scholarly journals Method for determining the kinematic parameters of the vertical rotor blades for the destruction of the tuberous layer

2020 ◽  
pp. 82-90
Author(s):  
V. A. Volsky V. A. ◽  
V. S. Bonchik
Keyword(s):  
Hydraulic Drive ◽  
Extreme Points ◽  
Geometric Shape ◽  
Kinematic Parameters ◽  
End Points ◽  
End Point ◽  
Vertical Rotor ◽  
Starting Point ◽  
The Absolute ◽  
Angle Of Rotation

Annotation Purpose. Development of a technique for determining the velocities of collision of the blades with the tuberous layer, the trajectory of movement, the magnitude and direction of the velocities of the most characteristic points. Methods. The research was carried out using the basic provisions of theoretical mechanics, statistics, probability theory, methods of differential calculations, mathematical modeling and applied programming. The studies were carried out on a specially designed laboratory installation using a vertical rotor hydraulic drive and strain gauge equipment mounted on a tractor, as well as a set of variable connecting plates for setting the machine operating modes. Results. The calculations of the absolute collision velocities of the blades of the lower and upper beaters of the vertical rotor at the start and end points, respectively, are performed. The geometric shape of the working surfaces and the direction of rotation for the extreme points of the outer contours of the blades of the lower and upper beaters of the vertical rotor of the potato harvester are substantiated. Conclusions. Using the above technique, as well as graphical dependences, we calculated the rational kinematic parameters of the blades of the lower and upper beaters of the vertical rotor, respectively, at the start and end points, where the greatest destruction of the tuber layer. For the lower beater blade, the absolute collision speed at the angle of rotation ωнt = 120° at the starting point = 1.6 m/s, at the end point – = 1.94 m/s. For the upper beater blade, the absolute collision speed at the angle of rotation ωвt = 120° at the starting point = 1.4 m/s, at the end point – = 1.92 m/s. Therefore, according to the specified rational kinematic parameters of the blades of the lower and upper beaters of the vertical rotor, it is possible to design the geometric shape of the surfaces of the crushing working bodies of potato harvesters. Keywords: blade, breaking surface, breasts, potatoes.

scholarly journals Time Interval to Biochemical Failure as a Surrogate End Point in Locally Advanced Prostate Cancer: Analysis of Randomized Trial NRG/RTOG 9202

2019 ◽  
Vol 37 (3) ◽  
pp. 213-221 ◽  
Author(s):  
James J. Dignam ◽  
Daniel A. Hamstra ◽  
Herbert Lepor ◽  
David Grignon ◽  
Harmar Brereton ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Randomized Trial ◽  
Locally Advanced ◽  
Biochemical Failure ◽  
Mediating Effect ◽  
Time Interval ◽  
Short Term ◽  
End Points ◽  
End Point

Background In prostate cancer, end points that reliably portend prognosis and treatment benefit (surrogate end points) can accelerate therapy development. Although surrogate end point candidates have been evaluated in the context of radiotherapy and short-term androgen deprivation (AD), potential surrogates under long-term (24 month) AD, a proven therapy in high-risk localized disease, have not been investigated. Materials and Methods In the NRG/RTOG 9202 randomized trial (N = 1,520) of short-term AD (4 months) versus long-term AD (LTAD; 28 months), the time interval free of biochemical failure (IBF) was evaluated in relation to clinical end points of prostate cancer–specific survival (PCSS) and overall survival (OS). Survival modeling and landmark analysis methods were applied to evaluate LTAD benefit on IBF and clinical end points, association between IBF and clinical end points, and the mediating effect of IBF on LTAD clinical end point benefits. Results LTAD was superior to short-term AD for both biochemical failure (BF) and the clinical end points. Men remaining free of BF for 3 years had relative risk reductions of 39% for OS and 73% for PCSS. Accounting for 3-year IBF status reduced the LTAD OS benefit from 12% (hazard ratio [HR], 0.88; 95% CI, 0.79 to 0.98) to 6% (HR, 0.94; 95% CI, 0.83 to 1.07). For PCSS, the LTAD benefit was reduced from 30% (HR, 0.70; 95% CI, 0.52 to 0.82) to 6% (HR, 0.94; 95% CI, 0.72 to 1.22). Among men with BF, by 3 years, 50% of subsequent deaths were attributed to prostate cancer, compared with 19% among men free of BF through 3 years. Conclusion The IBF satisfied surrogacy criteria and identified the benefit of LTAD on disease-specific survival and OS. The IBF may serve as a valid end point in clinical trials and may also aid in risk monitoring after initial treatment.

