PROGNOSTIC ROLE OF NLR AND RBS LEVELS IN DIABETIC PATIENTS WITH SEVERE COVID-19 DISEASE

2021 ◽  
pp. 1-2
Author(s):  
Anubha Srivastava ◽  
Anubhuti Bhardwaj

Objective-This retrospective study was done to assess the role of NLR (Neutrophil to lymphocyte ratio) and RBS (RANDOM BLOOD SUGAR) levels at the time of admission as prognostic markers and correlate them with clinical outcome. Materials and methods:Atotal of 100 diabetic patients with severe COVID-19 Disease, requiring ICU admission were studied at SRN Hospital, Prayagraj. Blood samples were sent for various inammatory markers along with random blood glucose levels. Patients were divided as survivors and non- survivors. Results: The mean NLR was higher in the group of patients who did not survive (11.35±8.09) than in the patients who survived (7.79±5.27). Mean RBS (in mg/dL) in the survivor group and the non-survivor group at the time of admission was 232.19±133.75 and 333.41±130.81 respectively. The NLR, RBS, CRP cutoff were identied as >7.247, >254.6 mg/dL,>12.86 mg/Lrespectively to predict mortality using the ROC curve (p value <0.05). Conclusion:NLR and RBS at the time of admission can be easily used as surrogate markers for predictors of mortality. Screening and intensive glucose control is strictly recommended for all diabetic patients.

2017 ◽  
Vol 2 (1) ◽  
pp. 8
Author(s):  
Siswanto Siswanto ◽  
Ismail Kamba ◽  
Siti Aminah

Diabetes mellitus is one of the communicable diseases that have become a public health problem, not only in Indonesia but also the world. Currently morbidity of diabetes mellitus is increasing every year, where in 2006 there were 14 million people in 2011 and ranks fourth with 773 cases. DM is also a cause of disease mortality by 5.8%. And Samarinda own particular Islamic Hospital years 2009, there were 449 patients with DM, and 2011 an increase in the 1931 patients with diabetes mellitus. To increase patients’ knowledge about diabetes and diabetic patients be directing attitudes that support or positive attitude towards keeping blood glucose levels to remain normal. Methode to use pra eksperiment with one group pretest posttest. individual conseling withAudiovisual media. There is increased knowledge about diabetes diabetic patients before and after intervention with increasing value of 3.77 (p value = 0.000) and increase in attitudes regarding diabetes mellitus diabetic patients with an increase in the value of 5,35 (p value = 0.003). There was an increase in knowledge and attitudes of patients hospitalized with diabetes mellitus hospital after islam samarinda given nutritional counseling using audio-visual media


2018 ◽  
Vol 3 (2) ◽  
pp. 72
Author(s):  
Setyoadi Setyoadi ◽  
Heri Kristianto ◽  
Siti Nur Afifah

Diabetes mellitus is a disease that required good self-management. Noncompliance in diet and meal plans cause the instability of blood glucose levels. Nutrition education calendar method can improve knowledge and ability to consume food that matches the number, hours and types with dietary adjustments listed in the calendar diet. This study aimed to determine the effect of nutrition education calendar method on blood glucose levels of patients with type 2 diabetes mellitus in Community Health Center Pakis Malang. Pre-experimental design one group pretest-posttest with purposive sampling was conducted in this study and sample obtained as many as 21 people. Blood glucose levels were measured before and after the nutrition education calendar methods. Compliance in using calendar method with the observation sheet. Statistical analysis values obtained by Wilcoxon, the p-value of 0.007 (p <0.05). The results of the analysis, 16 respondents showed a decrease in blood glucose levels and 5 respondents experienced an increase in blood glucose levels after the given intervention. It can be concluded that there are differences between blood glucose levels before and after nutrition education calendar method. Differences in blood glucose levels can be influenced by controlling diet respondent in accordance with the calendar method in education, but also antidiabetic drugs, and sports. Should be added to the control group to determine objectively the effect of nutrition education on the calendar method.


