scholarly journals State and prospects of modern research in biotechnology of licens as a medicinal raw material

2021 ◽  
pp. 120-129
Author(s):  
E. F. Semyonova ◽  
I. M. Teplitskaya ◽  
M. A. Goncharov ◽  
D. A. Goncharov
Keyword(s):  
Usnic Acid ◽  
Biologically Active Compounds ◽  
Water Soluble ◽  
Biologically Active ◽  
Raw Material ◽  
Active Compounds ◽  
Alternaria Sp ◽  
Ancient Times ◽  
Methodological Approaches ◽  
Original Experimental Data

Based on the content analysis of the sources of patent and scientific literature on the biotechnology of lichens as a medicinal raw material, systematized modern information is provided, as well as original experimental data regarding the cultivation of botanical species of lichens of various ecological and geographical groups under controlled conditions. Since ancient times, lichens havebeen used as medicines and are included in the pharmacopoeias of various countries. At present, methodological approaches have been developed for the cultivation of lichens (genera Usnea, Rhinocarpon, Umbilicara ) and their components: phycobiont (genera Nostoc, Chlorella ), mycobiont ( Petrusaria pertiza, Leydea parasema, Alternaria sp.). The main biologically active compounds (usnic acid, lichenin, cetrarin, water-soluble vitamins, calcium oxalate) and the pharmacological effects caused by them (antimicrobial, stimulating appetite, enveloping, anti-inflammatory, anti-burn, regenerating). Biotechnological approaches can be implemented for species cloning, reproduction, creation of a bank of cell cultures of lichens and their components in order to preserve economically valuable producers in an active state and develop technologies for obtaining biomass and pharmacologically valuable biologically active compounds.

scholarly journals Lonicera caerulea L. as a Source of Biologically Active Compounds for the Enrichment of Fermented Milk Product

2021 ◽  
Vol 75 (6) ◽  
pp. 449-456
Author(s):  
Dalija Segliņa ◽  
Inta Krasnova ◽  
Sanita Alsiņa
Keyword(s):  
Raw Materials ◽  
Fermented Milk ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Raw Material ◽  
Future Research ◽  
Milk Product ◽  
Lonicera Caerulea ◽  
Active Compounds ◽  
Promising Source

Abstract Lonicera caerulea L., also known as honeysuckle berries, are rich in biologically active compounds, which makes them a valuable raw material for the development of functional foods. The objects of the research were three honeysuckle cultivars (‘Zoluška’, ‘Siņaja Ptica’, ‘Goluboje Vereteno’), four genotypes (No 2A; No 3; No 5; No 8) and kefir, enriched with various amounts (3–10%) of fruit puree. Physical and chemical analyses to determine the qualitative indicators of raw materials and products were performed. The degree of liking of kefir was assessed using sensory analysis: hedonic and line scales. The results obtained showed that among the cultivars the highest content of anthocyanins (1103.5 mg·100 g−1), total phenols (693.3 mg·100 g−1), flavonoids (753.9 mg·100 g−1), and tannins (1.6 mg·100 g−1), were found in ‘Siņaja Ptica’ berries, while among the genotypes, berries of No 8 had the highest concentration of the aforesaid compounds. Both samples also showed the highest antiradical activity: ABTS+• on average by 71.7% and DPPH− by 43.7%. According to the sensory evaluation, kefir with 10% honeysuckle puree was rated the highest. Honeysuckle berries could be used as a promising source of natural anti-oxidants in future research aimed at developing different new products that could meet consumer expectations.

scholarly journals Comparative analysis of the total quantity of flavonoids in domestic and imported raw material of stevia

2020 ◽  
Vol 20 (5-6) ◽  
pp. 164-169
Author(s):  
Evgeny E. Кurdyukov ◽  
Elena F. Semenova ◽  
Aleksandr V. Mitishev ◽  
Yаkov P. Moiseev ◽  
Anna V. Kuznetsova
Keyword(s):  
Medicinal Plants ◽  
Stevia Rebaudiana ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Raw Material ◽  
Total Flavonoids ◽  
Active Compounds ◽  
Phytochemical Study ◽  
Stevia Rebaudiana Bertoni ◽  
Different Origin

