THE ROLE OF THE CENTRAL NERVOUS SYSTEM IN THE INHIBITION OF POSTCASTRATION SYNDROME IN CERVICAL CANCER PATIENTS OF REPRODUCTIVE AGE BASED ON PROGRAMMABLE XENON THERAPY REGIMENS

2019 ◽  
Vol 65 (5) ◽  
pp. 708-714
Author(s):  
Yuriy Sidorenko ◽  
Oleg Kit ◽  
Natalya Popova ◽  
Yuliya Arapova ◽  
Alla Shikhlyarova ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Spatial Organization ◽  
Low Dose ◽  
Brain Activity ◽  
Locally Advanced ◽  
Young Patients ◽  
Psychological Testing ◽  
The State ◽  
Reproductive Age ◽  
Significant Correction

The aim was to study the possibility of normalizing rhythmic brain activity and psychoemotional status in young patients with locally advanced cervical cancer after surgical castration and the development of severe postovariectomic syndrome using low dose xenon therapy regimens. Material and methods. The study included data obtained from 30 patients aged 39.4±3.7 years with cervical cancer pT1bN0M0 (n=14), pT2aN0M0 (n=16); after the extirpation of the uterus with appendages and the upper third of the vagina with pelvic lymphadenectomy, patients received low-dose xenon therapy in an exponential programmed regimen of xenon concentration and exposure. The state of brain rhythms was controlled using the electroencephalograph-recorder “En-cephalan EEGR-19/26”. 19 unipolar leads were recorded with the calculation of the EEG spectral power and topographical mapping using the Encephalan-3D program. Psychological testing of patients with cervical cancer was performed using the questionnaires of 7-point individual subjective self-assessment developed by Garkavi L.Kh.- KuzmenkoT.S. Results. The normalizing effect of xenon therapy involved restructuring of cortical brain activity with a decrease in the power of slow- and high-frequency alpha-rhythm subranges and the predominance of physiologically significant mid-frequency alpha rhythms of 9.6 Hz quiet wakefulness together with slow delta and theta ranges. This correlated with the data of topographic mapping of the power spectrum on the presence of two foci of the spatial organization of alpha and theta rhythms. Evaluation criteria for psychological testing showed the reduction of anxiety, depression, fatigue, normalization of sleep, appetite, work capacity, and increased activity and optimism in 82-98% of patients. Conclusion. The possibility of inhibiting the postcastration syndrome in patients with cervical cancer is evidently realized through the xenon-induced effect of brain rhythmogenesis restructuring, leading to the normalization of impaired cortical-subcortical relationships and the formation of positive psycho-emotional status. The therapeutic expediency of low-dose xenon therapy for oncogynecological patients is determined by a significant correction of the state of the CNS state and the early achievement of functional and social rehabilitation.

scholarly journals Development of postcastration syndrome and corrective effect of xenon in exponential dose regimen in young patients with gynecological cancers

2020 ◽  
Vol 1 (3) ◽  
pp. 6-17
Author(s):  
O. I. Kit ◽  
N. N. Popova ◽  
A. I. Shikhlyarova ◽  
E. M. Frantsiyants ◽  
T. I. Moiseenko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cervical Cancer ◽  
Low Dose ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Gynecological Cancers ◽  
Corrective Effect

Purpose of the study. Investigation of possible optimization of treatment in patients with breast cancer and cervical cancer with low-dose xenon therapy.Patients and methods. The study included 156 patients with pT1В2N0M0 cervical cancer (CC) and pT2N1M0 breast cancer (BC) of the reproductive age (29–45 years) after radical treatment, including forced surgical castration in hormone-positive breast cancer with concomitant gynecological pathology. Since the formation of pathological syndromes, 1 cycle (5 sessions) of low-dose xenon inhalation therapy (XT) was performed, with an algorithm for xenon dose calculation and exposure according to the exponential pattern of decreasing concentration and increasing exposure, with an individual approach. Together with general clinical and laboratory examinations, we used international scales for assessing the severity of the patient condition by the Kupperman menopausal index (MMI), ESAS, quality of life (MOS-SF-36), in a modification of the Russian International Center, pain (VAS); the types of general adaptive reactions were identified by the method of L.Kh. Garkavi.Results. Important advantages of a new method associated with a rapid regression of pathological psychosomatic symptoms were revealed after XT. MMI values (p<0.05) decreased, 96.8% of patients reported no pain at all on activity, manifestations of neurovegetative disorders significantly decreased (p=0.02–0.04), and the coefficient of antistress reactions to stress increased, which was congruent with the data on improving the quality of life. Conclusion. High efficiency of the technology demonstrated possible prevention of surgical menopause development and clinical manifestations of postcastration syndrome in order to improve the quality of life and social rehabilitation of young patients with gynecological cancers.

