scholarly journals BIOLOGICAL ACTIVE COMPOUNDS SALSOLA TRAGUS L. (CHENOPODIACEAE) AS A PROMISING PHARMACOLOGICAL OBJECT OF UKRAINE

2021 ◽  
Vol 26 (2(49)) ◽  
pp. 23-42
Author(s):  
N. A. Kyrylenko ◽  
F. P. Tkachenko ◽  
О. О. Molodchenkova ◽  
S. V. Baieva
Keyword(s):  
Fatty Acids ◽  
Phenolic Compounds ◽  
Unsaturated Fatty Acids ◽  
Essential Fatty Acids ◽  
Total Content ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Raw Material ◽  
The Black Sea ◽  
Active Compounds

Introduction. Evaluation of high-quality composition and content of biologically active compounds of Salsola tragus grass as promising raw materials for the pharmaceutical industry. Aim. To determine the chemical composition of the above-ground part of the Black Sea species of S. tragus for the purpose of its use in medicine. Materials and Methods. The study of biologically active compounds S. tragus were conducted in the summer of 2020. Grass samples were collected along the field road near the coast of the Tiligul estuary. The above-ground biomass of this species was analysed. The total content of lipids and their fatty acid composition, the content of carbohydrates, phenolic compounds and their derivatives were studied by generally accepted methods. The acidity titre was determined using a solution of oxalic acid. Main results. 11 compounds of phenolic nature, among which 5 phenoloxides (ferulic, cinnamic, caffeic, gallic and chicoric), 1 coumarin (esculetin) and 5 flavonoids (quercetin, rutin, luteolin-7-glucoside, hyperoside, hesperedin) were identified and quantitatively determined. Ferulic and gallic acid prevail among phenolic acids. Among the flavonoids luteoline-7-glucoside and hesperedin prevailed. Grass S. tragus was quite rich on lipid components. In their composition, 8 fatty acids were found. The content was dominated by unsaturated fatty acids with the domination of linoleic and oleic acids – 27.67 and 19.27 % respectively. The largest content among the investigated biologically active compounds of S. tragus belongs to the total carbohydrates (8.31%). The titre of raw material was 1.8%. Conclusions. On the basis of a comprehensive study of biologically active compounds of grass S. Tragus it is possible to conclude that it can be used as a source of phenolic compounds, in particular flavonoids having a significant antioxidant, anti-inflammatory, antitumor, antimony activity, and oleic acid, which positively affects the exchange of cholesterol and essential fatty acids (ω-3 and ω-6) for the production of new phytomedications.

scholarly journals Lonicera caerulea L. as a Source of Biologically Active Compounds for the Enrichment of Fermented Milk Product

2021 ◽  
Vol 75 (6) ◽  
pp. 449-456
Author(s):  
Dalija Segliņa ◽  
Inta Krasnova ◽  
Sanita Alsiņa
Keyword(s):  
Raw Materials ◽  
Fermented Milk ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Raw Material ◽  
Future Research ◽  
Milk Product ◽  
Lonicera Caerulea ◽  
Active Compounds ◽  
Promising Source

Abstract Lonicera caerulea L., also known as honeysuckle berries, are rich in biologically active compounds, which makes them a valuable raw material for the development of functional foods. The objects of the research were three honeysuckle cultivars (‘Zoluška’, ‘Siņaja Ptica’, ‘Goluboje Vereteno’), four genotypes (No 2A; No 3; No 5; No 8) and kefir, enriched with various amounts (3–10%) of fruit puree. Physical and chemical analyses to determine the qualitative indicators of raw materials and products were performed. The degree of liking of kefir was assessed using sensory analysis: hedonic and line scales. The results obtained showed that among the cultivars the highest content of anthocyanins (1103.5 mg·100 g−1), total phenols (693.3 mg·100 g−1), flavonoids (753.9 mg·100 g−1), and tannins (1.6 mg·100 g−1), were found in ‘Siņaja Ptica’ berries, while among the genotypes, berries of No 8 had the highest concentration of the aforesaid compounds. Both samples also showed the highest antiradical activity: ABTS+• on average by 71.7% and DPPH− by 43.7%. According to the sensory evaluation, kefir with 10% honeysuckle puree was rated the highest. Honeysuckle berries could be used as a promising source of natural anti-oxidants in future research aimed at developing different new products that could meet consumer expectations.

scholarly journals Biologically Active Compounds and Antioxidant Activity of the Plants from CSBG SB RAS Collection of the Asteraceae Family

