scholarly journals Prospective, randomized, and comparative study of efficacy of ivermectin, benzyl benzoate 25%, permethrin 5% and gamma benzene hexachloride 1% in the treatment of uncomplicated scabies

2020 ◽  
Vol 9 (5) ◽  
pp. 712
Author(s):  
K. Chitra ◽  
Swathi Ratnam R. ◽  
J. Sudha ◽  
G. Suryanarayana
Keyword(s):  
Single Dose ◽  
Treatment Modalities ◽  
Efficacy And Safety ◽  
Single Application ◽  
Benzyl Benzoate ◽  
Chi Square ◽  
Medical College ◽  
Number Of Patients ◽  
Intergroup Comparison ◽  
Benzene Hexachloride

Background: Scabies is an infectious and contagious human skin disease. The aim of the study was to study the efficacy and safety of four different treatment modalities in clinically diagnosed cases of scabies of single dose of oral ivermectin and commonly used topical scabicidal agent’s benzyl benzoate 25% (BB), permethrin 5% and gamma benzene hexachloride 1% (GBHC).Methods: This study was carried out in the Department of Dermatology, Andhra Medical College, Visakhapatnam. 200 patients diagnosed of scabies were included in the study during the period from August 2013 to July 2014. The percentage of improvement was compared between four groups. Intergroup comparison between two groups was done Chi square test.Results: In the present study a greater number of patients were students (54.5%). Subsidence of lesion and itching with oral ivermectin given as a single dose (200 μg/kg body weight) was 45 (90%) and 44 (88%), with topical permethrin 5% lotion single application 48 (96%), 47 (94%), with topical GBHC 1% lotion 40 (80%) patients, 38 (76%). Topical application of BB lotion 25% was 38 (76%), and 36 (72%) at fourth week.Conclusions: In the present study permethrin 5% cream was found to be more effective among topical agents. Both BB and GBHC 1% lotion are being inexpensive and they can be used as an alternative treatment in developing country like India.

scholarly journals Comparative efficacy and safety of intra-articular analgesics after knee arthroscopy: a Bayesian network meta-analysis protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e035346
Author(s):  
Yuchen He ◽  
Hongyi He ◽  
Dong-Xing Xie ◽  
Xiaoxiao Li ◽  
Yilun Wang
Keyword(s):  
Single Dose ◽  
Pain Relief ◽  
Bayesian Network ◽  
Knee Arthroscopy ◽  
Meta Analysis ◽  
Arthroscopic Surgery ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
Comparative Efficacy ◽  
Number Of Patients

IntroductionMost of the patients who received arthroscopic knee surgery will suffer moderate to severe pain, which can delay the rehabilitation process and increase the risk of postoperative complications. Therefore, seeking a safe and effective postoperative analgesia is necessary for promoting the application of arthroscopic surgery. This protocol aims to detail a planned systematic review and meta-analysis on the comparative efficacy and safety of single-dose intra-articular injection of analgesics for pain relief after knee arthroscopy.Method and analysisPubMed, Embase, Web of Science and Cochrane Library will be searched from inception to 1 June 2020 to retrieve randomised controlled trials (RCTs) that compared the commonly used single-dose intra-articular analgesics (ie, morphine; bupivacaine (including levobupivacaine); ropivacaine and magnesium alone or in combination) with placebo or between each other for postoperative pain relief among patients who had received knee arthroscopy. The primary outcome is pain intensity at 2-hour and 24-hour postoperatively; the secondary outcomes include side effects (eg, knee effusion, nausea, vomiting and flushing), the number of patients requiring supplementary analgesia and the time to first analgesic request. The methodological quality of the included RCTs will be assessed based on the Cochrane risk of bias table. The Bayesian network meta-analysis will be conducted using WinBUGS V.1.4.3.Ethics and disseminationSince no private or confidential patient data will be contained in the reporting, approval from an ethics committee is not required. Our study raises no ethical issue, and the results will be published in a peer-reviewed journal.PROSPERO registration numberCRD42019130876.

scholarly journals A comparison of sublingual with vaginal administration of misoprostol for induction of labor at term