Author(s):  
INDAH ROHMAWATI ◽  
Dora Dayu Rahma Turista

Coronary arteries are blood vessels that carry oxygen and nutrients to the heart muscle. These vessels can experience constriction due to the accumulation of plaque which causes atherosclerosis. Atherosclerosis is characterized by reduced coronary artery elasticity. Blood glucose levels are one of the factors that cause atherosclerosis. The aims of this study was to determine whether there was a correlation of blood sugar levels with the elasticity of coronary arteries. This study is an analytical study with cross sectional design. The population in this study were all patients who visited the Gipateda Tulungagung treatment clinic that was more than 30 years old and female. Through accidental sampling technique, 30 respondents were obtained. The study was conducted from March 1, 2016 to May 1, 2016. Data was collected using a quantum resonance magnetic analyzer (QMRA) to determine the value of blood sugar levels and the value of elasticity of coronary arteries. The data obtained were analyzed statistically by bivariate linear regression tests to determine whether there was a significant correlation of blood sugar levels with the elasticity of coronary arteries. The results showed that the p value is 0.000 < 0.05, which means that there was a significant correlation between blood sugar levels and the elasticity of the coronary arteries. High blood glucose levels can damage the vascular endothelium and also increasing platelet agegrat, so that can resulting atherosclerosis. Every individual should be able to control blood sugar levels with a healthy lifestyle and early detection regularly to prevent the decrease of coronary arteries elasticity because that can lead to coronary heart disease (CHD).


2021 ◽  
Author(s):  
Shams Mohammad Abrar

AbstractPurposeDiabetes Mellitus (DM) patients were exposed to subacute risk as a result of the unanticipated lockdown. Furthermore, most DM patients were unable to engage in physical activity during that period. This impediment to proper healthcare management had increased Blood Glucose Levels (BGL). Therefore, initiatives must be adopted to prevent the same result in the second lockdown in 2021 for the well-being of patients.MethodThis statistical analysis aimed to assess the rise in BGL of diabetic patients before and during the lockdown. A survey was conducted among the DM patients in the Bangladeshi cohort, who came from various socioeconomic backgrounds and included both men and women. The statistical modeling, performed with the help of stat-ease software, was conducted by applying the Analysis of Variance (ANOVA) method to Response Surface Methodology (RSM).ResultOut of the 3 models applied (quadratic, main effect and sequential sum of squares for 2 factor interaction (2FI)) in 2 different response vectors the 2FI model was the best suited (p value - 0.0441 and 0.0015). The results yielded by the 2FI model were used to evaluate RSM.ConclusionThe analysis had shown a significant rise in the BGL among the DM patients during the lockdown, and the patients with the higher BMI tend to have a more significant increment in the BGL. Male patients experienced a greater rise in BGL. Furthermore, elderly patients with high Random Blood Glucose (RBG) levels before lockdown were more likely to have high RBG levels during the lockdown.


2015 ◽  
Vol 6 (6) ◽  
pp. 11-15 ◽  
Author(s):  
Pinaki Saha ◽  
Piyasa Banerjee ◽  
Prasenjit Pal ◽  
Lakshmisona Auddya ◽  
Santanu Sen ◽  
...  

Introduction: A number of recent literatures suggest a potential role of H2S and H2S modifying agents in the etiology and management of type-2 diabetes mellitus. Objective: The current study was aimed to evaluate the plasma levels of H2S in the patients with type 2 Diabetes mellitus and to find out if there is any relationship of H2S concentrations with the fasting blood glucose levels. Methods: Plasma H2S levels were measured in sixty two recently diagnosed type 2 diabetic patients and compared with similar number of healthy volunteers as controls. Results: The plasma H2S level in the patients ( 81.17 ± 16.40 micromol/l ) is significantly higher (P< 0.001) than the healthy controls (50.69 ± 8.69 micromol/l) and the H2S levels in plasma have significant positive correlation (r= 0.359, P=0.004) with fasting blood glucose levels. Conclusion: The present study has elucidated that the patients with type-2 diabetes mellitus are associated with elevated plasma H2S levels which are well correlated with glucose levels. This reveals a potential the role of H2S modulators towards the management of this non-communicable epidemic disorder. DOI: http://dx.doi.org/10.3126/ajms.v6i6.12532Asian Journal of Medical Sciences Vol.6(6) 2015 11-15


