scholarly journals ACUTE COMPLICATED PANCREATITIS AND DIABETES MELLITUS: THE ROLE AND SIGNIFICANCE OF THE BIOCHEMICAL INDICATORS OF CARBOHYDRATE AND LIPID METABOLISM AS A PROGNOSTIC CRITERION FOR THE SEVERITY OF THE DISEASE CLINICAL COURSE

2021 ◽  
Vol 74 (1) ◽  
pp. 22-27
Author(s):  
Adrian D. Kvit ◽  
Mykhaylo M. Tutka ◽  
Volodymyr V. Kunovskiy
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Biochemical Parameters ◽  
Treatment Effectiveness ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Glucose Levels ◽  
Carbohydrate And Lipid Metabolism ◽  
Prognostic Criterion ◽  
Severity Of The Disease

The aim: A clinical evaluation of biochemical parameters especially carbohydrate and lipid metabolism, their effect on the treatment program in patients with acute complicated pancreatitis. Material and methods: The results of complex treatment of a sample group of 127 patients with acute pancreatitis were studied. A moderately severe clinical course of the disease was found in 42 patients (33.1%) and severe in 85 patients (66.9%), the ethanol genesis of the disease was stated in 73 (57.5%), biliary genesis – in 54 (42.5%) patients. The evaluation of the treatment effectiveness was based on the analysis of the dynamics of disease clinical manifestations and the monitoring of laboratory biochemical parameters and glucose levels Results: It was stated, that the clinical course of the disease, severity, and prognosis of the patient’s condition correlate with the dynamics of markers of endotoxicosis and hepatic insufficiency, and glucose level is one of the most sensitive criteria. The carbohydrate metabolism dynamics analysis in the blood of patients has shown that in most patients glucose levels increase notably with the increase in pancreatic swelling and reaches a peak by its destruction Conclusions: The incidence of diabetes mellitus due to primary inflammation of the pancreatic parenchyma in ACP has a linear dependence on the frequency and duration of the disease; with the probability of developing diabetes with an exacerbation of the process during 5-8 years is 17.5%. The level of blood glucose in patients with ACP can be a reliable indicator of the severity of the disease course and correlates with other indicators of metabolism

SEX DIFFERENCES OF CARBOHYDRATE AND LIPID METABOLISM IMPAIRMENT IN RATS WITH TYPE 2 DIABETES MELLITUS

2018 ◽  
Vol 64 (2) ◽  
pp. 39-45 ◽  
Author(s):  
Nataliia Gorbenko ◽  
Oleksii Borikov ◽  
Olha Ivanova ◽  
K. V. Taran ◽  
T. S. Litvinova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Lipid Metabolism ◽  
Female Rats ◽  
Glucose And Lipid Metabolism ◽  
Carbohydrate And Lipid Metabolism ◽  
Lipid Metabolism Disorders

A sex difference of carbohydrate and lipid metabolism disorders in rats with type 2 diabetes has been studied. It was established that type 2 diabetes leads to a more pronounced deterioration in carbohydrate toleranceand insulin sensitivity in males compared to female rats, but the sex doesn’t affect basal glycemia and fructosamine levels. It was found that the increase of body weight and visceral fat in rats with type 2 diabetes is moremanifested in females than in males. It has been determined that hypertriglyceridemia is higher in diabeticmales compared to diabetic females, and the level of common lipids in the liver, both intact females and femaleswith type 2 diabetes, is lower than that of the males. The obtained results indicate a more expressive impairment of glucose and lipid metabolism in males compared to females with type 2 diabetes

scholarly journals Hypoglycemic and Hypolipidemic Potential of a High Fiber Diet in Healthy versus Diabetic Rabbits

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Raquel Díez ◽  
Juan J. García ◽  
M. José Diez ◽  
Matilde Sierra ◽  
Ana M. Sahagún ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Biochemical Parameters ◽  
Glycosylated Hemoglobin ◽  
Atherogenic Index ◽  
Oral Glucose ◽  
Plantago Ovata ◽  
High Fiber ◽  
Glucose Levels ◽  
Patients With Diabetes ◽  
Diabetic Rabbits