2017 ◽  
Vol 6 (4) ◽  
pp. 1398
Author(s):  
Monika D. Akare ◽  
Purvi K. Patel
Keyword(s):  
Side Effects ◽  
Induction Of Labor ◽  
Efficacy And Safety ◽  
Vaginal Route ◽  
Chi Square ◽  
Medical College ◽  
Vaginal Administration ◽  
Chi Square Test ◽  
Live Fetus ◽  
Failed Induction

Background: To compare the efficacy and safety of sublingual route of misoprostol with vaginal route of administration.Methods: This study was conducted at Department of Obstetrics and Gynecology, Medical College, Baroda, Gujarat, India. 50 cases each with a singleton term pregnancy and a live fetus requiring induction of labor were allocated to sublingual and vaginal administration of misoprostol. Outcome measures related to labor and maternal and fetal side effects were compared between the 2 groups and evaluated using Chi square test and relative risk (RR) with 95% confidence intervals (CI).Results: The sublingual route of misoprostol was associated with a reduced risk of failed induction, reduced time from initiation to induction, reduced induction to delivery interval and a higher incidence of maternal and fetal side effects. However, the differences were not statistically significant.Conclusions: The sublingual route of administration of misoprostol is comparable in efficacy and safety to the vaginal route for induction.

scholarly journals A COMPARATIVE EVALUATION OF SINGLE DOSE TRANSDERMAL PATCH OF DICLOFENAC VERSUS KETOPROFEN FOR POST OPERATIVE ANALGESIA IN ABDOMINAL HYSRETECTOMY.

2020 ◽  
pp. 1-2
Author(s):  
Gaurav Panchal ◽  
Bhavna Sojitra ◽  
Divyang Shah
Keyword(s):  
Social Sciences ◽  
Single Dose ◽  
Comparative Evaluation ◽  
Diclofenac Sodium ◽  
Abdominal Hysterectomy ◽  
Transdermal Patch ◽  
Efficacy And Safety ◽  
Rescue Analgesia ◽  
Number Of Patients ◽  
To Receive

Introduction: Transdermal patch is very simple and painless method for providing postoperative analgesia. The aim of the study was to compare the efficacy and safety of transdermal patch of ketoprofen in comparion to diclofenac for post operative analgesia. It is randomized observational study. Method: Thirty six patients of 18 to 60 years were randomly allocated to receive either ketoprofen or diclofenac transdermal patch at the end of surgery under spinal anaethesia. Stastical analyasis used, data were analysed using statistical package for social sciences version 15.0 and open EPI software version 2.3. The primary end point is VAS score and total requirement of rescue analgesic first 24 hours of surgery. The secondary end points are time to rescue analgesic and adverse effects like nausea and vomiting. Conclusion: Single dose transdermal patch of Ketoprofen provided better post operative analgesia as compared to diclofenac sodium patch in abdominal hysterectomy (infraumblical surgeries) and less number of patients required rescue analgesia in ketoprofen group.

scholarly journals Conservative management, a preferred first line method for treatment of epistaxis.

2019 ◽  
Vol 26 (11) ◽  
pp. 1998-2002
Author(s):  
Muhammad Awais Javed
Keyword(s):  
Cold Water ◽  
Nasal Packing ◽  
Treatment Modalities ◽  
Chi Square ◽  
Conservative Method ◽  
Number Of Patients ◽  
Chi Square Test ◽  
Number Of Treatment ◽  
Medical University ◽  
Age Range

Epistaxis is defined as hemorrhage from nose where source of bleeding is inside the nose. There are many factors which can precipitate epistaxis. A number of treatment modalities are used for its treatment, conservative measures and nasal packing being the commonest method of treatment. Conservative method is an effective method of treatment and avoids potential complications of nasal packing. Objectives: To assess efficacy of conservative mode of treatment for epistaxis. Study Design: Prospective study. Settings: Department of Otorhinolaryngology, E.N.T. Unit-I, Allied Hospital/ Faisalabad Medical University, Faisalabad. Period: Three months i.e. from 16-10-2018 to 15-01-2019. Sample Size: 60. Material and Method: Procedure: 60 patients were enrolled according to inclusive and exclusive criteria. Conservative measures were applied to patients including cold water gargles, nasal pinching and Trotter’s method. Patients were observed for control of epistaxis and number of patients noted in whom conservative measures were not successful and nasal packing was done. No patient among the sample needed the surgical intervention due to failed conservative measures or nasal packing. Frequency and percentage calculated for data and chi-square test applied and level of <0.05 taken significant. Results: 60 patients enrolled with age range from 5-75 years and mean age as 39.53 years. Out of 60 patients, 38 were male and 22 were females. Out of 60 patients, 42 patients (70%) were treated successfully using conservative measures and 18 patients (30%) were treated with nasal packing. Conclusion: Based upon results of this study, it is concluded that conservative method of treatment of epistaxis is an effective and safe method and avoids potential complications which can occur due to nasal packing.

