scholarly journals IMMUNE STATUS OF PATIENTS WITH FRONTAL BASILAR TRAUMA HAVING BC “SYNTEKOST” APPLIED IN THE SURGICAL TREATMENT. REPORT 1. THE STATE OF THE SYSTEMIC CELLULAR AND HUMORAL IMMUNITY FACTORS OF PATIENTS WITH FRONTAL BASILAR TRAUMA IN THE ACUTE POSTTRAUMATIC PERIOD PRIOR TO SURGICAL TREATMENT

2019 ◽  
Vol 72 (9) ◽  
pp. 1791-1794
Author(s):  
Vasyl Kishchuk ◽  
Oleksandr Bondarchuk ◽  
Ihor Dmitrenko ◽  
Kateryna Lobko ◽  
Yaroslav Hrytsun ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Humoral Immunity ◽  
Bone Fracture ◽  
Initial Period ◽  
Positive Influence ◽  
Frontal Bone ◽  
Control Group ◽  
Healthy Donors ◽  
Cellular And Humoral Immunity

Introduction: At present biocomposite materials are used in the surgical treatment of frontal bone fracture. They improve osteogenesis, reduce the number of complications. Immunologic aspects of application of these materials are studied insufficiently, therefore this report presents the results of immunoassay of patients with frontal bone fracture in the proximate posttraumatic period before implanting preparation “Syntekost”. The aim: To define the role of immune mechanisms in the realization of the biocomposite material’s positive influence on the development of effective posstraumatic rehabilitation schemes. Materials and methods: 16 patients with frontal bone fracture (FBF) were examined on admission to the Otolaryngology Clinics of Vinnitsa Region Hospital. Additionally, 10 patients of the similar age were examined as a control group. The content of cells with markers of surface antigens-CD3,14,16,20,25, concentration of immunoglobulins of classes M,G,A,E, С4 complement component and lactoferrin was determined in blood. Immunoenzyme methods were applied. Nonparametric Wilcoxon — Mann — Whitney test, computer programme WIN Pepi were used for statistical measurements. Results: A decrease in the level of IgM in comparison with practically healthy donors and an increase in the concentration of lactoferrin were identified as humoral immunity factors of patients with frontal basilar trauma. The most significant deviation in the peripheral blood cellular makeup in CD-markers was an increase in cells with markers CD14 and CD16. Conclusions: The level of cells and prodefensin-lactoferrin that maintain inborn immunity increases and the concentration of coarse defensive protein decreases in the initial period after frontal bone fracture, which must be taken into consideration during post-surgical treatment.

Immunoregulatory role of placental glycoproteins in cellular and humoral immunity

1983 ◽  
Vol 5 ◽  
pp. 29 ◽  
Author(s):  
Gopal S. Gupta ◽  
Radslav G. Kinsky ◽  
Huynh Thien Duc ◽  
Guy André Voisin
Keyword(s):  
Humoral Immunity ◽  
Cellular And Humoral Immunity

scholarly journals FEATURES OF CLINICAL MANIFESTATIONS, CELLULAR AND HUMORAL IMMUNITY OF NEWBORNS WITH INTRAUTERINE MIXED INFECTIONS

2020 ◽  
pp. 427-433
Author(s):  
M.A. YUSUPOVA ◽  
◽  
K.I. ISMOILOV ◽  
Keyword(s):  
Humoral Immunity ◽  
Phagocytic Activity ◽  
Clinical Manifestations ◽  
Main Group ◽  
Phagocytic Index ◽  
Control Group ◽  
Mixed Infections ◽  
Secondary Immunodeficiency ◽  
Group I ◽  
Cellular And Humoral Immunity

