STUDY IN EFFECT OF SILDENAFIL IN MANAGEMENT OF INTRAUTERINE GROWTH RESTRICTION IN MGM MEDICAL COLLEGE & L.S.K HOSPITAL, KISHANGANJ

2021 ◽  
pp. 59-61
Author(s):  
Smriti Singh ◽  
Rahul Raj ◽  
Udyan Sarkar ◽  
Debarshi Jana
Keyword(s):  
Intrauterine Growth Restriction ◽  
Descriptive Study ◽  
Fetal Outcome ◽  
Control Group ◽  
Case Group ◽  
Intrauterine Growth ◽  
Medical College ◽  
Fetal Doppler ◽  
The Mean ◽  
Nicu Admission

Introduction: IUGR is one of the most common complications of pregnancy and major cause of iatrogenic prematurity. Amis and objectives: To study effect of sildenal on pregnancy complicated with IUGR and to see its effect on fetal outcome and perinatal outcome by seeing parameters like increased AC, AFI and liquor, improvement in fetal Doppler parameters and birth weight ,APGAR scoring ,no. of NICU admission. Material and methods: MGM MEDICALCOLLEGE & L.S.K HOSPITAL, KISHANGANJ. Observational, prospective and descriptive study. Conclusion: We found that the mean PRE T/t MCA S/D in Control group was greater that case group which was statistically signicant. It was found that mean PRE T/t MCAPI at Case group was greater that control group which was statistically signicant. It was found that mean POSTT/ t MCA S/D at Control group was greater that case group which was statistically signicant. We found that mean POST T/ t MCA PI at Case group was greater that control group which was statistically signicant. We found that the mean PRE T/t UA PI in case group was greater that control group which was statistically signicant. It was found that mean PRE T/t UARI at Case group was greater that control group which was statistically signicant. It was found that mean POSTT/t UARI at Control group was greater that case group which was statistically signicant.

Is ProBNP a New Marker for Predicting Intrauterine Growth Restriction?

2021 ◽  
Vol 225 (02) ◽  
pp. 125-128
Author(s):  
Hasan Eroğlu ◽  
Nazan Vanlı Tonyalı ◽  
Gokcen Orgul ◽  
Derya Biriken ◽  
Aykan Yucel ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Final Analysis ◽  
First Trimester ◽  
Maternal Serum ◽  
Growth Restriction ◽  
Control Group ◽  
Aneuploidy Screening ◽  
Intrauterine Growth ◽  
Potential Marker ◽  
The Mean

Abstract Purpose To evaluate the usability of first-trimester maternal serum ProBNP levels in the prediction of intrauterine growth restriction (IUGR). Methods In this prospective study, blood samples taken from 500 women who applied to our polyclinic for routine serum aneuploidy screening between the 11–14th gestational weeks were centrifuged. The obtained plasma samples were placed in Eppendorf tubes and stored at −80+°C. For the final analysis, first-trimester maternal serum ProBNP levels of 32 women diagnosed with postpartum IUGR and 32 healthy women randomly selected as the control group were compared. FGR was defined as estimated fetal weight below the 10th percentile for the gestational age. Results The mean ProBNP levels were statistically and significantly higher in the women with intrauterine growth restriction (113.73±94.69 vs. 58.33±47.70 pg/mL, p<0.01). At a cut-off level of 50.93, ProBNP accurately predicted occurrence of IUGR (AUC+= 0.794 (95% confidence interval 0.679–0.910), p+= 0.001) with sensitivity and specificity rates of 78.1 and 69.0%, respectively. Conclusion First-trimester serum ProBNP level was significantly higher in women who developed IUGR compared to healthy controls. First-trimester ProBNP level can be used as a potential marker to predict the development of IUGR in pregnant women.

scholarly journals A prospective case control study of the effects of oligohydramnios on fetomaternal outcome in mothers with term pregnancy in a rural medical college

2018 ◽  
Vol 7 (11) ◽  
pp. 4706
Author(s):  
Dipak Mandi ◽  
Sayantan Sen ◽  
Vasundhara Goswami
Keyword(s):  
Demographic Data ◽  
Tertiary Care ◽  
Birth Asphyxia ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Perinatal Complications ◽  
Medical College ◽  
Increased Risk ◽  
Nicu Admission

Background: The aim of the current study was to assess the fetomaternal effects of oligohydramnios on term pregnancies in a rural tertiary care setup.Methods: A perspective case control hospital-based trial was conducted at Burdwan Medical College and Hospital for a period of one year. Pregnancies at term (37-42 weeks) were included in the study. 103 patients with sonographically diagnosed oligohydramnios were included in the case group. The control group comprised of 103 mothers at term with normal liquor volume. Demographic data and fetomaternal outcome parameters were assessed and compared.Results: There was increased incidence of fetal and perinatal complications including low birth weight, birth asphyxia and NICU admission. There were more perinatal deaths in the case group compared to the control group. Induction of labour, operative delivery, meconium stained liquor and incidence of preeclampsia were also increased in mothers with low AFI.Conclusions: Oligohydramnios is associated with an increased risk of labour and perinatal complications. Adequate antenatal surveillance and intranatal monitoring coupled with correction of underly-ing factors is the mainstay of management.