2021 ◽  
Vol 1 ◽  
pp. 1128-1137
Author(s):  
Laili Hikmawati ◽  
S Sugiharto

AbstractDiabetes mellitus (DM) is one of the comorbidities most susceptible to COVID-19 infection. The morbidity and mortality rates for diabetic patients who are infected with COVID-19 are also very high. This is related to blood sugar levels, immunity, and DM complications. The study aimed to describe DM as a comorbid of COVID-19. The study applied a scoping review method, by searching for articles through PubMed and ProQuest. The inclusion criteria are articles published in 2019-2021, and the respondents are diabetic patients. The results show that the average age of diabetic patients who infected COVID-19 was 64.24 years old, and mostly (52.7%) were female. Type 2 DM is most infected compared to other types of DM. The ACE-2 receptor owned by DM patients is the entry point for the SARS-CoV-2 virus into the human body. Blood glucose levels are a factor in the severity of COVID-19 patients with DM. Moreover, it is necessary to consider the administration of antidiabetics in the setting of COVID-19 related to the risk of hypoglycemia or other side effects. The progression of COVID-19 in patients with co-morbidities of diabetes mellitus is influenced by the stability of blood glucose levels and length of suffering. Therefore, it is recommended to monitor blood sugar levels regularly. For diabetic patients, it is advisable to always maintain health protocols because hyperglycemia conditions can stimulate chronic inflammation and weaken the immunity system against infection.Keywords: Comorbid, COVID-19, Diabetes Mellitus, Scoping Review AbstrakDiabetes mellitus (DM) merupakan salah satu penyakit penyerta yang paling rentan terinfeksi COVID-19. Angka morbiditas dan mortalitas pada diabetisi yang terinfeksi COVID-19 pun sangat tinggi. Hal tersebut terkait dengan kadar gula darah, imunitas, dan juga komplikasi dari DM. Penelitian ini bertujuan untuk mendeskripsikan DM sebagai komorbid pada kejadian COVID-19. Penelitian ini menggunakan metode scoping review, dengan mencari artikel melalui PubMed dan ProQuest. Artikel yang dianalisis adalah artikel yang diterbitkan 2019-2021, dengan respondennya adalah pasien DM. Berdasarkan hasil review dari kelima artikel diperoleh rata- rata usia diabetisi yang terinfeksi COVID-19 adalah 64,24 tahun, dimana 52,7% responden berjenis kelain  perempuan. DM tipe 2 merupakan jenis DM yang paling banyak terinfeksi dibandingkan dengan DM tipe lain. Reseptor ACE-2 yang dimiliki pasien DM merupakan pintu masuk virus SARS-CoV-2 kedalam tubuh manusia. Kadar glukosa darah menjadi salah satu faktor tingkat keparahan pasien COVID-19 dengan DM. Dalam penanganannya, perlu pertimbangan dalam pemberian antidiabetika dalam setting COVID-19 terkait dengan risiko hipoglikemia ataupun efek samping lain. Progresifitas COVID-19 pada pasien dengan penyakit penyerta diabetes melitus dipengaruhi oleh kestabilan kadar gula darah dan lama menderita. Oleh karena itu, disarankan untuk dilakukan pemantauan kadar gula darah secara rutin. Bagi para diabetisi, disarankan untuk selalu menjaga protokol kesehatan karena kondisi hiperglikemia dapat merangsang inflamasi kronik dan melemahkan sistem pertahanan tubuh melawan infeksi.Kata kunci : COVID-19, Diabetes Mellitus, Komorbid, Scoping Review


Author(s):  
INDAH ROHMAWATI ◽  
Dora Dayu Rahma Turista

Coronary arteries are blood vessels that carry oxygen and nutrients to the heart muscle. These vessels can experience constriction due to the accumulation of plaque which causes atherosclerosis. Atherosclerosis is characterized by reduced coronary artery elasticity. Blood glucose levels are one of the factors that cause atherosclerosis. The aims of this study was to determine whether there was a correlation of blood sugar levels with the elasticity of coronary arteries. This study is an analytical study with cross sectional design. The population in this study were all patients who visited the Gipateda Tulungagung treatment clinic that was more than 30 years old and female. Through accidental sampling technique, 30 respondents were obtained. The study was conducted from March 1, 2016 to May 1, 2016. Data was collected using a quantum resonance magnetic analyzer (QMRA) to determine the value of blood sugar levels and the value of elasticity of coronary arteries. The data obtained were analyzed statistically by bivariate linear regression tests to determine whether there was a significant correlation of blood sugar levels with the elasticity of coronary arteries. The results showed that the p value is 0.000 < 0.05, which means that there was a significant correlation between blood sugar levels and the elasticity of the coronary arteries. High blood glucose levels can damage the vascular endothelium and also increasing platelet agegrat, so that can resulting atherosclerosis. Every individual should be able to control blood sugar levels with a healthy lifestyle and early detection regularly to prevent the decrease of coronary arteries elasticity because that can lead to coronary heart disease (CHD).


