scholarly journals Burden of illness for metastatic melanoma in Canada, 2011–2013

2016 ◽  
Vol 23 (6) ◽  
pp. 563 ◽  
Author(s):  
D.S. Ernst ◽  
T. Petrella ◽  
A.M. Joshua ◽  
A. Hamou ◽  
M. Thabane ◽  
...  
Keyword(s):  
Metastatic Melanoma ◽  
Burden Of Illness ◽  
Registry Data ◽  
Research Network ◽  
Mutation Status ◽  
Factors Affecting ◽  
Time To Recurrence ◽  
Disease Characteristics ◽  
Initial Stage ◽  
Sites Of Metastases

Background Detailed epidemiology for patients with advanced metastatic melanoma in Canada is not well characterized. We conducted an analysis of patients with this disease in the province of Ontario, with the aim being to study the presentation, disease characteristics and course, and treatment patterns for malignant melanoma.Methods In this Canadian observational prospective and retrospective study of patients with malignant melanoma, we used data collected in the Canadian Melanoma Research Network (cmrn) Patient Registry. We identified patients who were seen at 1 of 3 cancer treatment centres between April 2011 and 30 April 2013. Patient data from 2011 and 2012 were collected retrospectively using chart records and existing registry data. Starting January 2013, data were collected prospectively. Variables investigated included age, sex, initial stage, histology, mutation type, time to recurrence, sites of metastases, resectability, and previous therapies.Results A cohort of 810 patients with melanoma was identified from the cmrn registry. Mean age was 58.7 years, and most patients were men (60% vs. 40%). Factors affecting survival included unresectable or metastatic melanoma, initial stage at diagnosis, presence of brain metastasis, and BRAF mutation status. The proportion of surviving patients decreased with higher initial disease stages.Conclusions Using registry data, we were able to determine the detailed epidemiology of patients with melanoma in the Canadian province of Ontario, validating the comprehensive and detailed information that can be obtained from registry data.

Measurement of Vulnerability of Financial Portfolio of Sharia Commercial Banks by Cardona Method

2017 ◽  
Vol 9 (2) ◽  
pp. 109
Author(s):  
Paulina Harun ◽  
Atman Poerwokoesoemo
Keyword(s):  
Commercial Banks ◽  
Quantitative Research ◽  
Banking Sector ◽  
Banking Industry ◽  
Policy Makers ◽  
Factors Affecting ◽  
Section Data ◽  
Initial Stage ◽  
The Face ◽  
Asset Portfolio

his study aims to: (1) to know and analyze the extent of volatility (vulnerability) of sharia banking industry in Indonesia in the face of competition (2) to know and analyze factors affecting vulnerability of sharia commercial banks; (3) to know and analyze the extent of sustainable development of sharia banking industry to Indonesia's economic development.The research conducted to measure the vulnerability (volatility) of proto folio of syariah bank using observation period 2015, and the data used is cross section data. The research design used in this research is quantitative research, using asset dimension (asset portfolio, liability portfolio, equity portfolio) and stressor (pressure, including: credit risk, market risk, and liquidity risk).The activity plan of this research is: in the initial stage of conducting theoretical study related to the vulnerability related to banking especially BUS; The next step is to determine the asset and stressor dimensions associated with the BUS; Further determine the indicators related to assets and stressors; The next step performs calculations to determine the index of each BUS as well as the dimensions that affect the vulnerabilities faced by each BUS.Target expected outcomes can be generated from this research is: for the object of research (BUS) provide a solution for BUS to deal with and overcome the vulnerabilities encountered and policies that must be done. For policy makers, the results of this study are expected to provide input in decision-making and other policies.Measurement of vulnerability to be performed related to banking operations in the face of competition and the continuity of BUS in Indonesia. The outcomes of this study are expected to be included in Bank Indonesia journals, the selection of this journal is based on studies conducted in the banking sector, especially BUS in Indonesia.

scholarly journals Recurrence after Curative Resection for Intrahepatic Cholangiocarcinoma: How to Predict the Chance of Repeat Hepatectomy?

2021 ◽  
Vol 10 (13) ◽  
pp. 2820
Author(s):  
Serena Langella ◽  
Nadia Russolillo ◽  
Paolo Ossola ◽  
Andrea-Pierre Luzzi ◽  
Michele Casella ◽  
...  
Keyword(s):  
Liver Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Major Hepatectomy ◽  
Multivariable Analysis ◽  
Study Data ◽  
Good Survival ◽  
Lower Probability ◽  
Factors Affecting ◽  
Time To Recurrence ◽  
Second Resection

