scholarly journals New opportunities for treatment of severe bronchial asthma: from clinical studies to portraits of patients

2015 ◽  
Vol 12 (3) ◽  
pp. 51-61
Author(s):  
N M Nenasheva
Keyword(s):  
Quality Of Life ◽  
Severe Asthma ◽  
Bronchial Asthma ◽  
Significant Proportion ◽  
Poor Quality ◽  
New Class ◽  
Definition Of ◽  
First Time

The proportion of patients with controlled asthma has increased over the last 15 years, however, still there is a significant proportion of patients who do not achieve control of the disease, and therefore have a high risk of exacerbations, hospitalizations, and poor quality of life. Patients with severe asthma, for which there were limited additional pharmacotherapy are the major problem. For the first time in recent years in the treatment of asthma a new class of drugs appeared: longacting anticholinergics - tiotropium which had been entered in stepwise therapy of asthma by GINA 2015. The definition of severe asthma, the role of the cholinergic nervous system in bronchial asthma, mechanism of action and clinical efficacy of tiotropium in severe bronchial asthma adults are described in the article.

Resveratrol: A new potential therapeutic agent for melanoma?

2019 ◽  
Vol 26 ◽  
Author(s):  
Mohamad Hossein Pourhanifeh ◽  
Kazem Abbaszadeh-Goudarzi ◽  
Mohammad Goodarzi ◽  
Sara G.M. Piccirillo ◽  
Alimohammad Shafiee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Therapeutic Agent ◽  
Current Knowledge ◽  
Treatment Resistance ◽  
Anti Cancer ◽  
Apoptosis Inducer ◽  
Life Threatening ◽  
First Time

: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. : Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

Development and validation of a yoga module for Parkinson disease

2017 ◽  
Vol 14 (3) ◽  
Author(s):  
Noopur Kakde ◽  
Kashinath G. Metri ◽  
Shivarama Varambally ◽  
Raghuram Nagaratna ◽  
H.R. Nagendra
Keyword(s):  
Quality Of Life ◽  
Data Analysis ◽  
Parkinson Disease ◽  
Content Validity ◽  
Poor Quality ◽  
Inclusion Criteria ◽  
Future Studies ◽  
Development And Validation

AbstractBackgroundParkinson’s disease (PD), a progressive neurodegenerative disease, affects motor and nonmotor functions, leading to severe debility and poor quality of life. Studies have reported the beneficial role of yoga in alleviating the symptoms of PD; however, a validated yoga module for PD is unavailable. This study developed and validated an integrated yoga module(IYM) for PD.MethodsThe IYM was prepared after a thorough review of classical yoga texts and previous findings. Twenty experienced yoga experts, who fulfilled the inclusion criteria, were selected validating the content of the IYM. A total of 28 practices were included in the IYM, and each practice was discussed and rated as (i) not essential, (ii) useful but not essential, and (iii) essential; the content validity ratio (CVR) was calculated using Lawshe’s formula.ResultsData analysis revealed that of the 28 IYM practices, 21 exhibited significant content validity (cut-off value: 0.42, as calculated by applying Lawshe’s formula for the CVR).ConclusionsThe IYM is valid for PD, with good content validity. However, future studies must determine the feasibility and efficacy of the developed module.

Underdiagnosis and Undertreatment of Migraine in Italy: A Survey of Patients Attending for The First Time 10 Headache Centres

Cephalalgia ◽  
2009 ◽  
Vol 29 (12) ◽  
pp. 1285-1293 ◽  
Author(s):  
S Cevoli ◽  
D D'Amico ◽  
P Martelletti ◽  
F Valguarnera ◽  
E Del Bene ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Healthcare Utilization ◽  
Short Form ◽  
Poor Quality ◽  
Current Therapy ◽  
Previous Diagnosis ◽  
Headache Diagnosis ◽  
First Time ◽  
Headache Centres

The aim of this study was to asses the clinical features, pattern of healthcare and drug utilization of migraine patients attending 10 Italian headache centres (HC). Migraine is underdiagnosed and undertreated everywhere throughout the world, despite its considerable burden. Migraine sufferers often deal with their problem alone using self-prescribing drugs, whereas triptans are used by a small proportion of patients. All patients attending for the first time 10 Italian HCs over a 3-month period were screened for migraine. Migraine patients underwent a structured direct interview about previous migraine diagnosis, comorbidity, headache treatments and their side-effects and healthcare utilization for migraine. Patient satisfaction with their usual therapy for the migraine attack was evaluated with the Migraine-Assessment of Current Therapy (ACT) questionnaire. The quality of life of migraine patients was assessed by mean of Short Form (SF)-12 and Migraine-Specific Quality of life (MSQ) version 2.1 questionnaires. Of the 2675 patients who attended HCs for the first time during the study period, 71% received a diagnosis of migraine and the first 953 subjects completed the study out of 1025 patients enrolled. Only 26.8% of migraine patients had a previous diagnosis of migraine; 62.4% of them visited their general practitioner (GP) in the last year, 38.2% saw a specialist for headache, 23% attended an Emergency Department and 4.5% were admitted to hospital for migraine; 82.8% of patients used non-specific drugs for migraine attacks, whereas 17.2% used triptans and only 4.8% used a preventive migraine medication. Triptans were used by 46.4% of patients with a previous diagnosis of migraine. About 80% of migraine patients took over-the-counter medications. The Migraine-ACT revealed that 60% of patients needed a change in their treatment of migraine attacks, 85% of whom took non-specific drugs. Both the MSQ version 2.1 and the SF-12 questionnaires indicated a poor quality of life of most patients. Migraine represents the prevalent headache diagnosis in Italian HCs. Migraine is still underdiagnosed in Italy and migraine patients receive a suboptimal medical approach in our country, despite the healthcare utilization of migraine subjects being noteworthy. A cooperative network involving GPs, neurologists and headache specialists is strongly desirable in order to improve long-term migraine management in Italy.