2018 ◽  
Vol 1 (2) ◽  
pp. 5
Author(s):  
Rosalina Rosalina

Diabetes mellitus is a disease or disorder of chronic metabolism with multiethiology characterized by high blood sugar (hyperglycemia). Diabetes Mellitus can not be cured but can be controlled by regulating blood sugar levels. One important factor in controlling blood sugar levels is the role of the family To know the correlation between family's informal role and the control of blood glucose levels in people with diabetes mellitus at RSUD Ungaran Semarang Regency.The design of this study was descriptive correlational with cross sectional approach with the number of population of 176 people and samples of 64 respondents by using accidental sampling method. Data collection tools used questionnaires. Data analysis used SPSS version 23.0. Bivariate analysis was processed by using chi square test. The informal role of the family in people with diabetes mellitus is mostly in good category (75.0%). Control of blood glucose level in people with diabetes mellitus is mostly in good category (62,5%). There is significant correlation between family informal role and blood glucose control in patients with diabetes mellitus at RSUD Ungaran Semarang Regency, with p value 0,043 <0,05 (α). There is correlation between family's informal role and the control of blood glucose levels in people with diabetes mellitus at RSUD Ungaran Semarang Regency.We recommend that patients with DM further improve the control of blood glucose levels by increasing the role of the family so as to prevent the occurrence of complications


2019 ◽  
Vol 2 (1) ◽  
pp. 39-44
Author(s):  
Erik Irham Lutfi

Introduction: Uncontrolled DM hyperglycaemia will cause an increase in osmolarity which will disrupt the body's fluid and electrolyte balance. Rehydration therapy will replace the composition of body fluids caused by hyperosmolarity. Observation of management of hyperglycaemia only focuses on looking at blood sugar levels after rehydration therapy is given without looking at the body's osmolarity as an indicator of body fluid balance. This study aims to analyse changes in osmolarity in hyperglycaemic patients receiving rehydration therapy.Methods: This study was a comparative study with a prospective cohort approach. The number of samples in this study were 56 respondents with data collection using the consecutive sampling technique. Study sample of hyperglycaemic DM patients receiving rehydration therapy at the emergency room at a hospital in Tulungagung. The research instrument used an observation sheet. Data analysis used paired t-test.Results: Based on bivariate analysis there are changes due to rehydration therapy in the osmolarity variable with p value 0.000.Conclusion: Changes in osmolarity occur due to a decrease in blood glucose levels after fluid rehydration is carried out. This further proves that rehydration therapy is very effective in reducing blood glucose levels (hyperosmolarity) in the blood. Continuous osmolarity and hemodynamic examination are very necessary for hyperglycaemic patients with rehydration therapy to determine the effects of rehydration therapy as well as to determine the side effects of rehydration therapy so prevention can be done so that it does not become a problem causing emergency emergency situations.


Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2179
Author(s):  
Wamidh H. Talib ◽  
Asma Ismail Mahmod ◽  
Sara Feras. Abuarab ◽  
Eliza Hasen ◽  
Amer A. Munaim ◽  
...  

Cancer is considered the second leading cause of death worldwide and in 2018 it was responsible for approximately 9.6 million deaths. Globally, about one in six deaths are caused by cancer. A strong correlation was found between diabetes mellitus and carcinogenesis with the most evident correlation was with type 2 diabetes mellitus (T2DM). Research has proven that elevated blood glucose levels take part in cell proliferation and cancer cell progression. However, limited studies were conducted to evaluate the efficiency of conventional therapies in diabetic cancer patients. In this review, the correlation between cancer and diabetes will be discussed and the mechanisms by which the two diseases interact with each other, as well as the therapeutics challenges in treating patients with diabetes and cancer with possible solutions to overcome these challenges. Natural products targeting both diseases were discussed with detailed mechanisms of action. This review will provide a solid base for researchers and physicians to test natural products as adjuvant alternative therapies to treat cancer in diabetic patients.


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