A STUDY OF HYPERURICACIDEMIA AND THE PRESENCE AND SEVERITY OF ACUTE CORONARY SYNDROME IN INDEX MEDICAL COLLEGE, HOSPITAL AND RESEARCH CENTER, INDORE ( M.P.)

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
B. Khanam ◽  
M. Imran Khan ◽  
Ajay Kumar Singh ◽  
Sumit Solanki ◽  
S.M. Holkar
Keyword(s):  
Acute Coronary Syndrome ◽  
Control Group ◽  
Case Group ◽  
College Hospital ◽  
Medical College ◽  
Coronary Syndrome ◽  
Luminal Stenosis ◽  
Angiographic Evidence ◽  
The Mean ◽  
High Uric Acid

Background: Few studies have assessed the relation of hyperuricacidemia with the acute coronary syndrome (ACS). This study investigated the association between high uric acid levels with the presence and severity of ACS.  Methods: Three hundred and seventy patients having angiographic evidence of atherosclerosis (CAD + case group) compared to 170 patients with no luminal stenosis (n=110) or with <50% luminal stenosis (n=60) at coronary angiography (CAD – control group). Results: The mean age of the patients was 60 ± 10 years (317 men, 58.7%). Hyperuricacidemia was more likely associated with a trend toward higher vessel scores, indicating a more severe CAD (adjusted OR=1.51, 95% CI=1.09-2.09; P=0.005) in the whole population. A comparison of sex-specific values showed a significant association existed only in men. Conclusions: Asymptomatic hyperuricacidemia may be associated with the presence and severity of ACS. Keywords: Hyperuricacidemia, Severity & Acute Coronary Syndrome.

scholarly journals Hematological changes in pregnancy induced hypertension in their third trimester at Jhalawar Medical College, Jhalawar, India

2019 ◽  
Vol 8 (9) ◽  
pp. 3497
Author(s):  
Neelam Jhajharia ◽  
Madhureema Verma
Keyword(s):  
Control Group ◽  
Case Group ◽  
Haematocrit Level ◽  
Haematological Parameter ◽  
Pregnancy Induced Hypertension ◽  
Medical College ◽  
Induced Hypertension ◽  
Life Threatening ◽  
The Mean ◽  
And Control

Background: Pregnancy induced hypertension (PIH) is one of the most common and potential life-threatening complications of pregnancy. This study is aimed to investigate and correlate the hemoglobin, haematocrit, white blood cell count, lymphocytes and platelets in PIH patients in their third trimester.Method: Total 126 subjects were studied out of them 63 patients (case) and 63 healthy pregnant women (control) visiting the Obstetrics and Gynaecology department Jhalawar Medical College, Jhalawar were registered in the study and followed during their pregnancy. Two millilitre of blood sample was drawn aseptically using the 5ml syringe from the median ante cubital vein of all the cases and control participants into EDTA-anticoagulated tubes. Haematological parameter calculated by using Sysmex XN-9100™ Automated Haematology System.Results: The mean hemoglobin level of the case group (8.8206±2.53779) was significantly lower than that of the control group (9.7289±2.47033) (p<0.05). The mean platelet count of the case group (131.4937±62.05999) was significantly lower than that of the control group (324.9683±230.78764) (p<0.05). The mean lymphocytes level of case group (1.2510±0.56369) was significantly lower than that of the control group (1.9295±1.4150) (p<0.05). The mean WBC level of case group (36.3467±119.90635) was significantly high than control group (11.5260±4.83059) (p<0.05). The mean haematocrit level of case group (32.6851±7.29789) was significantly high than control group (30.0424±23.38116) (p<0.05).Conclusion: The mean hemoglobin, mean platelets and mean lymphocytes are lower in PIH patients. The mean WBC and haematocrit are higher in PIH patient. 

