CORRELATION OF DIFFUSION WEIGHTED MR DETERMINED INFARCT VOLUME WITH ALBERTA STROKE PROGRAM EARLY COMPUTED TOMOGRAPHY SCORE IN ACUTE STROKE PROGNOSIS

Mapping Intimacies ◽

10.36106/ijsr/5904235 ◽

2021 ◽

pp. 41-44

Author(s):

Kataria Bhavya ◽

Mehra Shibani

Keyword(s):

Patient Outcome ◽

Acute Stroke ◽

Infarct Volume ◽

Inverse Correlation ◽

Cross Sectional Study ◽

Slice Thickness ◽

Cross Sectional ◽

Diffusion Weighted ◽

Patient Prognosis ◽

Adverse Patient Outcome

AIMS AND OBJECTIVES: To correlate the Diffusion MRI assessed infarct volume with the ASPECT Score to prognosticate clinical outcome in patients of acute stroke. METHOD AND MATERIALS: This was a cross sectional study comprising 36 patients of acute stroke. Diffusion weighted MR was obtained at b values of 0,500 & 1000 on Siemens Magnetom Skyra 3 Tesla scanner. Diffusion restriction on b=1000 image was measured with VOI tool using manual contouring in each slice. Volume was calculated using the formula (Area x slice thickness) after summating the infarct area measured in each slice. ASPECT Score was assessed on CT in each patient at the time of admission of the patient. Correlation of the infarct volume with ASPECTS was done using student t-test with p < 0.05 considered statistically signicant. ROC curve was used to predict cut off of volume of infarct & ASPECTS predicting adverse patient outcome. RESULTS: There was a statistically signicant inverse correlation between the volume of infarct and ASPECTS (p=0.001; r=-0.844). The AUC for a cut-off of 115 cc of the volume of infarct in predicting adverse patient outcome was 0.931 whereas that for ASPECT Scale of 6 was 0.931. CONCLUSION: Infarct volume correlates well with ASPECT Score, both serving as prognostic tools in predicting patient outcome in acute stroke and having comparable efcacy in predicting prognosis. BACKGROUND: Infarct volume and CT ASPECT Score are resourceful parameters in predicting patient prognosis. Limited studies have been done in the Indian population correlating the Volume of infarct and the CT ASPECT Scale.

Download Full-text

Correlation of Diffusion-Weighted Magnetic Resonance Imaging Determined Infarct Volume with Clinically Assessed National Institutes of Health Stroke Scale in Patients of Acute Stroke: A Cross-sectional Study

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/49862.15309 ◽

2021 ◽

Author(s):

Bhavya Kataria ◽

Shibani Mehra

Keyword(s):

Acute Stroke ◽

Infarct Volume ◽

Cross Sectional Study ◽

National Institutes Of Health ◽

Sectional Study ◽

Resonance Imaging ◽

Cross Sectional ◽

Diffusion Weighted ◽

Weighted Magnetic Resonance Imaging ◽

Time Of Admission

Introduction: Infarct volume is an essential factor in predicting patient prognosis. National Institutes of Health Stroke Scale (NIHS) allows consistent reporting of neurological deficits in stroke patients. Limited studies have been done in the Indian population correlating the volume of infarct and the NIHS Scale. Aim: To correlate the Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) assessed infarct volume with the clinically assessed NIHS to prognosticate clinical outcomes in patients of acute stroke. Materials and Methods: This was a cross-sectional study comprising 36 patients of acute stroke with a study duration from November 2017 to April 2019. Diffusion-Weighted MRI was obtained on Siemens Magnetom 3 Tesla, and diffusion restriction on b=1000 image was measured with a Region of Interest (ROI) tool using manual contouring in each slice. Assessment of the neurological deficit was done by NIHS scale at the time of admission and 7 days post admission for each patient. Correlation of the infarct volume with NIHS Scale was done with p<0.05 considered statistically significant. Receiver Operating Characteristic Curve (ROC) was used to predict cut-off of the volume of infarct and NIHS Scale to predict adverse patient outcome. Results: Present study consisted of 36 patients of acute stroke with a mean age of 52.05±18.53 years. The minimum age of the patient was one year, and the maximum age was 78 years. There was a statistically significant correlation between the volume of infarct and NIHS Scale at time of admission admission (p=0.001; r=0.807) and the NIHS Scale at one week (p=0.002; r=0.602).The Area Under the Curve (AUC) for a cut-off of 115 cc of the volume of infarct in predicting adverse patient outcomes was 0.931, whereas that for the NIHS scale of 20 was 0.998. Conclusion: Volume of infarct of 115 cc and NIHS Scale of 20 are excellent as prognostic tools in predicting patient outcome and have comparable efficacy.

