Efficiency of Salen Functionalized Ionic Liquids and their Application towards Biological Activity

2020 ◽  
Vol 13 (4) ◽  
pp. 5020-5027
Author(s):  
C. Isac Sobanara ◽  
M. Antilin Princela
Keyword(s):  
Ionic Liquid ◽  
Biological Activity ◽  
Metal Ions ◽  
Morphological Changes ◽  
Vital Role ◽  
Spectroscopic Techniques ◽  
Salen Complex ◽  
Salen Complexes ◽  
Ft Ir ◽  
Ancient Times

Schiff bases were often used as chelating ligands for the stabilization of metal ions with various oxidation states. It is called privileged ligands, due to their own peculiar capacity to make a four and six coordinated salen complex to stabilize the metal ions. On the other hand, Ionic liquid (IL) also plays a key material in engineering and scientific fields. Due to their own physiochemical properties and widespread applications in different areas of research. It has been recently found that, the suitable choice and appropriate size of cation and anion can alter the geometry of ILs and it directly influenced the biological activity of ILs. Herein ionic liquid tagged new salen complexes of first row transition metals such as Fe, Co, Ni, Cu and Zn have been synthesized successfully and characterized. The structure of synthesized salen complexes were studied by UV, FT-IR, NMR and Mass spectroscopic techniques. Metal complexes play a vital role in drug discovery since ancient times. Especially, these complexes can interact with the cell membrane and make the morphological changes in the affected site. Moreover, the efficiency of salen complexes were assessed by antimicrobial and antifungal studies. Among all the IL tagged salen complexes the Ionic liquid tagged cobalt salen complexes was very effective against the tested microorganisms.

scholarly journals Synthesis, Characterization and Biological Activity Study of New Compounds Tetrazole Derivatives Azo-Schiff Base

2019 ◽  
Vol 25 (103) ◽  
pp. 68-89
Author(s):  
Hiba Ibrahim Abdulla AL-Joubory ◽  
Khalid Mohamad Motny Al-janaby
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Pathogenic Bacteria ◽  
Diazonium Salt ◽  
Aldehyde Group ◽  
Spectroscopic Techniques ◽  
Phenyl Hydrazine ◽  
Ft Ir ◽  
New Compounds ◽  
Tetrazole Derivatives

This work included synthesis of azo dye (H1) by the reaction of diazonium salt to sulfacetamide with 4-hydroxy benzaldehyde at (0-5) oC  and synthesis of schiff base (H2-H6) through reaction substituted aromatic amine (aniline, 4-nitro aniline, 4-chloro aniline, 4-amino benzoic acid and phenyl hydrazine)  with aldehyde group in azo compound (H1) in ethanol compounds (H2-H6) and tetrazole derivatives prepared by reaction schiff base with sodium azide in ethanol compounds (H7-H11) and characterization by using spectroscopic techniques Uv/Vis, FT-IR, C.H.N. and H1-NMR of some the prepared compounds using DMSO-d6 a solvent, in addition melting point and determination a purity of TLC, and this work consists a study of biological activity for the some prepared compounds against four types of pathogenic bacteria and know to be resistant to anti biotic.

scholarly journals Catalytic Conversion of Glucose into Levulinic Acid Using 2-Phenyl-2-Imidazoline Based Ionic Liquid Catalyst

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 348
Author(s):  
Komal Kumar ◽  
Mukesh Kumar ◽  
Sreedevi Upadhyayula
Keyword(s):  
Ionic Liquid ◽  
Reaction Time ◽  
Levulinic Acid ◽  
Value Added ◽  
Spectroscopic Techniques ◽  
Hydrothermal Conversion ◽  
Acidic Ionic Liquid ◽  
Brønsted Acidic Ionic Liquid ◽  
Ft Ir ◽  
Ir Spectroscopic

