scholarly journals The supplementation effect of Red Dragon fruit’s skin extract on the fasting blood glucose and lipid profiles in male Wistar rats with diabetes mellitus and dyslipidemia

2020 ◽  
Vol 3 (3) ◽  
pp. 87-92
Author(s):  
Stefani Marietta ◽  
AAG Budhiarta ◽  
I Wayan Weta
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Wistar Rats ◽  
Fasting Blood Glucose ◽  
Mean Difference ◽  
Control Group ◽  
Skin Extract ◽  
Before And After ◽  
Male Wistar Rats ◽  
Mean Differences

Background: Flavonoids, saponins, tannins, phenols, and vitamin-C contained in the Red Dragon fruit’s skin have a positive impact on glycemic control and lipid oxidation. This study aimed to determine the effect of Red Dragon fruit’s skin extract on reducing the fasting blood glucose (FBG) and improving the lipid profile of Wistar rats with diabetes and dyslipidemia. Methods: A randomized pre-test post-test control group experimental study was done on 22 male Wistar rats, aged 2-3 months that suffered from diabetes and dyslipidemia. Subjects were divided into the control group (given 2cc distilled water + 9 mg metformin) and the treatment group (given 160 mg red dragon fruit’s skin extract + 9 mg metformin) for 14 days. FBG and lipid profile measurements were done before and after the treatment. Data were analyzed using the compare mean test. Results: There was no significant mean difference of GDP between groups before (p=0.414) and after treatment (p=0.125), total cholesterol between groups before (p = 0.572) and after treatment (p=0.361), triglycerides between groups before (p=0.073) and after treatment (p=0.111). There was a significant mean difference of HDL between groups before (p=0.003) and after treatment (p=0.047), LDL between groups before (p=0.006) and after treatment (p=0.043). Although there were significant mean differences in HDL and LDL between groups before and after treatment, the pre-post treatment of HDL and LDL mean differences showed no significant mean difference (p=0.328 and p=0.704 consecutively). Conclusion: Red Dragon fruit’s skin extract treatment did not significantly reduce the mean FBG and lipid profile levels.

scholarly journals Ekstrak Etanol Daun Jati Belanda (Guazuma ulmifolia Lamk) Memperbaiki Profil Lipid Tikus (Rattus norvegicus) Wistar Jantan Dislipidemia

2020 ◽  
Vol 1 (1) ◽  
pp. 25-30
Author(s):  
Melita Hidajat ◽  
I Gusti Made Aman ◽  
Hendro Sukoco ◽  
Ferbian Milas Siswanto
Keyword(s):  
Treatment Group ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Control Group ◽  
Wistar Strain ◽  
Before And After ◽  
Male Wistar Rats ◽  
Guazuma Ulmifolia

The purpose of this study was to prove that the administration of Jati (Guazuma ulmifolia Lamk) leaves extract improves the lipid profile of dyslipidemic male Wistar rats. Subjects were 20 rats (Rattus norvegicus), male, Wistar strain, dyslipidemia (total cholesterol ≥ 200 mg dl-1), aged 2 months old, weighing 180-200 grams. The control group (10 rats) were given a placebo of 3 ml aquadest (P0) and the treatment group was given extracts of the Jati (Guazuma ulmifolia Lamk) leaves extract of 25 mg kg-1 BW (P1). Before and after treatment for 14 days, total cholesterol, triglyceride, LDL, and HDL levels were examined. The results showed that in the P0 group there were no changes in total cholesterol, triglyceride, LDL, and HDL levels (p>0.05), whereas the P1 group experienced a decrease in total cholesterol, triglyceride and LDL levels (p<0.05) and an increase in HDL levels (p<0.05). The results of this study indicated that the Jati leaves extract was effective to improve the lipid profile of dyslipidemic rats. It was necessary to compare the effectiveness of Jati leaves extract with synthetic dyslipidemia drugs used in the community such as statin.