Download Full-text

IMAGING CHARACTERISTIS OF MDCT IN NASOPHARYNGEAL CARCINOMA

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2014.4_5.22 ◽

2014 ◽

pp. 159-167

Author(s):

Huu Thuan Ngo ◽

Minh Loi Hoang ◽

Van Dinh Nguyen ◽

Dinh Duyen Nguyen

Keyword(s):

Nasopharyngeal Carcinoma ◽

Lymph Nodes ◽

Lateral Wall ◽

Cross Sectional Study ◽

Slice Thickness ◽

Cross Sectional ◽

Lymph Nodes Metastasis ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Key Words Nasopharyngeal Carcinoma

Objectives: Imaging characteristis of MDCT in nasopharyngeal carcinoma. Subject and methods: Cross- sectional study in 51patients with nasopharyngeal carcinoma by MDCT at Danang Cancer Hospital from January 2013 to July 2014. Results: The findings reveal that the tumor in lateral wall (66.7%), diameter > 2cm (64.7%), hypodensity (98%), contrast- enhanced CT (62.7%). Blunting of fossa of Rosenmuller (96.1%), invasion of parapharyngeal space (62.7%), destruction of pterygoid bone (19.6%), invasion of skull base (17.6%), destruction of sphenoid bone (9.8%). Lymph nodes metastasis (96.1%), diameter (> 1- 3cm) is 58.8%. T-staging by CT showed T1 (35.3%), T2 (37.3%), T3 (17.6%) and T4 (9.8%). N- staging by CT showed N2 (66.7%), N3a- N3b (19.6%). Staging of Nasopharyngeal carcinoma: stage II-III (60.8%), stage IVA-IVB (23.5%) and stage IVC (11.8%). Conclusions: MDCT with a thinner slice thickness and high quality images is able to detect lymph nodes metastasis with small size and those in deep neck area and assess comprehensively the invasion of the tumor. Key words: Nasopharyngeal carcinoma, MDCT

Download Full-text

The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients

BMC Infectious Diseases ◽

10.1186/s12879-021-05855-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Simone Canovi ◽

◽

Giulia Besutti ◽

Efrem Bonelli ◽

Valentina Iotti ◽

...

Keyword(s):

Clinical Laboratory ◽

Laboratory Data ◽

Organ Damage ◽

Cross Sectional Study ◽

Chest Ct ◽

Arterial Oxygen ◽

Emergency Rooms ◽

Cross Sectional ◽

Ct Findings ◽

Patient Prognosis

Abstract Background Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. Methods This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2. Results Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation. Conclusions Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation.

Download Full-text

KADAR FIBRIN MONOMER DAN UKURAN INFARK DI STROK ISKEMIK AKUT

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v20i3.470 ◽

2016 ◽

Vol 20 (3) ◽

pp. 171

Author(s):

Ani Kartini ◽

Mansyur Arif ◽

Hardjoeno Hardjoeno

Keyword(s):

Ischemic Stroke ◽

Infarct Size ◽

Acute Ischemic Stroke ◽

Thrombus Formation ◽

Infarct Volume ◽

Cross Sectional Study ◽

Cerebral Infarct ◽

Cross Sectional ◽

Fibrin Monomer ◽

Significant Difference

Coagulation activation and thrombosis frequently exist in ischemic stroke, thrombus formation can be detected early by the presence of fibrin monomer. The purpose of this study was to know the correlation of fibrin monomer level with cerebral infarct size in acute ischemic stroke patients. This was a cross sectional study with a total of 39 samples. The fibrin monomer level was determined by immunoturbidimetry method using STA-Compact and the measurement of the infarct size was done by CT scan of the head using Broderick formula. The results of this study showed that the median level of fibrin monomer in acute ischemic stroke with nonlacunar infarct type and lacunar infarct type were 14.46 μg/mL and 4.29 μg/mL, respectively. Mann-Whitney test showed there was a significant difference of fibrin monomer levels between nonlacunar infarct type and the lacunar type, p=0.000. The cut-off point analysis result of the fibrin monomer level was 5.96 μg/mL with a sensitivity of 88.9% and specificity of 76.4%, respectively. Spearman correlation test showed that fibrin monomer level was positively correlated with cerebral infarct volume in acute ischemic stroke (r=0.56, p=0.000). Based on this study, it can be concluded that fibrin monomer level can be used as a marker to predict the type of cerebral infarct and volume of acute ischemic stroke as well.