Relevance. Standardization of plant raw material derived from stevia is a topical issue, since this plant (Stevia rebaudiana Bertoni) contains sweet diterpene glycosides and is used as a natural sugar substitute. In addition, stevia contains flavonoids which are biologically active compounds that exert antioxidant, anti-inflammatory and capillary-strengthening properties. Currently, spectrophotometric methods are used to identify and quantify flavonoids in medicinal plants. They are fast, convenient and do not require sophisticated equipment. The aim of our paper is comparative phytochemical study of the content of the total flavonoids in stevia raw material of different origin. Materials and methods. The study material was dried stevia leaves (Stevia rebaudiana Bertoni), grown in the Penza Region, the Republic of Crimea, the Krasnodar territory, and raw materials imported from Paraguay and India. The content of the total flavonoids was estimated by differential spectrophotometry calculated with reference to cynaroside. Results. The study of the quantity of flavonoids in the raw material of stevia of different origin was carried out. In the presence of aluminum chloride stevia flavonoids form a complex compound at the absorption maximum of 408 2 nm. The content of flavonoids in different species of stevia are found to range from 1.13% to 1.74%. Conclusion. The obtained results allow to recommend stevia leaves as a source of flavonoids along with other available medicinal plants. It is advisable to classify the complex of flavonoids as the second group of biologically active compounds of stevia leaves.

BIOLOGICALLY ACTIVE COMPOUNDS CONTENE ASSESSMENT IN CINNAMON ROSE (ROSA MAJALIS HERRM.) FRUITS FROM THE KUZBASS FLORA

2021 ◽  
pp. 47-51
Author(s):  
Egorova I.N. ◽  
Maltseva E.M. ◽  
Bolshakov V.V.
Keyword(s):  
Ascorbic Acid ◽  
Organic Acids ◽  
Acid Content ◽  
Ascorbic Acid Content ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Raw Material ◽  
Material Base ◽  
Active Compounds ◽  
The Rose

Cinnamon rose (Rosa majalis Herrm.) is the one of two species of rose hips growing in the Kemerovo region. The rose hips pharmacopoeial raw material are fruits which used as a vitamin agent. The rose hips pharmacological effect is due to the rich complex of biologically active substances contained in its fruits. Cinnamon rose belongs to the high-vitamin species. Ascorbic acid content can reach 4-14% in it. Due to the high content of organic acids and polyphenols, rose hips and preparations based on it have a fairly strong antioxidant effect. They are often used to prevent vitamin C deficiency, which is especially important for the region local population living in a territory with a harsh continental climate, characterized by long cold winters. Therefore, the rose hips from Kuzbass flora further study is an urgent goal to expand the medicinal plant raw material base and to provide the population of the region with a vitamin product. The study was aimed at assessing some biologically active compounds content (tannins, organic acids, ascorbic acid) in the cinnamon rose fruits growing in the region. Ascorbic acid quantitative determination was carried out by HPLC, organic acids and tannins - by titration. The analysis showed that the ascorbic acid content in the raw materials collected in the Topkinsky district of the region reaches 0,450±0,003 %, organic acids - 3,728±0,051 %, which corresponds to the PI requirements for this type of raw material. Tannins quantitative content reaches 5.76 %. Obtained experimental data comparative analysis with the literature confirmed the fact that one of the main factors affecting the rose hips vitamin content is the geographical factor.

Water-soluble polymers for binding hydrophobic biologically active compounds

2015 ◽  
Vol 64 (9) ◽  
pp. 2152-2159 ◽  
Author(s):  
M. L. Levit ◽  
O. V. Nazarova ◽  
T. N. Nekrasova ◽  
A. V. Dobrodumov ◽  
E. F. Panarin
Keyword(s):  
Biologically Active Compounds ◽  
Water Soluble ◽  
Biologically Active ◽  
Active Compounds ◽  
Water Soluble Polymers ◽  
Soluble Polymers

scholarly journals BIOLOGICAL ACTIVE COMPOUNDS SALSOLA TRAGUS L. (CHENOPODIACEAE) AS A PROMISING PHARMACOLOGICAL OBJECT OF UKRAINE

2021 ◽  
Vol 26 (2(49)) ◽  
pp. 23-42
Author(s):  
N. A. Kyrylenko ◽  
F. P. Tkachenko ◽  
О. О. Molodchenkova ◽  
S. V. Baieva
Keyword(s):  
Fatty Acids ◽  
Phenolic Compounds ◽  
Unsaturated Fatty Acids ◽  
Essential Fatty Acids ◽  
Total Content ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Raw Material ◽  
The Black Sea ◽  
Active Compounds