scholarly journals Study of efficacy and safety of a new local cream ("healer") in the treatment of chronic anal fissure: a prospective, randomized, single-blind, comparative study

2009 ◽  
Vol 46 (3) ◽  
pp. 179-182 ◽  
Author(s):  
Mostafa Yakoot ◽  
M. Abdel Salaam
Keyword(s):  
Anal Fissure ◽  
Chronic Anal Fissure ◽  
Comparative Trial ◽  
Complete Relief ◽  
Efficacy And Safety ◽  
Chi Square ◽  
Lidocaine Group ◽  
Daily Group ◽  
Number Of Patients ◽  
Group B

OBJECTIVES: To determine the efficacy and safety of "healer" cream as monotherapy in the treatment of acute and chronic anal fissure. STUDY DESIGN: A prospective, randomized, single blinded, comparative trial. METHODS: Sixty patients suffering from anal fissure were included in the study. Patients were randomly divided into three groups: group A: treated with "healer" local cream application 3 times daily; group B: treated with nitroglycerine 0.25% local cream 3 times daily; group C: treated with a lidocaine 2% cream applied locally 3 times daily. All the followings were followed up and compared between groups. (1) Visual pain analogue score after defecation; (2) severity of straining and discomfort during defecation; (3) frequency of ulcer healed at 30 days; (4) any side effects or complications. RESULTS: The pain scoring after defecation was significantly reduced in the three treatment groups. The group treated with "healer" isosorbide-di-nitrate showed the greatest reduction of the visual pain analogue score median from 9 before treatment to 3 & 1 after 10 and 20 days respectively, while the median visual pain analogue score in group B treated with nitroglycerine cream was 9 reduced to 4 & 2 after 10 and 20 days respectively, and the median visual pain analogue score in lidocaine group only dropped from 9 to 6 and 4, respectively. The reduction of both pain scoring and defecation scoring with "healer" was statistically significantly greater than the other two treatments by Kruskal-Wallis test, P<0.001. The number of patients experiencing complete relief and passing stools easily after 10 days was significantly higher in "healer" group, by Pearson Chi square = 22.94, P<0.001. After 30 days, the fissures were healed in 18 (90%) of 20 patients in the "healer" group and in 12 (60%) of 20 in the nitroglycerin group, while only 6 (30%) of patients treated with lidocaine cream had their fissures healed by the 30 days treatment. Chi square = 15 (P = 0.001). CONCLUSION: "Healer" is a promising effective and safe line of treatment in acute and chronic anal fissure. The characteristic pharmacokinetics of isosorbide-di-nitrate leads to a better effect than nitroglycerin in healing (more prolonged action). Also the less fast absorption than nitroglycerin leading to a smoother dose concentration curve, may be the cause that headache is less frequent and less severe in "healer" treatment versus nitroglycerin.

scholarly journals Novel Therapy for Pseudocyst of Pinna – An Institutional Study

2018 ◽  
Vol 26 (2) ◽  
pp. 112-116
Author(s):  
Debdulal Chakraborty ◽  
Chiranjib Das
Keyword(s):  
Cost Effective ◽  
Neck Surgery ◽  
Cosmetic Outcome ◽  
Treatment Modalities ◽  
Novel Therapy ◽  
Medical College ◽  
Good Cosmetic Outcome ◽  
Number Of Patients ◽  
Good Cosmetic ◽  
A Prospective Study

