scholarly journals Investigation of association between ABO blood groups and COVID-19 clinical severity

2021 ◽  
Vol 8 (12) ◽  
pp. 673-676
Author(s):  
Arzu İrvem ◽  
Abdurrahman Sarmış ◽  
Özlem Akgün Doğan ◽  
Jale Yıldız ◽  
Zafer Habib ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Group ◽  
Blood Groups ◽  
Ct Imaging ◽  
Clinical Severity ◽  
Imaging Findings ◽  
Mortality And Morbidity ◽  
Significant Difference ◽  
Important Center ◽  
Severity Of The Disease

Objective: COVID-19 has been detected in Turkey since March 11, 2020. Istanbul has become an important center of the pandemic in Turkey. Various risk factors for COVID-19 infection, mortality, and morbidity are under investigation. Recent studies have suggested that certain blood groups are risk factors for the disease. The aim of this study is the evaluation the relationship between blood groups and the risk of contracting COVID-19 disease, clinical severity of the disease, and CT (computed tomography) imaging findings. Material and Methods: Age, gender, blood group data, clinical severity and CT images of 300 patients who were positive with RT PCR (Reverse transcription-polymerase chain reaction) and were followed up in the clinic were retrospectively scanned and recorded. The clinical severity of the disease and CT imaging findings were scored, and the data were evaluated statistically. Results: While the incidence of COVID-19 was high in the A blood group, it was low in the 0 blood group. Although there was no significant difference between blood types and clinical severity, the involvement in the B blood group was more severe on CT imaging. Conclusion: People with A blood group should pay more attention to protection and isolation. Investigating this difference and underlying pathogenic mechanisms can guide science with advanced studies.

scholarly journals ABO Blood Group System and the Association with Cardiovascular Risk Factors between Men and Women with Cardiovascular Diseases—A Comparative Study

2020 ◽  
Vol 5 (02) ◽  
pp. 111-116
Author(s):  
Rachana Katna ◽  
Ch Srinivasa Rao ◽  
Aswin Kumar M. ◽  
Farheen Fatima ◽  
Madhuri Taranikanti
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Blood Group ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Blood Groups ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Significant Difference

Abstract Objectives The present study was designed to explore the relation between ABO blood group and cardiovascular risk factors in the patients attending tertiary care hospital in South India. Materials and Methods One hundred nine patients, each male and female with different cardiovascular diseases, were included in the study and their ABO blood groups were analyzed with the cardiovascular risk factors. A detailed history was taken from all the patients regarding cardiovascular risk factors like high blood pressure, diabetes, and lipidemic. Total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, and serum triglycerides were determined for assessing lipidemia. Blood grouping was done using standard tube technique. Red cell and serum grouping was performed and results documented. Association between ABO blood groups and cardiovascular risk factors was done using chi-square test and Spearman’s correlation. Results The distribution of ABO blood groups shows that blood group O (41.28%) was more common in patients followed by group B (29.36%), group A (19.27%), and group AB (10.09%). One-hundred six cases (97.2%) were Rh D positive. A statistically significant difference was observed between gender and total cholesterol, LDL cholesterol and BMI with p value <0.05. In the study population, distribution of major cardiovascular risk factors, especially diabetes mellitus and dyslipidaemia, with ABO blood groups shows that there was no significant difference observed between blood groups and these cardiovascular risk factors. However, statistical significance was there between blood group O and hypertension (p = 0.03). Conclusion There was no significant difference between the blood groups and the major cardiovascular risk factors were diabetes and lipids, but there was an association between blood group O and hypertension.

scholarly journals Association of ABO blood groups with presentation and outcomes of confirmed SARS CoV-2 infection: A prospective study in the largest COVID-19 dedicated hospital in Bangladesh

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249252
Author(s):  
Reaz Mahmud ◽  
Mohammad Aftab Rassel ◽  
Farhana Binte Monayem ◽  
S. K. Jakaria Been Sayeed ◽  
Md Shahidul Islam ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Duration Of Symptoms ◽  
Presenting Symptoms ◽  
Blood Group A ◽  
Group I ◽  
Significant Difference ◽  
Group A ◽  
Group Ii

