scholarly journals Vascular stiffness evaluation in elderly patients with hypertension in conjunction with geriatric syndromes

2021 ◽  
pp. 263
Author(s):  
A. V. Luzina ◽  
M. I. Trifonov ◽  
O. N. Tkacheva ◽  
N. K. Runikhina ◽  
Yu. V. Kotovskaya
Keyword(s):  
Elderly Patients ◽  
Vascular Stiffness ◽  
Geriatric Syndromes ◽  
Stiffness Evaluation

Цель: изучить параметр жесткости артериальной стенки (сердечно-лодыжечный сосудистый индекс (СЛСИ)) у пациентов 60 лет и старше с артериальной гипертонией (АГ) во взаимосвязи с синдромом старческой астении (ССА) и другими гериатрическими синдромами.

scholarly journals Association of vascular stiffness and geriatric syndromes in hypertensive elderly patients

2021 ◽  
Vol 26 (4) ◽  
pp. 4187
Author(s):  
A. V. Luzina ◽  
N. K. Runikhina ◽  
O. N. Tkacheva ◽  
Yu. V. Kotovskaya
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Elderly Patients ◽  
Body Mass ◽  
Total Cholesterol Level ◽  
Vascular Stiffness ◽  
Geriatric Syndromes ◽  
Clock Drawing Test ◽  
Relationship Of ◽  
The Relationship

Aim. To study the relationship of vascular stiffness (cardio-ankle vascular index (CAVI)) with frailty and other geriatric syndromes in hypertensive elderly patients.Material and methods. The study included 160 patients aged 60 to 101 years with verified stage I-III hypertension. The previous therapy was assessed. A comprehensive geriatric assessment was performed with functional and neuropsychological tests to identify geriatric syndromes. Vascular stiffness was assessed by VaSera-VS-1500 vascular screening system (FUKUDA DENSHI, Japan) with determination of the CAVI.Results. The mean age of the patients was 77,2±8,1 years (n=160): in the group of patients without frailty — 72,4±6,9 years (n=50), with prefrailty — 76,6±8,1 years (n=50), with frailty — 81,7±6,6 (n=60). Patients with frailty had a higher CAVI than those without frailty and with prefrailty (10,3±1,6 vs 9,3±1,0 and 9,6±1,8, respectively; p=0,002).In patients with frailty, a negative correlation was found between the vascular stiffness and body mass index (BMI) (Rs=-0,392 (p=0,002)), and a positive correlation between the CAVI and orthostatic response (Rs=0,382 (p=0,003). In patients with prefrailty, negative relationships were found with the dynamometric parameters (Rs=-0,329 (p=0,019)), BMI (Rs=-0,343 (p=0,015) and physical activity (Rs=-0,285 (p=0,047)).In patients without frailty, the vascular stiffness was associated with an increased total cholesterol level (Rs=0,379 (p=0,009)), a low physical activity (Rs=-0,355 (p=0,015)), as well as negative correlations were found with the clock-drawing test and falls (Rs=-0,458 (p=0,011) and Rs=-0,306 (p=0,031), respectively).Conclusion. Vascular stiffness in elderly patients with frailty is associated with a decrease in body mass index and orthostatic hypotension. At the stage of prefrailty, the relationship between the vascular stiffness and muscle strength decrease (according to dynamometry) was revealed.Thus, the vascular stiffness is associated with frailty markers itself.

Prevalence of geriatric syndromes and study of early post-surgical functionality in elderly patients with colorectal cancer and surgical indication

2021 ◽  
Vol 12 (8) ◽  
pp. S54-S55
Author(s):  
N.M. Gonzalez-Senac ◽  
M.L. Cruz-Arnes ◽  
C. Paniagua Carrasco ◽  
J. Mayordomo-Cava ◽  
M.T. Vidan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Elderly Patients ◽  
Surgical Indication ◽  
Geriatric Syndromes