Effect ofCitrus maximajuice on fasting blood glucose, lipid profile, liver enzyme and body weight

2018 ◽  
Vol 48 (5) ◽  
pp. 755-763 ◽  
Author(s):  
Peace Nwanneka Ani ◽  
Precious Chisom Aginam
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Liver Enzyme ◽  
Wistar Rats ◽  
Fruit Juice ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Potential Contribution ◽  
Content Type

PurposeThis paper aims to investigate the effect ofCitrus maximajuice on fasting blood glucose, lipid profile, liver enzyme and body weight of alloxan-induced diabetic adult wistar rats.Design/methodology/approachThe fruits were thoroughly washed with potable water. They were peeled; the epicarp and seeds were removed. Fruit juice was extracted from the pulp. Animal experiment was carried out using 21 adult male wistar rats weighing about 110-130 g. The rats were categorized into three groups (A-C), with each group consisting of seven rats of similar body weights. Diabetes was induced using alloxan. Rats in Groups A and B were administered 300 mg and 600 mg ofC. maximafruit juice/kg body weight/day, respectively, for 14 days, while Group C rats acted as control and received placebo. Biochemical analysis was performed using standard procedures. Data were analyzed using SPSS, version 21.FindingsBlood glucose of rats in the treated groups decreased significantly (p< 0.05) from 454.7 and 569.7 mg/dl to 149.3 and 297.3 mg/dl, respectively, while the control increased from 257.0 to 46.57 mg/dl. Total cholesterol and triglyceride levels of Group B rats reduced significantly (p< 0.05), while the high-density lipoprotein cholesterol level increased (p< 0.05). Body weight of rats in the treated groups increased significantly (p< 0.05) by 30.1 and 20.2 per cent in Groups A and B, respectively, compared to the control group, which reduced by 0.21 per cent. There was no significant effect on markers of liver damage.Practical implicationsThe rate at which diabetes and other non-communicable diseases increase recently calls for affordable and sustainable management.Social implicationsDiabetes is one of the major health and development challenges of the 21st century, its complications are disabling and life threatening.Originality/valueThe hypoglycemic and hypocholesterolemic properties demonstrated byC. maximafruit juice suggest its potential contribution in reducing/stabilizing blood glucose level and managing complications of diabetes.

scholarly journals Effect of 4-h time restricted feeding on body weight, leptin concentration and lipid profile in healthy non-obese male Wistar rats

2021 ◽  
Author(s):  
Michael A. Olamoyegun ◽  
Folasade O. Ajao ◽  
Marcus O. Iyedupe
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Wistar Rats ◽  
Metabolic Diseases ◽  
Restricted Feeding ◽  
Mean Values ◽  
Male Wistar Rats ◽  
Ad Libitum ◽  
Obese Male

Abstract Background: Obesity greatly increases the risk of metabolic diseases and preventive approaches for obesity are often inadequate to effectively prevent and manage the diseases. Altering feeding time strategy intervention decreases caloric intake without calorie counting and may be an effective therapy. Therefore, this study investigates the effect of 4-h time restricted feeding on body weight, leptin concentration and lipid profile in healthy non-obese male Wistar rats. Methods: Rats placed on time-restricted feeding (TRF) regimen had freely access to food for 4 hour per day at designated periods. Twenty four rats divided into four groups (n=6) were used. Group I animals were placed on a 4 hour per day TRF between 8am-12noon. Group II rats were also placed on a 4 hour per day TRF between 12noon-4pm. Group III rats also placed on a 4 hour per day TRF between 8pm-12 midnight while Group IV rats had access food and water ad libitum. This diet strategy resembles taking only breakfast, lunch or dinner once a day. The study lasted for a period of 4 weeks with daily food intake and weekly body weight determined throughout the period. At the end of the experimental period, blood glucose, lipid profile and leptin concentration were assessed. SPSS 21.0 package was used for data analysis, one-way analysis of variance (ANOVA) was used to compare the mean values of variables among the groups and bonferroni’s posthoc test was used for significance of pair wise comparisons of mean values among the groups. Significance was set at p < 0.05.Results: In this study, the body weights and leptin concentrations of 8pm – 12am and ad libitum groups significantly increased compared with the 8am - 12noon and 12noon -4pm groups. Dyslipidemia was observed in the ad libitum group when compared with the 8am - 12noon and 12noon - 4pm groups. Conclusion: From this study, 4-hr time restricted feeding has beneficial effects on body weight, blood glucose, lipid profile and leptin concentration. This feeding restriction patterns may be helpful in obesity management and in preventing metabolic diseases development in non obese.