Introduction Pseudocyst of pinna is a cystic swelling with collection of serous fluid between the auricular cartilage and perichondrium. Successful treatment of pseudocyst of pinna is challenging because of its high propensity for recurrence and cosmetic deformity. None of the treatment modalities described in literature gives fully satisfactory result. So a novel treatment modality is required which gives good cosmetic outcome with zero recurrence. Materials and Methods                                                        A prospective study was done in the Department of ENT and Head and Neck Surgery of a Government Medical College, West Bengal from April 2014 to March 2017. The effusion was aspirated aseptically with sterilized 10 ml syringe with 18G IV needle. An equal amount of Inj. Dexamethasone and Inj. Gentamicin 80 mg in 1:1 ratio mixed in a new 10 ml syringe was injected into the swelling through the same prick point. Result Most of the patients in this study were males between 31-40 years of age and labourer by profession. Maximum number of patients had swelling involving concha. Only one case of one month old infant had bilateral involvement. All patients were cured without any recurrence or disfigurement. Conclusion The results of present study points to the fact that aspiration and instillation of equal amount of Inj. Dexamethasone and Inj. Gentamicin works very good in treatment of pseudocyst of pinna. This therapy is minimally invasive, less painful, cost-effective and less cumbersome for the surgeon. It gives faster recovery, good cosmetic outcome and recurrence is prevented.

New Trends and Developments in Patients with Severe Aortic Stenosis – Towards Optimal Treatment?

2009 ◽  
Vol 5 (2) ◽  
pp. 81 ◽  
Author(s):  
Martijn WA van Geldorp ◽  
Johanna JM Takkenberg ◽  
Ad JJC Bogers ◽  
A Pieter Kappetein ◽  
◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Severe Aortic Stenosis ◽  
Surgical Techniques ◽  
Treatment Strategies ◽  
Tissue Doppler ◽  
Doppler Imaging ◽  
Treatment Modalities ◽  
Diagnostic Tools ◽  
Number Of Patients ◽  
Transcatheter Valve

Over the next few decades the number of patients diagnosed with aortic stenosis is expected to rise as the population ages and the use of several diagnostic tools expands. This will result in a growing need for both medical and surgical treatment and stimulate the development of new diagnostic and surgical techniques. This article briefly describes the prevalence, pathogenesis and clinical presentation of patients with aortic stenosis and focuses on developments in diagnostic tools, treatment strategies and treatment modalities: the use of echocardiography, tissue Doppler imaging, stress testing and biomarkers is discussed, as well as timing of surgery and the role microsimulation can play in prosthesis selection. Furthermore, newly developed transcatheter valve implantation techniques and their possible role in treating ‘inoperable’ or ‘elderly’ patients are discussed.

Childhood Intussusception: Timely Management Leads to Decreased Surgical Risk

2018 ◽  
Vol 3 (01) ◽  
Author(s):  
Dr. Sunil Kumar Mehra, Dr. Dinesh Kumar Barolia, Dr. Arun Kumar Gupta, Dr. Vinita Chaturv
Keyword(s):  
Operative Procedure ◽  
Delayed Diagnosis ◽  
Diagnostic Methods ◽  
Treatment Modalities ◽  
Surgical Morbidity ◽  
Surgical Risk ◽  
Medical College ◽  
Pneumatic Reduction ◽  
Surgery Department ◽  
Resection And Anastomosis

Intussusception is the most common cause of intestinal obstruction in infants and children in < 1yr of age (1). Intussusception cases usually reported late therefore operative procedure was inevitable and results in significant morbidity and mortality. By this study we emphasized on timely transfer of intussusception case to a pediatric surgical center so as to decrease surgical risk. The surgical morbidity was low in those who were admitted early or directly to our center.  Methods - We retrospectively reviewed cases of intussusception in children <15 years. Children were treated from October 2015 to December 2107 at pediatric surgery department of SMS medical college Jaipur Rajasthan. Age, sex, month of admission, symptom with duration, diagnostic methods, and treatment modalities were recorded and analyzed.  Results - We studied 300 patients with intussusception.272 (90%) were treated surgically. We recently started ultrasonography guided pneumatic reduction and 24(85.7%) out of 28 treated successfully by it. Out of the patients requiring surgery 202 (67.34%) patients were reduced by per-operative manual reduction and in 60(22%) patients resection and anastomosis with 10(3.6%) treated with resection and ileostomy. 25.34% cases have delayed diagnosis and lately  transferred from peripheral hospitals requiring resection and diversion. Conclusion - In conclusion, Intussusception cases usually reported late therefore high likelihood of surgical management. The patients who underwent resection have longer duration of hospital stay.