(1) Background: Tumor recurrence after liver resection (LR) for intrahepatic cholangiocarcinoma (ICC) is common. Repeat liver resection (RLR) for recurrent ICC results in good survival outcomes in selected patients. The aim of this study was to investigate factors affecting the chance of resectability of recurrent ICC. (2) Methods: LR for ICC performed between January 2001 and December 2020 were retrospectively reviewed. Patients who had undergone first LR were considered for the study. Data on recurrences were analyzed. A logistic regression model was used for multivariable analysis of factors related to RLR rate. (3) Results: In total, 140 patients underwent LR for ICC. Major/extended hepatectomies were required in 105 (75%) cases. The 90-day mortality was 5.7%, Clavien–Dindo grade 3, 4 complications were 9.3%, N+ disease was observed in 32.5%, and the median OS was 38.3 months. Recurrence occurred in 91 patients (65%). The site of relapse was the liver in 53 patients (58.2%). RLR was performed in 21 (39.6%) patients. Factors that negatively affected RLR were time to recurrence ≤12 months (OR 7.4, 95% CI 1.68–33.16, p = 0.008) and major hepatectomy (OR 16.7, 95% CI 3.8–73.78, p < 0.001) at first treatment. Survival after recurrence was better in patients who underwent RLR as compared with not resected patients (31 vs. 13.2 months, p = 0.02). (4) Conclusions: Patients with ICC treated at first resection with major hepatectomy and those who recurred in ≤12 months had significantly lower probability to receive a second resection for recurrence.

scholarly journals The use of classical methods and neural networks in deformation studies of hydrotechnical objects

2020 ◽  
Vol 12 (1) ◽  
pp. 718-725
Author(s):  
Maria Mrówczyńska ◽  
Jacek Sztubecki ◽  
Małgorzata Sztubecka ◽  
Izabela Skrzypczak
Keyword(s):  
Neural Networks ◽  
Artificial Neural Networks ◽  
Cylinder Surface ◽  
Building Structures ◽  
Steel Cylinder ◽  
Factors Affecting ◽  
Initial Stage ◽  
Artificial Neural ◽  
Set Of Points

Abstract Objects’ measurements often boil down to the determination of changes due to external factors affecting on their structure. The estimation of changes in a tested object, in addition to proper measuring equipment, requires the use of appropriate measuring methods and experimental data result processing methods. This study presents a statement of results of geometrical measurements of a steel cylinder that constitutes the main structural component of the historical weir Czersko Polskie in Bydgoszcz. In the initial stage, the estimation of reliable changes taking place in the cylinder structure involved the selection of measuring points essential for mapping its geometry. Due to the continuous operation of the weir, the points covered only about one-third of the cylinder area. The set of points allowed us to determine the position of the cylinder axis as well as skews and deformations of the cylinder surface. In the next stage, the use of methods based on artificial neural networks allowed us to predict the changes in the tested object. Artificial neural networks have proved to be useful in determining displacements of building structures, particularly hydro-technical objects. The above-mentioned methods supplement classical measurements that create the opportunity for carrying out additional analyses of changes in a spatial position of such structures. The purpose of the tests is to confirm the suitability of artificial neural networks for predicting displacements of building structures, particularly hydro-technical objects.

Stereotactic radiosurgery for cerebral metastatic melanoma: factors affecting local disease control and survival

1998 ◽  
Vol 42 (3) ◽  
pp. 581-589 ◽  
Author(s):  
Yoshimasa Mori ◽  
Douglas Kondziolka ◽  
John C Flickinger ◽  
John M Kirkwood ◽  
Sanjiv Agarwala ◽  
...  
Keyword(s):  
Disease Control ◽  
Metastatic Melanoma ◽  
Stereotactic Radiosurgery ◽  
Factors Affecting ◽  
Local Disease ◽  
Local Disease Control

scholarly journals Factors influencing dissolution of carbonaceous materials in liquid Fe–Mn

2020 ◽  
Vol 27 (10) ◽  
pp. 1153-1162
Author(s):  
Hamideh Kaffash ◽  
Merete Tangstad
Keyword(s):  
Dissolution Mechanism ◽  
Carbonaceous Materials ◽  
Resistance Furnace ◽  
Metal Interface ◽  
Dissolution Rates ◽  
Factors Affecting ◽  
Carbon Dissolution ◽  
Initial Stage ◽  
Ash Layer ◽  
Solid Liquid

Abstract Carbon dissolution from four types of metallurgical cokes and graphite was investigated by using immersion rods in a resistance furnace to clarify the influence of factors governing the rate of carbon dissolution from carbonaceous materials into Fe–Mn melts at 1550 °C. The factors studied were the microstructure of carbonaceous materials, roughness, porosity and the wettability between carbonaceous materials and the melt. Carbon/metal interface was characterised by scanning electron microscopy accompanied with energy-dispersive X-ray spectrometry to investigate the formation of an ash layer. The results showed that coke E had the highest dissolution rate. Surface roughness and porosity of the carbonaceous materials seemed to be dominant factors affecting the dissolution rates. Further, crystallite size did not have a significant effect on the dissolution rates. Solid/liquid wettability seemed to affect the initial stage of dissolution reaction. The dissolution mechanism was found to be both mass transfer and interfacial reactions.