Paclitaxel, ifosfamide, and cisplatin regimen as neoadjuvant chemotherapy in young women with locally advanced squamous cervical cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 5587-5587
Author(s):  
M. Marinaccio ◽  
E. De Marino ◽  
E. Mele ◽  
R. Catacchio ◽  
C. Pellegrino ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Young Women ◽  
Radical Surgery ◽  
Locally Advanced ◽  
Young Patients ◽  
Progression Free Survival ◽  
Advanced Cervical Cancer ◽  
Curative Radiotherapy

5587 Background: Chemoradiotherapy is the standard treatment of advanced cervical cancer. Neoadjuvant chemotherapy (NAC) may represent an alternative for locally advanced cervical cancer (LACC).This study was undertaken to evaluate the efficacy of NAC in young patients with squamous LACC. Methods: Since 2000 to 2008, 61 pts (mean age 43 yrs) with squamous LACC were treated with NAC and afterwards evaluated for radical surgery. Eligibility included proven histologically diagnosis of squamous cervical carcinoma, FIGO stage IB2/IIA>4cm/IIB, measurable disease, ECOG PS 0–2, no prior therapy and age under 49 years. All patients received TIP regimen (cisplatin 50 mg/m2 i.v. day 1, paclitaxel 175 mg/m2 over 3 hrs i.v.day1, ifosfamide 5,000 mg/m2 plus mesna 6,000 mg/m2 over 24 hrs i.v. day 1–2). Each cycle was repeated every 21 days. Patients were evaluated 4–6 weeks after the completion of the third cycle with the purpose to perform radical surgery according to clinical response. Results: 35pts (57.4%) were stage IB2; 9 (14.7%) were IIA >4cm; and 17 (27.9%) were IIB. After restaging the clinical results were: CR = 4/61 (6.6%), PR = 51/61 (83.6%); no response = 5/61 (8.2%); progression = 1/61 (1.6%). A total of 55 pts (90.1%) were eligible for surgery; 6/61 pts (9.8%) were submitted to curative radiotherapy (until 2004) or chemoradiotherapy. Pathological responses after surgery were: 4 pCR (7.3%); 46 pPR (83.6%); and 5 (9.1%) pPR with presence of positive surgical margins or metastatic lymph nodes. Out of 55 pts, 50 received 2 cycles of TIP regimen as a consolidation therapy before follow-up; 5 pts with incomplete pPR underwent radio/chemoradiotherapy. After NAC an overall downstaging of LACC was obtained in 50/61 pts (82.0%). In this group of pts at the median follow-up of 42 months (range 4–98) updated as of December 2008, the 3-years progression-free survival and overall survival are 85.9% and 82.0%, respectively. Conclusions: Our results indicate that TIP regimen-based NAC is an attractive option in young women with squamous LACC (IB2,IIA >4cm, IIB) that strongly desire surgery.The rate of patients with a prolonged remission of disease (82.0%) suggests that the clinical benefit of TIP regimen-based NAC followed by surgery may be comparable to chemoradiotherapy. No significant financial relationships to disclose.

Breast cancer in young women less than 30 years from southern India: Study on clinical profile and outcome

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22196-e22196
Author(s):  
R. Rejiv ◽  
D. Biswajit ◽  
R. Neelesh ◽  
V. Sridevi ◽  
T. G. Sagar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Ductal Carcinoma ◽  
Locally Advanced ◽  
Young Patients ◽  
Stage Iv ◽  
Radical Mastectomy ◽  
Reproductive Age ◽  
Breast Cancer Patients ◽  
Pregnancy And Lactation

e22196 Background: Breast cancer in young patients have an aggressive behaviour with poorer outcome. The patients are in their reproductive age group and are concerned with fertility issues,pregnancy and lactation. The literature pertaining to patients less than 30 years is limited. Methods: 213 Patients under the age of 30 years with breast cancer were studied for Demographics, clinical presentations, pathological profiles, treatment and survival. The case records were retrospectively analyzed between Jan 1993 - Dec 2003 at Cancer Institute (WIA) Chennai. Results: The mean age of the study population was 28 years and ranged between 17 to 30 years. Early menarche, defined as less than 12 years (17.5 %), Nulliparity (21.1%), first child birth less than 18 years (26.8%) were the major risk factors noted. Family history of breast and ovarian cases were seen in 6.6% of the patients. The Stage distribution included Stage I (1.4%), Stage II (31%), Stage III (49.6) and Stage IV (11%) and unclassifiable (7%). Node positive tumours constituted 158 patients (74.1%). Hormone receptor studies were negative in 62% of the patients. Modified radical mastectomy was performed in 164 (77%) of the patients. Non infiltratring ductal carcinoma histopathology was noted in 13.6%. Surgical and radiocastration was performed in 35.2% and 17% of the cases respectively. Of 201 (94.3%) patients who received chemotherapy anthracycline based chemotherapy was delivered in 30.3%. Recurrence pattern included local, local and distant and distant recuurences in 8.5%, 23.5% and 2.3% respectively. The 5 year over all survival for the evaluable patients was 53.2%. Conclusions: Very young Indian patients less than 30 years constitute a unique subset of breast cancer patients with majority being hormone receptor negative and locally advanced stage at presentation. The over all outcome is inferior compared to older patients with breast cancer. More aggressive adjuvant treatment may help in improving survival. No significant financial relationships to disclose.

