SMALL AND MEDIUM-SIZED ENTERPRISES IN REPUBLIC OF MOLDOVA

The paper examines the role of SME sector in Moldova’s economy and its likely implications in the RD processes. Several key features of the relationship between knowledge economy, RD and SMEs are emphasized, and also their effect on regional and local communities. Then, a summary of RD particular features in Moldova is presented. The role of SME sector, examined in terms of its performance by ownership and activity types, as a whole and by main firms’ categories (micro-, small, and medium-sized) is analyzed. Small enterprises have been considered as the most adequate solution for promoting RD in general case. National-level analysis is completed by regional insight into the sector as a whole. Finally, some critical aspects of SMEs’ role in RD in Moldova are discussed.

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On Metaphysics and the Political: A Polemics of Reading Baudelaire in the 1930s

Nottingham French Studies ◽

10.3366/nfs.2019.0252 ◽

2019 ◽

Vol 58 (2) ◽

pp. 249-259

Author(s):

Joseph Acquisto

Keyword(s):

Twentieth Century ◽

Political Crisis ◽

The Political ◽

Modern Poetry ◽

Progressive Politics ◽

The World ◽

Relationship Of ◽

The Relationship ◽

Insight Into

This essay examines a polemic between two Baudelaire critics of the 1930s, Jean Cassou and Benjamin Fondane, which centered on the relationship of poetry to progressive politics and metaphysics. I argue that a return to Baudelaire's poetry can yield insight into what seems like an impasse in Cassou and Fondane. Baudelaire provides the possibility of realigning metaphysics and politics so that poetry has the potential to become the space in which we can begin to think the two of them together, as opposed to seeing them in unresolvable tension. Or rather, the tension that Baudelaire animates between the two allows us a new way of thinking about the role of esthetics in moments of political crisis. We can in some ways see Baudelaire as responding, avant la lettre, to two of his early twentieth-century readers who correctly perceived his work as the space that breathes a new urgency into the questions of how modern poetry relates to the world from which it springs and in which it intervenes.

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Designing for international law: The architecture of international organizations 1922–1952

Leiden Journal of International Law ◽

10.1017/s092215652000059x ◽

2020 ◽

pp. 1-22

Author(s):

Miriam Bak McKenna

Keyword(s):

New York ◽

International Law ◽

International Organizations ◽

International Organization ◽

International Labour Organization ◽

The Relationship ◽

Physical Manifestation ◽

Insight Into ◽

Do So

Abstract Situating itself in current debates over the international legal archive, this article delves into the material and conceptual implications of architecture for international law. To do so I trace the architectural developments of international law’s organizational and administrative spaces during the early to mid twentieth century. These architectural endeavours unfolded in three main stages: the years 1922–1926, during which the International Labour Organization (ILO) building, the first building exclusively designed for an international organization was constructed; the years 1927–1937 which saw the great polemic between modernist and classical architects over the building of the Palace of Nations; and the years 1947–1952, with the triumph of modernism, represented by the UN Headquarters in New York. These events provide an illuminating allegorical insight into the physical manifestation, modes of self-expression, and transformation of international law during this era, particularly the relationship between international law and the function and role of international organizations.

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Insight into the Double-Edged Role of Ferroptosis in Disease

Biomolecules ◽

10.3390/biom11121790 ◽

2021 ◽

Vol 11 (12) ◽

pp. 1790

Author(s):

Lei Zhang ◽

Ruohan Jia ◽

Huizhen Li ◽

Huarun Yu ◽

Keke Ren ◽

...

Keyword(s):

Cell Death ◽

Digestive System ◽

Kidney Injury ◽

Oxygen Species ◽

Disease Treatment ◽

The Relationship ◽

Insight Into ◽

New Strategies ◽

Research Hotspots

Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson’s disease, and Alzheimer’s disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis.

