EXPERIENCE OF NIFURATEL USAGE IN COMPLEX TREATMENT OF CHRONIC SPECIFIC BACTERIAL FIBROUSE AND CALCULOUS PROSTATITIS ASSOCIATED WITH TRICHOMONIASIS AND CANDIDOSIS

Men’s Health, Gender and Psychosomatic Medicine ◽

10.37321/ujmh.2018.01-02 ◽

2018 ◽

pp. 33-37

Author(s):

Юрий Заседа

Keyword(s):

Oral Administration ◽

Mixed Infection ◽

Trichomonas Vaginalis ◽

Infectious Agents ◽

Complex Treatment ◽

Total Dosage ◽

Candida Spp ◽

Sonographic Examination ◽

Pcr Method ◽

Therapeutic Model

The aim of the study was to analyze the effi cacy of the drug “Macmiror” (active substance – nifuratel) in the treatment of chronic specifi c bacterial fi brous and calculous prostatitis associated with trichomoniasis and candidiasis.Materials and methods. The study was conducted on 50 patients of the “Clinic “Men’s Health”, suff ering from chronic specifi c bacterial fi brous and calculous prostatitis (mixed infection: trichomonadial-bacterial-candidiasis associates of various structure). As methods of research, in addition to the standard complex, the following were chosen: IN POUCH TV-test; PCR method; sonographic examination ofthe prostate and spermogram.Results of the study. Patients who completed the study were treated with chronic specifi c bacterial fi brous and calculous prostatitis (N41.1) for 14 days, according to the following therapeutic model: oral administration of nifuratel as part of the “Macmiror” preparation at a total dosage of 1200 mg per day (6 tablets of 200 mg) divided into 3 doses and physiotherapy.Conclusions. A general (in relation to diff erent types and combinations of infectious agents) of the therapeutic model has been established at a level of 71% to 100%. Treatment had absolute (clinical and laboratory) effi cacy against isolated Candida spp.; absolute clinical effi cacy and 71-85% laboratory effi cacy against isolated Trichomonas vaginalis; 92% clinical and 76-84% laboratory effi cacy against the combination of these infectious agents; 92% clinical and 80% laboratory effi cacy against the combination of these infectious agents and non-specifi c bacterial fl ora, as the etiological factors of chronic specifi c bacterial prostatitis.

Download Full-text

EXPERIENCE OF USE OF OFOR AND GYNEKIT IN THE TREATMENT OF PROSTATITIS ASSOCIATED WITH SPECIFIC AND MIXED MICROBIAL FLORA

Men’s Health, Gender and Psychosomatic Medicine ◽

10.37321/ujmh.2017.0102-01 ◽

2017 ◽

pp. 39-43

Author(s):

Юрий Заседа ◽

Фарид Шыхалиев ◽

Руслан Соломенный

Keyword(s):

Prospective Study ◽

Trichomonas Vaginalis ◽

Prostate Gland ◽

Microbial Flora ◽

Health Clinic ◽

Sonographic Examination ◽

Clinical Recovery ◽

Combined Application ◽

Pcr Method ◽

Therapeutic Model

Purpose of the study – establish the eff ectiveness of «Ofor» and «Gynekit» use in sequential combined application in the therapy of prostate gland infl ammatory diseases, which associated with a specifi c and mixed microbial flora.Materials and methods. A clinical prospective study was conducted, 30 patience of outpatient department of the «Men’s Health» clinic, suff ering from infl ammatory diseases of the prostate gland, took part in it. As methods of research, in addition to standard complex, the following were chosen: IN POUCH TV-test; Androfl or (PCR method); sonographic examination of the prostate and spermogram. Results of the study. The study found that in the general contingent clinical recovery was registered in 29 patients (96.7% of the total contingent), laboratory – in 27 cases (90% of the total contingent). The return of symptoms in 3 months was registered in 2 patients (6.7% of the total contingent).Conclusions. The level of eff ectiveness of “Ofor” and “Gynekit” use in combination with a set of auxiliary pharmaco and physiotherapy for patients, who suff ering from infl ammatory diseases of the prostate gland, associated with specifi c and mixed microbial fl ora, reaches 96.7%. Analysis of the etiological variability of the clinical eff ect indicates the presence of single cases of incomplete eff ect of this therapeutic model, with the etiology of the disease associated with Trichomonas vaginalis.

