COVID-19 IN PREGNANCY AND LITERATURE REVIEW

2021 ◽  
pp. 9-11
Author(s):  
Hari Kishan Boorugu
Keyword(s):  
Mechanical Ventilation ◽  
Intensive Care ◽  
Literature Review ◽  
Pregnant Women ◽  
Congenital Anomalies ◽  
Severe Illness ◽  
Increased Risk ◽  
Pregnancy And Lactation ◽  
In Pregnancy

COVID-19 pandemic has affected humankind in a major way. Pregnant women are as susceptible to SARS-COV-2 infection as non-pregnant population. Infections prevention is paramount as pregnancy is associated with increased risk of severe illness, admission to intensive care and mechanical ventilation. Pregnancy poses unique challenges in view of paucity of information regarding safety of drugs used in management of patients with COVID-19 infection. Fortunately SARS-COV-2 infection during pregnancy does not appear to cause congenital anomalies. Vaccination should not be withheld based on pregnancy and lactation status.

scholarly journals Clinical features and the maternal and neonatal outcomes of pregnant women with coronavirus disease 2019

2020 ◽  
Author(s):  
Rui Nie ◽  
Shao-shuai Wang ◽  
Qiong Yang ◽  
Cui-fang Fan ◽  
Yu-ling Liu ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Pregnant Women ◽  
Clinical Features ◽  
Neonatal Outcomes ◽  
Clinical Severity ◽  
Severe Illness ◽  
Increased Risk ◽  
Maternal And Neonatal Outcomes

ABSTRACTBACKGROUNDThere is little information about the coronavirus disease 2019 (Covid-19) during pregnancy. This study aimed to determine the clinical features and the maternal and neonatal outcomes of pregnant women with Covid-19.METHODSIn this retrospective analysis from five hospitals, we included pregnant women with Covid-19 from January 1 to February 20, 2020. The primary composite endpoints were admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. Secondary endpoints included the clinical severity of Covid-19, neonatal mortality, admission to neonatal intensive care unit (NICU), and the incidence of acute respiratory distress syndrome (ARDS) of pregnant women and newborns.RESULTSThirty-three pregnant women with Covid-19 and 28 newborns were identified. One (3%) pregnant woman needed the use of mechanical ventilation. No pregnant women admitted to the ICU. There were no moralities among pregnant women or newborns. The percentages of pregnant women with mild, moderate, and severe symptoms were 13 (39.4%),19(57.6%), and 1(3%). One (3.6%) newborn developed ARDS and was admitted to the NICU. The rate of perinatal transmission of SARS-CoV-2 was 3.6%.CONCLUSIONSThis report suggests that pregnant women are not at increased risk for severe illness or mortality with Covid-19 compared with the general population. The SARS-CoV-2 infection during pregnancy might not be associated with as adverse obstetrical and neonatal outcomes that are seen with the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) infection during pregnancy. (Funded by the National Key Research and Development Program.)

scholarly journals COVID-19 OUTCOMES IN PREGNANCY: A REVIEW OF 275 SCREENED STUDIES

2021 ◽  
Author(s):  
Rupalakshmi Vijayan ◽  
Hanna Moon ◽  
Jasmine Joseph ◽  
Madiha Zaidi ◽  
Chhaya Kamwal ◽  
...  
Keyword(s):  
Literature Review ◽  
Pregnant Women ◽  
Direct Evidence ◽  
Case Series ◽  
Adverse Outcomes ◽  
Morbidity And Mortality ◽  
World Health ◽  
Increased Risk ◽  
Immunological Changes ◽  
In Pregnancy