The aim of this study was to investigate potential hypoglycaemic and hypolipidemic effects of Plantago ovata husk included in the diet, in healthy and diabetic rabbits. We also examined the effects of this fiber in other biochemical parameters. Two groups of 18 rabbits were used. The first group was fed with standard chow and the second with chow supplemented with Plantago ovata husk (3.5 mg/kg/day). On day 14 diabetes mellitus was induced by the intravenous administration of alloxan (80 mg/kg). After an oral glucose load (3 g), glucose, insulin, and other biochemical parameters were determined on day 14 (healthy rabbits) and on day 28 (diabetic rabbits). In healthy rabbits, fiber did not modify glucose or insulin levels but decreased significantly total cholesterol, LDL-cholesterol, atherogenic index, and glycosylated hemoglobin. In diabetic rabbits, fiber was more beneficial in mild diabetics than in severe diabetics with significant decreases in glucose levels and increases in insulin concentrations. In these animals fiber caused an important reduction in cholesterol, indicating a beneficial effect of Plantago ovata husk in diabetic rabbits. Although further studies in patients are necessary, we think that Plantago ovata husk offers interesting perspectives to be administered to patients with diabetes mellitus.

scholarly journals Impact of hypolipidemic therapy on carbohydrate and lipid metabolism and their hormonal regulators in patients with type diabetes mellitus

2003 ◽  
Vol 49 (1) ◽  
pp. 25-27
Author(s):  
N. T. Starkova ◽  
V. V. Dolgov ◽  
A. L. Davydov ◽  
A. P. Roitman ◽  
L. Yu. Baranova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Normal Values ◽  
Control Group ◽  
Obese Patients ◽  
Carbohydrate And Lipid Metabolism ◽  
Daily Dose

The effects of lipostat and maninil on carbohydrate and lipid metabolisms and their hormonal regulators were studied in 36 obese patients aged 50- 70 years who had type 2 diabetes mellitus concurrent with dyslipidemia. A course of therapy with lipostat in a daily dose of 20 mg for 3 months was shown to lead to nor­malization of lipid metabolism, to diminished glycemia and hy- perinsulinemia, and to an increase in fasting plasma somatotrop­ic hormone levels to normal values, these were not observed in the control group.

scholarly journals Direct renin inhibitor aliskiren in women with menopausal metabolic syndrome and arterial hypertension

2011 ◽  
Vol 10 (4) ◽  
pp. 33-38
Author(s):  
Yu. V. Zhernakova ◽  
V. B. Mychka ◽  
Yu. A. Ponomarev ◽  
S. N. Tolstov ◽  
E. V. Tishina ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Arterial Stiffness ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Postprandial Glucose ◽  
Renin Inhibitor ◽  
Glucose Levels ◽  
Direct Renin Inhibitor ◽  
Carbohydrate And Lipid Metabolism

Aim. To study the effectiveness of a direct renin inhibitor, aliskiren, in patients with menopausal metabolic syndrome (MMS), and to assess aliskiren effects on blood pressure (BP), carbohydrate and lipid metabolism parameters, microalbuminuria, and arterial stiffness. Material and methods. The study included 23 women with MMS, to whom aliskiren monotherapy (150-300 mg/d) was administered. At baseline and in the end of the study, anthropometry, carbohydrate and lipid metabolism parameters assessment, 24-hour BP monitoring, and arterial stiffness assessment by volume sphygmography were performed. Results. By the end of the study, most parameters of circadian BP profile significantly decreased. Target levels of systolic and diastolic BP were achieved in 80 % of the patients. There was a significant reduction in postprandial glucose levels. According to the volume sphygmography results, a decrease in arterial stiffness was accompanied by a significant reduction in pulse wave velocity and augmentation index, with normalization of the former parameter. Conclusion. Aliskiren therapy demonstrated not only high antihypertensive effectiveness in MMS patients, but also a reduction in postprandial glucose levels and arterial stiffness.