Levulinic acid (LA) is an industrially important product that can be catalytically valorized into important value-added chemicals. In this study, hydrothermal conversion of glucose into levulinic acid was attempted using Brønsted acidic ionic liquid catalyst synthesized using 2-phenyl-2-imidazoline, and 2-phenyl-2-imidazoline-based ionic liquid catalyst used in this study was synthesized in the laboratory using different anions (NO3, H2PO4, and Cl) and characterized using 1H NMR, TGA, and FT-IR spectroscopic techniques. The activity trend of the Brønsted acidic ionic liquid catalysts synthesized in the laboratory was found in the following order: [C4SO3HPhim][Cl] > [C4SO3HPhim][NO3] > [C4SO3HPhim][H2PO4]. A maximum 63% yield of the levulinic acid was obtained with 98% glucose conversion at 180 °C and 3 h reaction time using [C4SO3HPhim][Cl] ionic liquid catalyst. The effect of different reaction conditions such as reaction time, temperature, ionic liquid catalyst structures, catalyst amount, and solvents on the LA yield were investigated. Reusability of [C4SO3HPhim][Cl] catalyst up to four cycles was observed. This study demonstrates the potential of the 2-phenyl-2-imidazoline-based ionic liquid for the conversion of glucose into the important platform chemical levulinic acid.

scholarly journals Investigating the Adsorption Behavior and Mechanism of Eu(III) and Au(III) on β-cyclodextrin/polyethylenimine Functionalized Waste Paper

2021 ◽  
Author(s):  
Fenglei Liu ◽  
Shan Hua ◽  
Qingyuan Hu ◽  
Chao Wang ◽  
baowei hu
Keyword(s):  
Vital Role ◽  
Adsorption Behavior ◽  
Waste Paper ◽  
Spectroscopic Techniques ◽  
Spectroscopy Analysis ◽  
Step Method ◽  
Structure Morphology ◽  
Pseudo Second Order ◽  
Ft Ir ◽  
Redox Interaction

Abstract A bio-adsorbent (DAWP-PEI-β-CD) was facilely prepared by introducing polyethylenimine (PEI) and β-cyclodextrin (β-CD) into dialdehyde waste paper (DAWP) via a facile two-step method. Various physicochemical and spectroscopic techniques (FT-IR, XRD, SEM, NMR, XPS) were applied to characterize the structure, morphology and composition of the as-prepared adsorbents. Investigation results showed that the pH values, reaction temperature and contact time played a vital role in uptake of Eu(III) and Au(III). Meanwhile, the adsorption behavior of Eu(III) and Au(III) could be fitted felicitously with the Langmuir and the Pseudo-second-order models, and the saturated adsorption amounts of Eu(III) (pH = 6.0) and Au(III) (pH = 2.0) onto DAWP-PEI-β-CD were 424.2 and 241.3 mg/g, respectively. Further advanced spectroscopy analysis revealed that the elimination of Eu(III) was attributed to host-guest inclusion and surface complexation interaction, while adsorption of Au(III) might stem from a combination of electrostatic attraction, chelation, host-guest inclusion and redox interaction. This study demonstrated that DAWP-PEI-β-CD was a promising environmental functional material to separation and enrichment of Eu(III) and Au(III) from contaminated water.

scholarly journals Synthesis and SAR Evaluation of Mercaptotriazolo derivatives as anti-inflammatory agents.

2020 ◽  
Vol 13 (1) ◽  
pp. 187-198
Author(s):  
S. V Mamatha ◽  
S. L. Belagali ◽  
Mahesh Bhat
Keyword(s):  
Experimental Data ◽  
Biological Activity ◽  
Membered Ring ◽  
Spectroscopic Techniques ◽  
Methyl Substituent ◽  
1H And 13C Nmr ◽  
Structure Activity ◽  
Activity Structure ◽  
Ft Ir ◽  
Anti Inflammatory