Download Full-text

THE ANALYSIS OF EFFICACY OF “CEFPOTEC” AND “CLABEL” PREPARATIONS IN TREATMENT OF SPECIFIC AND NONSPECIFIC PROSTATITIS

Men’s Health, Gender and Psychosomatic Medicine ◽

10.37321/ujmh.2018.02-03 ◽

2019 ◽

pp. 44-50

Author(s):

Юрий Заседа

Keyword(s):

Oral Administration ◽

Chronic Prostatitis ◽

Prostate Gland ◽

Health Clinic ◽

Mixed Infections ◽

Infectious Agents ◽

Bacteriological Examination ◽

Prospective Design ◽

Sonographic Examination ◽

Pcr Diagnostics

Objective: to establish the eff ectiveness of Сefpotek (cefpodoxime) and Сlabel (clarithromycin) drugs in the treatment of chronic prostate infl ammation in the stage of pronounced exacerbation caused by nonspecifi c infectious agents and infections of the mycoplasma and chlamydia groups.Materials and methods. The study was conducted in a prospective design on parallel groups. The study contingent consisted of 60 patients of the “Men’s Health Clinic”, suff ering from chronic prostatitis in state of pronounced exacerbation. The following research methods were used: sonographic examination of the prostate gland, bacteriological examination of the ejaculate, analysis of ejaculate and PCR diagnostics of specifi c infections.The results of the study. A diff erentiated course of etiotropic therapy was carried out. In case of non-specifi c prostatitis: oral administration of the drug “Cefpotek” (cefpodoxim) 1 tablet (200 mg) 2 times a day for a course of 14 days with the possibility of extending the course to 28 days. With specifi c prostatitis: oral administration of the drug “Clabel” (clarithromycin) 1 tablet (500 mg) 2 times a day for a course of 14 days.Conclusions. In the treatment of chronic infl ammation of the prostate gland in the stage of pronounced exacerbation caused by nonspecifi c infectious agents using oral administration of the drug “Сefpotek”, the full eff ectiveness was achieved in range from 83.3% to 96.6% of observations.In the treatment of chronic infl ammation of the prostate gland in the stage of pronounced exacerbation caused by infectious agents of the mycoplasma and chlamydia groups using oral administration of the drug “Clabel”, the full eff ectiveness was achieved in the range from 80.0% to 86.6% of observations (regardless of features of combinations of specifi c mixed infections).

Download Full-text

Identification of female genital tract infectious agents in patients treated for cytopathological diagnosis

Scientific Electronic Archives ◽

10.36560/13920201079 ◽

2020 ◽

Vol 13 (9) ◽

pp. 80

Author(s):

J. S. Borges ◽

V. M. Giudice ◽

R. N. Leandro ◽

K. V. Martinez ◽

L. P. R. Silva ◽

...

Keyword(s):

Trichomonas Vaginalis ◽

Correct Diagnosis ◽

Female Genital Tract ◽

Positive Culture ◽

Epidemiological Data ◽

Vaginal Candidiasis ◽

Yeast Culture ◽

Infectious Agents ◽

Candida Spp ◽

Vaginal Sample

Vaginal candidiasis, fungal infection caused by species of Candida spp. that affects women of all ages, cultures, habits, social and economic conditions. The present study had as its main objective to determine the identification of Candida spp. isolated in a vaginal sample, collected together with the collection for the cytopathological exam, in women treated in a university extension project, aiming at allowing a suitable therapeutics afterwards. The extension project began in January 2014 to June 2019 at the UFRGS. The patients who sought the Laboratory of Clinical and Toxicological Analysis (LACT) of the Faculty of Pharmacy of UFRGS first answered a questionnaire to obtain epidemiological data. Cytopathological diagnosis, Papanicolao smear, and presence of Candida spp. yeast, culture and identification and Trichomonas vaginalis, light microscopy. During the study period, 227 patients, 25.11%, aged 15 to 82 years, presented positive culture for Candida spp. Six species were identified, C. albicans (40.35%), C. glabrata (28.07%) and C. parapsilosis, 15.79%. C. krusei, C. guilliermondii and C. tropicalis totaled (15.79%). Regarding the inflammatory process, present in 49.12%, in C. krusei (75%) and C. guilliermondii (100%), and absence in C. tropicalis. The correct diagnosis and treatment of patients with vaginal candidiasis, even if not considered sexually transmitted, enables to prevent contamination through direct contact, sexual or otherwise, with other individuals and the improvement of self-esteem and quality of life. The prevalence of Candida albicans is still the main cause of vaginal candidiasis, but not neglecting the increase in the number of cases associated with non-albicans species, as well as other infectious agents such as Trichomonas vaginalis, and bacteria.