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Regulation of TRPV5 and TRPV6 by associated proteins

AJP Renal Physiology ◽

10.1152/ajprenal.00443.2005 ◽

2006 ◽

Vol 290 (6) ◽

pp. F1295-F1302 ◽

Cited By ~ 61

Author(s):

Stan F. J. van de Graaf ◽

Joost G. J. Hoenderop ◽

René J. M. Bindels

Keyword(s):

Molecular Mechanisms ◽

Hormonal Control ◽

Trp Channel ◽

Intestinal Lumen ◽

Blood Compartment ◽

Associated Proteins ◽

The Relationship ◽

Insight Into ◽

Prime Target

The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho)physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes.

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Hypoxia-inducible factor–1 and associated upstream and downstream proteins in the pathophysiology and management of glioblastoma

Neurosurgical FOCUS ◽

10.3171/2014.9.focus14496 ◽

2014 ◽

Vol 37 (6) ◽

pp. E8 ◽

Cited By ~ 18

Author(s):

Matthew Womeldorff ◽

David Gillespie ◽

Randy L. Jensen

Keyword(s):

Cellular Response ◽

Treatment Options ◽

Hypoxia Inducible Factor ◽

Hypoxia Inducible Factor 1 ◽

Poor Patient ◽

Growth Development ◽

The Relationship ◽

Insight Into ◽

Upstream Regulators

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with an exceptionally poor patient outcome despite aggressive therapy including surgery, radiation, and chemotherapy. This aggressive phenotype may be associated with intratumoral hypoxia, which probably plays a key role in GBM tumor growth, development, and angiogenesis. A key regulator of cellular response to hypoxia is the protein hypoxia-inducible factor–1 (HIF-1). An examination of upstream hypoxic and nonhypoxic regulation of HIF-1 as well as a review of the downstream HIF-1–regulated proteins may provide further insight into the role of this transcription factor in GBM pathophysiology. Recent insights into upstream regulators that intimately interact with HIF-1 could provide potential therapeutic targets for treatment of this tumor. The same is potentially true for HIF-1–mediated pathways of glycolysis-, angiogenesis-, and invasion-promoting proteins. Thus, an understanding of the relationship between HIF-1, its upstream protein regulators, and its downstream transcribed genes in GBM pathogenesis could provide future treatment options for the care of patients with these tumors.

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Emerging Trends and Opportunities for Industry Development at the Sub-National Level in Russia

Industrial and Urban Growth Policies at the Sub-National, National, and Global Levels - Advances in Public Policy and Administration ◽

10.4018/978-1-5225-7625-9.ch017 ◽

2019 ◽

pp. 342-363 ◽

Cited By ~ 1

Author(s):

Leyla A. Gamidullaeva ◽

Natalia S. Merkulova ◽

Ludmila I. Kryachkova ◽

Zoya A. Kondratieva ◽

Yulia A. Efimova ◽

...

Keyword(s):

Industry 4.0 ◽

Industrial Revolution ◽

National Level ◽

Climatic Conditions ◽

Strong Impact ◽

Emerging Trends ◽

Level Of Economic Development ◽

Level Of Knowledge ◽

The Relationship

The authors believe that the transition to Industry 4.0 will have a strong impact on the level of urbanization in Russia. The level of urbanization is influenced by many factors, which include the level of economic development of the country, migration of the population, natural and climatic conditions. The highest level of urbanization is typical for industrialized regions. This suggests that it is necessary to develop industry and move to Industry 4.0. The purpose of this chapter is to show the relationship between urbanization and Industry 4.0, as well as to increase the level of knowledge about digital production, the internet of things, the Industry 4.0, and urbanization. The chapter explains the role of Industry 4.0 in the current changing environment. The chapter deals with the most important problems and opportunities of the fourth industrial revolution.