Clinicopathological analysis of KRAS mutation in an Irish population.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 467-467
Author(s):  
M. Teo ◽  
S. O'Reilly ◽  
E. Moylan ◽  
D. G. Power
Keyword(s):  
Metastatic Disease ◽  
Tumor Resection ◽  
Irish Population ◽  
Wild Type ◽  
Patient Demographics ◽  
Disease Characteristics ◽  
Clinicopathological Analysis ◽  
Kras Status ◽  
Significant Difference ◽  
Sites Of Metastases

467 Background: Clinical trials have shown that tumor KRAS status predicts response to anti-EGFR monoclonal antibodies in metastatic colorectal cancer (mCRC). We sought to compare distribution of wild-type and mutated KRAS in an Irish population and identify clinicopathologic correlates. Methods: From our prospectively maintained database we retrospectively identified patients with mCRC and documented KRAS status between Jan 2007 to June 2010. Medical notes were examined for patient demographics and disease characteristics. Variables were extracted and compared using unpaired t test and chi2 test. Results: 52 patients were identified, 29 (55.8%) with mutated (mt) and 23 (44.2%) with wild type (wt) KRAS from tumor tissue. Males accounted for 61.5% (n=31). Median age at diagnosis of metastatic disease for the KRASmt group was 66.4 years (range 56.7-82.1) and for the KRAS wt group was 64.2 years (40.1-76.8), p= 0.08. 21 (72.4%) of the KRASmt group and 16 (69.6%) of the KRASwt group had metastatic disease at presentation (p=0.81). For patients who presented initially with localised disease, time to development of metastases was 22.5mo (range 14-37.6) for the KRASmt group and 16.7mo (3.2-123.7) for the KRASwt (p=0.30). 21 (72.4%) of KRASmt and 17 (74.1%) of KRASwt tumors had left-sided primary (p = 0.84) with equal numbers of primary tumor resection in both groups. There was no statistical difference in TN-stage or the presence of liver metastases. Numbers of patients with KRASmt tumors with one, two and three or more different sites of metastases was 22 (75.9%), 5 (17.2%), and 2 (6.9%), and in KRASwt tumors there was no significant difference: 18 (78.3%), 4 (17.4%), and 1 (4.3%), respectively (p = 0.93). Median CEA at diagnosis for both groups were 19.7 μg/l (range 1.2-5958) and 6.1 (1.3-696.9; p = 0.11). Conclusions: We found that the ratio of KRASmt to KRASwt tumours in an Irish population is comparable to that in large international trials. Our analysis revealed no association between KRAS status and clinicopathologic variables. The inclusion of BRAF status, not readily available in our institution, may help define poor prognosis tumors. At present there is no validated molecular biomarker that is superior to standard clinicopathologic variables. No significant financial relationships to disclose.

A phase III trial of nab-paclitaxel versus dacarbazine in chemotherapy-naive patients with metastatic melanoma: A subanalysis based on BRAF status.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 9030-9030 ◽  
Author(s):  
Evan Hersh ◽  
Michele Del Vecchio ◽  
Michael Paul Brown ◽  
Richard Kefford ◽  
Carmen Loquai ◽  
...  
Keyword(s):  
Metastatic Melanoma ◽  
Braf Mutation ◽  
Performance Status ◽  
Braf Inhibitor ◽  
Stage Iv ◽  
Progression Free Survival ◽  
Phase Iii ◽  
Ecog Performance Status ◽  
Mutation Status ◽  
Phase Iii Trial

9030 Background: Activating mutations of BRAF V600 can be found in 40%-50% of melanomas and are related to poor prognosis. In a phase 3 trial for the treatment of metastatic melanoma (MM) in chemotherapy-naive patients, nab-paclitaxel (nab-P) vs dacarbazine (DTIC) demonstrated a significant improvement in the primary endpoint of progression-free survival (PFS), assessed by independent radiological review (IRR), and a trend toward prolonged overall survival (OS) at the interim survival analysis. The study also explored the effect of BRAF status on the efficacy parameters. Methods: Chemotherapy-naive patients with stage IV melanoma (M1c stage 65%; elevated LDH 28%) and ECOG performance status 0-1 were randomized to nab-P 150 mg/m2 on days 1, 8, and 15 of a 28-day cycle (n = 264) or DTIC 1000 mg/m2 on day 1 of each 21-day cycle (n = 265) independent of BRAF status. Prespecified subgroup analyses of final PFS and interim OS in subgroups by BRAF status (V600E mutant, wild-type, or unknown) were performed. Results: BRAF mutation status was balanced between the treatment arms, with 36% and 38% of patients with known BRAF mutation status in the nab-P and DTIC arms, respectively. Patient characteristics were also balanced within BRAF subgroups. As shown in the Table, advantage in the nab-P arm vs DTIC arm was observed for both PFS and interim OS regardless of BRAFmutation status. Poststudy BRAF inhibitor treatment was also balanced. Conclusions: In this phase III trial, treatment effect was independent of BRAF mutation status, benefiting all patients who received nab-P vs DTIC. Therefore nab-P should be considered in the armamentarium for all chemotherapy-naive patients with MM. Clinical trial information: NCT00864253. [Table: see text]

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