New Supervised Learning Theory Applied to Cerebellar Modeling for Suppression of Variability of Saccade End Points

2013 ◽  
Vol 25 (6) ◽  
pp. 1440-1471 ◽  
Author(s):  
Masahiko Fujita
Keyword(s):  
Supervised Learning ◽  
Cerebellar Cortex ◽  
Learning Theory ◽  
Learning System ◽  
Learning Ability ◽  
Motor Center ◽  
End Points ◽  
Noise Effects ◽  
End Point ◽  
Control Scheme

A new supervised learning theory is proposed for a hierarchical neural network with a single hidden layer of threshold units, which can approximate any continuous transformation, and applied to a cerebellar function to suppress the end-point variability of saccades. In motor systems, feedback control can reduce noise effects if the noise is added in a pathway from a motor center to a peripheral effector; however, it cannot reduce noise effects if the noise is generated in the motor center itself: a new control scheme is necessary for such noise. The cerebellar cortex is well known as a supervised learning system, and a novel theory of cerebellar cortical function developed in this study can explain the capability of the cerebellum to feedforwardly reduce noise effects, such as end-point variability of saccades. This theory assumes that a Golgi-granule cell system can encode the strength of a mossy fiber input as the state of neuronal activity of parallel fibers. By combining these parallel fiber signals with appropriate connection weights to produce a Purkinje cell output, an arbitrary continuous input-output relationship can be obtained. By incorporating such flexible computation and learning ability in a process of saccadic gain adaptation, a new control scheme in which the cerebellar cortex feedforwardly suppresses the end-point variability when it detects a variation in saccadic commands can be devised. Computer simulation confirmed the efficiency of such learning and showed a reduction in the variability of saccadic end points, similar to results obtained from experimental data.

scholarly journals Composite Primary End Points in Cardiovascular Outcomes Trials Involving Type 2 Diabetes Patients: Should Unstable Angina Be Included in the Primary End Point?

Diabetes Care ◽  
2017 ◽  
Vol 40 (9) ◽  
pp. 1144-1151 ◽  
Author(s):  
Nikolaus Marx ◽  
Darren K. McGuire ◽  
Vlado Perkovic ◽  
Hans-Juergen Woerle ◽  
Uli C. Broedl ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Unstable Angina ◽  
Cardiovascular Outcomes ◽  
End Points ◽  
End Point ◽  
Diabetes Patients

scholarly journals Effective intracortical microstimulation parameters applied to primary motor cortex for evoking forelimb movements to stable spatial end points

2013 ◽  
Vol 110 (5) ◽  
pp. 1180-1189 ◽  
Author(s):  
Gustaf M. Van Acker ◽  
Sommer L. Amundsen ◽  
William G. Messamore ◽  
Hongyu Y. Zhang ◽  
Carl W. Luchies ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Large Scale ◽  
Primary Motor Cortex ◽  
Emg Activity ◽  
Intracortical Microstimulation ◽  
End Points ◽  
End Point ◽  
Motor Effects ◽  
Forelimb Movements ◽  
Stimulation Of

High-frequency, long-duration intracortical microstimulation (HFLD-ICMS) applied to motor cortex is recognized as a useful and informative method for corticomotor mapping by evoking natural-appearing movements of the limb to consistent stable end-point positions. An important feature of these movements is that stimulation of a specific site in motor cortex evokes movement to the same spatial end point regardless of the starting position of the limb. The goal of this study was to delineate effective stimulus parameters for evoking forelimb movements to stable spatial end points from HFLD-ICMS applied to primary motor cortex (M1) in awake monkeys. We investigated stimulation of M1 as combinations of frequency (30–400 Hz), amplitude (30–200 μA), and duration (0.5–2 s) while concurrently recording electromyographic (EMG) activity from 24 forelimb muscles and movement kinematics with a motion capture system. Our results suggest a range of parameters (80–140 Hz, 80–140 μA, and 1,000-ms train duration) that are effective and safe for evoking forelimb translocation with subsequent stabilization at a spatial end point. The mean time for stimulation to elicit successful movement of the forelimb to a stable spatial end point was 475.8 ± 170.9 ms. Median successful frequency and amplitude were 110 Hz and 110 μA, respectively. Attenuated parameters resulted in inconsistent, truncated, or undetectable movements, while intensified parameters yielded no change to movement end points and increased potential for large-scale physiological spread and adverse focal motor effects. Establishing cortical stimulation parameters yielding consistent forelimb movements to stable spatial end points forms the basis for a systematic and comprehensive mapping of M1 in terms of evoked movements and associated muscle synergies. Additionally, the results increase our understanding of how the central nervous system may encode movement.

scholarly journals THE TURN OF THE SCREW: HENRY JAMES AS AN AUTHOR AND A CRITIC

2020 ◽  
pp. 55-67
Author(s):  
M.B. Rarenko ◽  
Keyword(s):  
Henry James ◽  
William James ◽  
Absolute Truth ◽  
The Core ◽  
Works Of Art ◽  
Starting Point ◽  
The World ◽  
New Type ◽  
Points Of View ◽  
The Absolute

The article considers the story by Henry James (1843 – 1916) «The Turn of the Screw» (1898 – first edition, 1908 – second edition) in connection with the emergence of a new type of narrator in the writer's late prose. The worldview and creative method of H. James are formed under the influence of the philosophy of pragmatism, which became widespread at the turn of the XIX-XX centuries thanks to the works of the writer's elder brother, the philosopher William James (1842 – 1910). The core of pragmatism is the pluralistic concept of William James based on the assumption that knowledge can be realized from very limited, incomplete, and inadequate «points of view» and this leads to the statement that the absolute truth is essentially unknowable. The epistemological statements of William James's theory is that the content of knowledge is entirely determined by the installation of consciousness, and the content of the truth in this case depends on the goals and experience of the human, i.e. the central starting point is the consciousness of the person. Henry James not only creates works of art, but also sets out in detail the principles of his work both on the pages of fiction works of small and large prose, putting them in the mouths of their characters – representatives of the world of art, and in the prefaces to his works of fiction, as well as in critical works.