Perceptions of Final Year Medical Students about Family Medicine as A Career Choice in Pakistan

2020 ◽  
Author(s):  
Dur-e- Nishat
Keyword(s):  
Medical Students ◽  
Family Medicine ◽  
Medical Profession ◽  
Healthcare Services ◽  
Developed Countries ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Medical College ◽  
Chi Square Test

Background: Family medicine is a field in which complete and detailed set of healthcare services are provided to the patients and their families. In developed countries, freshly graduated students choose family medicine as a priority for their career. However, in Pakistan it is not the case. The present study is undertaken to determine the perceptions of final year medical students’ about Family Medicine as a viable career. Methods: A total number of 504 students participated in the study. This was a cross-sectional study. The study participants were in their final year of medical college. Data was collected using a preapproved questionnaire. Data was entered and analyzed via SPSS version 17 and Chi-Square test was used post-stratification. Results: Only 14.3% (n=72) medical students had heard about Family Medicine. Only 18% (n=92) would select family medicine as a profession. The most frequent rationale for choosing the field of Family Medicine was the variety of patients seen in general practice (55.4% n=51). Conclusion: There is a dire need to focus on increasing awareness about the field of family medicine among medical students. The students should be counseled on the advantages along with the disadvantages of choosing this field as a medical profession.

scholarly journals POS1274 THERAPEUTIC MANAGEMENT OF RHEUMATOLOGISTS VERSUS OTORHINOLARYNGOLOGISTS OF CERVICOGENIC DIZZINESS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 921.2-922
Author(s):  
M. Yasmine ◽  
K. Maatallah ◽  
H. Ferjani ◽  
W. Triki ◽  
D. Ben Nsib ◽  
...  
Keyword(s):  
Physical Therapy ◽  
Treatment Approach ◽  
Cross Sectional Study ◽  
Treatment Modalities ◽  
Sectional Study ◽  
Cross Sectional ◽  
Standard Assessment ◽  
Number Of Patients ◽  
Cervicogenic Dizziness ◽  
No Gold Standard

Background:The treatment of patients presenting with cervicogenic dizziness (CGD) may be challenging. Indeed, there is no consensual treatment approach for CGD, nor is there no gold-standard assessment for diagnosis.Objectives:Our study aimed to assess the management of CGD by rheumatologists versus otorhinolaryngologists.Methods:We conducted a cross-sectional study including Tunisian doctors dealing with CGD. Rheumatologists (RTO) and otorhinolaryngologists (ORL) were invited to answer a questionnaire via google form about CGD daily management. Outcomes of interest were treatment modalities.Results:The study included 30 RTO and 32 ORL. Most of the doctors (RTO, vs ORL) were females (88.3%, vs 56.3%), aged between 35 and 45 (43.3%, vs 62.5%), and worked at a private practice (33.3%, vs 59.4%). The number of patients diagnosed with CGD by RTO was as follows: 1-2 per year (33.3%), 1-2 per month (18.8%), 1-2 per week (20%), less than one patient a year (10%) and none in 3.3% of cases. The number of patients diagnosed with CGD by ORL was as follows: 1-2 per year (50%), 1-2 per month (33.3%), 1-2 per week (6.2%), less than one patient a year (15.7%) and none (9.4%). Most patients presenting with CGD were females in both groups (93.1%, vs 82.8% respectively) with a mean age between 36 and 65 (79.3%, vs 82.1%). Most of the respondents declared treating patients with CGD (93.1%, vs 79.1%). Regarding treatment modalities, physical therapy was the most prescribed in both specialties (81.5% and 48.3%, respectively). Only RTO (18.5%) prescribed manual therapy. Concerning medical treatment, anti-inflammatory were the most prescribed drugs in both groups (92.6, and 34.5%, respectively). Sixty-seven percent of RTO prescribed anti-vertigo medication. Interestingly, it was the least prescribed drug by ORL (6.9%). Only RTO (59.3%) prescribed Muscle relaxants.Conclusion:Despite the disparities in the management of CGD, physical therapy remains the first prescribed treatment by Tunisian doctors. Further studies are needed to establish a consensus to treat CGD.Disclosure of Interests:None declared

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