scholarly journals NON-SPECIFIC IMMUNOLOGICAL RESISTANCE IN DIFFERENT

2021 ◽  
Vol 10 (3) ◽  
pp. 16-25
Author(s):  
E. P. Golubinskaya ◽  
T. G. Filonenko ◽  
A. V. Kubyshkin ◽  
Y. A. Ermola ◽  
M. A. Kalfa ◽  
...  
Keyword(s):  
Immune Response ◽  
Plasma Cells ◽  
Educational Institution ◽  
Federal State ◽  
Cytotoxic Lymphocytes ◽  
Pulmonary Tissue ◽  
Resistant Tuberculosis ◽  
Scientific Equipment ◽  
Pathogenic Factors ◽  
Important Challenge

Tuberculosis (TB) is a socially significant disease for the entire world community. An important challenge in successfully combating this infection is the avalanche increase in the number of drug-resistant tuberculosis. Currently, among the reasons for the development of pulmonary tuberculosis, a complex of etiological and pathogenic factors contributing to the disruption of the immune response to M. tuberculosis and the formation of secondary immunological failure (SIF) accompanying the disease are of particular importance. However, the issues of discoordination of cellular components of the local immune system of the lungs leading to T-cell deficiency, as well as the ineffectiveness of the B-cell link, reduction of lymphocyte proliferative activity and activation of apoptosis, cytokine imbalance and activation of immunosuppression mechanisms are not fully studied and have a scattered nature, which does not allow us to assess the overall picture of violations. The goal: determining the immunophenotype of lymphocyte population in lung tissue biopsy specimens of patients with various forms of secondary tuberculosis depending on resistance in case fibrosecavernous tuberculosis (FCT). The material in the study was pulmonary tissue fragments of 30 patients with the verified diagnosis of FCT, and distributed in 2 main groups: resistant forms of secondary tuberculosis (n = 15) and 15 patients not resistant forms of secondary tuberculosis. The standard histological method was used. Immunohistochemically panel of markers included CD68, CD4, CD8, CD20, CD138. The study was conducted at the Center for the collective use of scientific equipment «Molecular Biology» of the Medical Academy named after S.I. Georgievsky in the framework of the grant № ВГ 09/2019, supported by federal state autonomous educational institution of higher education «V.I. Vernadsky Crimean Federal University». The results of the study have shown that in the conditions of secondary tuberculosis, regardless of resistance, the formation of local immunodeficiency with an immune response along the Th-2 pathway is determined. The prevalence of cytotoxic lymphocytes in the area of specific granulation tissue and the draining bronchus indicated the prolongation of inflammation and its transfer to the latent phase. The increase in the number of T-helpers and activated plasma cells can serve a reliable prognostic and diagnostic marker for the reactivation of the tuberculosis process.

scholarly journals Phenotyping of Dairy Cattle in Breeding Programs

2021 ◽  
Author(s):  
Irina Ivanova ◽  
Irina Trotsenko ◽  
Olga Lebedenko
Keyword(s):  
Dairy Cattle ◽  
Educational Institution ◽  
Analytical Data ◽  
Maximum Level ◽  
Phenotypic Characterization ◽  
Federal State ◽  
Milk Productivity ◽  
Animal Science ◽  
Black And White ◽  
Scientific Equipment

This article examines the phenotypic features of cattle and their use in breeding to improve the characteristics of milk productivity. As part of the research, 483 black-and- white pedigree cows in the breeding enterprises of the Omsk region were evaluated by a set of characteristics. It was found that the average age of calving cows was 2.5 years. 42.7% in the total cow population were full-grown cows. The maximum level of milk productivity was observed in second lactation cows. The milk yield for 305 days of the second lactation was 6.720 kg, which was 621 kg or 9.24% higher than that in first-calf heifers. The phenotypic characterization of breeding stock allowed us to identify all the necessary reserves for obtaining high-yielding offspring, in order to increase the level of milk production in the black-and-white cattle population of the region. This research was conducted with the use of the technical base and laboratory areas of the Department of Animal Science (Faculty of Animal Science, Commodity Science and Standardization), as well as the Center for the Collective Use of Scientific Equipment of the Federal State Budgetary Educational Institution of Higher Education “Omsk State Agrarian University named after P.A. Stolypin”. The analytical data and the results of the research presented in this publication may be of interest for students of specialized educational institutions, as well as for specialists in dairy cattle farming, and can be implemented at breeding enterprises. Keywords: Phenotyping, breeding, milk productivity, cattle