scholarly journals Red dragon fruit (Hylocereus spp.) peel marmalade effectively improve blood glucose and lipid profile of hypercholesterolemic wistar rats

2020 ◽  
Vol 9 (1) ◽  
pp. 61-67
Author(s):  
Natalia Desy Putriningtyas ◽  
Intan Permatasari ◽  
Dita Oktaviani ◽  
Anastasia Servia Raha ◽  
Siti Wahyuningsih
Keyword(s):  
Blood Glucose ◽  
Functional Food ◽  
Wistar Rats ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Fruit Peel ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Dragon Fruit ◽  
Significant Difference

Background: Polyphenols, antioxidants, dietary fiber, and vitamin contained in the red dragon fruit peel. Red dragon fruit peel can be processed into marmalade. Red dragon fruit peel marmalade has the potential to be a functional food. Functional food is food that has a physiological function based on scientific studies.Objectives: The objective of this study is to analyze the effect of red dragon fruit peel marmalade on fasting blood glucose levels, HDL, LDL, and triglycerides levels of hypercholesterolemic Wistar rats.Methods: This study used a pre-&post-test control group design. Hypercholesterolemic male Wistar rats were randomly assigned into five groups. Hypercholesterolemia was induced by 1% cholesterol powder and 0.5% cholic acid for two weeks. All groups received standard chow. Samples were grouped into five groups: K-; K+; K1 (0.94 g/kg b.wt/day); K2 (1.41 g/kg b.wt/day); K3 (1.88 g/kg b.wt/day). The intervention was carried out for 28 days. GDP level was measured using the GOD-PAP. HDL, LDL, and triglyceride were analyzed with spectrophotometry. GDP, HDL, LDL, and triglyceride levels were measured twice before fasting. A paired t-test and one-way ANOVA were used to analyze the data.Results: The result showed that K-; K1; K2; K3 had a significant difference between groups before and after the intervention (p<0.05). Red dragon fruit peel Marmalade was able to reduce the levels of GDP, LDL, triglycerides, and increase HDL (p <0.05).Conclusion: Red dragon fruit peel marmalade reduced fasting blood glucose levels, LDL, triglyceride levels, and increased HDL levels of hypercholesterolemic Wistar rats.

scholarly journals Combination treatment of metformin and red fruit (Pandanus conoideus l.) extract increased pancreatic β cell density but had no effect toward fasting blood glucose and glycated albumin levels in diabetic male wistar rats (Rattus norvegicus)

2019 ◽  
Vol 3 (2) ◽  
pp. 38
Author(s):  
Ingrid Rotinsulu ◽  
Wimpie I. Pangkahila ◽  
A.A. Gede Budhiarta
Keyword(s):  
Blood Glucose ◽  
Treatment Group ◽  
Wistar Rats ◽  
Glycated Albumin ◽  
Fasting Blood Glucose ◽  
Albumin Level ◽  
Control Group ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Fruit Extract

Background: Diabetes mellitus (DM) is a degenerative disease associated with premature aging characterized by hyperglycemia. Hyperglycemia in people with DM causes oxidative stress and increases Glycated Albumin level, which is the initial precursor to the formation of AGEs. In turn, AGEs will lead to pancreatic β cell damage and apoptosis. Red fruit (Pandanus conoideus L) contains phytochemicals with antioxidant that has the potential to reduce diabetic complications. Therefore, this study aimed to evaluate the effect of metformin and red fruit extract combination toward blood glucose, glycated albumin and pancreatic β cells density in diabetic rats (Rattus norvegicus). Methods: A post-test only control group study was conducted using 36 male Wistar rats as subject. All subjects were induced for type-2 DM with Streptozotocin and Nicotinamide. The diabetic rats were then divided into 2 groups: the positive control group treated with metformin + placebo and the treatment group treated with metformin + red fruit extract. Pancreatic β cell, fasting blood glucose and glycated albumin assessments were performed after 21 days of treatment. Results: The results showed the mean number of pancreatic β cells in the treatment group was higher than the control group (116.11±33.14 vs 83.20±23.94 cells/visual field; p=0.002). But the mean fasting blood glucose in the treatment group was not significantly different compared to the control group (107.67±14.93 vs. 113.67±11.19 mg/dl; p=0.181). The same result also found in the gycated albumin level (Treatment vs control: 6.97±3.63 vs 6.42±4.01 ng/ml; p=0.666). Conclusion: It can be concluded that the administration of red fruit extract increased the density of pancreatic β cell but did not reduce fasting blood glucose and glycated albumin levels in diabetic Wistar rats.