2021 ◽  
Vol 38 ◽  
pp. 00055
Author(s):  
Elena Khramova ◽  
Tatyana Kukushkina ◽  
Tatyana Shaldaeva ◽  
Yuliya Pshenichkina
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Achillea Millefolium ◽  
Artemisia Absinthium ◽  
Tanacetum Vulgare ◽  
Active Compounds ◽  
Artemisia Dracunculus ◽  
Pectin Substances

The article presents Data on the content of biologically active compounds (BAC) and the total phenolic antioxidants activity (TPA) evaluated for leaves and inflorescences of Achillea millefolium, Anthemis tinctoria, Artemisia absinthium, A. dracunculus, Leucanthemum vulgare, Pyrethrum balsamita, P. macrophyllum, Tanacetum vulgare. The leaves and inflorescences of the plants contain flavonols, catechins, tannins, carotenoids, pectin substances. High content of phenolic compounds was found in Artemisia dracunculus and Achillea millefolium (352.34 – 398.99 mg/g of DW). The highest level of catechins was registered in inflorescences (8.01 mg/g) and leaves (4.58 mg/g) of Artemisia absinthium. The content of pectin substances in the studied plants was quite high, with the biggest share of protopectins (50.6 – 95.9 mg/g). The maximum quantity of pectins was found in the leaves and inflorescences of Leucanthemum vulgare (11.2-12.7 mg/g), protopectins – in the leaves of Tanacetum vulgare (95.9 mg/g). The highest content of carotenoids was found in the leaves of plants, except for Leucanthemum vulgare. The highest antioxidant activity was recorded for water-ethanol extracts from leaves of Achillea millefolium (up to 1.09 mg/g) and inflorescences of Artemisia dracunculus (0.94 mg/g) plants due to the increased content of phenolic compounds, in particular flavonols and tannins, compared to the other species.

scholarly journals State and prospects of modern research in biotechnology of licens as a medicinal raw material

2021 ◽  
pp. 120-129
Author(s):  
E. F. Semyonova ◽  
I. M. Teplitskaya ◽  
M. A. Goncharov ◽  
D. A. Goncharov
Keyword(s):  
Usnic Acid ◽  
Biologically Active Compounds ◽  
Water Soluble ◽  
Biologically Active ◽  
Raw Material ◽  
Active Compounds ◽  
Alternaria Sp ◽  
Ancient Times ◽  
Methodological Approaches ◽  
Original Experimental Data

Based on the content analysis of the sources of patent and scientific literature on the biotechnology of lichens as a medicinal raw material, systematized modern information is provided, as well as original experimental data regarding the cultivation of botanical species of lichens of various ecological and geographical groups under controlled conditions. Since ancient times, lichens havebeen used as medicines and are included in the pharmacopoeias of various countries. At present, methodological approaches have been developed for the cultivation of lichens (genera Usnea, Rhinocarpon, Umbilicara ) and their components: phycobiont (genera Nostoc, Chlorella ), mycobiont ( Petrusaria pertiza, Leydea parasema, Alternaria sp.). The main biologically active compounds (usnic acid, lichenin, cetrarin, water-soluble vitamins, calcium oxalate) and the pharmacological effects caused by them (antimicrobial, stimulating appetite, enveloping, anti-inflammatory, anti-burn, regenerating). Biotechnological approaches can be implemented for species cloning, reproduction, creation of a bank of cell cultures of lichens and their components in order to preserve economically valuable producers in an active state and develop technologies for obtaining biomass and pharmacologically valuable biologically active compounds.

scholarly journals Research of biologically active compounds of catalpa (Catalpa bignonioides Walt.)

2020 ◽  
pp. 52-58
Author(s):  
O. V. Demeshko ◽  
S. V. Romanova ◽  
V. V. Kovalyov ◽  
I. I. Batiuchenko
Keyword(s):  
Acetic Acid ◽  
Phenolic Compounds ◽  
Chromatographic Analysis ◽  
Skin Diseases ◽  
Biologically Active Compounds ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Active Compounds ◽  
Chromatographic Paper ◽  
Active Substances