scholarly journals The Role of Physical Activity in the Rehabilitation of Patients Suffering From Mild Persistent Bronchial Asthma

2017 ◽  
pp. 140-150
Author(s):  
Igor Grygus
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Bronchial Asthma ◽  
Persistent Asthma ◽  
Physical Rehabilitation ◽  
Outpatient Basis ◽  
Adequate Treatment ◽  
Mild Persistent Asthma

Bronchial asthma – a chronic relapsing disease that affects 1-18 % of the population in various countries worldwide, die annually around 250,000 people. Asthma worsens quality of life, reduced exercise tolerance, causing respiratory dysfunction and poor physical condition of patients. The aim of research is to study the role of physical activity for rehabilitation of patients suffered from mild persistent asthma during their treatment at hospital. The study involved 30 patients being in hospital due to the exacerbation of asthmatic disease. To compare the effectiveness of the proposed physical rehabilitation program was formed two control groups of 30 patients who used medication and only with traditional methods of exercise. The average age of patients was 35,41 ± 1,05 years. Groups were formed by randomization patients were compared by sex and age. Monitoring the rehabilitation process conducted by the current and landmark controls, which ensure adequate treatment expansion and intensification of physical activity each patient. The program of physical rehabilitation is based on the survey results of patients, paying attention to their functional state, rapid assessment of health and physical features of the disease. The basis of the program was a gradual expansion of physical activity of patients. When building sessions followed a certain sequence purpose of physical training, which consisted of three parts: introduction, main and final. Used have morning hygienic gymnastics and gymnastics, independent study, individually and in small groups. One of the popular methods of training both in-patient and outpatient basis, was walking up the stairs. The second half of the course of rehabilitation systems used cyclic exercises. The use of dosed physical activity while physical rehabilitation of patients suffered from mild persistent asthma has improved functional status of their cardiovascular and respiratory systems, physical performance, quality of life, helped to control the disease.

Enmeshment Schema and Quality of Life Deficits: The Mediating Role of Social Anxiety

2015 ◽  
Vol 29 (1) ◽  
pp. 20-31 ◽  
Author(s):  
Jonah N. Cohen ◽  
Dane Jensen ◽  
M. Taylor Dryman ◽  
Richard G. Heimberg
Keyword(s):  
Quality Of Life ◽  
Social Anxiety ◽  
Functional Impairment ◽  
Personal Growth ◽  
Poor Quality ◽  
Subsequent Treatment ◽  
Mediating Role ◽  
Family Enmeshment

Social anxiety is associated with significant functional impairment and poor quality of life. However, there is a paucity of research on how early childhood and family dynamics may be related to social anxiety and its impact on quality of life. We investigated the role of enmeshment schemas, cognitive structures associated with emotional over-involvement with and lack of differentiation from family. Enmeshment is associated with considerable functional impairment, including elevated anxiety and depression and impaired relationship satisfaction. As enmeshment schemas predict withdrawal from stressful social interactions, they may facilitate the development of social anxiety and, through that mechanism, lead to reduced quality of life. Participants completed measures of these constructs. Social anxiety mediated the negative association between enmeshment and quality of life, particularly within the domains of personal growth, social functioning, and achievement. Implications for novel etiological conceptualizations of social anxiety and subsequent treatment interventions are discussed.

scholarly journals Remission in schizophrenia: validity, frequency, predictors, and patients' perspective 5 years later

2010 ◽  
Vol 12 (3) ◽  
pp. 393-407 ◽  
Keyword(s):  
Quality Of Life ◽  
Significant Proportion ◽  
Future Research ◽  
Consensus Definition ◽  
Remission Criteria ◽  
Adequate Quality ◽  
Symptomatic Remission ◽  
Operational Criteria ◽  
Definition Of

