scholarly journals Paranasal Carcinoma: A Case Series

2021 ◽  
Keyword(s):  
Concurrent Chemoradiotherapy ◽  
Malignant Tumors ◽  
Delayed Diagnosis ◽  
Case Series ◽  
Hospital Data ◽  
Retrospective Case ◽  
Sinonasal Cancer ◽  
Early Diagnosis Of Cancer ◽  
Diagnosis Of Cancer ◽  
Nose And Sinuses

Objective: To emphasize the importance of early diagnosis of cancer of paranasal sinus. Method: This is retrospective case series done in Liaquat National Hospital. Data were retrieved from August to October 2020. Results: Data of a total of 5 patients with sinonasal cancer was reviewed. Four patients presented with extensive disease. Three patients were male and two were female. The age of patients was between 40 and 70 years. All these five patients underwent surgery. Four patients were referred for concurrent chemoradiotherapy (CCRT) and one patient expired after surgery. Conclusion: Malignant tumors of the nose and sinuses are rare constituting 3% of head and neck malignancies. The early symptoms are relatively innocuous and are often ignored by the patient, their general practitioners and even ENT surgeons leading to a delayed diagnosis and treatment. Although paranasal tumors are rare they should be in our differential.

scholarly journals Impact of SARS-COV-2 Pandemic on Kidney Cancer Management

Kidney Cancer ◽  
2021 ◽  
pp. 1-14
Author(s):  
Melissa Bersanelli ◽  
Camillo Porta
Keyword(s):  
Survival Rates ◽  
Delayed Diagnosis ◽  
Case Series ◽  
Cost Benefit ◽  
Original Data ◽  
Immune Checkpoint Blockade ◽  
Retrospective Case ◽  
Renal Masses ◽  
Term Survival ◽  
Cancer Management

Background: The SARS-CoV-2 pandemic still has a huge impact on the management of many chronic diseases such as cancer. Few data are presently available reagarding how the management of renal cell carcinoma (RCC) has changed due to this unprecedented situation. Objective: To discuss the challenges and issues of the diagnosis and treatment of RCC in the COVID-19 era, and to provide recommendations based on the collected literature and our personal experience. Methods: Systematic review of the available Literature regarding the management of RCC during the SARS-CoV-2 pandemic. Results: Our review showed a prevalence of narrative publications, raising the issue of the real relevance of the evidence retrieved. Indeed, the only original data about RCC and COVID-19 found were a small retrospective case series and two surveys, providing either patients’ or physicians’ viewpoints. Conclusions: The expected delayed diagnosis of RCC could lead to an increase of advanced/metastatic cases; thus, proper therapeutic choices for patients with small renal masses should be carefully evaluated case by case, in order to avoid negative effects on long-term survival rates. The controversial interaction between immune checkpoint blockade and COVID-19 pathogenesis is more hypothetical than evidence-based, and thus immunotherapy should not be denied, whenever appropriate. To avoid treatments which won’t have an impact on patients’ survival, a honest and accurate evaluation of the cost/benefit ratio of each treatment option should be always performed. Finally, SARS-CoV-2 swab positivity should not prevent the continuation of ongoing active treatments in asymptomatic cases, or or after symptoms’ resolution.

scholarly journals Physician Delay for Delayed Diagnosis of Acute Lymphoblastic Leukemia among Children in a Tertiary Care Hospital

2020 ◽  
Vol 4 (1) ◽  
pp. 1-5
Author(s):  
Yasmin T ◽  
Keyword(s):  
Developing Countries ◽  
Tertiary Care Hospital ◽  
Lymphoblastic Leukemia ◽  
Tertiary Care ◽  
Delayed Diagnosis ◽  
Late Presentation ◽  
Care Hospital ◽  
Childhood Cancers ◽  
Early Diagnosis Of Cancer ◽  
Diagnosis Of Cancer