Download Full-text

Detection of Gardnerella vaginalis, Candida spp. and Trichomonas vaginalis DNA in symptomatic women

Microbiologia Medica ◽

10.4081/mm.2010.2429 ◽

2010 ◽

Vol 25 (3) ◽

Author(s):

Vittorio Focarelli ◽

Vincenzo Rondinelli ◽

Maria Gabriella Lepore ◽

Pasquale Minchella ◽

Raffaele Saraceno ◽

...

Keyword(s):

Trichomonas Vaginalis ◽

Gardnerella Vaginalis ◽

Candida Spp

Download Full-text

THE IDENTIFICATION OF «NEW» PATHOGENS FOR FOCAL INFECTIONS IN IXODES TICKS ON THE TERRITORY OF TULA REGION

Epidemiology and Infectious Diseases (Russian Journal) ◽

10.18821/1560-9529-2019-23-4-172-177 ◽

2018 ◽

Vol 23 (4) ◽

pp. 172-177

Author(s):

T. V. Kozlova ◽

T. I. Khomyakova ◽

V. G. Dedkov ◽

M. V. Safonova ◽

L. S. Karan ◽

...

Keyword(s):

Lyme Disease ◽

Ixodes Ricinus ◽

Mixed Infection ◽

Dermacentor Reticulatus ◽

Encephalitis Virus ◽

Tick Borne Encephalitis ◽

Ixodes Ticks ◽

Pcr Method ◽

Tick Borne Encephalitis Virus ◽

Human Monocytic Ehrlichiosis

The most of ixodes ticks in Tula region belongs to the group of pasture mites. It is generally accepted to estimate the tick’s contamination by the tick-borne encephalitis virus and raoueti inducing Lyme Borellia. The aim of the present work was to educe the aetiologic agents of the set of potentially-enable infections out of ticks Dermacentor reticulatus, Ixodes ricinus and Ixodes сrenulatus collected at the different terrains of Tula Region by PCR method. The results: a considerable number of pathogenic rickettsiae R. raoultii was educes from the ticks D. reticulatus, which including them as the component of mixed infection together with the human monocytic ehrlichiosis agent. R. raoultii was determined in more than a half of the cases in ticks I. ricinus including the mixed infection together with ticks’ borreliosis virus and Kemerovo fever agent. Conclusion. The reasons, induced the quantity changes of the ticks’ distribution at Tula Region terrains, apparently promote the rise in frequency of the ticks contamination with the agents of herd tick-transmissive infection. It demand an infectiologist’s attention rise and dictate the necessity of the above mentioned diseases monitoring as well as Fr. tularensis, the tick-borne encephalitis virus and Lyme disease.

Download Full-text

Prevalence of Infectious Organisms Observed in Cervical Smears Between 1997–2014 at Mubarak Al-Kabeer Hospital, Kuwait

Sultan Qaboos University Medical Journal [SQUMJ] ◽

10.18295/squmj.2018.18.03.010 ◽

2018 ◽

Vol 18 (3) ◽

pp. 324 ◽

Cited By ~ 1

Author(s):

Rana Al-Awadhi ◽

Azza Al-Shaheen ◽

Ahlam Al-Juwaiser ◽

Sara S. George ◽

Prem Sharma ◽

...