Mean Platelet Volume is Affected in Term Fetuses with Intrauterine Growth Restriction

2020 ◽  
Author(s):  
Gul Nihal Buyuk ◽  
Z.Asli Oskovi-Kaplan ◽  
Aysegul Oksuzoglu ◽  
H.Levent Keskin
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Mean Platelet Volume ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Control Group ◽  
Platelet Volume ◽  
Intrauterine Growth ◽  
Potential Marker ◽  
The Mean

Abstract Objectives The aim of our study was to analyze the mean platelet volume levels as a potential marker of altered placentation in intrauterine growth restriction (IUGR) cases. Methods A total of 126 term singleton pregnant women with IUGR fetuses and 345 healthy pregnant controls were recruited and compared. Results The mean platelet volume was significantly higher in the IUGR group (10.8±0.9 fl) than the control group (9.9±1.1 fl) (p=0.03). The mean hemoglobin was lower in IUGR group (11.3 (8.3–14.5) g/dl) than the control group (11.9 (8.2–13.0) g/dl) (p=0.04). The optimal cut-off MPV for prediction of IUGR was ≥10.55 fl, with a sensitivity of 59% and a specificity of 75%. Conclusion Increased MPV levels in term pregnant women may be particularly helpful for discrimination and prediction of high-risk fetuses when IUGR is suspected.

scholarly journals Association of Hypertension and Smoking with Ischaemic Stroke

2013 ◽  
Vol 3 (1) ◽  
pp. 16-18
Author(s):  
K Kirtania ◽  
N Sultana ◽  
S Ahmed ◽  
A Khatun
Keyword(s):  
Cigarette Smoking ◽  
Ischaemic Stroke ◽  
Matched Control ◽  
Strong Relationship ◽  
Control Group ◽  
Case Group ◽  
Medical College ◽  
Study Population ◽  
The Mean ◽  
Control Study

Hypertension is one of the most important modifiable risk factors for ischemic stroke. Cigarette smoking is a risk factor for atherosclerotic disease. There is a strong relationship between hypertension and cigarette smoking with ischaemic stroke. A case control study was undertaken to see the association of hypertension and cigarette smoking with ischaemic stroke. The study was done from January to December 2009 in the Department of Biochemistry, Dhaka Medical College, Dhaka. A total of 60 subjects were selected as study population. Among them 30 were diagnosed case of ischaemic stroke and 30 were age-and sex-matched control subjects. It was found that 60% patients of case group and 20% respondents of control group were hypertensive and diffrence was significant. Study showed that 56.66% of cases and 53.33% of controls were smoker and the findings were insignificant. The mean duration of smoking was 27.41 ± 2.98 years in cases and 15.63 ± 2.85 years in controls which was significant. The study suggests that hypertension is significantly associated with ischaemic stroke and longer duration of smoking also associated with ischaemic stroke. DOI: http://dx.doi.org/10.3329/bjmb.v3i1.13802 Bangladesh J Med Biochem 2010; 3(1): 16-18

Association Between Fetal Thymus Size and Intrauterine Growth Restriction

2021 ◽  
pp. 875647932110547
Author(s):  
Elham Keshavarz ◽  
Marjan Rustazade Sheikhyusefi ◽  
Ensi Khalili Pouya ◽  
Masoumeh Mirzamoradi ◽  
Mehdi Khazaei ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Intrauterine Growth Restriction ◽  
Umbilical Artery ◽  
Growth Restriction ◽  
Control Group ◽  
Fetal Thymus ◽  
Intrauterine Growth ◽  
The Mean ◽  
Thymus Size

Objective: The objective of this study was to evaluate the association between reduced fetal thymus size and intrauterine growth restriction (IUGR). This study was devised to determine the association between thymus size and any abnormal Doppler indices within the fetal umbilical artery (UA), as well as the middle cerebral artery (MCA). Materials and Methods: Forty-six pregnancies between 20 and 38 weeks of gestation with IUGR and 46 normal pregnancies within similar gestational age (GA) range were included. The transverse diameter of fetal thymus was measured. In the IUGR group, the fetal umbilical artery (UA) and middle cerebral artery (MCA) Doppler flow velocities were recorded. Results: The mean GA of fetuses with IUGR (33.5 weeks) was higher than control group (30.3 weeks). To adjust for the effect of GA, analysis of covariance (ANCOVA) was performed. The adjusted mean thymus diameters were 19.02 mm in IUGR and 21.25 within the control group (mean difference = 2.23 mm; P = .02). The mean (±SD) thymus size in 16 fetuses, with abnormal Doppler findings, was significantly lower than in the group with normal Doppler findings, 17.45 (±2.50) vs 22.02 (±5.39) mm; P < .001. Conclusion: IUGR may be associated with reduced fetal thymus size, especially when coupled with abnormal Doppler findings. The thymus size in a group of IUGR fetuses, with abnormal Doppler findings, was smaller than IUGR fetuses, with normal Doppler findings.

scholarly journals Doppler velocimetry of umbilical, and middle cerebral arteries in the prediction of fetal outcome