European Network on the Determination of Site End Points for Radiologically Contaminated Land

2007 ◽  
Author(s):  
Peter Booth ◽  
Chris Lennon
Keyword(s):  
Best Practice ◽  
Good Practice ◽  
State Agency ◽  
European Network ◽  
End Points ◽  
Contaminated Land ◽  
End Point ◽  
Land Site ◽  
High Level

Nexia Solutions are currently running a small European network entitled “European Network on the Determination of Site End Points for Radiologically Contaminated Land (ENDSEP)”. Other network members include NRG (Netherlands), UKAEA (UK), CEA (France), SOGIN (Italy), Wismut (Germany), Saxon State Agency of Environment and Geology (Germany). The network is focused on the technical and socio-economical issues associated with the determination of end points for sites potentially, or actually, impacted by radiological contamination. Such issues will cover: • Those associated with the run up to establishing a site end point; • Those associated with verifying that the end points have been met; and • Those associated with post closure. The network’s current high level objectives can be summarized as follows: • Share experience and best practice in the key issues running up to determining site end points; • Gain a better understanding of the potential effects of recent and forthcoming EU legislation; • Assess consistency between approaches; • Highlight potential gaps within the remit of site end point determination and management; and • Consider the formulation of research projects with a view to sharing time and expense. The programme of work revolves around the following key tasks: • Share information, experience and existing good practice. • Look to determine sustainable approaches to contaminated land site end point management. • Through site visits, gain first hand experience of determining an appropriate end point strategy, and identifying and resolving end point issues. • Highlight the key data gaps and consider the development of programmes to either close out these gaps or to build confidence in the approaches taken. • Production of position papers on each technical area highlighting how different countries approach/resolve a specific problem.

scholarly journals A Privacy-Preserving Trajectory Publication Method Based on Secure Start-Points and End-Points

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Yannian Zhao ◽  
Yonglong Luo ◽  
Qingying Yu ◽  
Zhaoyan Hu
Keyword(s):  
Theoretical Analysis ◽  
Privacy Preservation ◽  
Privacy Preserving ◽  
Third Parties ◽  
Algorithm Complexity ◽  
Experimental Results ◽  
End Points ◽  
End Point ◽  
Trajectory Similarity ◽  
Candidate Set

By judging whether the start-point and end-point of a trajectory conform to the user’s behavioral habits, an attacker who possesses background knowledge can breach the anonymous trajectory. Traditional trajectory privacy preservation schemes often generate an anonymous set of trajectories without considering the security of the trajectory start- and end-points. To address this problem, this paper proposes a privacy-preserving trajectory publication method based on generating secure start- and end-points. First, a candidate set containing a secure start-point and end-point is generated according to the user’s habits. Second, k−1 anonymous trajectories are generated bidirectionally according to that secure candidate set. Finally, accessibility corrections are made for each anonymous trajectory. This method integrates features such as local geographic reachability and trajectory similarity when generating an anonymized set of trajectories. This provides users with privacy preservation at the k-anonymity level, without relying on the trusted third parties and with low algorithm complexity. Compared with existing methods such as trajectory rotation and unidirectional generation, theoretical analysis and experimental results on the datasets of real trajectories show that the anonymous trajectories generated by the proposed method can ensure the security of trajectory privacy while maintaining a higher trajectory similarity.

Hegel as a Theorist of Secularization

2013 ◽  
Vol 34 (2) ◽  
pp. 223-244
Author(s):  
Espen Hammer
Keyword(s):  
Philosophy Of Religion ◽  
The State ◽  
The Other ◽  
The Political ◽  
Adequate Account ◽  
Religious Development ◽  
End Point ◽  
Religious Thinking ◽  
The Absolute ◽  
The One

Hegel's philosophy of religion is characterized by what seems to be a deep tension. On the one hand, Hegel claims to be a Christian thinker, viewing religion, and in particular Christianity, as a manifestation of the absolute. On the other hand, however, he seems to view modernity as largely secular, devoid of authoritative claims to transcendence. Modernity is secular in the political sense of requiring the state to be neutral when it comes to matters of religion. However, it is also secular in the sense of there being no recourse to authoritative representations of a transcendent God. Drawing on Charles Taylor's view of secularization, the article focuses on the second strand of his religious thinking, exploring how Hegel can be thought of as a theorist of secularization. It is claimed that his dialectic of religious development describes a process of secularization. Ultimately, Hegel's system offers a view of the absolute as immanent, suggesting that an adequate account of religion will necessarily have to accept secularization as the end-point of spirit's development. This is how the tension between religion and secularization can be resolved.

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