FEATURES AND RESULTS OF GERIATRIC EXAMINATION OF ELDERLY PATIENTS WITH VISUAL IMPAIRMENT

2021 ◽  
pp. 130-134
Author(s):  
Татьяна Игоревна Субботина ◽  
Павел Львович Володин ◽  
Игорь Моисеевич Кветной ◽  
Самир Усман-оглы Мурсалов ◽  
Сергей Владимирович Солошенко ◽  
...  
Keyword(s):  
Elderly Patients ◽  
The Elderly ◽  
Poor Quality ◽  
The Body ◽  
Angle Closure Glaucoma ◽  
Psychological State ◽  
Angle Closure ◽  
Geriatric Syndromes ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Старение организма сопровождается истощением физиологического резерва различных органов и систем, что приводит к развитию гериатрических синдромов в пожилом и старческом возрасте. Однако гериатрический статус пациентов с офтальмологическими заболеваниями изучен недостаточно. Цель исследования проведение гериатрического обследования пациентов с офтальмологическими заболеваниями и выявление особенностей гериатрического статуса больных. Гериатрические синдромы изучены нами у 115 больных старческого возраста с первичной закрытоугольной глаукомой и 118 больных того же возраста с катарактой. Установлено, что гериатрический статус пациентов с первичной закрытоугольной глаукомой ухудшается существеннее, чем при катаракте. Это обусловлено нарушениями ходьбы и устойчивости умеренной степени, синдромом гипомобильности, психологическим состоянием удовлетворительного и плохо качества, наличием нолипрагмазии. Установленные особенности гериатрического статуса рекомендуется использовать при организации специализированной офтальмологической и гериатрической помощи данным пациентам Aging of the body is accompanied by the depletion of the physiological reserve of various organs and systems, which leads to the development of geriatric syndromes in the elderly and senile age. However, the geriatric status of patients with ophthalmic diseases has not been sufficiently studied. The aim of the study was to conduct a geriatric examination of patients with ophthalmological diseases and to identify the features of the geriatric status of patients. Geriatric syndromes were studied in 115 elderly patients with primary angle-closure glaucoma and 118 patients of the same age with cataracts. It was found that the geriatric status of patients with primary angle-closure glaucoma deteriorates significantly more than in cataracts. This is due to moderate walking and stability disorders, hypomobility syndrome, a psychological state of satisfactory and poor quality, and the presence of nolipragmasia. The established features of the geriatric status are recommended for use in the organization of specialized ophthalmological and geriatric care for these patients

Efficacy and tolerability of eribulin in elderly patients

2021 ◽  
pp. 5-8
Author(s):  
E. I. Kovalenko ◽  
E. V. Artamonova
Keyword(s):  
Elderly Patients ◽  
Multidisciplinary Approach ◽  
Randomized Trials ◽  
Metastatic Breast ◽  
The Elderly ◽  
Geriatric Syndromes ◽  
Older Patient ◽  
Elderly Cancer Patients ◽  
Good Tolerance ◽  
Planning Ct

Elderly cancer patients represent a very heterogeneous pop ulation not only in chronological age, but also in functional status, concomitant diseases and therapy, geriatric syndromes and, as a consequence, in the tolerability of cancer treatment. The choice of chemotherapy (CT) for metastatic breast cancer in this category of patients is often a challenge for oncologists. Eribulin, a drug with a fairly good tolerance, has proven itself well both in randomized trials and in real clinical practice, including older patient population. Pooled analyzes of several studies have shown that the incidence of hematologic adverse events in elderly patients treated with eribulin does not exceed that in younger patients and does not generally affect the planned volume of treatment. At the same time, the elderly are more likely to experience side effects such as weakness, fatigue and polyneuropathy, which must be taken into account when planning CT. Only a comprehensive multidisciplinary approach with a geriatric assessment will make it possible to maximally individualize the approach to the treatment of this difficult category of patients.

Management and survival of frail elderly cancer patients within a Geriatric Oncology Program

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 8547-8547 ◽  
Author(s):  
U. Basso ◽  
L. Vamvakas ◽  
C. Falci ◽  
E. Lamberti ◽  
L. M. Pasetto ◽  
...  
Keyword(s):  
Overall Survival ◽  
Elderly Patients ◽  
Cancer Patients ◽  
Endocrine Therapy ◽  
Frail Elderly ◽  
Geriatric Oncology ◽  
Drop Out ◽  
Geriatric Syndromes ◽  
Elderly Cancer Patients ◽  
Frail Patients

