scholarly journals Relationship Between Expression of MAGE-A3 with The Histopathology in NSCLC Patients

2020 ◽  
Vol 40 (2) ◽  
pp. 112-118
Author(s):  
Mokhammad Mukhlis ◽  
Isnin Anang Marhana
Keyword(s):  
Lung Cancer ◽  
Tumor Antigens ◽  
Early Stage ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Exact Test ◽  
Pulmonary Surgery ◽  
Ct Antigens ◽  
Nsclc Patients ◽  
The Relationship

Backgrounds: Most patients with lung cancer was diagnosted in advanced stage (around 57%). Those diagnosed at early stage were only 15%. To increase the cure rate and life expectancy, lung cancer detection should be performed early. Melanoma-associated antigen 3 (MAGE-A3) is a testicular cancer antigen and is widely expressed in various types of tumor tissue. MAGE-A3 is expressed in about 35-40% of NSCLC. Previous research reported the expression of MAGE-A3 in lung cancer was 30-50%. To detect tumor antigens, CT antigens of the MAGE family can be detected through real time polymerase chain reaction (RT-PCR). This study aimed to analyze the relationship between MAGE A3 expression and histopathology type from forceps biopsy specimens in NSCLC patients. Methods: This study was a cross-sectional study conducted on 14 patients with lung cancer in September 2018 to February 2019. Subjects underwent force biopsy with guidance from bronchoscopy in the pulmonary surgery room Dr. Soetomo. The analysis used was the Fisher's exact test. Results: There were six subjects with histopathology type of adenocarcinoma (42.9%) and eight subjects (57.1%) with the histopathology of squamous cell carcinoma. Expression of MAGE-A3 was positive in 5 subjects (35.7%). Conclusions: There was no significant relationship between the expression of MAGE-A3 and the type of histopathology. (J Respir Indo. 2020; 40(2): 113-9)

scholarly journals Effect of number of medications and use of potentially inappropriate medications on frailty among early-stage older outpatients

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yuya Uragami ◽  
Kazuhiro Takikawa ◽  
Hajime Kareki ◽  
Koji Kimura ◽  
Kazuyuki Yamamoto ◽  
...  
Keyword(s):  
Early Stage ◽  
Linear Trend ◽  
Cross Sectional Study ◽  
Potentially Inappropriate Medications ◽  
Sectional Study ◽  
Antithrombotic Drugs ◽  
Cross Sectional ◽  
The Relationship ◽  
Inappropriate Medications ◽  
Frailty Score

Abstract Background Frailty is an urgent concern among an aging population worldwide. However, the relationship between frailty and number and types of medications has not been studied in detail among early-stage older patients, and it is unclear what prescriptions may have a role in preventing frailty. This study aimed to clarify the effects of number of medications and use of potentially inappropriate medications (PIMs) on frailty among early-stage older outpatients in Japan. Methods A cross-sectional study was undertaken. Frailty scores and medications of outpatients aged 65–74 years who regularly visited community pharmacies were investigated. Frailty scores were classified as 0 (non-frailty), 1–2 (pre-frailty), and ≥ 3 (frailty). The association between frailty and number of medications was analyzed by age and compared between PIM use and non-use groups. The proportion of patients who used PIMs was also analyzed by frailty score. Results Of 923 older outpatients, 49 (5.3%) and 318 (34.5%) patients had frailty and pre-frailty scores, respectively. The numbers of medications among patients with pre-frailty and frailty were significantly higher than among those with non-frailty (p <  0.001 for both). A similar increase was shown for PIM use groups aged 69–71 and 72–74 years, but not for the PIM use group aged 65–68 years and all groups without PIM use. An increasing linear trend was observed for the relationship between the proportion of patients who used any PIM, as well as some subcategories of PIMs (such as NSAIDs, benzodiazepines, loop diuretics and antithrombotic drugs) and frailty score. Conclusions Unnecessary medication use among early-stage older outpatients, especially patients aged ≥69 years who use PIMs and many medications, seems to be associated with frailty, but further research is needed to confirm these findings.