Download Full-text

Increased Interleukin-6 as Inﬂ ammatory Response and Magnesium Deﬁ ciency in Pre-dialysis Chronic Kidney Disease of Indonesian Children

Indonesian Journal of Tropical and Infectious Disease ◽

10.20473/ijtid.v9i2.21479 ◽

2021 ◽

Vol 9 (2) ◽

pp. 93

Author(s):

Astrid Kristina Kardani ◽

Ninik Asmaningsih Soemyarso ◽

Jusli Aras Aras ◽

Risky Vitria Prasetyo ◽

Mohammad Sjaifullah Noer

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Interleukin 6 ◽

Inverse Correlation ◽

Cross Sectional Study ◽

The Body ◽

Cross Sectional ◽

Duration Of Illness ◽

History Of ◽

Spearman’S Correlation

Chronic kidney disease (CKD) is a serious health problem in children, with increasing morbidity and mortality rates throughout the world. Children with CKD tend to experience magnesium (Mg) deﬁ ciency that can stimulate an inﬂ ammatory response in the body. One of the inﬂ ammatory responses is an increase of Interleukin-6 (IL-6). Study to analyze the correlation between Mg and IL-6 in pre-dialysis CKD children. The methods a cross sectional study was conducted in Dr Soetomo General Academic Hospital from November 2018 to April 2019. Children with pre-dialyis CKD were included in this study. Variables of serum Mg level (mg/dL) and inﬂ ammatory marker (IL-6) were measured from the blood and analyzed by ELISA method. The correlation between Mg and IL-6 was analyzed with Spearman’s correlation test with p <0.05. Result a total of 47 children (27 boys vs 20 girls) between 3 months to 18 years old, with pre-dialysis CKD and no history of magnesium supplementation were included. The primary disease that causes of CKD were lupus nephritis (38.3%), nephrotic syndrome (23.4%), urologic disorder (23.4%), tubulopathy (10.6%) and others (4.3%). The average IL-6 level was 55.42±43.04 pg/dL and Mg level was 2.06±1.54 mg/dL. There were no signiﬁ cant correlation between IL-6 level and Mg level with staging of CKD and duration of illness (p>0.05), but there was a signiﬁ cant correlation between serum Mg level and IL-6 level (r=-0.748; p<0.001). Magnesium levels have a signiﬁ cant inverse correlation with IL-6 levels in pre-dialysis CKD children. The lower the Mg levels in the blood, the higher IL-6 levels and vice versa.

Download Full-text

Abstract 164: Treatment Differences in Acute Stroke By Mode of Transport

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.5.suppl_1.a164 ◽

2012 ◽

Vol 5 (suppl_1) ◽

Author(s):

Prasanthi Govindarajan ◽

Anisha Chandra ◽

David Ghilarducci ◽

Steve Shiboski ◽

Barbara Grimes ◽

...

Keyword(s):

Acute Stroke ◽

Demographic Data ◽

Patient Discharge ◽

Cross Sectional Study ◽

Primary Diagnosis ◽

Cross Sectional ◽

Discharge Data ◽

Patient Demographic Data ◽

Mode Of Transport ◽

Time Of Admission

Background: EMS (Emergency Medical Services) is an important component of the stroke chain of survival. While in hospital stroke time targets have shown to be better when prehospital providers provide advance notification, population-wide studies on thrombolysis rates (IV t-PA) for those who arrive by EMS is sparse. Objective: To examine differences in treatment rates for acute stroke by mode of transport. Methods: This is a cross-sectional study of all patients who were transported to hospitals in two Northern California counties by providers of a single EMS agency during a three year period. Patient demographic data, prehospital provider clinical assessment was obtained from the computerized prehospital transport records and patient location, hospital demographics, physician diagnosis and treatment rates were obtained from statewide administrative patient discharge data. The data sources were linked using probabilistic linkage methodology. Patients ≥18 years of age with validated ICD- 9 code for stroke were included. We excluded inter-facility transports and direct admissions. Results: Of 10,456 patients who had a hospital based discharge diagnosis of stroke, 3787 (36%) were transported by EMS. Mean age at the time of admission was 75 years (+/- 14); 55% (2093) were females, 65% (2471) were whites and 86% (3247) were Hispanics. Most of the patients had Medicare (72%, 2737) and 92% (3471) were transported from home. Majority of the patients were treated at stroke centers [n=3014, (80%)]) and at community hospitals [n=3664, (97%)]. Of 3757 patients with a primary diagnosis of stroke, 4% (150) were treated with IV t-PA. After controlling for covariates, patients transported by EMS had higher odds of treatment with IV t-PA (OR 2.6, 95 CI 1.9-3.3). Treatment at stroke centers (OR 1.5, 95 CI 1-2.2) and academic centers were independently associated with treatment rates (OR 2.4, 95 CI 1.6-3.6). Conclusions: Arrival by EMS to emergency department is associated with higher treatment rates with thrombolytics for acute stroke patients and efforts should be targeted to improve use of EMS for stroke.