Objective: To study the features of clinical manifestations, cellular and humoral immunity of newborns with intrauterine mixed infections (IUMI). Methods: A comprehensive survey of 45 infants with IUMI was carried out. Depending on the classification of IUMI they were divided into 3 main groups: group I – 24 patients (53%) with the viral-bacterial association, group II – 12 patients (27%) with the viral-viral association, and group III – 9 patients (20%) with the viral-parasitic association. The control group consisted of 10 newborns born from uninfected, somatically healthy mothers. Diagnosis of IUMI was based on the detection of specific antibodies of the IgA, IgG and IgM classes, as well as phagocytic activity and phagocytic index of leukocytes. In addition, general clinical, biochemical, bacteriological and instrumental research methods have been conducted. Results: The blood serum IgA and IgM indices in patients of the main group were significantly higher, and the mean IgG values were lower compared to the control group. Analysis of cellular immunity parameters in the main group showed a decrease in the number of mature T-lymphocytes (CD3), B-lymphocytes (CD20), the number of T-helpers and cells that produce IL-2 in the peripheral blood, compared with the control group. In the main group, there was also an increase in the number of apoptosis cells (CD95), cells with high cytotoxic activity (CD25, CD71) and the percentage of natural killer cells (CD16). A decrease in the phagocytic activity and phagocytic index of neutrophils was recorded, which indicates the insufficiency of the nonspecific component of immunity. Conclusions: In newborns, various changes were found both on the part of specific and nonspecific components of immunity. This indicates the development of secondary immunodeficiency in this category of patients and makes it necessary to add to the main treatment of immune corrective therapy. Keywords: Congenital infections, mixed intrauterine infections, TORCH syndrome, opportunistic infections, secondary immunodeficiency.

scholarly journals Using Games to Promote English as a Foreign Language Learners’ Willingness to Communicate: Potential Effects and Teachers’ Attitude in Focus

2021 ◽  
Vol 12 ◽  
Author(s):  
Fei Liu ◽  
Balachandran Vadivel ◽  
Ehsan Rezvani ◽  
Ehsan Namaziandost
Keyword(s):  
Foreign Language ◽  
Language Learners ◽  
Positive Influence ◽  
Willingness To Communicate ◽  
Control Group ◽  
Foreign Language Learners ◽  
Item Questionnaire ◽  
Language Classes ◽  
Students Attitudes

This study aims to find out the role of games in promoting students’ willingness to communicate (WTC) and their teachers’ attitude toward it. In order to collect the data, the researchers employed a 28-item questionnaire which was given to 60 English as a Foreign Language (EFL) learners in an English institute. Then, the students were randomly divided into two groups of 30 learners functioning as control and experimental groups. The students in the experimental group received games in their language lessons and classes, while control group learners did not. At the end of the term, the same questionnaire was given to the students to know if playing games had a significant impact on their WTC. In addition, the teachers were asked to answer a 30-item questionnaire to investigate their attitudes toward playing games in language classes. The results showed that most of the teachers in this study believe that games have a positive influence on the students’ attitudes towards learning English and that using them in class serves many educational purposes. In addition, games played a significant role in improving the EFL leaners’ willingness to communicate. In the light of these findings, the researchers suggested using games as energizers and practical activities at the end of class not only to improve enthusiasm for learning, but also to improve the learners’ WTC.

scholarly journals Alterations in B Cell and Follicular T-Helper Cell Subsets in Patients with Acute COVID-19 and COVID-19 Convalescents

2021 ◽  
Vol 44 (1) ◽  
pp. 194-205
Author(s):  
Igor V. Kudryavtsev ◽  
Natalia A. Arsentieva ◽  
Oleg K. Batsunov ◽  
Zoia R. Korobova ◽  
Irina V. Khamitova ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Humoral Immunity ◽  
N Protein ◽  
Follicular Helper ◽  
Healthy Donors ◽  
Specific Igg ◽  
Sparse Methods

Background. Humoral immunity requires interaction between B cell and T follicular helper cells (Tfh) to produce effective immune response, but the data regarding a role of B cells and Tfh in SARS-CoV-2 defense are still sparse. Methods. Blood samples from patients with acute COVID-19 (n = 64), convalescents patients who had specific IgG to SARS-CoV-2 N-protein (n = 55), and healthy donors with no detectable antibodies to any SARS-CoV-2 proteins (HC, n = 44) were analyses by multicolor flow cytometry. Results. Patients with acute COVID-19 showed decreased levels of memory B cells subsets and increased proportion plasma cell precursors compared to HC and COVID-19 convalescent patients, whereas for the latter the elevated numbers of virgin naïve, Bm2′ and “Bm3+Bm4” was found if compared with HC. During acute COVID-19 CXCR3+CCR6− Tfh1-like cells were decreased and the levels of CXCR3–CCR6+ Tfh17-like were increased then in HC and convalescent patients. Finally, COVID-19 convalescent patients had increased levels of Tfh2-, Tfh17- and DP Tfh-like cells while comparing their amount with HC. Conclusions. Our data indicate that COVID-19 can impact the humoral immunity in the long-term.