A new series of benzothiazole appended triazole derivatives were synthesized. Characterization is done by FT-IR, Mass, 1H and 13C NMR spectroscopic techniques. The newly synthesized compounds were screened for antioxidant and anti inflammatory activities. Experimental data hypothesized compound 7b as highly potent cytotoxicant with lengthened activity. Structure–activity relation interrelates the biological activity and chemical moiety of the molecule. Structurally, 7b is a benzothiazolyltriazole having a pyrrolidine group (five membered ring) attached to two CH2 groups and methyl substituent at 7th position of the benzothiazole ring

scholarly journals Spectroscopic characterization of the interactions of bovine serum albumin with medicinally important metal ions: platinum (IV), iridium (III) and iron (II)

2021 ◽  
Author(s):  
Hassan A Alhazmi ◽  
Mohammed Al Bratty ◽  
Abdulkarim M. Meraya ◽  
Asim Najmi ◽  
Md Shamsher Alam ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Metal Ions ◽  
Conformational Changes ◽  
Bovine Serum ◽  
Spectroscopic Characterization ◽  
New Drugs ◽  
Spectroscopic Techniques ◽  
Protein Structure Analysis ◽  
Ft Ir

Serum albumin protein plays a key role in the transportation and distribution of bioactive species including metal ions and metal-based drugs and, therefore, the nature of their binding could provide important insight for the development of new drugs. In the present investigation, binding interactions of bovine serum albumin (BSA) with three biologically important metal ions: Pt4+, Ir3+ and Fe2+ were screened using easy-to-use and cost-effective Fourier-Transform Infrared (FT-IR) and Ultraviolet-Visible (UV-Vis) spectroscopic techniques. Prior to the screening, the protein and metal ions were allowed to interact at physiological pH (7.4) and the spectral changes were monitored upon interaction. In FT-IR spectrum, the position of amide I band (C=O stretching) was shifted from 1652 cm–1 in case of free BSA to 1659, 1657 and 1656 cm–1 in BSA-Pt4+, BSA-Ir3+ and BSA-Fe2+ complexes, respectively. This spectral shifting was due to the binding of metal ions to N and O atoms of BSA peptide bonds. The interaction was further demonstrated by a remarkable reduction in spectral intensities of amide I and II bands. Secondary protein structure analysis revealed conformational changes characterized by a substantial decrease in α-helix (11.29–27.41%) accompanied by an increase in β-sheet and β-antiparallel contents. The absorption of BSA at a constant concentration at 280 nm was successively reduced as the concentration of Pt4+ and Ir3+ ions increased. On the other hand, the absorption of BSA-Fe2+ complex successively increased with the increase in the concentration of Fe2+ in the test solution. The binding constants for BSA-Pt4+, BSA-Ir3+ and BSA-Fe2+ complexes were calculated to be 1.55×104, 5.67×104 and 3.78×104 M-1, respectively. The results revealed that the three metal ions showed binding affinities with the BSA protein in the order: Ir3+>Fe2+>Pt4+.

scholarly journals Synthesis, characterization and electrochemistry of triethyl ammonium sulphate ionic liquid

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Jalal Khan ◽  
Sayyar Muhammad ◽  
Luqman Ali Shah ◽  
Javed Ali ◽  
Muhammad Ibrar ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Species ◽  
Spectroscopic Techniques ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid ◽  
Oxide Layers ◽  
Onset Potential ◽  
H Nmr ◽  
Surface Electrochemistry ◽  
Ft Ir