Мониторинг показателей эффективности целевого приема в дальневосточном государственном медицинском университете

2019 ◽  
pp. 57-61
Keyword(s):  
Educational Institution ◽  
Medical Personnel ◽  
Comparative Assessment ◽  
Federal State ◽  
Specialty Training ◽  
State Budget ◽  
Eastern State ◽  
Medical University ◽  
Far Eastern ◽  
Passing Score

The article analyzes the dynamics of the indicators of target enrollment and education at the Federal State Budget Educational Institution of Higher Education of the Far Eastern State Medical University of the Ministry of Health of Russia for the period from 2013 to 2018, a comparative assessment of the passing score for the places of targeted enrollment and the main places depending on the specialty (training direction) was made, average mark of a unified state exam (USE) was analyzed; the agreements on targeted training with the assessment of measures of social support were analyzed, as well as proposals were formulated to improve the activities of targeted training of medical personnel.

Aging society: prospects for improving the quality of life

2020 ◽  
Vol 92 (3) ◽  
pp. 193-201
Author(s):  
O. A. Bortniuk ◽  
Keyword(s):  
Elderly People ◽  
Senile Dementia ◽  
Educational Institution ◽  
The Elderly ◽  
Social Institution ◽  
Federal State ◽  
Functional Impairments ◽  
Eastern State ◽  
Aging Society ◽  
Free Environment

The article is devoted to the issues related to the phenomenon of “aging society”. The relevance of creating a barrier-free environment for the elderly is dictated by the current demographic trend towards an increase in life expectancy, an increase in its quality. The number of centenarians with functional impairments (senile dementia, Parkinson’s and Alzheimer’s) who require care at a qualitatively new level is increasing. Innovative form of organizing the leisure of the elderly «Kindergarten for the elderly people» is considered as one of the ways to solve the problem. Based on the data of a study conducted by the Federal state budgetary educational institution of higher education of the Far-Eastern state medical university of the Ministry of Health of Russia in 2020, identified the need to create a social institution «Kindergarten for the elderly people». The article notes the need for older people to adapt to the changing conditions of their life in the society saturated with gadgets and information.

The system of disposal of equipment in the agro-industrial complex and issues of the legislative framework

2021 ◽  
pp. 56-67
Author(s):  
V. I. Ignatov ◽  
Y. V. Kataev ◽  
V. S. Gerasimov ◽  
N. K. Baulin
Keyword(s):  
Educational Institution ◽  
The State ◽  
Federal State ◽  
General Strategy ◽  
Industrial Complex ◽  
Resource Saving ◽  
Recycling System ◽  
Effective System ◽  
Legislative Framework ◽  
Agroindustrial Complex

The paper is devoted to the analysis of the state of the equipment recycling system in Russia and the issues of improving the legislative framework that accompanies it. The role of state structures in solving the problems of forming a resource-saving ecooriented system for the disposal of decommissioned equipment is reflected. To analyze the work in the field of waste management, to reflect the state of the legislative framework for the existing system of recycling equipment in Russia and abroad, to make recommendations for its improvement. Problems with waste appear when, in the process of production and consumption of substances, objects (equipment), he/she becomes unnecessary for their owners, their owner tries to get rid of this object in the most accessible way. According to numerous information, the disposal of equipment in Russia is mainly carried out (black waste collectors), which control more than 60 % of the scrap of non-ferrous and ferrous metals, so the solution to the problem of creating an effective system for the disposal of equipment becomes not just relevant, but vital for our state. The scientific community in Russia is constantly conducting research on the creation and implementation of a system for the disposal of decommissioned equipment, so, for example, MADI scientists proposed a regional car recycling system for implementation, the scientists of the Federal State Budgetary Educational Institution FNAC VIM also developed a regional system for the disposal of agricultural recycling equipment. In order to quickly solve the problem of working out a general strategy for creating an effective system of recycling equipment in Russia, taking into account the revision of the legislative framework, it is advisable to "run-in" it at the industry level, for example, in the agroindustrial complex, with subsequent replication in other industries.