In March 2005, the Remission in Schizophrenia Working Group (RSWG) proposed a consensus definition of symptomatic remission in schizophrenia and developed specific operational criteria for its assessment. They pointed out, however, that the validity and the relationship to other outcome dimensions required further examination. This article reviews studies on the validity, frequency, and predictors of symptomatic remission in schizophrenia and studies on patients' perspectives. These studies have demonstrated that the RSWG remission criteria appear achievable and sustainable for a significant proportion of patients, and are related to a better overall symptomatic status and functional outcome and, to a less clear extent, to a better quality of life and cognitive performance. However, achieving symptomatic remission is not automatically concurrent with an adequate status in other outcome dimensions. The results of the present review suggest that the RSWG remission criteria are valid and useful. As such, they should be consistently applied in clinical trials. However the lack of consensus definitions of functional remission and adequate quality of life hampers research on their predictive validity on these outcome dimensions. Future research should therefore search for criteria of these dimensions and test whether the RSWG remission criteria consistently predict a "good" outcome with respect to functioning and quality of life.

scholarly journals Smart Cities Marketing and Its Conceptual Grounds

2019 ◽  
Vol 65 (4) ◽  
pp. 110-116
Author(s):  
Anita Maček ◽  
Rasto Ovin ◽  
Urška Starc-Peceny
Keyword(s):  
Quality Of Life ◽  
Smart City ◽  
Smart Cities ◽  
City Management ◽  
Endogenous Growth Theory ◽  
Definition Of ◽  
Smart Communities ◽  
Changing Role

AbstractThe most frequent definition of the smart city in the literature defines it as a developed urban area that creates sustainable economic development and high quality of life. Therefore, a city should always be capable of identifying and effectively resolving its key development challenges in order to improve the quality of life of its citizens. Regarding economics approach, the authors rely on endogenous growth theory derived from Arrow. The authors explore the role of smart city management and governance, which will have to combine the need for capital with the need to ensure the environment that this capital will enhance modern urban producing factors. Hence, the authors discuss communication aspects and the importance of the evolution toward smart communities, where the idea is not on making places smart anymore, but rather focus on humans and their needs. For an emerging smart city, market built up of smaller cities and municipalities describes the changing role of marketing and the shift of roles in its processes in order to show the urge to become familiar with the spirit of open innovation and rethink marketing strategy in this emerging reality.

scholarly journals Eat or Skip Breakfast? The Important Role of Breakfast Quality for Health-Related Quality of Life, Stress and Depression in Spanish Adolescents

2018 ◽  
Vol 15 (8) ◽  
pp. 1781 ◽  
Author(s):  
Rosario Ferrer-Cascales ◽  
Miriam Sánchez-SanSegundo ◽  
Nicolás Ruiz-Robledillo ◽  
Natalia Albaladejo-Blázquez ◽  
Ana Laguna-Pérez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Life Stress ◽  
Poor Quality ◽  
Health Related Quality ◽  
Home Life ◽  
Related Quality ◽  
Health Related ◽  
Skipping Breakfast

This study examined the associations between eating or skipping breakfast and the quality of breakfast eaten on health-related quality of life (HRQOL), perceived stress and depression in 527 Spanish adolescents. Results showed differences in stress and two domains of HRQOL; Moods and Emotions and Parent Relations and Home Life between adolescent breakfast skippers and eaters, those having breakfast showing higher levels of stress and poor HRQOL. When breakfast quality was analyzed in breakfast eaters, adolescents who ate a good quality breakfast showed better HRQOL and lower levels of stress and depression than those who ate a poor or very poor quality breakfast. Further, breakfast skippers showed better HRQOL and lower levels of stress and depression than breakfast eaters who ate a poor or very poor quality breakfast. These findings indicate the importance of eating a good quality breakfast, rather than just having or not having breakfast. The conclusions of the present study are especially relevant for clinicians and nutritional educators, given the significant impact of breakfast quality on health-related quality of life, stress and depression observed in the adolescents studied.

scholarly journals Effect of erectile dysfunction on quality of life

2001 ◽  
Vol 7 (3) ◽  
pp. 510-518
Author(s):  
M. A. Abolfotouh ◽  
N. S. Al Helali
Keyword(s):  
Quality Of Life ◽  
Erectile Dysfunction ◽  
Cross Sectional Study ◽  
Poor Quality ◽  
Sectional Study ◽  
Cross Sectional ◽  
Male Sexual Dysfunction ◽  
Lack Of Exercise ◽  
First Time

Erectile dysfunction [ED] is one of the most common diseases of male sexual dysfunction. A cross-sectional study of 388 ED patients who attended six andrology and urology clinics in Jeddah for the first time was performed during a period of 3 months. ED was rated as mild [21% of patients], moderate [60%] or severe [19%], and was strongly associated with age. After adjusting for age, only lack of exercise, alcohol consumption and drug addiction were significantly associated with severity; hypertension, cardiac diseases and smoking were not. About two-thirds of the patients had poor quality of life; severe ED was the only significant predictor of this. Severe ED was not an indicator for co-morbidities.

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