Catalpa bignonioides Walt. (catalpa) the family Bignoniaceae – a tree, which originates from North America. Catalpa bark contains resins and tannins. Monoterpene glycosides were found in the leaf. Catalpa seeds contain up to 30% of eleostearic acid. Decoctions are made of the bark of the tree. They serve as a gastric agent and have an anthelmintic effect. Decoction of the bark exhibits bronchodilator action, is used in the complex treatment of cancer. The leaves are used to treat skin diseases. The infusion of fruits has anti-herpetic and hypoglycemic properties. The aim of the work is to investigate biologically active compounds of the leaves of catalpa bignini. The object of the study was the leaves of common catalpa harvested in the summer of 2018 in Sevastopol. Chemical identification reactions and methods of chromatographic analysis were used to determine the major groups of biologically active substances of the leaves of the catalpa (chromatographic paper Filtrak FN No. 4, Munktell, Czech Republic). Chromatography was performed in pre-selected solvent systems: n-butanol‒acetic acid‒water (BAW) (4:1:2) ‒ I direction and 15% acetic acid ‒ II direction. Identification reactions were performed with aqueous and aqueous-alcoholic extracts of catalpa leaves. The qualitative composition of the phenolic compounds was investigated by paper chromatography. The content of the sum of phenolic compounds, hydroxycyclic acids and flavonoids was determined by the spectrophotometric method. Based on the held reactions and chromatographic analysis, by the characteristic fluorescence in the filtered UV light before and after treatment with chromogenic reagents and the values of Rf in the raw material the presence of the following groups of biologically active substances were determined: flavonoids, phenol glycosides, hydroxycoric acids. According to the chromatographic analysis, at least 9 substances of phenolic nature have been detected in the alcohol-aqueous extracts. For the first time, the presence of the following groups of biologically active substances: hydroxycoric acids, phenologic glycosides, flavonoids was determined in the leaves of catalpa. Quantitative content of natural compounds in the leaves of common catalpa: the sum of phenolic compounds (4,76 ± 0,04%), of hydroxycoric acids (3,42 ± 0,02%), of flavonoids (1,88 ± 0,02%). The results of the study will be used in the development of the draft quality control methods for medicinal plant raw materials.

scholarly journals The effect of aseptic cultivation of Crambe mitridatis Juz. plants on its biochemical composition

2020 ◽  
Vol 17 (2) ◽  
pp. 172-178
Author(s):  
N. O. Pushkarova ◽  
T. M. Kyrpa-Nesmiian ◽  
M. V. Kuchuk
Keyword(s):  
Phenolic Compounds ◽  
Biochemical Composition ◽  
Leaf Explants ◽  
Biologically Active Compounds ◽  
Hydroxycinnamic Acids ◽  
Biologically Active ◽  
Active Compounds ◽  
Petiole Explants ◽  
Aseptic Conditions

The aim of the research was to establish efficient microclonal propagation conditions of endangered Crambe mitridatis plants in vitro and to study the possible effect of aseptic cultivation on biochemical composition (hydroxycinnamic acids, flavonoids, phenolic compounds) of plants. Methods. In vitro plant culture methods were applied. Seeds were used for aseptic culture initiation. Morphogenic potential of root, leaf and petiole explants was studied on Murashige-Skoog medium with addition of plant growth regulators. The content of biologically active compounds was measured using spectrometry in plants grown in aseptic conditions and in the greenhouse. Results. Morphogenic potential of root, leaf and petiole explants was studied and the highest regeneration frequency of plantlets was established for root explants (80 %), for petiole explants (50 %) and the lowest for leaf explants (20 %). It was found that plants cultivated in aseptic conditions have higher hydroxycinnamic acids, flavonoids and phenolic compounds compared to plants grown in vivo. Conclusions. It is advisable to multiply C. mitridatis plants in vitro via root and petiole explants. Aseptic cultivation contributes to synthesis of biologically active compounds (auxin synergists) in C. mitridatis plants.Keywords: in vitro culture, hydroxycinnamic acids, flavonoids, phenolic compounds, Crambe mіtridatis.

scholarly journals Comparative analysis of the total quantity of flavonoids in domestic and imported raw material of stevia

2020 ◽  
Vol 20 (5-6) ◽  
pp. 164-169
Author(s):  
Evgeny E. Кurdyukov ◽  
Elena F. Semenova ◽  
Aleksandr V. Mitishev ◽  
Yаkov P. Moiseev ◽  
Anna V. Kuznetsova
Keyword(s):  
Medicinal Plants ◽  
Stevia Rebaudiana ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Raw Material ◽  
Total Flavonoids ◽  
Active Compounds ◽  
Phytochemical Study ◽  
Stevia Rebaudiana Bertoni ◽  
Different Origin