scholarly journals Phosphatase Regenerating Liver3 and ECadherin Expression in Epithelial Ovarian Cancer

2017 ◽  
pp. 170-175
Author(s):  
Risma Maharani ◽  
Syahrul Rauf ◽  
Rina Masadah
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Early Stage ◽  
Cross Sectional Study ◽  
Teaching Hospitals ◽  
Advanced Stage ◽  
Cross Sectional ◽  
Exact Test ◽  
Significant Difference ◽  
E Cadherin

Objective: To determine the expression of Phosphatase Regenerating Liver-3 (PRL-3) and E-Cadherin in the epithelial ovarian cancer on various stages and differentiation grades. Method: This was a cross-sectional study design conducted at Obstetrics and Gynecology Department of several teaching hospitals, Faculty of Medicine Universitas Hasanuddin from January to June 2015. The expression of PRL-3 and E-cadherin was assessed immunohistochemically in 40 patients with epithelial ovarian cancer including 15 patients in early stage and 25 patients in advanced stage. We used the Fisher’s exact test with the significance of p0.05). The significant difference was found in the expression of E-cadherin whereas the high expression was shown at early stage than advanced stage (p0.05). This study also pointed out no correlation between the expression of PRL-3 and E-cadherin in epithelial ovarian cancer (p>0.05). Conclusion: PRL-3 overexpression does not decrease E-cadherin expression in epithelial ovarian cancer. Keywords: E-cadherin, epithelial ovarian cancer, PRL-3

scholarly journals Association of epileptiform abnormalities and seizures in Alzheimer disease

Neurology ◽  
2020 ◽  
Vol 95 (16) ◽  
pp. e2259-e2270 ◽  
Author(s):  
Alice D. Lam ◽  
Rani A. Sarkis ◽  
Kyle R. Pellerin ◽  
Jin Jing ◽  
Barbara A. Dworetzky ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Late Onset ◽  
Early Stage ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Cognitively Normal ◽  
Scalp Eeg ◽  
Epileptiform Discharges ◽  
Potential Biomarker ◽  
The Relationship

ObjectiveTo examine the relationship between scalp EEG biomarkers of hyperexcitability in Alzheimer disease (AD) and to determine how these electric biomarkers relate to the clinical expression of seizures in AD.MethodsIn this cross-sectional study, we performed 24-hour ambulatory scalp EEGs on 43 cognitively normal elderly healthy controls (HC), 41 participants with early-stage AD with no history or risk factors for epilepsy (AD-NoEp), and 15 participants with early-stage AD with late-onset epilepsy related to AD (AD-Ep). Two epileptologists blinded to diagnosis visually reviewed all EEGs and annotated all potential epileptiform abnormalities. A panel of 9 epileptologists blinded to diagnosis was then surveyed to generate a consensus interpretation of epileptiform abnormalities in each EEG.ResultsEpileptiform abnormalities were seen in 53% of AD-Ep, 22% of AD-NoEp, and 4.7% of HC. Specific features of epileptiform discharges, including high frequency, robust morphology, right temporal location, and occurrence during wakefulness and REM, were associated with clinical seizures in AD. Multiple EEG biomarkers concordantly demonstrated a pattern of left temporal lobe hyperexcitability in early stages of AD, whereas clinical seizures in AD were often associated with bitemporal hyperexcitability. Frequent small sharp spikes were specifically associated with epileptiform EEGs and thus identified as a potential biomarker of hyperexcitability in AD.ConclusionEpileptiform abnormalities are common in AD but not all equivalent. Specific features of epileptiform discharges are associated with clinical seizures in AD. Given the difficulty recognizing clinical seizures in AD, these EEG features could provide guidance on which patients with AD are at high risk for clinical seizures.

scholarly journals Correlation of Ship Sanitation with Cockroach Density in Kendari Port Area

2021 ◽  
Vol 4 (1) ◽  
pp. 102-112
Author(s):  
Sriwani Supardin
Keyword(s):  
High Risk ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Exact Test ◽  
Fisher's Exact Test ◽  
Port Area ◽  
Fisher’S Exact Test ◽  
The Relationship