scholarly journals The role of alpha-2-macroglobulin in pathogenesis of rheumatoid arthritis and system lupus erythematosus

2010 ◽  
Vol 9 (5) ◽  
pp. 39-44
Author(s):  
V. N. Zorina ◽  
I. G. Kozlov ◽  
R. M. Zorina ◽  
N. A. Trofimenko ◽  
T. S. Chirikova ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Progression ◽  
Acute Phase ◽  
Lupus Erythematosus ◽  
Acute Phase Proteins ◽  
Serum Levels ◽  
Control Group ◽  
Healthy Donors ◽  
Significant Difference

We investigated serum levels of alpha-2-macroglobulin (α2—MG) and some of its complexes, namely α2-MG-plasmin (α2-MG— Pl) and α2-MG—IgG at a rheumatoid arthritis (RA) 2—3 degrees of activity (65 patients), a system lupus erythematosus (SLE) of 2-3 degrees of activity (30 patients) and 55 healthy donors as a control group. It is shown, that at SLE the total level of α2-MG is invariable, and at RA — decreases significantly in comparison with the healthy. The concentration of complexes was raised at pathology, but at RA this rising was expressed much more strongly, than at SLE. At studying of correlations of levels of α2-MG, α2-MG—Pl and α2-MG— IgG among themselves and with some several cytokines and acute phase proteins, it is shown, that there is some significant difference between normal and pathological correlative relations and allows us to suspect that at SLE, the α2-MG and its complexes participate in a pathogenesis, and at RA α2-MG becomes the major immunogenesis factor and the significant reason of disease progression.

scholarly journals Evaluation of APRIL in serum of patients with Hashimoto’s Thyroiditis

2021 ◽  
Vol 16 (1) ◽  
pp. 46-51
Author(s):  
Adriana Carvalho Santos ◽  
Paulo Travassos Neto ◽  
Lia Rafaella Ballard Kuhnert ◽  
Marcelo Ribeiro Alves ◽  
Rita Vasconcellos ◽  
...  
Keyword(s):  
T Cells ◽  
Hashimoto’S Thyroiditis ◽  
Molecular Mechanisms ◽  
Cytotoxic T Cells ◽  
Hashimoto's Thyroiditis ◽  
Control Group ◽  
Thyroid Peroxidase ◽  
Healthy Donors ◽  
Specific Receptors

Hashimoto’s thyroiditis (HT) is an autoimmune and inflammatory disease in which antibodies are directed against the thyroid gland leading to chronic inflammation and hypothyroidism. The autoimmunity against thyroid antigens can be associated to genetic background and environmental factors. Thyroid peroxidase (TPO) and thyroglobulin (TG) are the major autoantigens for characterizing the disease. HT is related to the activation of autoreactive CD4+ T cells, CD8+ cytotoxic T cells and antithyroid antibody producing-B cells. Among several cytokines related to the pathogenesis of HT, a proliferation-inducing ligand (APRIL) has been studied in the context of the establishment and/or maintenance of autoimmune diseases. The role of APRIL in the pathogenesis of HT is still poorly understood. Therefore, the present study aimed to compare APRIL serum concentration in HT patients and healthy donors by ELISA. We observed a significant decrease in APRIL concentration in HT patients when compared to the control group, and a positive correlation between APRIL level and age. Our results suggest that the APRIL molecule can compose the cytokine profile along the inflammatory response in HT, however, other investigations should be proposed to understand its molecular mechanisms via specific receptors and other regulatory loops.

scholarly journals Effect of cryoprecipitate on neoangiogenesis in patients with purulent pyelonephritis

2020 ◽  
Vol 10 (1) ◽  
pp. 43-49
Author(s):  
Yuliya G. Chernova ◽  
Aleksandr I. Nejmark ◽  
Andrey P. Momot
Keyword(s):  
Surgical Treatment ◽  
Blood Vessels ◽  
Inflammatory Process ◽  
Conservative Therapy ◽  
High Efficiency ◽  
Control Group ◽  
Healthy Donors ◽  
Group 2 ◽  
Angiopoietin 2 ◽  
Group 1