In December 2019, a novel strain of severe acute respiratory syndrome (SARS-CoV-2), was declared as a cause of respiratory illness, called coronavirus 2019 (COVID-19), characterized by fever and cough. In diagnostic imaging, the afflicted population showed pathognomonic findings of pneumonia. What started out as an epidemic in China, rapidly spread across geographical locations with a significant daily increase in the number of affected cases. According to the World Health Organization (WHO) reports, the range of worldwide mortality is 3 to 4%. Maternal adaptations and immunological changes predispose pregnant women to a prolonged and severe form of pneumonia, which results in higher rates of maternal, fetal, and neonatal morbidity and mortality. There is limited data about the consequences of COVID-19 in pregnancy, thereby limiting the prevention, counseling, and management of these patients. The objective of this literature review is to explore pregnancy and perinatal outcomes of COVID-19, complications, morbidity, and mortality in this sub-population. We conducted a literature review pertaining to COVID-19 and pregnancy in databases such as: PubMed, Google Scholar, and Science Direct. The studies we chose to focus on were systematic reviews, meta-analysis, case series, and case reports. Twenty four articles were reviewed regarding COVID-19 and pregnancy, complications and their outcomes. Due to immunological changes during pregnancy as evidenced by the flaring of auto-immune diseases; pregnant women may be at an increased risk for infection. Women (19.7%) who had underlying comorbidities such as gestational DM, HTN, hypothyroidism, and autoimmune disease, COPD, or HBV infection were considered high risk. The most common maternal outcomes were premature rupture of membranes (PROM) and pre-eclampsia. Asthma was the most common comorbidity associated with maternal mortality. The most common neonatal complications were fetal distress leading to NICU admissions and preterm birth <37 weeks. The most common laboratory changes were elevated CRP and lymphocytopenia. Most patients underwent C-section due to their underlying comorbidities. Pregnant and lactating women did not shed viral particles through their vaginal mucus and milk, as evidenced by negative nucleic-acid tests of these secretions. Neonatal infections as demonstrated by positive RT-PCR were rare, but direct evidence supporting intrauterine transmission was not confirmed. Direct evidence indicating vertical transmission of COVID-19 is not available, but risk for transmission cannot be ruled out. Pregnant women should be closely monitored due to increased risk of adverse outcomes.

Vaccination against COVID-19 during Pregnancy and Lactation : An Overview

Healthline ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 3-4
Author(s):  
Sudha Yadav
Keyword(s):  
Pregnant Women ◽  
Psychological Health ◽  
Pregnant Patient ◽  
Severe Illness ◽  
Icu Admission ◽  
Obesity And Diabetes ◽  
Increased Risk ◽  
Pregnancy And Lactation ◽  
Term Births ◽  
Pacific Islander Women

Pandemic of SARS2- COVID 19 has caused disastrous impact globally in terms of sickness, deaths, and overburden on heath infrastructure, employment, economy and psychological health. All countries are affected, to greater or lesser degree; be it from developed, developing or under-developed region. Pregnancy has been identified as one of the risk factor for severe COVID 19 illness by CDC. About two-thirds of women who test positive for COVID 19 have no symptoms. But the data suggest that symptomatic pregnant patient with COVID 19 are at increased risk of more severe illness as well as have increased risk for ICU admission, ventilator support and deaths in comparison to their symptomatic non-pregnant peers Pregnant patients with co-morbidities such as obesity and diabetes, hypertension, heart disease and asthma are further at higher risk of getting serious illness .Pregnant woman’s Age above 35 years and pregnancy above 28 weeks makes women more at risk of severe COVID illness. Stillbirths and pre-term births are twice high in pregnant women with COVID -19 sickness as compared to pregnant women without COVID-19 infection. Ethnicity has also been found to affect the severity of COVID 19 illness. It has been found that Black and Hispanic pregnant women had disproportionately higher rates of COVID-19 infection and death Further risk of ICU admission were higher in pregnant Asian, and Native Hawaiian /Pacific Islander women.

scholarly journals Incidence, risk factors and impact of seasonal influenza in pregnancy: A national cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0244986
Author(s):  
Nicola Vousden ◽  
Kathryn Bunch ◽  
Marian Knight ◽  
Keyword(s):  
Cohort Study ◽  
Intensive Care ◽  
Pregnant Women ◽  
Neonatal Intensive Care ◽  
Seasonal Influenza ◽  
Perinatal Outcomes ◽  
Severe Infection ◽  
Risk Groups ◽  
Increased Risk ◽  
In Pregnancy