Early diagnosis of cancer gives an opportunity for early treatment which is very important. Unfortunately, late presentation and delayed diagnosis of childhood cancers remain a problem in developing countries including Bangladesh. Few studies on delayed diagnosis of childhood cancers have been conducted in Bangladesh.

scholarly journals Cervical tuberculous lymphadenitis: diagnosis and demographics, a five-year case series in the UK

2018 ◽  
Vol 100 (5) ◽  
pp. 392-396 ◽  
Author(s):  
D Moualed ◽  
M Robinson ◽  
A Qureishi ◽  
P Gurr
Keyword(s):  
Fine Needle Aspiration ◽  
Delayed Diagnosis ◽  
Case Series ◽  
Needle Aspiration ◽  
Tuberculous Lymphadenitis ◽  
Open Biopsy ◽  
Retrospective Case ◽  
Full Data ◽  
Fine Needle ◽  
The Uk

Introduction Cervical tuberculous lymphadenitis is a low-volume condition in the UK with a potential for delayed diagnosis. This study describes typical demographic and clinical features of patients diagnosed with cervical tuberculous lymphadenitis in a UK population. The utility of cytological, histological and microbiological investigations is reviewed with comparison between fine-needle aspiration and open biopsy. This information can facilitate recognition of new cases and guide initial management. Methods Patients diagnosed with cervical tuberculous lymphadenitis between January 2009 and December 2013 at two district general hospitals were identified from local infectious disease databases. Retrospective case-note review was undertaken to collect demographic and diagnostic data and associated complications. Results Full data were available for 51 patients aged 19–70 years (mean 32.4 years) with mean follow-up of 370 days; 49/51 patients were immigrants to the UK with a wide geographic spread in the countries of origin and time since arrival; 42/51 had no significant comorbidities, although two patients had coexistent HIV infection. The clinical presentation was most frequently without constitutional symptoms (39/51) and often with no history of tuberculosis contact. Posterior triangle neck nodes were most commonly involved (26/51). Conclusion The ‘typical’ patient with cervical tuberculous lymphadenitis in our region is a young healthy individual who came to the UK from a high-risk country several years earlier. Diagnosis by fine-needle aspiration is as effective as open biopsy if fluid/pus is aspirated. Open biopsy is potentially associated with complications but does not appear to increase chronic wound discharge rates in our series.

scholarly journals Circulating Autoantibodies to LGALS3BP: A Novel Biomarker for Cancer

2013 ◽  
Vol 35 ◽  
pp. 747-752 ◽  
Author(s):  
Antonino Grassadonia ◽  
Nicola Tinari ◽  
Clara Natoli ◽  
Galit Yahalom ◽  
Stefano Iacobelli
Keyword(s):  
Healthy Subjects ◽  
Malignant Tumors ◽  
Enzyme Linked Immunosorbent Assay ◽  
Age And Gender ◽  
Patients With Cancer ◽  
Early Diagnosis Of Cancer ◽  
Diagnosis Of Cancer ◽  
And Gender ◽  
Circulating Autoantibodies ◽  
Circulating Levels

Purpose. Circulating autoantibodies have been extensively investigated as possible markers for early diagnosis of cancer. The present study was carried out to investigate whether anti-LGALS3BP IgG autoantibodies could be classified as a biomarker for malignant tumors.Methods. An in-house developed enzyme-linked immunosorbent assay was used to detect autoantibodies to LGALS3BP in sera from 71 patients with various types of cancers and 54 healthy subjects matched by age and gender.Results. Patients with cancer have significant higher circulating levels of anti-LGALS3BP antibodies as compared to control subjects (). The test has a sensitivity of 33% and a specificity of 98%.Conclusions. Anti-LGALS3BP IgG autoantibodies are a promising biomarker for malignant tumors and could play a role in the development of a multimarker assay for the early detection of cancer.

scholarly journals In-flight Transmission Cluster of COVID-19: A Retrospective Case Series