AbstractProtic ionic liquids (PILs) being intrinsic proton conducting ionic species are considered as potential green electrolytes for study of electrocatalytic reactions and for fabrication of IL-based fuel cells (FCs) and batteries. We have prepared a sulfate anion based protic ionic liquid (PIL), triethylammonium sulfate (TEAS) through a reaction involving transfer of proton from H2SO4 to triethylamine (TEA). 1H NMR and FT-IR spectroscopic techniques were employed for confirmation of the synthesis of TEAS and water content of the PIL was quantified using coulometric Karl–Fischer (KF) titration. 1H NMR and FT-IR analysis confirm the synthesis of the PILs and KF-titration analysis shows that TEAS contains 1.43 w/w % water. Electrical conductivity of TEAS was determined at different temperatures showing that the PIL has excellent ionic conductivity that enhances with rise in temperature of the medium. The temperature dependence of the conductivity of the PIL follows the Arrhenius equation as the logσ versus 1/T plot is linear. The electrochemical windows (EWs) of the electrolyte were found using cyclic voltammetry at Pt and Au working electrodes and found to decrease with increase in temperature of the medium. The data revealed that the surfaces of the electrodes are covered with oxide layers due to oxidation of trace water (1.43 w/w %) present in the PIL. The oxide layers growth increase and their onset potential moves to less positive values as the temperature of the PILs is increased. The data was compared with the literature and would be helpful in understanding of the surface electrochemistry in this neoteric medium for being used as potential electrolyte in industry for various electrochemical applications.

Chiral Mn(III) Salen Complex Immobilized on CuFe2O4@SiO2-NH2 NPs: A Cheap and Efficient Catalyst for N-arylation of Aryl Halides and Phenylboronic Acid Under Mild Conditions

2020 ◽  
Vol 17 (11) ◽  
pp. 857-863
Author(s):  
Mohammad Ali Nasseri ◽  
Seyyedeh Ameneh Alavi ◽  
Milad Kazemnejadi ◽  
Ali Allahresani
Keyword(s):  
Phenylboronic Acid ◽  
Significant Loss ◽  
Aryl Halides ◽  
Coupling Reactions ◽  
Efficient Catalyst ◽  
Aryl Chlorides ◽  
Mild Conditions ◽  
Cross Coupling Reactions ◽  
Salen Complex ◽  
Ft Ir

A convenient and efficient chiral CuFe2O4@SiO2-Mn(III) Ch.salen nanocatalyst has been developed for the C-N cross-coupling reactions of aryl halides/ phenylboronic acid with N-heterocyclic compounds in water and/or DMSO under mild conditions. The catalyst could be applied for the N-arylation of a variety of nitrogen-containing heterocycles with aryl chlorides, bromides, iodides and phenylboronic acid under mild conditions. Moderate to good yields were achieved for all substrates. The structure of catalyst was characterized using various techniques including FT-IR, FE-SEM, EDX, XRD, TEM and TGA. The catalyst can be simply recovered and reused for several times without significant loss of activity.

Synthesis, Characterization and Application of N,N-Dimethyl-N-Sulfoethan Ammonium tetra-Chloro Aluminate: A Novel micro-Heterogeneous Cata-lyst for Synthesis of tri-Arylmethanes

2020 ◽  
Vol 17 ◽  
Author(s):  
Saeid Azimi ◽  
Niloofar Mohamadighader
Keyword(s):  
Ionic Liquid ◽  
Heterogeneous Catalyst ◽  
Mass Spectroscopy ◽  
Aromatic Aldehydes ◽  
Solid Catalyst ◽  
Sem Images ◽  
One Pot ◽  
Acidic Catalyst ◽  
Eds Analysis ◽  
Ft Ir

Abstract: A new solid catalyst was synthesized from an ionic liquid and heterogenised by changing anion reaction. The new heterogeneous acidic catalyst was characterized by SEM images, EDS analysis, AFM images, Ft-IR, HNMR, 13CNMR and Mass Spectroscopy. It was applied to synthesis of tri-arylmethanes throughout one-pot tri-component reactions among aromatic aldehydes, N,N-dimethylaniline and other carbonic nucleophiles such as anisole and indole. Hence, synthesis of convenient and inexpensive micro-heterogeneous catalyst was introduced, the efficiency of which was confirmed. Also, various useful products were synthesized throughout this simple and clean procedure.