scholarly journals The Effect of Belimbing Wuluh (Averrhoa Bilimbi L.) and Red Guava (Psidium Guajava L.) Extract on Fasting Blood Glucose Levels of Diabetic Wistar Rats Model

2019 ◽  
Vol 5 (2) ◽  
pp. 57
Author(s):  
Yesi Warisman ◽  
Arinda Lironika Suryana ◽  
Zora Olivia
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Wistar Rats ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Control Group ◽  
Standard Diet ◽  
Glucose Levels ◽  
Blood Glucose Levels

Diabetes mellitus is a metabolic disease with special characteristic which increased blood glucose level (hiperglicemic), its happens because of the abnormality of insulin secretion, insulin mechanisme or both of them. Belimbing wuluh and red guava extract can become alternative functional drink that contain rich of vitamin C to help controlling blood glucose level. The aimed of this study was to determined the effect of belimbing wuluh and red guava extract on blood glucose levels of Rattus novergicus strain Wistar diabetic model. This research was an true experimental study with a randomized post-test control group design. Twentyfour (24) male wistar strain rats weighing 200-250 grams, aged 2-3 months, were divided into 4 groups. The control group (K-) non-diabetic rats, the control group (K+) diabetic rats given standard diet, and the treatment group diabetic rats given standard diet and belimbing wuluh and red guava extract intervetion doses 10,7 ml/day (P1) and 21ml/day (P2). Measurement of pretest posttest fasting blood glucose levels was carried out using biolyzer. The data were analyzed by One Way Anova test. The results showed that there were significant differences in delta pretest and posttest fasting blood glucose levels between all groups. Blood glucose levels decreased at 55.6%. In conclusion, belimbing wuluh and red guava extract 21ml/day most effectively decreased fasting blood glucose levels in diabetic wistar rats moldel.   Keywords: belimbing wuluh, blood glucose level, diabetes mellitus, red guava

Abstract 260: Pedometer-assessed Workplace Walking Program Improves Cardio-Metabolic Profile Among the University’s Workforce

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Praveen Veerabhadrappa ◽  
Sushma Bhat ◽  
Heather Weiss ◽  
Chelsey Michael
Keyword(s):  
Physical Activity ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Fasting Blood Glucose ◽  
Post Intervention ◽  
Glucose Levels ◽  
Walking Intervention ◽  
Metabolic Outcomes ◽  
Before And After ◽  
The University

Introduction- The cost of physical inactivity in the workplace setting is significant. The purpose of this study was to evaluate the association between pedometer-assessed physical activity with cardio-metabolic outcomes such as, body weight, blood glucose levels, lipid profile among the University’s academic faculty and staff. Methods- Twenty nine (9M/20F, 50±6yrs; BMI 28.4±4.2 kg/m 2 ) apparently healthy participants who were sedentary, non-smoking, non-diabetic, free of cardiovascular disease, not on antihypertensive or cholesterol medications were recruited from the University workforce. Fasting blood glucose and lipid profile were analyzed using Cholestech LDX analyzer, before and after intervention. Pedometer settings were personalized and participants were instructed to maintain their regular diet during the study period. Participants completed a pedometer-based walking intervention (step-goal: 10,000-steps/day, 5-days/week, 4-weeks). Results- Baseline vs. post-intervention (Mean±SD) for total cholesterol (202.2±40.1 vs. 193.1±42.1 mg/dl; p≤0.05), blood glucose (101.2±8.7 vs. 97.8±8.9; g/dl; p=0.032), systolic blood pressure (BP; 120.7±11.1 vs. 115.1±11.1 mmHg; p=0.003) and diastolic BP (78.6±6.6 vs. 73.8±5.5 mmHg; p<0.0001) were statistically significant. Step-counts significantly increased from baseline to post-intervention (9057.7±3588.9 vs.10319.2±3177; p=0.021). Change in step-count (wk 1 to wk 4) were associated with changes in blood glucose (r=-0.39; p=0.048); diastolic BP (r=-0.43; p=0.029) and BMI (r=-0.45; p=0.022). Conclusion- Our preliminary study modestly increased workday walking by ~12% over four weeks, and significantly improved the cardio-metabolic outcomes among the University workforce. This suggests that, workplace physical activity programs could contribute to the achievement of 10,000 steps/day, which might maximize physical activity participation.