Background Globally, studies have shown conflicting results regarding the association of blood groups with SARS CoV-2 infection. Objective To observe the association between ABO blood groups and the presentation and outcomes of confirmed COVID-19 cases. Design, setting, and participants This was a prospective cohort study of patients with mild-to-moderately severe COVID-19 infections who presented in the COVID-19 unit of Dhaka Medical College Hospital and were enrolled between 01 June and 25 August, 2020. Patients were followed up for at least 30 days after disease onset. We grouped participants with A-positive and A-negative blood groups into group I and participants with other blood groups into group II. Results The cohort included 438 patients; 52 patients were lost to follow-up, five died, and 381 completed the study. The prevalence of blood group A [144 (32.9%)] was significantly higher among COVID-19 patients than in the general population (p < 0.001). The presenting age [mean (SD)] of group I [42.1 (14.5)] was higher than that of group II [38.8 (12.4), p = 0.014]. Sex (p = 0.23) and co-morbidity (hypertension, p = 0.34; diabetes, p = 0.13) did not differ between the patients in groups I and II. No differences were observed regarding important presenting symptoms, including fever (p = 0.72), cough (p = 0.69), and respiratory distress (p = 0.09). There was no significant difference in the median duration of symptoms in the two group (12 days), and conversion to the next level of severity was observed in 26 (20.6%) and 36 patients (13.8%) in group I and II, respectively. However, persistent positivity of RT-PCR at 14 days of initial positivity was more frequent among the patients in group I [24 (19%)] than among those in group II [29 (11.1%)]. Conclusions The prevalence of blood group A was higher among COVID-19 patients. Although ABO blood groups were not associated with the presentation or recovery period of COVID-19, patients with blood group A had delayed seroconversion.

scholarly journals Blood Groups of Recipients of COVID-19 Convalescent plasma

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S131-S131
Author(s):  
J M Petersen ◽  
D Jhala
Keyword(s):  
Blood Group ◽  
Asian American ◽  
Medical Center ◽  
Blood Groups ◽  
Control Population ◽  
Control Group ◽  
Plasma Therapy ◽  
Unrelated Control ◽  
Significant Difference ◽  
Group B

Abstract Introduction/Objective COVID -19 Convalescent plasma therapy (CCP) is under an FDA Emergency Use Authorization to treat hospitalized patients with COVID-19. However, being ill enough to require hospitalization for COVID-19 is a negative outcome. There is also contradictory literature on whether ABO blood group is associated with worse outcomes with COVID-19 disease. Therefore, we share a regional Veterans Administration Medical Center (VAMC) experience comparing the blood groups of patients intended to receive CCP to a control group of patients positive for SARS-CoV-2. Methods/Case Report A retrospective review of all patients who had CCP ordered in the year 2020 was performed to identify the blood group of these patients, which was compared to a control population of positive patients early in the pandemic (March 17th, 2020 to May 20th, 2020). Results (if a Case Study enter NA) A total of 15 patients had CCP ordered as part of their care with an age range of 56-85 (average 69.7) years of age, entirely male composition, and a racial breakdown of 13 African Americans (86.7%), 1 Caucasian American (6.7%), and 1 Asian American (6.7%). The blood group distribution amongst these 15 patients for CCP was 1 AB+ (6.7%), 5 A+ (33.3%), 4 B+ (26.7%), and 5 O+ (33.3%). The unrelated control population consisted of 81 SARS-CoV-2 positive patients whose blood groups were distributed as 3 group AB (3.7%), 21 group A (25.9%), 15 group B (18.5%), and 42 group O (51.8%). A Chi squared test did not show a statistically significant difference between the two groups in ABO composition. Conclusion The ABO proportions of patients for whom CCP was ordered compared to the control group was not statistically significant. This provides support to the literature arguing that ABO may not be related to worse outcomes such as hospitalization or need for CCP transfusion.

scholarly journals Association of Pre-hypertension with blood groups in young population.

2019 ◽  
Vol 26 (11) ◽  
pp. 1820-1824
Author(s):  
Benash Altaf ◽  
Shireen Jawed ◽  
Fakiha Behram ◽  
Zeeshan Ali Khan ◽  
Shakeela Naz
Keyword(s):  
Blood Group ◽  
Demographic Data ◽  
Cross Sectional Study ◽  
Blood Groups ◽  
P Value ◽  
Continuous Variables ◽  
Cross Sectional ◽  
Blood Group A ◽  
Significant Difference ◽  
Group A