Ship sanitation is an indicator of vessel cleanliness, vector control in 2017 no high-risk vessels were found, in 2018 there were 7 high-risk vessels and in 2019 there were 15 high-risk vessels. This study aims to determine the relationship between kitchen sanitation, food raft space and warehouse with cockroach density on ships in the Kendari port area. This type of research is an observational, Cross-Sectional Study design. The population is all ships berthed in the Kendari port area as many as 41 ships and a sample of 37 vessels taken by purposive sampling. Data analysis used fisher's exact test. The results showed that of the 37 ships, the highest density of cockroaches met the requirements (75.7%), the rest did not meet the requirements (24.3%). The kitchen sanitation met the requirements (75.7%), the rest did not meet the requirements (24.3%), then the food raft room sanitation met the requirements (83.8%) and did not meet the requirements (16.2%). Furthermore, warehouse sanitation fulfills the requirements (62.2%) and does not meet the requirements (37.8%). The results of Fisher's exact test obtained p value (0,000). The conclusion of this study is that there is a relationship between kitchen sanitation, food raft space and warehouse with cockroach density on ships in the Kendari port area. Suggestions for the KKP to establish policies to prevent cockroach development.

scholarly journals HUBUNGAN KEBIASAAN MEROKOK DENGAN KEJADIAN HIPERTENSI PADA LANSIA LAKI-LAKI DI DESA BEKKU KECAMATAN AWANGPONE KABUPATEN BONE

2021 ◽  
Vol 5 (2) ◽  
pp. 898-903
Author(s):  
Ruslang Ruslang ◽  
Nirmawati Darwis ◽  
Tetti Surianti ◽  
Riki Rusanda
Keyword(s):  
Smoking Habit ◽  
Cross Sectional Study ◽  
Smoking Habits ◽  
Fisher Exact Test ◽  
Sectional Study ◽  
Elderly Men ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
The Relationship

ABSTRACT The prevalence of hypertension increases in line with the lifestyle of elderly men that harm their own health, namely smoking which without them knowing it can cause hypertension. The purpose of this study was to determine the relationship between smoking habits and the incidence of hypertension in elderly men in Bekku Village, Awangpone District, Bone Regency. The purpose of this study was to determine the relationship between smoking habits and the incidence of hypertension. This type of research is quantitative research with a Cross Sectional Study approach. Data were collected through a questionnaire given to each respondent. The analysis test used a computer program, namely SPSS 21 to assess the frequency statistical data and the Chi-Square test on the bivariate variable obtained the Fisher exact test value, on the smoking habit variable the value of = 0.01 < 0.05, so it can be stated that there is a relationship between Smoking Habits with Hypertension Incidence in Elderly Males in Bekku Village, Awangpone District, Bone Regency. The researcher's suggestion is for elderly men in Bekku Village to reduce their smoking habits so that their hypertension does not continue. Keywords : Hypertension, Smoking, Elderly Male ABSTRAK Prevalensi hipertensi meingkat sejalan dengan gaya hidup lanjut usia laki-laki yang merugikan kesehatan mereka sendiri yakni kebiasaan merokok yang tanpa mereka sadari dapat menyebabkan terjadinya hipertensi. Tujuan penelitian ini untuk mengetahui Hubungan Kebiasaan Merokok Dengan Kejadian Hipertensi Pada Lanjut Usia Laki-Laki Di Desa Bekku Kecamatan Awangpone Kabupaten Bone. Tujuan penelitian ini untuk mengetahui hubungan kebiasaan merokok dengan kejadian hipertensi. Jenis penelitian ini yaitu penelitian kuantitatif dengan pendekatan Cross Sectional Study. Data dikumpulkan melalui kuesioner yang diberikan kepada masing-masing responden. Uji analisis menggunakan program komputer yaitu SPSS 21 untuk menilai data statistik frekuensi dan uji Chi-Square pada pada variabel bivariat diperoleh nilai fisher exact test, pada variabel kebiasaan merokok diperoleh nilai ρ=0,01< α=0,05, sehingga dapat dinyatakan ada hubungan antara Kebiasaan Merokok Dengan Kejadian Hipertensi Pada Lanjut Usia Laki-Laki Di Desa Bekku Kecamatan Awangpone Kabupaten Bone. Adapun saran peniliti yaitu bagi para lanjut usia laki-laki di desa bekku agar kebiasaan merokoknya dikurangi agar penyakit hipertensi yang dideritanya tidak terus berlanjut. Kata Kunci : Hipertensi, Merokok, Lanjut Usia Laki- Laki

scholarly journals Evidence for the Continued Occurrence of Chorioretinopathy in Working Sheep Dogs in New Zealand in 2010