Synthesis of New α-Amino Phosphonates Containing 3-Amino-4(3H) Quinazolinone Moiety as Anticancer and Antimicrobial Agents: DFT, NBO, and Vibrational Studies

2018 ◽  
Vol 15 (2) ◽  
pp. 286-296 ◽  
Author(s):  
Mohamed K. Awad ◽  
Mahmoud F. Abdel-Aal ◽  
Faten M. Atlam ◽  
Hend A. Hekal
Keyword(s):  
Biological Activity ◽  
Cell Line ◽  
Quantum Chemical ◽  
Density Functional ◽  
Carcinoma Cell ◽  
Liver Carcinoma ◽  
Anticancer Activities ◽  
Functional Theory ◽  
Ft Ir ◽  
Good Agreement

Aim and Objective: Synthesis of new .-aminophosphonates containing quinazoline moiety through Kabachnik-Fields reaction in the presence of copper triflate catalyst [32], followed by studying their antimicrobial activities and in vitro anticancer activities against liver carcinoma cell line (HepG2) with the hope that new anticancer agents could be developed. Also, the quantum chemical calculations are performed using density functional theory (DFT) to study the effect of the changes of molecular and electronic structures on the biological activity of the investigated compounds. Materials and Method: The structures of the synthesized compounds are confirmed by FT-IR, 1H NMR, 13C NMR, 31P NMR and MS spectral data. The synthesized compounds show significant antimicrobial and also remarkable cytotoxicity anticancer activities against liver carcinoma cell line (HepG2). Density functional theory (DFT) was performed to study the effect of the molecular and electronic structure changes on the biological activity. Results: It was found that the electronic structure of the substituents affects on the reaction yield. The electron withdrawing substituent, NO2 group 3b, on the aromatic aldehydes gave a good yield more than the electron donating substituent, OH group 3c. The electron deficient on the carbon atom of the aldehydic group may increase the interaction of the Lewis acid (Cu(OTf)2) and the Lewis base (imine nitrogen), and accordingly, facilitate the formation of imine easily, which is attacked by the nucleophilic phosphite species to give the α- aminophosphonates. Conclusion: The newly synthesized compounds exhibit a remarkable inhibition of the growth of Grampositive, Gram-negative bacteria and fungi at low concentrations. The cytotoxicity of the synthesized compounds showed a significant cytotoxicity against the liver cancer cell line (HepG 2). Also, it was shown from the quantum chemical calculations that the electron-withdrawing substituent increases the biological activity of the α-aminophosphonates more than the electron donating group which was in a good agreement with the experimental results. Also, a good agreement between the experimental FT-IR and the calculated one was found.

Synthesis and Biological Potentials of Quinoline Analogues: A Review of Literature

2019 ◽  
Vol 16 (7) ◽  
pp. 653-688 ◽  
Author(s):  
Leena Kumari ◽  
Salahuddin ◽  
Avijit Mazumder ◽  
Daman Pandey ◽  
Mohammad Shahar Yar ◽  
...  
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Building Blocks ◽  
Vital Role ◽  
Review Of Literature ◽  
Drug Discovery Process ◽  
Active Compounds ◽  
Lead Compounds ◽  
Synthetic Approaches ◽  
Derivatives Of

Heterocyclic compounds are well known for their different biological activity. The heterocyclic analogs are the building blocks for synthesis of the pharmaceutical active compounds in the organic chemistry. These derivatives show various type of biological activity like anticancer, antiinflammatory, anti-microbial, anti-convulsant, anti-malarial, anti-hypertensive, etc. From the last decade research showed that the quinoline analogs plays a vital role in the development of newer medicinal active compounds for treating various type of disease. Quinoline reported for their antiviral, anticancer, anti-microbial and anti-inflammatory activity. This review will summarize the various synthetic approaches for synthesis of quinoline derivatives and to check their biological activity. Derivatives of quinoline moiety plays very important role in the development of various types of newer drugs and it can be used as lead compounds for future investigation in the field of drug discovery process.

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