Background Pregnant women are particularly vulnerable to severe infection from influenza resulting in poor neonatal outcomes. The majority of evidence relates to pandemic 2009 A/H1N1 influenza. The objective of this study was to describe the characteristics and outcomes of pregnant women hospitalised with seasonal influenza. Methods This national, prospective, observational cohort study used the UK Obstetric Surveillance System (UKOSS) to identify all pregnant women admitted to hospital between 01/11/2016 and 31/10/2018 with laboratory confirmed influenza at any gestation and up to two days after giving birth. These were compared to women admitted to give birth that did not have influenza. Baseline characteristics, immunization status, maternal and perinatal outcomes were compared. Results There were 405 women admitted to hospital with laboratory confirmed influenza in pregnancy: 2.7 per 10,000 maternities. Compared to 694 comparison women, women with influenza were less likely to be professionally employed (aOR 0.59, 95%CI 0.39–0.89) or immunised in the relevant season (aOR 0·59, 0·39–0·89) and more likely to have asthma (aOR 2.42, 1.30–4.49) or have had a previous pregnancy complication (aOR 2·47, 1·33–4·61). They were more likely to be admitted to intensive care (aOR 21.3, 2.78–163.1) and to have a cesarean birth (aOR 1·42, 1·02–1.98). Their babies were more likely to be admitted to neonatal intensive care (aOR 1.86, 1·01–3·42). Conclusions Immunization reduces the risk of hospitalisation with influenza in pregnancy which is associated with increased risk of morbidity for both the mother and baby. There is a continued need to increase awareness of safety and effectiveness of immunization in pregnancy and provision within antenatal care settings, especially for high-risk groups.

scholarly journals Incidence, risk factors and impact of seasonal influenza in pregnancy: A national cohort study

2020 ◽  
Author(s):  
Nicola Vousden ◽  
Kathryn Bunch ◽  
Marian Knight ◽  
Keyword(s):  
Cohort Study ◽  
Intensive Care ◽  
Pregnant Women ◽  
Neonatal Intensive Care ◽  
Seasonal Influenza ◽  
Perinatal Outcomes ◽  
Severe Infection ◽  
Risk Groups ◽  
Increased Risk ◽  
In Pregnancy

Background Pregnant women are particularly vulnerable to severe infection from influenza resulting in poor neonatal outcomes. The majority of evidence relates to pandemic 2009 A/H1N1 influenza. The objective of this study was to describe the characteristics and outcomes of pregnant women hospitalised with seasonal influenza. Methods This national, prospective, observational cohort study used the UK Obstetric Surveillance System (UKOSS) to identify all pregnant women admitted to hospital between 01/11/2016 and 31/10/2018 with laboratory confirmed influenza together with a comparison group of pregnant women. Baseline characteristics, immunisation status, maternal and perinatal outcomes were compared. Results There were 405 women admitted to hospital with laboratory confirmed influenza in pregnancy: 2.7 per 10,000 maternities. Compared to 694 comparison women, women with influenza were less likely to be professionally employed (aOR 0.59, 95%CI 0.39-0.89) or immunised in the relevant season (aOR 0.59, 0.39-0.89) and more likely to have asthma (aOR 2.42, 1.30-4.49) or have had a previous pregnancy complication (aOR 2.47, 1.33-4.61). They were more likely to be admitted to intensive care (aOR 21.3, 2.78-163.1) and to have a caesarean birth (aOR 1.42, 1.02-1.98). Their babies were more likely to be admitted to neonatal intensive care (aOR 1.86, 1.01-3.42). Conclusions Immunisation reduces the risk of hospitalisation with influenza in pregnancy which is associated with increased risk of morbidity for both the mother and baby. There is a continued need to increase awareness of safety and effectiveness of immunisation in pregnancy and provision within antenatal care settings, especially for high risk groups.

scholarly journals An Unusual Presentation of COVID-19 Associated Multisystem Inflammatory Syndrome in Adults (MIS-A) in a Pregnant Woman

2022 ◽  
Vol 2022 ◽  
pp. 1-5
Author(s):  
Mohamed Rishard ◽  
Suren Perera ◽  
Kushan Jayasinghe ◽  
Amila Rubasinghe ◽  
Sanjaya Athapaththu ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
Pregnant Women ◽  
Respiratory Illness ◽  
Severe Illness ◽  
Obstetric Outcomes ◽  
Rare Presentation ◽  
Diagnostic Dilemma ◽  
Increased Risk ◽  
Inflammatory Syndrome ◽  
In Pregnancy