Keyword(s):

Candida Species ◽

Trichomonas Vaginalis ◽

Tertiary Care ◽

Care Hospital ◽

Infectious Agents ◽

Papanicolaou Test ◽

Papilloma Virus ◽

Cervical Smears ◽

Significant Difference ◽

Simplex Virus

Objectives: This study aimed to examine gynaecological infectious agents observed in conventional and modified Papanicolaou cervical smears (CS) at a tertiary care hospital in Kuwait. Methods: This retrospective study analysed 121,443 satisfactory CS samples collected between 1997–2014 at the Mubarak Al-Kabeer Hospital, Kuwait. Conventional CS samples were obtained between 1997–2005, while modified CS were obtained between 2006–2014 following the introduction of ThinPrep® testing (Hologic Corp., Bedford, Massachusetts, USA). All samples were initially screened by cytoscreeners before being analysed by cytopathologists to determine the presence of specific infectious agents. Results: Overall, 8,836 (7.28%) of the cervical samples had infectious agents; of these, 62.48% were conventional and 37.52% were modified CS samples. The most frequently observed infectious agents were Candida species (76.05%), Trichomonas vaginalis (9.72%), human papillomavirus (HPV; 9.3%), Actinomyces-like organisms (3.23%), Chlamydia trachomatis (1.27%) and the herpes simplex virus (HSV; 0.43%). There were significantly more cases of Candida species, HPV-associated changes, C. trachomatis, T. vaginalis and Actinomyces-like organisms detected in conventional compared to modified CS samples (P <0.050 each). However, there was no statistically significant difference in the frequency of HSV-associated changes (P = 0.938). The presence of two infectious agents in the same sample was identified in 0.87% of samples. Conclusion: Among CS samples collected during an 18-year period, Candida species were most frequently detected, followed by T. vaginalis and HPV. The identification of potential infectious agents is a valuable additional benefit of Papanicolaou smear testing.Keywords: Cervical Smears; Papanicolaou Test; Infection; Candida; Trichomonas vaginalis; Human Papilloma Virus; Cytology; Kuwait.

Download Full-text

Atypical Squamous Cells in Liquid-Based Cervical Cytology: Microbiology, Inflammatory Infiltrate, and Human Papillomavirus-DNA Testing

Acta Cytologica ◽

10.1159/000481654 ◽

2017 ◽

Vol 62 (1) ◽

pp. 28-33 ◽

Cited By ~ 1

Author(s):

Geilson Gomes de Oliveira ◽

Renata Mirian Nunes Eleutério ◽

Ana Katherine Silveira Gonçalves ◽

Paulo César Giraldo ◽

José Eleutério Jr.

Keyword(s):

Human Papillomavirus ◽

Trichomonas Vaginalis ◽

Inflammatory Infiltrate ◽

Cross Sectional Study ◽

Candida Spp ◽

Cross Sectional ◽

Squamous Cells ◽

Hpv Test ◽

Intraepithelial Lesion ◽

Papillomavirus Dna

Objective: The aim of this study was to assess the correlation between atypical squamous cells (ASC) and inflammatory infiltrate and vaginal microbiota using cervical liquid-based cytological (SurePath®) and high-risk human papillomavirus (HR-HPV) tests. Study Design: A cross-sectional study was conducted using a 6-year database from a laboratory in Fortaleza (Brazil). Files from 1,346 ASC cases were divided into subgroups and results concerning inflammation and vaginal microorganisms diagnosed by cytology were compared with HR-HPV test results. Results: An absence of specific microorganisms (ASM) was the most frequent finding (ASC of undetermined significance, ASC-US = 74%; ASC - cannot exclude high-grade squamous intraepithelial lesion, ASC-H = 68%), followed by bacterial vaginosis (ASC-US = 20%; ASC- H = 25%) and Candida spp. (ASC-US = 6%; ASC-H = 5%). Leukocyte infiltrate was present in 71% of ASC-US and 85% of ASC-H (p = 0.0040), and in these specific cases HR-HPV tests were positive for 65 and 64%, respectively. A positive HR-HPV test was relatively more frequent when a specific microorganism was present, and Candida spp. was associated with HR-HPV-positive results (p = 0.0156), while an ASM was associated with negative HR-HPV results (p = 0.0370). Conclusion: ASC-US is associated with an absence of inflammation or vaginosis, while ASC-H smears are associated with Trichomonas vaginalis and inflammatory infiltrate. A positive HR-HPV is associated with Candida spp. in ASC cytology.