Introduction. Evaluation of high-quality composition and content of biologically active compounds of Salsola tragus grass as promising raw materials for the pharmaceutical industry. Aim. To determine the chemical composition of the above-ground part of the Black Sea species of S. tragus for the purpose of its use in medicine. Materials and Methods. The study of biologically active compounds S. tragus were conducted in the summer of 2020. Grass samples were collected along the field road near the coast of the Tiligul estuary. The above-ground biomass of this species was analysed. The total content of lipids and their fatty acid composition, the content of carbohydrates, phenolic compounds and their derivatives were studied by generally accepted methods. The acidity titre was determined using a solution of oxalic acid. Main results. 11 compounds of phenolic nature, among which 5 phenoloxides (ferulic, cinnamic, caffeic, gallic and chicoric), 1 coumarin (esculetin) and 5 flavonoids (quercetin, rutin, luteolin-7-glucoside, hyperoside, hesperedin) were identified and quantitatively determined. Ferulic and gallic acid prevail among phenolic acids. Among the flavonoids luteoline-7-glucoside and hesperedin prevailed. Grass S. tragus was quite rich on lipid components. In their composition, 8 fatty acids were found. The content was dominated by unsaturated fatty acids with the domination of linoleic and oleic acids – 27.67 and 19.27 % respectively. The largest content among the investigated biologically active compounds of S. tragus belongs to the total carbohydrates (8.31%). The titre of raw material was 1.8%. Conclusions. On the basis of a comprehensive study of biologically active compounds of grass S. Tragus it is possible to conclude that it can be used as a source of phenolic compounds, in particular flavonoids having a significant antioxidant, anti-inflammatory, antitumor, antimony activity, and oleic acid, which positively affects the exchange of cholesterol and essential fatty acids (ω-3 and ω-6) for the production of new phytomedications.

scholarly journals ASSESSMENT OF THE CONTENT OF POLYPHENOLS IN BIOTECHNOLOGICAL RAW MATERIAL IRIS SIBIRICA L. STAR VARIETY IN COMPARISON WITH INTACT PLANTS

2019 ◽  
pp. 239-250 ◽  
Author(s):  
Ekaterina Alekseevna Antipova ◽  
Lyudmila Evdokimovna Kudrikova ◽  
Lyudmila Ivanovn Tikhomirova ◽  
Natalya Grigoryevna Bazarnova ◽  
Marina Yurievna Cheprasova ◽  
...  
Keyword(s):  
Raw Materials ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Raw Material ◽  
Soil Conditions ◽  
Quantitative Composition ◽  
Active Compounds ◽  
Plant Raw Materials ◽  
Intact Plants ◽  
Growing Conditions

Cultivation of plant raw materials in artificial conditions will inevitably lead to a change in the qualitative and quantitative composition of secondary metabolites in comparison with the composition of plants obtained in soil conditions. The study of the metabolic profile of such plants is very important on the one hand for our understanding of temporal (ontogenetic) and spatial changes in the metabolome of plants, on the other hand in the applied plan to obtain an alternative quality medicinal plant raw materials. In this regard, the aim of this study was to study the content of phenolic compounds in biotechnological raw materials Iris sibirica Grade Стерх in comparison with intact plants. As objects of study used plants propagated mikrokanale (regenerants), which were further grown under conditions of hydroponics (hydroponic). Intact plants were harvested in the field at the age of six years. As a result of research in raw materials Iris sibirica Grade Стерх, grown under different conditions, were found following a group of biologically active compound (БАС), corresponding to the genus Iris L.: fenilpropionovoy acid (Komarova and ferulic acid and their derivatives), flavonoids (glycosides of apigenin, apigenin-7-O-glycoside), isoflavones, and phenolic acids (vanillic acid), neytralizuya flavonoids-glycosides (glycosides of kaempferol and apigenin), stilbene. The qualitative composition of biologically active compounds of Iris sibirica Стерх depended on the growing conditions, while the biotechnological raw materials (hydroponic plants) are the closest to intact plants in terms of the content of biologically active compounds.  This allows us to consider the biotechnology of obtaining the raw material Iris sibirica L. based on hydroponic cultivation coupled with the micropropagation in an alternative way.

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