Based on available literature, pregnant women are at an increased risk of severe illness from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, compared to nonpregnant women. Consequences of coronavirus disease 2019 (COVID-19) in pregnancy have many implications in women’s lives other than unfavorable obstetric outcomes. In addition to managing acute respiratory illness and symptoms, caregivers should be equipped to detect and manage the short-term, intermediate, and long-term consequences of SARS-CoV-2 infection as well. Many pregnant women can remain asymptomatic and continue their pregnancy without being diagnosed. Pregnancy outcomes and consequences of SARS-CoV-2 infected yet asymptomatic mothers have not been very well explained. Reports of a new multisystem inflammatory syndrome in children (MIS-C) and multisystem inflammatory syndrome in adults (MIS-A) following COVID-19 have been described. However, MIS-A in pregnancy is an extremely rare presentation that can cause a huge diagnostic dilemma to caregivers. We describe the successful management of a pregnant woman with MIS-A following SARS-CoV-2 infection.

scholarly journals AB0747 MATERNAL AND FETAL OUTCOMES IN PREGNANT WOMEN WITH JUVENILE IDIOPATHIC ARTHRITIS: A SYSTEMATIC LITERATURE REVIEW

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1402.1-1402
Author(s):  
R. Pinheiro Torres ◽  
M. H. Fernandes Lourenco ◽  
A. Neto ◽  
F. Pimentel Dos Santos ◽  
I. Silva ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Literature Review ◽  
Pregnant Women ◽  
Systematic Literature Review ◽  
English Language ◽  
Placenta Previa ◽  
Bibliographic Databases ◽  
Fetal Outcomes ◽  
Term Birth ◽  
Increased Risk

Background:Juvenile idiopathic arthritis (JIA), one of the most common chronic diseases in children, can be classified in seven different categories according to its onset presentation. Concerns about pregnancy outcomes play a secondary role in disease approach. However, recent data showed an increased risk of pre-term birth in women with JIA instead the small patient samples analysed.Objectives:In this review, our aim is to describe the current available knowledge on JIA adverse, maternal and fetal, outcomes.Methods:A systematic literature review was conducted since January of 2000 until December 2020, by searching the PubMed and Embase bibliographic databases. The search was limited to articles in English language, presenting a comparator group (healthy individuals or patients without known auto-immune rheumatic diseases) and at least one clinical outcome of interest. Two independent reviewers screened the titles and abstracts followed by a full-text review to assess papers regarding their eligibility.Results:Ten observational studies out of 1560 references, fulfilled the inclusion criteria, of which, 9 were retrospective and 1 prospective. A total of 6.214 women with JIA (with 6.811 pregnancies) and 18.659.513 healthy controls (with 21.339.194 pregnancies) were included in this review.Concerning maternal outcomes, delivery by caesarian section (CS) was more frequent among JIA women (in 4 out of 6 studies). Pre-eclampsia was referred in 3 out of 6 studies and a higher risk of vaginal bleeding and placenta previa in one additional study. No study found an increased risk for gestational diabetes or hypertension in pregnant women with JIA.Regarding fetal outcomes, 8 studies revealed significantly increased of pre-term birth (only in first births in one study) but one study didn’t show any increased risk. Two studies showed a higher risk of small gestational age (SGA) and in another 2, increased risk for low birth weight (LBW). No evidence of increased risk of major congenital malformations.Conclusion:This systematic review suggests an increased risk for pre-eclampsia, preterm birth, delivery by CS, SGA and LBW, among pregnant women with JIA. Conclusions should be carefully interpreted, giving the heterogeneity of studied populations regarding demography, disease type, disease activity, and prescribed medication.Disclosure of Interests:None declared

scholarly journals Considerations in the provision of teleconsultations for outpatient obstetric anaesthesia care during the Covid-19 pandemic

2021 ◽  
pp. 201010582199117
Author(s):  
Leonard Wei Wen Loh ◽  
Yingke He ◽  
Hairil Rizal Abdullah ◽  
Kai Lee Ng ◽  
Un Sam Mok
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Severe Illness ◽  
Continuing Care ◽  
Short Report ◽  
Obstetric Anaesthesia ◽  
Increased Risk ◽  
Process And Outcome ◽  
Risk Of Exposure ◽  
Anaesthesia Care