2020 ◽  
Author(s):  
Naibin Yang ◽  
Yuefei Shen ◽  
Chunwei Shi ◽  
Ada Hoi Yan Ma ◽  
Xie Zhang ◽  
...  
Keyword(s):  
Case Series ◽  
Clinical Information ◽  
Chest Ct ◽  
Flight Attendants ◽  
Common Symptom ◽  
Hospital Data ◽  
Retrospective Case ◽  
Illness Onset ◽  
Chest Ct Scan ◽  
Ground Glass Nodules

AbstractObjectivesNo data were available about in-flight transmission of SARS-CoV-2. Here, we report an in-flight transmission cluster of COVID-19 and describe the clinical characteristics of these patients.MethodsAfter a flight, laboratory-confirmed COVID-19 was reported in 12 patients. Ten patients were admitted to the designated hospital. Data were collected from 25th January to 28th February 2020. Clinical information was retrospectively collected.ResultsAll patients are passengers without flight attendants. The median age was 33 years, and 70% were females. None was admitted to intensive care unit, and no patients succumbed through 28th February. The median incubation period was 3.0 days and from illness onset to hospital admission was 2 days. The most common symptom was fever. Two patients were asymptomatic and negative for chest CT scan throughout the disease courses. On admission, initial RT-PCR were positive in 9 patients, however initial chest CT were positive in only half patients. The median lung “total severity score” of chest CT was 6. Notably, “Crazy-Paving” pattern, pleural effusion, and ground-glass nodules were also seen.ConclusionIt is potential for COVID-19 transmission by airplane, but the symptoms are mild. Passengers and attendants must be protected during the flight.

scholarly journals Intra- and juxta-articular Osteoid Osteoma in Children and Adolescents

2021 ◽  
Author(s):  
Xiaoyan Ni ◽  
Zhiqiang Zhang ◽  
Ping Xu ◽  
Bo Ning ◽  
Dahui Wang
Keyword(s):  
Children And Adolescents ◽  
Range Of Motion ◽  
Benign Tumor ◽  
Delayed Diagnosis ◽  
Case Series ◽  
Retrospective Case ◽  
Epidemiological Factors ◽  
Common Benign Tumor ◽  
Preoperative Radiograph

Abstract BackgroundOsteoid osteoma (OO) is a common benign tumor in children and adolescents, but intra-and juxta-articular OO is rare and difficult to diagnose. The purpose of this study is to investigate the distinctions between intra- and juxta-articular OO, trying to avoid delaying diagnosis and optimize treatment strategies.MethodsThirty patients diagnosed with OO in the intra- and juxta joint at our institution who underwent surgical resection were included. Clinical and epidemiological factors, preoperative radiograph parameters, including CT, MRI, and bone scan, were documented. The outcomes of the involved extremity were evaluated at the final follow-up.ResultsMean age at diagnosis, interval time, and follow-up time was 8.37 ± 3.79 years old, 4.67 ± 5.88 months, 3.57 ± 2.18 years, respectively. Factors identified to be significantly associated with intra- and juxta-articular OO including pain with activity (p=0.004) and abnormal range of motion (p=0.00). The factor of abnormal range of motion (p=0.03) also influenced the existence of complications. Four children had a secondary operation to cure the recurrence.ConclusionIt is essential for clinicians and radiologists to be aware of the atypical clinical and radiographic features of intra- and juxta-articular OO, as the delayed diagnosis can lead to unnecessary pain and further complications after surgeries. The pain with activity and abnormal range of motion is helpful to identify the location of OO. The persistently abnormal range of motion also significantly leads to complications. The open surgeries to resect the nidus in juxta-articular OO were effective.Level of Evidence: Level IV-retrospective case series


scholarly journals Methods of early diagnosis of cancer of the oral mucosa

2020 ◽  
Vol 19 (5-6) ◽  
pp. 86-90
Author(s):  
Valentina P. Kirillova ◽  
Oleg I. Kaganov ◽  
Aleksey G. Gabrielyan ◽  
Mikhail A. Postnikov ◽  
Andrey E. Orlov
Keyword(s):  
Health Care ◽  
Early Diagnosis ◽  
Literature Review ◽  
Oral Mucosa ◽  
Unsolved Problem ◽  
Malignant Tumors ◽  
Early Diagnosis Of Cancer ◽  
Diagnosis Of Cancer ◽  
The Russian Federation ◽  
The Given