The aim of the study is to investigate the effectiveness of conservative therapy with the inclusion of cryoprecipitate in its composition and its effect on the angiogenesis of renal blood vessels in patients with purulent pyelonephritis. Materials and methods. The study included 30 patients aged from 20 to 45 years (6 men, 24 women) with acute purulent pyelonephritis. All patients were assessed for markers of angiogenesis in blood plasma: vascular endothelial growth factor (VEGF-A), angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2). The patients were divided into two groups. Patients of group 1 (n = 15) received conservative therapy with the inclusion of cryoprecipitate, patients of group 2 (n = 15) received surgical treatment. The control group consisted of 10 healthy donors aged 2035 years, whose blood angiogenesis markers were determined to obtain reference values. Results. In the course of preliminary studies, the blood content of angiogenesis markers was determined in 10 healthy donors. The level of VEGF-A in patients of both groups and the level of Ang1 in patients of group 1 at admission to the hospital significantly exceeded the corresponding values in the control group. In group 2 patients, the level of VEGF-A and Ang1 remained elevated during treatment, which indirectly indicated an ongoing inflammatory process. The level of Ang2 in patients of both groups did not change significantly. Conservative treatment of group 1 patients showed high efficiency, which was confirmed by positive dynamics of clinical and laboratory indicators, as well as data from instrumental examination. Conclusions. The results obtained indicate the effectiveness of conservative therapy with the administration of cryoprecipitate in patients with purulent pyelonephritis, and the effectiveness of such treatment is comparable to the effectiveness of surgical treatment . The use of cryoprecipitate has an endothelioprotective and anti-inflammatory effect on blood vessels, stabilizes the processes of angiogenesis, which contributes to limiting the inflammatory process and its regression.

scholarly journals Contribution of explicit processes to reinforcement-based motor learning

2018 ◽  
Vol 119 (6) ◽  
pp. 2241-2255 ◽  
Author(s):  
Peter Holland ◽  
Olivier Codol ◽  
Joseph M. Galea
Keyword(s):  
Motor Learning ◽  
Initial Period ◽  
Large Angle ◽  
Control Group ◽  
Visuomotor Rotation ◽  
Therapeutic Benefits ◽  
Maximum Angle ◽  
Explicit Processes ◽  
Reach Angle

Despite increasing interest in the role of reward in motor learning, the underlying mechanisms remain ill defined. In particular, the contribution of explicit processes to reward-based motor learning is unclear. To address this, we examined subjects’ ( n = 30) ability to learn to compensate for a gradually introduced 25° visuomotor rotation with only reward-based feedback (binary success/failure). Only two-thirds of subjects ( n = 20) were successful at the maximum angle. The remaining subjects initially followed the rotation but after a variable number of trials began to reach at an insufficiently large angle and subsequently returned to near-baseline performance ( n = 10). Furthermore, those who were successful accomplished this via a large explicit component, evidenced by a reduction in reach angle when they were asked to remove any strategy they employed. However, both groups displayed a small degree of remaining retention even after the removal of this explicit component. All subjects made greater and more variable changes in reach angle after incorrect (unrewarded) trials. However, subjects who failed to learn showed decreased sensitivity to errors, even in the initial period in which they followed the rotation, a pattern previously found in parkinsonian patients. In a second experiment, the addition of a secondary mental rotation task completely abolished learning ( n = 10), while a control group replicated the results of the first experiment ( n = 10). These results emphasize a pivotal role of explicit processes during reinforcement-based motor learning, and the susceptibility of this form of learning to disruption has important implications for its potential therapeutic benefits. NEW & NOTEWORTHY We demonstrate that learning a visuomotor rotation with only reward-based feedback is principally accomplished via the development of a large explicit component. Furthermore, this form of learning is susceptible to disruption with a secondary task. The results suggest that future experiments utilizing reward-based feedback should aim to dissect the roles of implicit and explicit reinforcement learning systems. Therapeutic motor learning approaches based on reward should be aware of the sensitivity to disruption.

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