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2229
Author(s):  
Adam B. O’Connell ◽  
A. Craig Irving ◽  
Paul L. Hughes ◽  
Naomi Cogger ◽  
Boyd R. Jones ◽  
...  
Keyword(s):  
New Zealand ◽  
Cross Sectional Study ◽  
P Value ◽  
Fisher Exact Test ◽  
Cross Sectional ◽  
Exact Test ◽  
South West ◽  
Chi Squared ◽  
The Relationship

A study in conducted 1987 by Hughes et al., found that 39% of working sheep dogs had multifocal retinitis. One of the identified causes was ocular larval migrans, which were a result of migrating ascarid larvae. Since that paper was published, anthelmintic use in farm dogs has been highly recommended. There has been no follow-up study to determine if fundic lesions are still present. The current study aimed to investigate the prevalence of chorioretinopathy in working sheep dogs in the South-West, Waikato, New Zealand. This was a cross-sectional study of 184 working sheep dogs and 51 owners, undertaken in 2010 with owners sampled from New Zealand’s South-West Waikato and Tux North Island Dog Trial Championship. Two-way tables were used to explore the relationship between variables. Significance of association was assessed using a Chi-squared or Fisher exact test as appropriate, with a p-value of <0.05 considered significant. Overall prevalence of chorioretinopathy in the working sheep dogs was 44/184 (24%). A significantly higher prevalence of chorioretinopathy was shown in dogs with increasing age, from 2 years to >8 years (p = 0.0007) and in males (p < 0.0001). This study concluded that lesions of chorioretinopathy are still present in working sheep dogs in New Zealand.

scholarly journals Self-Efficacy Mediates The Relationship Between Social Support And Psychological Resilience In Patients With Lung Cancer: A Cross-Sectional Study

2021 ◽  
Author(s):  
Yizhen Yin ◽  
Jie Zhang ◽  
Mengmemg Lv ◽  
Hui Li ◽  
Huiyuan Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Social Support ◽  
Self Efficacy ◽  
Cross Sectional Study ◽  
Mediating Effect ◽  
Chinese Version ◽  
Psychological Resilience ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

Abstract Purpose: The prognosis of patients with lung cancer might be influenced by mental health. Psychological resilience is one of the important indicators to reflect the psychological state. It has been shown that patients with higher social support and self-efficacy have better psychological resilience. The aim of this study was to determine whether or not self-efficacy mediates the relationship between social support and psychological resilience in patients with lung cancer.Methods: A cross-sectional study of 303 lung cancer patients was conducted. Participants completed questionnaires, including the Chinese version of the Perceived Social Support Seale Scale, the Chinese version of Strategies Used by People to Promote Health Scale, and the Chinese version of the Connor-Davidson Resilience Scale. Results: Mediation analysis indicated that self-efficacy had a partially mediating effect between social support and psychological resilience. Direct paths from social support to self-efficacy, self-efficacy to psychological resilience, and social support to psychological resilience were significant (p< 0.001). Moreover, indirect paths from social support to self-efficacy and self-efficacy to psychological resilience were also significant at the 95% level [0.120–0.550]; the mediating effect accounted for 38.16% of the total effect.Conclusions: Self-efficacy plays an important role in the relationships between social support and psychological resilience in cancer patients. Social support not only directly influenced the psychological resilience, but also indirectly influenced psychological resilience through self-efficacy.

scholarly journals The Relationship Between COVID-19-induced Death and Chronic Diseases

