronary artery disease. Conclusion: High level of hs-CRP strongly suggestive of extensive coronary artery disease Key words: hs-CRP; angiogram; coronary artery disease; vessel score; stenosis score and extent score. DOI: 10.3329/jdmc.v19i2.7076J Dhaka Med Coll. 2010; 19(2) : 91-97

scholarly journals The Predictors of the Severity of Dengue Fever: A Cross-Sectional Study in a Tertiary Care Center of Bangladesh

2021 ◽  
Vol 29 (1) ◽  
pp. 77-82
Author(s):  
Mohammad Zaid Hossain ◽  
Nusrat Sultana ◽  
Afroza Akbar Sweety ◽  
Reaz Mahmud ◽  
Mohammed Masudul Hassan Khan ◽  
...  
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Cross Sectional Study ◽  
Severe Dengue ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Group I ◽  
Study Population

Background: Dengue is an endemic disease for Bangladesh with occasional outbreak. Little is known about the predictors of severe dengue. Methods: This cross sectional study was conducted in the medicine department of Dhaka Medical College from April 2019 to March 2020. Total 199 consecutive patients were enrolled in this study. For the purpose of the analysis, dengue fever was classified as group I and dengue hemorrhagic fever and dengue shock syndrome was classified as group II. Results: The mean (SD) age of the study population was 28.5(12.1) and 87.4% were less than 40 years of age. The male and female ratio was about 3:1. Among the total study population, 149(74.9%) patients had DF, 46 (23.1%) had DHF and only 4 (2%) had DSS on presentation. Baseline demography and clinical presentation did not significantly differ between classical dengue and severe dengue. Previous history of dengue had low association with severity (RR, 95%CI, phi, P value; 1.2, 1.04-1.40, 0.25, 0.001).Most of the laboratory parameters were similar between the groups. The number of platelet count was significantly lower in DHF and DSS [median (IQR) 43500(16500-95250], than DF [median (IQR) 65000(33000-1170000, p-value 0.01] Conclusion: Previous infection with dengue virus and decreasing platelet count are the predictors of the severe dengue. J Dhaka Medical College, Vol. 29, No.1, April, 2020, Page 77-82

scholarly journals Lipid Profile Level among Healthy Subjects and Their Relation with Obesity- A Clinical Study

2020 ◽  
Vol 3 (1) ◽  
pp. 42-46
Author(s):  
Radhika M ◽  
Vinu Thomas
Keyword(s):  
Lipid Profile ◽  
Healthy Subjects ◽  
Cross Sectional Study ◽  
General Information ◽  
Visceral Adiposity Index ◽  
Cross Sectional ◽  
Adiposity Index ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Background: Obesity is a common metabolic disease world-wide and dyslipidemias among the most common metabolic disorders associated with obesity. The present study was undertaken to assess lipid profile level among healthy subjects and their relation with obesity.Subjects and Methods: This cross sectional study was conducted on 100 subjects. General information related to data such as name, age, gender etc. was recorded in case history proforma. BMI was evaluated based on formula of BMI = Weight (kg)/Height (m)2. Based on BMI, subjects were divided into two groups according to their BMI values as- group I- Obese and Group II- Non obese. Group I had 65 and group II had 35 subjects. Lipid profile was done.Results: There was significant difference in group I and group II regarding waist circumference (WC), BMI (kg/m2), body adiposity index (BAI), visceral adiposity index (VAI), total cholesterol (TC) (P< 0.05). Waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), HDL- C, LDL- C, TG, TC/HDL- C, LDL-C/HDL-C and TG/HDL-C was non- significant (P< 0.05). There was negative correlations between BMI and TC, LDL-C, HDL-C; WC, WHR, VAI and HDL-C and positive significant correlations were found between WC, WHR, and TG/HDL-C, as well as between VAI andTC, TG, TC/HDL-C, LDL/HDL-C, and TG/ HDL-C.Conclusion:Authors found that there was alteration of lipid profile in obese subjects. VAI is strongly related with lipid profile and may be considered as reliable obesity index in obese patients with dyslipidemias.

scholarly journals Cross-sectional study of effect of adiposity and hypertensive states on airway dynamics

2019 ◽  
Vol 7 (6) ◽  
pp. 2142
Author(s):  
Kunal Kishor Gautam ◽  
Deepak Saxena ◽  
Arvind Kanchan ◽  
Nisar Ahmad ◽  
Rahul Saini ◽  
...  
Keyword(s):  
Rank Correlation ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Group Iii ◽  
Pulmonary Functions ◽  
Spearman’S Rank Correlation ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Airway Dynamics

Background: Adiposity and hypertensive states are major burden for community. It causes many health-related issues, including problems related to respiratory system. It is proposed that pulmonary functions can be affected in obese hypertensive and obese normotensive adults compared to non-obese normotensive adults. The objective of the study was to find out the effect of adiposity and hypertensive states on the airway dynamics.Methods: About 30 male obese normotensives and 30 male obese hypertensive subjects were selected as study participants. 30 age-controlled non-obese, normotensive males were selected as controls. All participants were in the age group of 40 to 60 years. The pulmonary functions measured were FVC, FEV1, FEV1% and PEFR. All the participants performed 3 attempts of spirometry and maximum among the three recordings were used for analysis. ANOVA followed by Post hoc analysis to find out any significant differences between these groups. Spearman’s rank correlation was used.Results: There was a statistically significant differences in BMI between the group I and group II and III. There was a significant difference in SBP and DBP between obese normotensive (group II) and obese hypertensive (group III) subjects. There were significant decline in % predicted values of PFT parameters, on comparing obese normotensive and obese hypertensive when compared to non-obese normotensive participants. There were statistically significant negative correlations between age and FEV1 as well as BMI and PEFR.Conclusions: There was a significant decrease the pulmonary functions in obese normotensive and obese hypertensive adults in comparison to non-obese normotensive adults. It can be concluded that body weight and adiposity as well as high blood pressure creates deleterious effect on airway dynamics.

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