How to detect occupational diseases associated with the exposure to chemical factors

2020 ◽  
pp. 26-35
Author(s):  
Sergey Babanov
Keyword(s):  
Urinary Tract ◽  
Occupational Diseases ◽  
Educational Institution ◽  
Physical Nature ◽  
Federal State ◽  
Physical Factors ◽  
Ministry Of Health ◽  
Production Factors ◽  
Chemical Factors ◽  
Medical University

Diseases of the kidneys and urinary tract, primarily of toxic and chemical etiology, constitute a large proportion of occupational diseases. Various production factors of both chemical and physical nature can cause the development of nephropathies. Sergey Babanov, Doctor of Medicine, Professor, Head of the Department of occupational diseases and clinical pharmacology at the Federal State-Funded Educational Institution of Higher Education Samara State Medical University of the Ministry of Health of the Russian Federation, chief freelance specialist in occupational pathology at the Ministry of Health of the Samara region, speaks about occupational diseases of the kidneys and urinary tract associated with the exposure to chemical and physical factors.

scholarly journals LONG-LIVED BONE MARROW PLASMA CELLS DURING IMMUNE RESPONSE TO ALPHA (1→3) DEXTRAN

2015 ◽  
Vol 17 (2) ◽  
pp. 127
Author(s):  
I. N. Chernyshova ◽  
M. V. Gavrilova ◽  
L. V. Komarova ◽  
E. V. Sidorova
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
Plasma Cells ◽  
Bone Marrow Plasma

scholarly journals Humanization of the educational space – 2021: Digitalization of the educational environment (Overall results of the international forum)

2021 ◽  
Vol 10 (2) ◽  
pp. 176-184
Author(s):  
Elena E. Morozova ◽  
◽  
Nikolay V. Sayapin ◽  
Maria P. Zinovyeva ◽  
◽  
...  
Keyword(s):  
Higher Education ◽  
Educational Institution ◽  
Educational Environment ◽  
Federal State ◽  
State University ◽  
International Forum ◽  
Scientific Institution ◽  
Special Needs Education ◽  
West Kazakhstan ◽  
Technological University

The results of the international forum “Humanization of the educational space – 2021: digitalization of the educational environment”, which was held on February 18–19, 2021 in Saratov, are presented. The conference was organized by the Federal State Budgetary Educational Institution of Higher Education “Saratov National Research State University named after N. G. Chernyshevsky”, the Faculty of Pedagogical and Special Needs Education; Federal State Budgetary Scientific Institution “Institute for the Study of Childhood, Family and Education of the Russian Academy of Education”; Baranovichi State University (Republic of Belarus); West Kazakhstan Innovation and Technological University (Republic of Kazakhstan); Fergana State University (Republic of Uzbekistan).

scholarly journals MOVING TO THE FUTURE BY STUDYING THE PAST: ON THE COURSE IN THE HISTORY OF TRANSPORT IN RUSSIA

2020 ◽  
Vol 17 (5) ◽  
pp. 332-336
Author(s):  
S. S. Ilizarov
Keyword(s):  
Technological Progress ◽  
Educational Institution ◽  
Transport Sector ◽  
Federal State ◽  
Higher Vocational Education ◽  
Historical Process ◽  
The Past ◽  
Transport Industry ◽  
Wide Circle ◽  
History Of

The history of transport in Russia: Textbook. Ed. by T. L. Pashkova. Moscow, Federal State Budgetary  Educational Institution of Higher Vocational Education «Training Methodological Center for Railway Education», 2019, 380 р. ISBN 978-5-907055-03-2. The peer-reviewed textbook is dedicated to the history of origination and development of all modes of transport in Russia. Its main goal is to show evolution historical process of development of technological progress in the transport sector. It is intended for the 1st and 2nd year students of higher education institutions training personnel for transport industry. The publication may be useful to researchers, Ph.D. students, employees of ministries and departments, as well as to a wide circle of readers, whose attention is drawn to the history of transport and of the transport industry. 

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