Objectives: Pakistan has highest mortality rate due to hypertension and its complications. Hypertension is a squealed of Pre- hypertension which is believed to start at adolescent and continue to adulthood. Association of blood group with hypertension is evident but still hypothesized. This study aims to find the frequency of prehypertension and its association with blood group. Study Design: Cross sectional study. Setting:  Aziz Fatimah Medical and Dental College, Faisalabad. Period: 15 March’18 to 15 Sep’18. Material and Methods:  It was comprised of in comprised of 100 MBBS students. Demographic data including age, weight, height, waist and hip circumference, and BMI was determined. Blood group was determined with help of conventional slide method. Blood pressure was measured by auscultatory method. Data was analyzed by using SPSS 21. Continuous variables are given in mean and standard deviation. Categorical data was given in frequency and percentages. P value≤ 0.05 is taken as significant. Results: Out of 100 participants most common blood group was group ‘O’ (43%) followed by B (35 %) and AB (13%) and A (9%).36% of total population was pre-hypertensive and 64% were normotensive. Prehypertension is most commonly found in blood group ‘A’ (77%) followed by blood group ‘O’ (46.5%). Significant difference was found in means of SBP (p value= 0.001*) and DBP (p value= 0.000*) among the various blood groups. Conclusion: Most common blood group in studied population was ‘O’ although hypertension was most commonly observed in blood group A followed by ‘O’.

scholarly journals Distribution of ABO, Rhesus D and Subgroups of ABO among Blood Donors in Sokoto, North Western Nigeria

2020 ◽  
pp. 6-13
Author(s):  
A. B. Ibrahim ◽  
H. Attahiru ◽  
O. Erhabor ◽  
P. F. Udomah ◽  
A. Yakubu ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Donors ◽  
Blood Groups ◽  
Blood Group A ◽  
Significant Difference ◽  
Tile Method ◽  
Group A ◽  
The Common ◽  
Group B ◽  
North Western

ABO, Rhesus D and subgroups of ABO are highly immunogenic and are the common cause of antibody production in mismatched blood transfusions, haemolytic transfusion reaction and maternal alloimmunization. The aim of this study was to determine the occurrence of ABO, Rh D and subgroups of ABO among blood donors attending Specialist Hospital Sokoto, Nigeria. ABO, Rhesus D and subgroups of ABO antigen status of 176 blood donors with mean age of 30.44 ± 8.210 years attending Specialist Hospital Sokoto were determined using tile method for ABO and Rh D and conventional tube method for anti- A1, anti- H reagents for ABO subgroups respectively. Among the 176 subjects tested, blood group O+ was the most frequent group with 93 (52.8%), 39 (22.2%) were blood group B+, 37(21.0%) were blood group A+, 5 (2.8%) were blood group AB+, 2 (1.1%) were blood group O-. No data was obtained for A-, B- and AB- blood groups.  Out of 37 A blood groups obtained, 31 (83.8%) had A1 antigens and 6 (16.2%) had A2 antigens. Out of the 5 AB blood groups, all had A1B antigens. The study also shows that there was statistically significant difference between blood group A and ethnic groups (Hausa, Fulani and Yoruba) (p<0.05). Blood group O was found to be the most frequent followed by B, A and AB except among Hausa which revealed a pattern of O> A> B> AB. ABO, subgroups shows majority had A1 followed by A2 and A1B respectively.

scholarly journals Blood Group O Positive is Susceptible for Different Types of Malignancy

KYAMC Journal ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 133-136
Author(s):  
Ayesha Yasmin ◽  
Md Nazmul Alam ◽  
Md Ershadul Haque ◽  
Kamrunnahar Alo ◽  
Badar Uddin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Group ◽  
Genetic Risk ◽  
Blood Groups ◽  
Cancer Center ◽  
Age Group ◽  
Standard Methods ◽  
The World ◽  
Different Types ◽  
Negative Conclusion

Background: Blood group is one of the major genetic risk factors for developing different types of malignancy throughout the world. Objectives: To find out the susceptible blood group in ABO and Rhesus systems in patients with malignancy. Methods and Materials: This study was one at KYAMCH cancer center, Enayetpur, Sirajganj, from October 2018 to February 2019. Total 150 cancer patients attending OPD were included irrespective of age, sex, socioeconomic status. ABO and Rhesus blood groups were determined in laboratory by standard methods. Results: Among 150 patients, 55% were female and 45% were male. Malignancy was predominant in the age group of41-50 years (25.3%) and 33.33% patients were found to have O blood group. Out of the patients, 98.7% had Rh positive of all blood groups of which 32% was belonged to blood group O. Metastasis was found among 34.66% patients and out of this 14.67% were having O blood group. Among 22 metastatic O blood group patients, 90.9% was Rh positive and 9.09% was Rh negative. Conclusion: Various types of malignancy are common among O positive blood group. KYAMC Journal Vol. 10, No.-3, October 2019, Page 133-136