scholarly journals Oscillation-based connectivity architecture is dominated by an intrinsic spatial organization, not cognitive state or frequency

2020 ◽  
Author(s):  
Parham Mostame ◽  
Sepideh Sadaghiani
Keyword(s):  
Information Exchange ◽  
Spatial Organization ◽  
Brain Activity ◽  
The State ◽  
Neural Oscillations ◽  
Cognitive State ◽  
State Dependency ◽  
Frequency Bands ◽  
Cognitive States ◽  
The Impact

AbstractFunctional connectivity (FC) of neural oscillations (~1-150Hz) is thought to facilitate neural information exchange across brain areas by forming malleable neural ensembles in the service of cognitive processes. However, neural oscillations and their FC are not restricted to certain cognitive demands and continuously unfold in all cognitive states. To what degree is the spatial organization of oscillation-based FC affected by cognitive state or governed by an intrinsic architecture? And what is the impact of oscillation frequency and FC mode (phase-versus amplitude coupling)? Using ECoG recordings of 18 presurgical patients, we quantified the state-dependency of oscillation-based FC in five canonical frequency bands and across an array of 6 task states. For both phase- and amplitude coupling, static FC analysis revealed a spatially largely state-invariant (i.e. intrinsic) component in all frequency bands. Further, the observed intrinsic FC pattern was spatially similar across all frequency bands. However, temporally independent FC dynamics in each frequency band allow for frequency-specific malleability in information exchange. In conclusion, the spatial organization of oscillation-based FC is largely stable over cognitive states, i.e. primarily intrinsic in nature, and shared across frequency bands. The state-invariance is in line with prior findings at the other temporal extreme of brain activity, the infraslow range (~<0.1Hz) observed in fMRI. Our observations have implications for conceptual frameworks of oscillation-based FC and the analysis of task-related FC changes.

scholarly journals Comparison of Response to the Concurrent Low Dose Daily Cisplatin Vs Weekly Cisplatin Vs Three Weekly Cisplatin with External Beam Radiotherapy in Carcinoma Cervix Patients of Stage IIB, IIIA & IIIB: A Prospective Study from Single Institution

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Amol Ubale ◽  
Shruti Chandra ◽  
S N Prasad ◽  
P K Singh
Keyword(s):  
Cervical Cancer ◽  
Low Dose ◽  
External Beam Radiotherapy ◽  
Locally Advanced ◽  
External Beam Radiation ◽  
External Beam ◽  
Carcinoma Cervix ◽  
Beam Radiation ◽  
Significant Difference ◽  
Weekly Cisplatin

Introduction: Cervical cancer continues to be a major public health problem affecting middle-aged women, particularly in less-resourced countries. External beam radiation therapy along with intra cavitary insertion has long been the treatment of choice for locally advanced (IIB-IVA) cervical cancer, but long-term successes are limited in terms of pelvic recurrence or distant metastasis. Outcome of low dose daily versus weekly versus three weekly Cisplatin concurrent with External beam radiotherapy in locally advanced cervical carcinoma was compared in this study. Methods: A prospective cross sectional study was carried out in J K cancer institute, Kanpur. Total 60 patients of cervical cancer were randomized into 3 arms. Arm I, Arm II and Arm III received External beam radiotherapy concurrent with either daily (8mg/m2), weekly (40 mg/m2) or three weekly (100 mg/m2) Cisplatin respectively. External beam radiotherapy was given with a dose of 50 Gy / 25 # / 5 week / 2 field or 4 field. Patients were evaluated weekly during treatment and afterwards up to 1year. Results: Most of the patients were from fourth and fifth decade, low socioeconomic strata and illiterate. Majority of the cases belong to squamous cell carcinoma (96.6%) and stage III B (55%). Objective response in arm I was 80.0%, in arm II was 75.0% and in arm III was 60.0% respectively. Statistically significant difference was noted between arm III and Arm I (80%Vs60% p<0.05). Results were better in arm I as compare to arm II but not statistically significant. (80%Vs75% P>0.05) Conclusions: This study showed that response was better in ARM I as compared to ARM III and best results was seen with Cisplatin concurrent daily with radiation. Keywords: Cisplatin, concurrent chemotherapy, daily, weekly, three weekly, carcinoma cervix

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