Download Full-text

Concordancia entre autotoma y colección estándar de muestras endocervicales para identificar infecciones de trasmisión sexual en un área urbano-rural del Perú

Revista Peruana de Medicina Experimental y Salud Pública ◽

10.17843/rpmesp.2021.381.6571 ◽

2021 ◽

Vol 38 (1) ◽

pp. 83-8

Author(s):

Tatiana Marlene Galvez ◽

Juan A. Flores ◽

Danny Giancarlo Pérez ◽

César Gutiérrez ◽

Marleny Huertas ◽

...

Keyword(s):

Chlamydia Trachomatis ◽

Neisseria Gonorrhoeae ◽

Trichomonas Vaginalis ◽

Candida Spp ◽

Infecciones De Transmisión Sexual

Con el objetivo de evaluar la concordancia entre la autotoma de muestras vaginales y la toma estándar de muestras endocervicales para la identificación de Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis y Candida spp. realizadas por el personal de salud en mujeres de un área urbano-rural del Perú, se realizó un estudio prospectivo y transversal en 206 mujeres en edad fértil, identificamos algunas infecciones de transmisión sexual como Chlamydia trachomatis o Trichomonas vaginalis en 9 mujeres (4,4%). Obtuvimos una concordancia casi perfecta en la identificación de Candida spp. (k=0,97), Chlamydia trachomatis (k=0,92) y Trichomonas vaginalis por microscopía (k=1,00), y considerable para la identificación de Trichomonas vaginalis por cultivo (k=0,66). La técnica de la autotoma de muestras vaginales podría ser usada para la identificación de algunas infecciones de transmisión sexual en población urbano-rural.

Download Full-text

TREATMENT OF BACTERIAL VAGINOSIS IN PREGNANT WOMEN USING A DRUG CONTAINING A COMPLEX OF LACTOBACILLI (FLORIUM)

Farmaciâ Kazahstana ◽

10.53511/pharmkaz.2021.48.29.012 ◽

2021 ◽

pp. 56-60

Author(s):

Р.Н. ЕСПАЕВА

Keyword(s):

Comparative Analysis ◽

Oral Administration ◽

Bacterial Vaginosis ◽

Pregnant Women ◽

Active Substance ◽

First Trimester ◽

Control Group ◽

Complex Treatment ◽

Results Of Treatment ◽

Unpleasant Smell

В статье показаны результаты лечение бактериального вагиноза у 40 беременных в I триместре. 25 беременным проводилось комплексное лечение, включающее применение вагинальных свечей с действущим веществом хлоргексидин, по 1 свече на ночь во влагалище в течение 10 дней в сочетании с пероральным применением Флориум по 1 капсуле х 2 раза в день за 30 минут до еды в течение 14 дней. Остальные 15 беременных получали только свечи с действующим веществом хлоргексидин местно по 1 свече на ночь во влагалище в течение 10 дней. Сравнительный анализ результатов лечения показал, что в группе лечения с применением комплекса лактобактерий у 100% беременных «ключевые клетки» в контрольном мазке после лечения не определялись, в то время как у 16% женщин контрольной группы в мазке после лечения всё ещё определялись «ключевые клетки». А также, беременные основной группы отмечали прекращение жидких выделений с неприятным запахом в 100% случаев, в то время как у 23% беременных контрольной группы продолжались такие выделения, причиняющие дискомфорт. The article shows the results of treatment of bacterial vaginosis in 40 pregnant women in the first trimester. 25 pregnant women underwent complex treatment, including the use of vaginal candles with the active substance chlorhexidine, 1 candle per night in the vagina for 10 days in combination with oral administration of Florium 1 capsule x 2 times a day 30 minutes before meals for 14 days. The remaining 15 pregnant women received only candles with the active substance chlorhexidine locally, 1 candle per night in the vagina for 10 days. A comparative analysis of the results of treatment showed that in the group of treatment with the use of lactobacilli complex in 100% of pregnant women, " key cells "were not determined in the control smear after treatment, while in 16% of women of the control group,"key cells" were still determined in the smear after treatment. And also, pregnant women of the main group noted the cessation of liquid secretions with an unpleasant smell in 100% of cases, while 23% of pregnant women of the control group continued such secretions causing discomfort.

Download Full-text