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The Relationship Between Social Justice Issues and Emotional Intelligence (EI)

Technology Adoption and Social Issues ◽

10.4018/978-1-5225-5201-7.ch055 ◽

2018 ◽

pp. 1202-1220

Author(s):

Misha Chakraborty ◽

Dominique T. Chlup

Keyword(s):

Social Justice ◽

Emotional Intelligence ◽

Human Resource Development ◽

Human Resource ◽

Well Being ◽

Review Of The Literature ◽

Social Oppression ◽

The Relationship ◽

Critical Aspects

This chapter discussed issues of injustice as often affecting the emotional, and in some cases, the physical well-being of a person. In recent years, researchers have begun to explore the role of Emotional Intelligence (EI) in creating awareness when it comes to social justice issues related to areas such as racism, sexism, heterosexism, etc. The purpose of this chapter is twofold: First, to concentrate on the area of social justice issues to find out what the literature has explored in terms of the role Emotional Intelligence (EI) might play when it comes to dealing with social oppression, and second, to advocate emotional intelligence traits that can be successfully used to cope with social oppression. We reviewed the literature as a way to deepen our understanding of how to foster “socially conscious” practices within the workplace. The chapter has implications for Human Resource Development (HRD) practitioners to remind them of the responsibility they have to encourage and welcome studies and practices addressing critical aspects such as social justice issues as a way to help ensure a productive and safe workplace. Through this review of the literature, we found that emotional intelligence traits, if practiced responsibly, can make society a better place for everyone to live and work in.

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The Investment Model: Its Antecedents and Predictors of Relationship Satisfaction

Journal of Relationships Research ◽

10.1017/jrr.2020.15 ◽

2020 ◽

Vol 11 ◽

Author(s):

Kathleen A. Moore ◽

Austin Campbell

Keyword(s):

Relationship Satisfaction ◽

Intimate Relationships ◽

Investment Model ◽

Knowing How ◽

The Relationship ◽

Insight Into

Abstract Intimate relationships are an integral part of our lives, but the rate of relationship breakups is high. We explored the role of the investment model and the traits that influence investments on relationship satisfaction among 146 volunteers (age M = 28.76 years, SD = 10.23). Relationship satisfaction was predicted by investments, which in turn were predicted by attachment, personality and love style. Clinicians working with individuals or couples with relationship issues may benefit from knowing how invested they are in the relationship and their love style. Insight into imbalances in these constructs between partners may be used to facilitate relationship satisfaction.

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Levinas and the Responsibility to Provide in Southeast Asia

The Responsibility to Provide in Southeast Asia ◽

10.1332/policypress/9781529200720.003.0008 ◽

2019 ◽

pp. 153-178

Author(s):

See Seng Tan

Keyword(s):

Southeast Asia ◽

Southeast Asian ◽

The Self ◽

The Other ◽

Moral Force ◽

Communitarian Ethics ◽

Key Features ◽

Asian Context ◽

The Relationship

Firstly, this chapter introducesLevinas’ ‘responsibility for the other’ notion as an alternative to the liberal and communitarian conceptions of responsibility and sovereignty. Both liberal and communitarian ethics are problematic because of theirshared assumption that responsibility is first and foremost to the self. The chapter introduces key features of Levinas’ ethics – the place and role of hospitality, reciprocity and justice in the responsibility for the other. It also examines how friendly critiques by interlocutors(Derrida, Ricoeur, Caputo, etc.) help moderate Levinas’ idealism without necessarily taking things in overly pragmatic or realist directions or, worse, blunting its moral force. Secondly, the chapter assesses the relevance of Levinas’ ethics to the questions of responsible sovereignty and the R2Provide in Southeast Asia. With reference to the regional conduct described in Chapters 4, 5 and 6, it is argued that Levinas’ ideas redefine the terms of the relationship between responsible providers and their recipients in three key ways: one, our assumptions and expectations over one’s extension of hospitality to one’s neighbours; two, the rethinking of mutuality and reciprocity between providers and recipients; and three, the ways in which the considerations for justice play out within the Southeast Asian context are concerned.

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