2021 ◽  
Vol 7 (3) ◽  
pp. 167-174
Author(s):  
Hasan Alinejad ◽  
◽  
Reza Vazirinejad ◽  
Ahmadreza Sayadi ◽  
Zeinab Hajaliakbari ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Multivariate Regression Analysis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Exact Test ◽  
Risk Of Death ◽  
Kaplan Meier ◽  
Increased Risk ◽  
Chi Squared ◽  
The Relationship

Background: Morbidity and mortality due to Coronavirus Disease 2019 (COVID-19) are mainly related to age and comorbidity diseases (hypertension, diabetes, cardiovascular disease, malignancies, etc.). These conditions are associated with poorer clinical outcomes and sometimes lead to long-term hospitalization. The current study aimed to investigate the relationship between COVID-19-induced mortality and various chronic diseases in patients admitted to Ali Ibn Abitaleb Hospital in Rafsanjan City, Iran, in 2020. Methods: In this retrospective, descriptive, and cross-sectional study, patients with COVID-19 referring to Ali Ibn Abitaleb Hospital in Rafsanjan City, Iran, from March 2020 to September 2020 were assessed. The required data were collected using patients’ records and telephone calls by a researcher-made checklist and analyzed by Independent Samples t-test, Chi-squared test, Fisher’s Exact test, Kaplan-Meier plots, and multivariate regression analysis in SPSS v. 20. Results: This study assessed 238 hospitalized patients with COVID-19. The risk of death was significantly higher in patients aged over 75 years; they were 5.5 times more prone to expire, compared to the youngest age group (P<0.001). Chronic diseases, such as hypertension, heart disease, lung disease, and various cancers were more prevalent in patients who expired, compared to those who survived (P≤0.05). Of the patients who died, 73.8% were transferred to the Intensive U (ICU), while only 7.5% of surviving patients were transferred to the ICU (P<0.001). Longer hospitalization was associated with an increased risk of death among patients with underlying diseases and hypertension (P<0.05). Conclusion: This study identified the role of chronic diseases and other important indicators in the survival of patients with COVID-19 who were admitted to a hospital in Rafsanjan. It is recommended that nurses and healthcare staff consider these findings in the care of patients with COVID-19.

scholarly journals The Relationship between Family’s Assessment Support and MDR TB Patient’s Adherence on Treatment in RSUD Dr. Soetomo Surabaya

2019 ◽  
Vol 10 (2) ◽  
pp. 75
Author(s):  
Safira Nur Ainiyah ◽  
Soedarsono Soedarsono ◽  
Pirlina Umiastuti
Keyword(s):  
Cross Sectional Study ◽  
Fisher Exact Test ◽  
Treatment Needs ◽  
Cross Sectional ◽  
Exact Test ◽  
Resistant Tuberculosis ◽  
Multi Drug Resistant Tuberculosis ◽  
Mdr Tb ◽  
Long Time ◽  
The Relationship

Introduction: Multi Drug-Resistant Tuberculosis (MDR TB) is caused by Mycobacterium tuberculosis and has been resistant to isoniazid and rifampicin. Its treatment needs long time and causes some side effects which can make the patients non-adherent so that family support is needed. This study aims to know the relationship between family’s assessment support and MDR TB patient’s adherence on treatment in RSUD Dr. Soetomo Surabaya. Methods: This was an analytic observational cross-sectional study, to know the frequency distribution of family’s assessment support, MDR TB patient’s adherence, and the relationship between them in 24 MDR TB patients, recruited from MDR TB Clinic, RSUD Dr. Soetomo, Surabaya, from October 2017 to June 2018 and their family. The analysis was descriptive statistic and inferential statistic using Fisher Exact Test. Results: The results of this study showed that 83.3% of MDR TB patients’ family give high assessment support and 58.3% of MDR TB patients in RSUD Dr. Soetomo from October 2017 to June 2018 have high adherence on treatment. There is significant (p = 0.020), moderate (c = 0.468), and direct relationship between family’s assessment support and MDR TB patient’s adherence on treatment in RSUD Dr. Soetomo Surabaya. Conclusion: To improve MDR TB patient’s adherence on treatment, family must give high assessment support.

Sign in / Sign up

Export Citation Format

Share Document