Early diagnosis of cancer of the oral mucosa is still an unsolved problem of current Oncology. Despite the large number of proposed methods of diagnosis of precancerosis and cancer, the incidence of advanced malignant tumors of the oral mucosa are quite high. The analysis of the available scientific articles on the early diagnosis of cancer of the oral mucosa has been performed. The given literature review studies the most common methods of early diagnosis of cancer of the oral mucosa and their availability for practical health care of the Russian Federation.

Central Nervous System Infections Due to Streptococcus anginosus Group: A Single-Center Case Series

2021 ◽  
pp. 088307382110521
Author(s):  
Sujana Madathil ◽  
Satsuki Matsumoto ◽  
Katherine D. Mathews ◽  
Joseph Glykys
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Infection ◽  
Delayed Diagnosis ◽  
Case Series ◽  
Central Nervous System Infections ◽  
Retrospective Case ◽  
University Of Iowa ◽  
Timely Initiation ◽  
Streptococcus Anginosus

Background The Streptococcus anginosus group is known for its pathogenicity and tendency for abscess formation. The S anginosus group also causes brain abscesses, yet few studies describe this presentation in the pediatric neurology literature. We describe 5 patients with central nervous system infection due to S anginosus group evaluated by child neurologists at the University of Iowa from 2014 to 2020. Methods We performed a retrospective case series review of electronic medical records detailing the clinical presentation and course of pediatric patients with S anginosus group–associated central nervous system infection. Results We identified 4 males and 1 female (8, 11, 14, 16, and 21 years). Brain imaging showed abscesses in 4 cases and empyema in 1. All underwent neurosurgical intervention and antibiotic treatment. Cultures obtained during the neurosurgical procedure grew S anginosus group (4 cases with Streptococcus intermedius and 1 with Streptococcus constellatus). An 8-year-old boy with a delayed diagnosis died from brain herniation. Conclusions Central nervous system infections due to the S anginosus group can be life-threatening. Neuroimaging plays a key role in the early identification of abscesses. Prompt surgical intervention and timely initiation of antibiotics are critical for optimal outcomes.

scholarly journals Ophthalmic Evaluation of Diagnosed Cases of Eye Cystinosis: A Tertiary Care Center’s Experience

Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 911 ◽  
Author(s):  
Malgorzata Kowalczyk ◽  
Mario Damiano Toro ◽  
Robert Rejdak ◽  
Wojciech Załuska ◽  
Caterina Gagliano ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Adverse Events ◽  
Progressive Disease ◽  
Topical Therapy ◽  
Tertiary Care ◽  
Delayed Diagnosis ◽  
Case Series ◽  
Retrospective Case ◽  
Inappropriate Treatment ◽  
Full Check

Background: We aimed to identify diagnosed cases of ocular cystinosis and describe clinical, epidemiological and therapeutic characteristics. Methods: This is a descriptive and retrospective case series. All patients underwent a full check-up examination every 4–6 months by ophthalmologists, nephrologists and other required specialists. Results: Of the seven cases, six (85.7%) were females and one (14.2%) was male. The infantile nephropathic form of cystinosis was observed in five patients and the juvenile nephropathic form in two patients. No patients with the ocular form of cystinosis were identified. Corneal cystine crystals (CCC) were found in all analyzed patients. Severe ocular and general complications of the disease that had been standing for years, connected to the infantile nephropathic form, delayed diagnosis or inappropriate treatment, were observed only in two patients. All patients received topical therapy. No adverse events related to the therapy were observed. Conclusions: Cystinosis is a rare, progressive disease. Early diagnosis and treatment prevent serious complications from numerous systemic organs. Patients require constant systematic monitoring by various specialists.

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