Anti-Von Willebrand Factor Antibody Is Responsible for Lower Levels of Plasma vWF in Blood Group O Individuals.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 254-254 ◽  
Author(s):  
Letian Dai ◽  
Shawn Cotton ◽  
Alistair Macartney ◽  
Geoffrey Savidge ◽  
Anwar Alhaq
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
Bleeding Tendency ◽  
Plasma Samples ◽  
Abo Blood Groups ◽  
Acquired Von Willebrand Syndrome ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Von Willebrand

Abstract Plasma levels of vWF are known to be influenced by ABO blood groups, although the mechanism remains unresolved. Group O individuals have a significantly lower level of plasma vWF than those with group A, B or AB. This relative lower level of plasma vWF may result in a bleeding tendency and a shorter half-life of infused factor VIII in group O individuals. The formation of immune complexes between vWF and autoantibodies has been shown to accelerate vWF clearance from plasma in acquired von Willebrand syndrome. However, so far no evidence has been presented that the presence of autoantibodies against vWF is involved in lowering plasma level of vWF in group O individuals. In the present study, plasma samples were obtained from 199 healthy blood donors of blood group O (50), group A (50), group B (49), and group AB (50). A time-resolved fluorescence immunoassay (TRFIA) was developed to detect anti-vWF IgG in plasma samples. Briefly, 100 μl of diluted plasma was loaded on to duplicated vWF-coated and untreated control wells of a microplate. After incubation and washing, 100 μl of Europium-labeled anti-human IgG conjugate (1:500 dilution) was added to the plate to detect vWF IgG. The time-delayed fluorescence was then measured with a Victor microplate reader (PerkinElmer, Turku, Finland). The fluorescence counts of the control wells were subtracted from those of the vWF-coated wells. The results show that anti-vWF IgG was present in all four blood groups (Table 1). Of these blood groups, group O had the highest anti-vWF IgG level with 9.8 x 105 fluorescence counts, which was 2.7- to 3.5-fold higher than that of group A, B or AB. There was a significant difference in the anti-vWF IgG levels between group O and the rest of group A, B or AB. Quantitative analysis of plasma vWF by ELISA showed that the concentration of plasma vWF of group O was 29 to 35% lower than that of group A, B or AB (Table 1). These results suggest that TRFIA is a sensitive assay for detection of anti-vWF IgG in plasma samples, and the presence of the high level of anti-vWF Ig G in group O individuals may be responsible for lowing plasma vWF by acceleration of vWF clearance. Anti-VWF IgG levels and vWF concentrations in diffeent ABO blood groups Group O (n=50) Group A (n=50) Group B (n=49) Group AB (n=50) Data are presented as a mean ± SD. *P<0.01 compared with group A, B or AB. +P<0.01 compared with group A,B or AB. Anti-vWF IgG (x 105 Fluorescence counts) 9.8 ± 6.9* 2.8 ± 2.8 3.1 ± 3.0 3.6 ± 3.5 Concentration of vWF (% of normal controls) 116 ± 42+ 165 ± 46 165 ± 42 179 ± 49

Frequency and Risk Factors of Red Blood Cell Alloimmunization in Thalassemia Major Patients in Markazi province

2019 ◽  
Author(s):  
Aziz Eghbali MD ◽  
Roghaieh.Rahimi-Afzal MD ◽  
Sarvenaz Mehrabi MD ◽  
Seyed Amir Sanatkar MD ◽  
Morteza Mousavi-Hasanzadeh MD
Keyword(s):  
Risk Factors ◽  
Blood Transfusion ◽  
Genetic Disorders ◽  
Demographic Data ◽  
Thalassemia Major ◽  
Blood Groups ◽  
The Body ◽  
Factors Associated ◽  
Significant Difference ◽  
The Mean