scholarly journals The Effects of Combined Fruit-Infused Water (Apple, Pineapple, Strawberry, Cucumber) on Blood Pressure and Fasting Blood Glucose in Patients with Metabolic Syndrome

2021 ◽  
Vol 5 (4) ◽  
pp. 313
Author(s):  
Astri Purwanti ◽  
Sugiarto Sugiarto ◽  
Dono Indarto
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Radical Reaction ◽  
Control Group ◽  
Chi Square ◽  
Control Group Design ◽  
Before And After ◽  
Randomized Control

ABSTRACTBackground: Fruit-infused water (FIW) contains antioxidants and potassium as a antihyperglycemic and antihypertension via inhibition or break the chain of radical reaction but has not been proven in patients with MS.Purpose: To evaluate the effects of FIW on blood pressure and fasting blood glucose (FBG) in patients with MS.Method: This is a Randomized-Control Trial with pre-posttest control group design. 24 patients of Cakranegara Health Center who fulfilled the criteria were randomly divided into control (given counseling only) and treatment (counseling + FIW consists of apple, cucumber, pineapple and strawberry in 250 ml water for 14 days) groups. Blood pressure and FBG were measured before and after intervention. Chi Square was used for descriptive analyze, whereas T-test, Mann Whitney and Wilcoxon was used for differences in means.Result: In the treatment group (n=11), systolic and diastolic mean levels were decreased by 5,4 mmHg (p=0,140) and 0,9 mmHg (p=0,792) respectively. However, FBG levels were increased by 9,2 mg/dL (p=0.929). There were no differences on systolic (p=0,448), diastolic (p=0,835) and FBG (p=0,599) between two groups.Conclusion: FIW consumption are unable to improve blood pressure and FBG levels on metabolic syndrome. Keywords: Fruit-Infused Water, Blood Pressure, Fasting Blood Sugar Level, Metabolic Syndrome

scholarly journals RESPON AKTIVITAS TIKUS WISTAR JANTAN AKIBAT KONDISI DIET TINGGI SUKROSA DIUKUR MENGGUNAKAN PEREKAM AKTIVITAS

Jurnal BIOMA ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. 104
Author(s):  
Yanuar Restu Wijaya ◽  
Koekoeh Santoso ◽  
Isdoni Isdoni ◽  
Atin Supiyani
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Feeding Activity ◽  
Control Group ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Track System ◽  
Male Wistar Rats ◽  
Auto Track

Excessive energi consumption play a role in increasing blood glucose levels (hyperglycemia), due to the inability of the hormone insulin to compensate the high blood glucose levels. Blood glucose receptor found in the hypothalamus of VMH (Ventro Medial Hypothalamus) and LH (the Lateral Hypothalamus) is able to detect and change the settings for the feeding activity. The aim of this study was to obtain the relationship between high sucrose feeding on male Wistar rats of behavior and activity. This method uses Wistar rats (Rattus norvegicus) as an animal model. Sixteen rats were grouped into 4 treatment groups. The first group was given additional feed 20% sucrose, the second group was given additional feed 40% sucrose, a third group was given additional feed 60% sucrose, and the last as a control group. This feed given continuously for 70 days.Observation of activities conducted using Opto-varimex® auto-track system ver.4.31. The results showed an corellation between activity based doses of sucrose.

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