Relevance. Standardization of plant raw material derived from stevia is a topical issue, since this plant (Stevia rebaudiana Bertoni) contains sweet diterpene glycosides and is used as a natural sugar substitute. In addition, stevia contains flavonoids which are biologically active compounds that exert antioxidant, anti-inflammatory and capillary-strengthening properties. Currently, spectrophotometric methods are used to identify and quantify flavonoids in medicinal plants. They are fast, convenient and do not require sophisticated equipment. The aim of our paper is comparative phytochemical study of the content of the total flavonoids in stevia raw material of different origin. Materials and methods. The study material was dried stevia leaves (Stevia rebaudiana Bertoni), grown in the Penza Region, the Republic of Crimea, the Krasnodar territory, and raw materials imported from Paraguay and India. The content of the total flavonoids was estimated by differential spectrophotometry calculated with reference to cynaroside. Results. The study of the quantity of flavonoids in the raw material of stevia of different origin was carried out. In the presence of aluminum chloride stevia flavonoids form a complex compound at the absorption maximum of 408 2 nm. The content of flavonoids in different species of stevia are found to range from 1.13% to 1.74%. Conclusion. The obtained results allow to recommend stevia leaves as a source of flavonoids along with other available medicinal plants. It is advisable to classify the complex of flavonoids as the second group of biologically active compounds of stevia leaves.

BIOLOGICALLY ACTIVE COMPOUNDS CONTENE ASSESSMENT IN CINNAMON ROSE (ROSA MAJALIS HERRM.) FRUITS FROM THE KUZBASS FLORA

2021 ◽  
pp. 47-51
Author(s):  
Egorova I.N. ◽  
Maltseva E.M. ◽  
Bolshakov V.V.
Keyword(s):  
Ascorbic Acid ◽  
Organic Acids ◽  
Acid Content ◽  
Ascorbic Acid Content ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Raw Material ◽  
Material Base ◽  
Active Compounds ◽  
The Rose

Cinnamon rose (Rosa majalis Herrm.) is the one of two species of rose hips growing in the Kemerovo region. The rose hips pharmacopoeial raw material are fruits which used as a vitamin agent. The rose hips pharmacological effect is due to the rich complex of biologically active substances contained in its fruits. Cinnamon rose belongs to the high-vitamin species. Ascorbic acid content can reach 4-14% in it. Due to the high content of organic acids and polyphenols, rose hips and preparations based on it have a fairly strong antioxidant effect. They are often used to prevent vitamin C deficiency, which is especially important for the region local population living in a territory with a harsh continental climate, characterized by long cold winters. Therefore, the rose hips from Kuzbass flora further study is an urgent goal to expand the medicinal plant raw material base and to provide the population of the region with a vitamin product. The study was aimed at assessing some biologically active compounds content (tannins, organic acids, ascorbic acid) in the cinnamon rose fruits growing in the region. Ascorbic acid quantitative determination was carried out by HPLC, organic acids and tannins - by titration. The analysis showed that the ascorbic acid content in the raw materials collected in the Topkinsky district of the region reaches 0,450±0,003 %, organic acids - 3,728±0,051 %, which corresponds to the PI requirements for this type of raw material. Tannins quantitative content reaches 5.76 %. Obtained experimental data comparative analysis with the literature confirmed the fact that one of the main factors affecting the rose hips vitamin content is the geographical factor.

Biologically Active Compounds from Microalgae and its Health Function

2012 ◽  
Vol 554-556 ◽  
pp. 1709-1712
Author(s):  
Yun Yun Xu ◽  
Tao Zhang ◽  
Lei Chen ◽  
Zhen Rong Lin ◽  
Xiao Yu Ge
Keyword(s):  
Fatty Acids ◽  
Functional Foods ◽  
Biologically Active Compounds ◽  
Human Nutrition ◽  
Biologically Active ◽  
New Drugs ◽  
Health Food ◽  
Active Compounds ◽  
Specialty Chemicals ◽  
Health Function

Microalgae are a biochemically diverse assemblage of microorganisms amenable to fermentation and mass culture.Most of these microalgae species produce unique products like carotenoids，antioxidants，fatty acids，enzymes，polymers，peptides，toxins and sterols.Microalgae might become economic sources of new drugs，other specialty chemicals and functional foods because production can be optimized in controlled culture.This paper introduced the biologically active compounds from microalgae and its health function，studies of microalgae in human nutrition and new trends in microalgae food，researched on microalgal health food，and the development of information was provided.

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