Background: Thalassemia is one of the most common genetic disorders throughout the world. Blood transfusion plays an important role in the treatment of thalassemia but it leads to numerous complications such as iron overload and alloimmunization. This study evaluated the frequency and risk factors associated with alloimmunization in thalassemia major patients living in Markazi province, Iran. Materials and Methods: In this descriptive study, 48 thalassemia major patients who underwent blood transfusion at Amirkabir hospital were included. Patients' demographic data were recorded using a questionnaire. In order to perform alloimmunization screening and autoantibody assessment, patients were referred to Tehran Blood Transfusion Organization Laboratory. Results: The current study was performed on 48 patients with thalassemia major,. The mean age of patients was 12.5 ± 8.3 years. Among patients 26 (54.16%) were male and 22 (45.83%) were female, 13 patients (27.08%) had alloantibodies. Among 48 patients, 19 (39.58%) had undergone splenectomy. The patients' age of the first blood transfusion ranged from 1 month to 14 months      and the mean age of the first blood transfusion was 9.5 ± 7.08 months. The blood transfusion intervals in patients were from 21 days to 40 days and the blood volume received at each transfusion session was 10-15 cc/kg of the body weight. In the current study, the data analysis indicated no significant correlation between alloantibodies and RH phenotype (P=0.43), patients' gender (P=0.9), or blood groups (P=0.4); whereas, a significant correlation was found between alloantibodies and splenectomy (P=0.02) as an increase in the prevalence of alloantibodies was reported in splenectomised patients. Conclusion: No significant difference was found between the patients with and without alloantibodies in terms of the prevalence of Rh phenotype, gender, and blood groups. However, there was a significant difference between the patients with and without alloantibodies in terms of splenectomy. Key words: Allo-immunization, Risk factors, Thalassemia major  

scholarly journals Distribution of ABO Blood Group and Major Cardiovascular Risk Factors with Coronary Heart Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Santanu Biswas ◽  
Pradip K. Ghoshal ◽  
Bhubaneswar Halder ◽  
Nripendranath Mandal
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Blood Group ◽  
Blood Groups ◽  
Control Group ◽  
Abo Blood Group ◽  
Healthy Controls

The purpose of this study is to establish whether ABO blood group is related to coronary heart disease in an individual in Asian Indian Bengali population of eastern part of India. Two hundred and fifty (250) CHD patients and two hundred and fifty (250) age and sex matched healthy subjects were enrolled in the study. ABO blood group distribution in patients was compared with control group. Frequency of major cardiac risk factors was determined to find any correlation between blood groups and cardiovascular risk factors. The distribution of ABO blood groups in patients versus control group was A in 24.00 versus 21.60%, B in 30.80 versus 32.40%, O in 38.40 versus 21.60%, and AB in 6.80 versus 24.40%. The analysis showed significant difference in frequency of O (OR = 1.857, 95%CI = 1.112–3.100,P=0.018) and AB (OR = 0.447, 95%CI = 0.227–0.882,P=0.020) blood group between healthy controls and CHD individuals. Our results may suggest that the AB blood group decreases the risk of CHD in healthy controls, and it might be due to the higher concentration of high density lipoprotein cholesterol (HDL-c), while the O blood group increases the risk of CHD due to lower HDL-c levels in Bengali population of eastern part of India.

ABO Blood Groups as Risk Factors for Thrombosis

1996 ◽  
Vol 2 (3) ◽  
pp. 196-199 ◽  
Author(s):  
Dayse M. Lourenço ◽  
Fausto Miranda ◽  
Letícia H. C. Lopes
Keyword(s):  
Risk Factors ◽  
Blood Group ◽  
Blood Donors ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Arterial Embolism ◽  
Fisher Test ◽  
Vein Thrombosis ◽  
Blood Group A ◽  
Group A

To evaluate the relationship between ABO blood group and thrombosis, we studied 127 patients tak ing oral anti-vitamin K drugs for thromboembolism pro phylaxis and compared them with 700 voluntary blood donors. There were 68 patients with venous thrombosis (VT)—68 with deep vein thrombosis and 8 with pulmo nary embolism—and 51 patients with arterial embolism (AE). There were 61 men and 66 women. Mean age at diagnosis was lower for all women, regardless of if they had VT or AE (43 years) than for men (55 years; Kruskal- Wallis test, p < 0.01). There was an imbalance between blood group A and O frequencies in patients with VT versus blood donors, with a higher frequency of blood group A or a lower frequency of blood group O, repre sented by a high A/O ratio. A/O ratio for blood donors was 0.63; it was 1.50 for men (Fisher test, p = 0.028) and 1.44 for women (Fisher test, p = 0.010). Patients with AE showed the same discrepancy, but it was significant for women (A/O = 2.25; Fisher test, p = 0.026) and not for men (A/O = 0.86; Fisher test, p = 0.836), suggesting that men with AE might have other risk factors for thrombo sis. These data are not conclusive about the causes of the association between ABO blood groups and thrombosis, and prospective studies are needed to verify whether blood typing could have a predictive value for prophylatic measures in clinical and surgical patients.

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