2017 ◽  
Vol 5 (11) ◽  
pp. 4789
Author(s):  
Sumangali P. K. ◽  
Omana E. K. ◽  
Shabnam S. Nambiar
Keyword(s):  
Intrauterine Growth Restriction ◽  
Umbilical Artery ◽  
Cerebral Arteries ◽  
Fetal Outcome ◽  
Close Monitoring ◽  
Doppler Velocimetry ◽  
Intrauterine Growth ◽  
Medical College ◽  
Non Invasive ◽  
Middle Cerebral Arteries

Background: Doppler ultrasound offers a unique non-invasive technology for investigating fetal, feto placental and utero placental circulation Intrauterine growth restriction is associated with increased perinatal morbidity and mortality.Methods: A hospital based descriptive study of Doppler velocimetry of umbilical Artery and Middle cerebral Artery was carried out in the Department of Obstetrics and Gynecology Pariyaram Medical College over a period of 1 year – April 2016 to March 2017. A total of 180 patients with clinically IUGR were selected for the study. Close monitoring done with daily NST and repeated Doppler study.Results: The S/D ratio in Umbilical artery and RI ratio of MCA is valuable for monitoring growth retarded and small for gestational age fetuses and to take decision for early termination of pregnancy. In our study, perinatal outcome is very good, only 3 NND happened. i.e., due to extreme prematurity.Conclusions: Colour Doppler helps in detection of compromised fetuses in high risk pregnancies like PIH, IUGR and other risk factors likely to cause placental insufficiency. 

scholarly journals Perinatal Outcomes of Hypertensive Pregnancy: A Case Control Study

2019 ◽  
Vol 17 (2) ◽  
pp. 39-42
Author(s):  
Niraj Acharya ◽  
Diwas Dhungana ◽  
Veena Gupta
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Perinatal Outcomes ◽  
College Teaching ◽  
Fetal Outcome ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Low Birth Weight Infants ◽  
Medical College

Background: Hypertensive disorders of pregnancy (HDP) are one of the maternal diseases that cause the most detrimental effects to the mother and the fetus. Objective: This study was conducted to compare the perinatal outcomes of neonates delivered by hypertensive mothers and normal mothers. Methods: This comparative hospital based study was conducted in Nepalgunj Medical College Teaching Hospital, Kohalpur from December 2014 to December 2015. Fifty mothers fulfilling the inclusion criteria and their fetal outcome in form of still birth and newborn babies were taken for the study and 50 healthy mothers with normotensive pregnancies and their newborn babies or fetal outcome were taken as control. They were followed up till their hospital stay in NICU or postnatal ward and final outcomes were noted. Results: The prevalence of HDP in our hospital was 2.16%. Among neonates, 27(54%) in case group and 9(18%) in control group were low birth weight which is statistically significant. It was found that 18(36%) neonates in case group and 7(14%) neonates in control group were IUGR(Intrauterine growth retardation). Seventeen (34%) neonates in case group were preterm as compared to 2(4%) neonates in control group (p value < 0.001). Conclusion: Pregnancies complicated by hypertension were characterized by an increase in the rate of preterm delivery and low birth weight infants compared with normal pregnancies.

scholarly journals Level of Serum Calcium in Psoriatic Patients

2016 ◽  
Vol 5 (2) ◽  
pp. 29-32
Author(s):  
Masuda Khatun ◽  
Mollah Md Abu Sayed ◽  
MD Shah Alam ◽  
Farida Yeasmin ◽  
Lubna Khondker
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
College Hospital ◽  
Medical College ◽  
Control Subjects ◽  
The Mean

Various forms of skin disease like psoriasis have been found to show disturbances in systemic calcium metabolism in some cases. Calcium is the major regulator of keratinocytes differentiation. The main objective of this study was to find out the serum calcium level of patients with psoriasis in comparison with control subjects without psoriasis. The present study was a case control study from July 2015 to June 2016. Consecutive type of sampling method was followed in this study. The case group was consisting of 30 psoriatic patients and the control group was consisting of 30 non psoriatic patients attended in Skin and VD department of Dhaka Medical College Hospital (DMCH) and Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. The mean age of the psoriatic group was 35.57±7.75 years (minimum 22 years and maximum 50 years), while it was 35.17±7.32 years (minimum 23 years and maximum 48 years) in the control group. The mean serum calcium level in psoriatic patients was 8.84±0.95 mg/dl (minimum 7.2mg/dl and maximum 10.2 mg/dl) while in controls it was 9.49±0.90 mg/dl (minimum 7.7 mg/dl and maximum 10.9 mg/dl). Statistical difference was observed between case and control participants with p-value <0.05. Hypocalcemia was observed in 33.33% psoriatic patients as compared 10% in controls (P value <0.05). In conclusion, serum calcium levels were lower in psoriatic patients than in control subjects. It is better to include dairy foods as calcium resource in daily diet of patients suffering from psoriasis. CBMJ 2016 July: Vol. 05 No. 02 P: 29-32

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