Evidence has emerged that pregnant women who contract coronavirus disease 2019 (Covid-19) are at increased risk of certain forms of severe illness as well as complications requiring intensive care unit admission and resultant mortality. Teleconsultations can facilitate continuing care for obstetric patients during the Covid-19 pandemic while reducing their risk of exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this short report, we share our experience in the provision of teleconsultations for ambulatory obstetric anaesthesia patients in our high-risk obstetric anaesthesia clinic during the Covid-19 pandemic. Appropriate labour analgesia or anaesthesia plans were able to be formulated and communicated to the patients by teleconsultation, resulting in no delay or compromise in their peripartum care. Both patients and clinicians reported satisfaction with the teleconsultation process and outcome. The considerations and challenges in setting up a teleconsultation service as well as the factors in favour of teleconsultation are also explored.

scholarly journals Prenatal electrocardiogram testing and postpartum depression: A population-based cohort study

2021 ◽  
pp. 1753495X2110125
Author(s):  
Jonathan S Zipursky ◽  
Deva Thiruchelvam ◽  
Donald A Redelmeier
Keyword(s):  
Cohort Study ◽  
Postpartum Depression ◽  
Pregnant Women ◽  
Odds Ratio ◽  
Population Based ◽  
Relative Increase ◽  
Organic Disease ◽  
Increased Risk ◽  
Clinical Clue ◽  
In Pregnancy

Background Cardiovascular symptoms in pregnancy may be a clue to psychological distress. We examined whether electrocardiogram testing in pregnant women is associated with an increased risk of subsequent postpartum depression. Methods We conducted a population-based cohort study of pregnant women who delivered in Ontario, Canada comparing women who received a prenatal ECG to women who did not. Results In total, 3,238,218 women gave birth during the 25-year study period of whom 157,352 (5%) received an electrocardiogram during prenatal care. Receiving an electrocardiogram test was associated with a one-third relative increase in the odds of postpartum depression (odds ratio 1.34; 95% confidence interval 1.29–1.39, p < 0.001). Conclusion The association between prenatal electrocardiogram testing and postpartum depression suggests a possible link of organic disease with mental illness, and emphasizes that cardiovascular symptoms may be a clinical clue to the presence of an underlying mood disorder.

Gambaran Kejadian Anemia Pada Ibu Hamil : Literature Review

2021 ◽  
Vol 1 ◽  
pp. 464-469
Author(s):  
Kiki Utari ◽  
R Ratnawati
Keyword(s):  
Literature Review ◽  
Pregnant Women ◽  
Google Scholar ◽  
Iron Intake ◽  
Exclusion Criteria ◽  
Food Reserves ◽  
Descriptive Method ◽  
In Pregnancy

AbstractPregnant women are very susceptible to anemia due to lack of food reserves and before pregnancy they were already anemic. Pregnant women need more iron intake than before pregnancy. Problems in pregnant women are problems in pregnancy that can cause anemia. This literature review aims to determine the description of the incidence of anemia in pregnant women from various articles. This study uses a descriptive method with a literature review approach. Search articles through PubMed and Google Scholar according to keywords and then analyzed according to inclusion and exclusion criteria and found 5 articles and reviewed using the Joanna Instrument (JBI). The description of the incidence of anemia in pregnant women showed anemia as many as 258 respondents (35.3%) and those who experienced anemia were not as many as 472 respondents (64.7%). In this literature review, it was concluded that most pregnant women did not experience anemia.Keywords: Anemia, Pregnant Women AbstrakIbu hamil sangat rentan mengalami anemia karena cadangan makanan kurang dan pada saat sebelum hamil sudah mengalami anemia. Ibu hamil membutuhkan asupan zat besi yang lebih banyak dibandingkan saat sebelum hamil. Permasalahan pada ibu hamil adalah masalah – masalah dalam kehamilan yang dapat menimbulkan anemia. Literatur Review ini bertujuan untuk mengetahui Gambaran Kejadian Anemia Pada Ibu Hamil dari berbagai artikel. Penelitian ini menggunakan metode deskriptif dengan pendekatan literature review. Pencarian artikel melalui PubMed dan Google Scholar sesuai dengan kata kunci kemudian dianalisa sesuai dengan keriteria inklusi dan ekslusi dan ditemukan 5 artikel dan di review menggunakan Instrument Joanna (JBI). Gambaran kejadian Anemia pada ibu hamil didapatkan hasil anemia sebanyak 258 responden (35,3%) dan yang mengalami tidak anemia sebanyak 472 responden (64,7%). Dalam penelitian literature review ini disimpulkan bahwa sebagian besar ibu hamil tidak mengalami anemia.Kata kunci : Anemia, Ibu Hamil

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