Download Full-text

Association Between Diet Quality and Food Waste in South Florida

Current Developments in Nutrition ◽

10.1093/cdn/nzaa042_008 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 143-143

Author(s):

Vanessa Mijares ◽

Jair Alcivar ◽

Cristina Palacios

Keyword(s):

Food Waste ◽

Diet Quality ◽

Inverse Correlation ◽

Cross Sectional Study ◽

Healthy Eating Index ◽

Quality Score ◽

South Florida ◽

Grocery Stores ◽

Cross Sectional ◽

Florida International University

Abstract Objectives In 2015, the USDA/EPA set a goal of reducing food waste in 50% by 2030. This goal will not only lower U.S. methane gas emissions but also redirect food to millions of food insecure Americans. Little is known on food waste and its association with diet quality. Therefore, our objective was to explore the associations between diet quality and food waste. Methods This was a cross sectional study among adults ³18 years in south Florida who are the primary household food provider conducting a primary shopping event for the week. Participants were recruited outside of local grocery stores and asked to fill out a quick food waste survey. Pictures of the participants’ grocery receipts were taken to analyze diet quality using the Grocery Purchase Quality Index 2016 (GPQI-2016). The GPQI-2016 is based on the Healthy Eating Index (HEI)– 2010 and has 11 different components (each with a maximum score of 5 or 10) for a total score of 75. Correlations were used to determine the associations between diet quality and amount of food waste (Pearson) or reasons for food waste (Point-biserial). Results A total of 109 participants were recruited but 103 had complete data. Mean age was 44.6 ± 13.6 years, most were females (74%) and Hispanics (79%). Most usually grocery shop in a main event and then go back for smaller items (44%) once (36%) or twice (28%) a week. Mean diet quality score was 40.9 ± 9.64 out of 75 points and mean amount of food waste was 17.7 ± 19.9 handfuls. Most reported throwing away food mainly because it went bad (90%) or it was past it's due date (80%). Handfuls of bread/rice waste were significantly inversely correlated with diet quality (r = −2.60; p = 0.013). Also, we found a significant inverse correlation between diet quality and food thrown away because it had gone past it's use by date (r = −.196; p = 0.049). Conclusions A lower diet quality score was related to higher amount of bread/rice wasted and with throwing away foods that has past it's use date. These results could justify directing reducing food waste efforts in the community by educating individuals on purchasing frozen products or on proper storage to prolong shelf life, as well as on understanding the different dates placed on products by manufacturers. Funding Sources Internal funds from Florida International University.

Download Full-text

Assessment of relationship between the use of cell phone and social networks and sleep quality in students of medical sciences: A cross-sectional study

Interventional Medicine and Applied Science ◽

10.1556/1646.10.2018.30 ◽

2020 ◽

Vol 11 (3) ◽

pp. 131-135

Author(s):

Javad Amini Saman ◽

Ali Valinejadi ◽

Saeed Mohammadi ◽

Hassanali Karimpor ◽

Maryam Mirzaei ◽

...

Keyword(s):

Social Networks ◽

Sleep Quality ◽

Cell Phone ◽

Data Gathering ◽

Inverse Correlation ◽

Cross Sectional Study ◽

Cluster Sampling ◽

Sectional Study ◽

Medical Sciences ◽

Cross Sectional

Introduction Sleep quality is an essential aspect in human health and function. Considering high prevalence of using smartphones and social networks among students and their impact on sleep quality, this study was conducted to determine the relationship between the overuse of cell phone and addiction to social networks and students’ sleep quality. Materials and methods This cross-sectional study was conducted in Kermanshah University of Medical Sciences, Kermanshah, Iran in 2018. Using cluster sampling, 321 students from different disciplines were selected. Data gathering tools consisted of the questionnaire of Pittsburgh Sleep Quality Index (PSQI). Cell phone use and addiction to social networks were assessed using Cell Phone Overuse Scale and a researcher-made questionnaire, respectively. Data were analyzed using SPSS software (version 19) and Pearson’s correlation test. Results The mean total score of sleep quality in students was 6.58 ± 1.05. There was a positive and significant correlation between sleep quality and social networks addiction score (p < 0.05, r = 0.5) and cell phone overuse (p < 0.05, r = 0.44); this is an inverse correlation, because higher scores of the total PSQI denote a lower sleep quality and, in Cell Phone Overuse Scale, higher scores shows overuse. Conclusions According to the findings of this study, there was a significant statistical relationship between the overuse of cell phone and social networks and students’ sleep quality. In other words, students who have had overuse of cell phones had poorer sleep quality. Therefore, providing effective educational programs to improve the sleep quality in this group is essential.

Download Full-text