FEATURES OF THE CLINICAL COURSE AND CHOICE OF THERAPY IN PERSONS OVER 70 YEARS OF AGE WITH NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS: A LITERARY REVIEW

2021 ◽  
pp. 39-43
Author(s):  
А.Р. КАЗБЕКОВА ◽  
Ж.К. БУРИБАЕВА ◽  
А. АБИЕВА
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Clinical Course ◽  
Newly Diagnosed ◽  
Comorbid Conditions ◽  
The Social ◽  
Severity Of The Disease ◽  
Choice Of Therapy ◽  
Independent Branch

Сахарный диабет - это эндокринное заболевание, при котором происходит нарушение выработки инсулина или понижение чувствительности клеточных рецепторов к нему, что в результате ведет к увеличению сахара в крови. Диабет 2 типа часто называют "болезнью цивилизации". Около четверти населения в возрасте старше 65 лет имеют сахарный диабет, а половина - предиабет, причем отмечается тенденция к усугублению данной ситуации в ближайшие десятилетия. В связи с улучшением социальнодемократической ситуации, старением населения, развитием гериатрии как самостоятельный раздел медицины, появилась возможность раннего выявления сахарного диабета. Но лечение данной группы пациентов имеет ряд проблем, связанных с когнитивными нарушениями, которые препятствуют обучению и приверженности пациентов к лечению; коморбидными состояниями, при которых невозможно адекватно оценивать тяжесть заболевания. Diabetes mellitus is an endocrine disorder in which the production of insulin is impaired or the sensitivity of cell receptors to it is impaired, which results in an increase in blood sugar. Type 2 diabetes is often referred to as the "disease of civilization". About a quarter of the population over the age of 65 has diabetes mellitus, and half have prediabetes, and this situation tends to worsen in the coming decades. In connection with the improvement of the social and democratic situation, the aging of the population, the development of geriatrics as an independent branch of medicine, it became possible to detect diabetes mellitus early. But the treatment of this group of patients has a number of problems associated with cognitive impairment that hinder the learning and adherence of patients to treatment; comorbid conditions in which it is impossible to adequately assess the severity of the disease

Multi-factor regression analysis of risk factors of developing microvascular complications of 2 type diabetes mellitus

2020 ◽  
pp. 58-67
Author(s):  
Elena V. NEVZOROVA ◽  
Andrey K. ZASYADKO ◽  
Oksana N. ZAGUMENNOVA
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Regression Analysis ◽  
Lipid Metabolism ◽  
Type Diabetes ◽  
Type Diabetes Mellitus ◽  
Microvascular Complications ◽  
Significant Risk ◽  
Carbohydrate And Lipid Metabolism ◽  
Factor Regression

Introduction. The relevance of the study of diabetes mellitus is due to social importance due to the high prevalence and progression of the disease in the form of late vascular complications, the first among which is vascular angiopathies. The results of studies on the dynamics of carbohydrate and lipid metabolism in the development of microvascular complications of 2 type diabetes mellitus remain quite contradictory. At the same time, the range of risk factors for the development of microvascular complications of 2 type diabetes mellitus and the strength of their effects vary greatly between studies and regions. Due to these circumstances, we are interested in studying the risk factors of developing microvascular complications of 2 type sugar diabetes as one of the main fatal complications of 2 type diabetes mellitus. Purpose and objectives. The most significant risk factors for developing microvascular complications of 2 type diabetes mellitus are determined using multi-factor regression analysis. Materials and methods. We used a multiple logistical regression model. Main results. As a result of multi-factor regression analysis, we determined the most significant risk factors for developing microvascular complications of 2 type diabetes mellitus: unsatisfactory compensation of carbohydrate and lipid metabolism, presence of arterial hypertension and dyslipidemia.

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