8547 Background: Abstention from administration of either chemo- or endocrine therapy to elderly cancer patients deemed frail at the Multidimensional Geriatric Assessment is still controversial, and few data are available concerning the actual survival of such patients. Methods: To evaluate the management and survival of all consecutive frail cancer patients older than 70 years, seen from October 2004 to December 2005 within our Geriatric Oncology Program. Frailty was defined by one or more of the following: age ≥ 85 years, dependence in one or more Activity of Daily Living (ADL), presence of at least three comorbidity of grade 3 or one of grade 4 according to CIRS-G, one or more geriatric syndromes [Balducci L, Cancer Control 2001]. Results: A total of 364 elderly patients were divided into three categories: fit (26.4%), vulnerable (49.5%) and frail patients (24.2%). These 88 frail patients had a median age of 79 years (range, 70–93), 43.2% males. Motives for being considered frail were age alone (13.6% of patients), ADL dependence (25%), comorbidity (14.8%), geriatric syndromes (6.8%) or, more frequently, the co-existence of two or more of these factors (39.8%). Thirty patients (34.1%) underwent chemotherapy: 8 for gastro-intestinal tumors, 7 lung, 7 hematological and 8 other sites. Patients received standard regimens at standard doses (27.6%) or with ≥ 25% dose reduction (24.1%), age-adapted regimens at standard doses (44.8%) or with reduced doses (6.9%). Six patients (20%) derived some clinical benefit but only two (6.7%) showed radiological response. Twenty-two patients interrupted chemotherapy prematurely due to toxicity/death (23.3%) or refusal/drop out (26.7%). All twenty-eight women with estrogen receptor positive breast cancer (31.9% of all frail patients) were prescribed endocrine therapy either adjuvantly, neo-adjuvantly or for metastatic disease, with a predominance of aromatase inhibitors (82.1%) compared to tamoxifen. Thirty out of 88 patients have died, with a 2-year overall survival of 35%. Conclusions: Frailty was observed in one fourth of all our elderly patients, but it did not prevent treatment of tumor with either chemo- or endocrine therapy in 66% of cases. Overall survival of frail elderly patients with cancer appears worse than in geriatric series. No significant financial relationships to disclose.

Elderly patients with chronic heart failure have higher risk of geriatric syndromes: results of the nursing study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
I Tsareva ◽  
N Vorobyeva ◽  
G Semochkina ◽  
Y Kotovskaya ◽  
O Tkacheva
Keyword(s):  
Heart Failure ◽  
Regression Analysis ◽  
Cognitive Impairment ◽  
Chronic Heart Failure ◽  
Elderly Patients ◽  
Barthel Index ◽  
Clinical Manifestations ◽  
Geriatric Syndromes ◽  
Depression Risk ◽  
Norton Scale

Abstract Background The prevalence of chronic heart failure (CHF) and geriatric syndromes increases with age, however the associations between these conditions have not yet been studied. Purpose To evaluate the associations between CHF and geriatric syndromes in elderly patients. Methods Four hundred and seventy-two in-patients (18% male) aged 75–100 (mean 81±4) years were included in the nursing study. Patients were examined by nurses with a specially designed nursing assessment algorithm that included Mini-Cog test, Morse Fall scale, Norton scale, Barthel Activities of daily living Index, Short Physical Performance Battery (SPPB) tests, Mini Nutritional Assessment (MNA) scale, Geriatric Depression Scale (GDS-15), and a number of other questionnaires. Results CHF was observed in 180 patients (38%). Functional class (FC) of II (NYHA) was diagnosed in 133 (74%) of them, FC of III – in 47 (26%). Patients with and without CHF did not differ by age and gender. CHF patients had lower points on Norton scale (17,6±2,0 vs 18,2±1,8; p<0,001), Barthel Index (92,0±13,9 vs 95,0±9,1; p=0,009), SPPB (5,3±3,2 vs 6,0±3,3; p=0,018), and higher points on Morse Fall scale (44,3±19,9 vs 39,3±21,1; p=0,007) and GDS-15 (4,7±3,2 vs 4,2±3,3; p=0,041) compared to non-CHF patients. CHF patients had higher frequency of frailty (75% vs 65%; p=0,029), depression (47% vs 38%; p=0,041), and cognitive impairment (54% vs 41%; p=0,008). Univariate regression analysis showed that CHF presence increased the frailty risk by 1,6 times (OR 1,59; 95% CI 1,05–2,40; p=0,029), the depression risk – by 1,5 times (OR 1,48; 95% CI 1,02–2,16; p=0,041), and the cognitive impairment risk – by 1,7 times (OR 1,65; 95% CI 1,14–2,40; p=0,009). Among CHF patients, severity of CHF clinical manifestations correlated with severity of geriatric syndromes. CHF patients with FC of II had higher points of Norton scale (17,8±1,9 vs 16,9±2,1; p=0,005), Barthel Index (93,4±12,9 vs 88,3±15,8; p=0,005), SPPB (4,4±3,3 vs 3,9±3,0; p=0,001), walk speed (0,58±0,26 vs 0,45±0,22 m/s; p=0,002), and lower points of GDS-15 (4,4±3,3 vs 5,5±2,9; p=0,008) compared to CHF patients with FC of III. The frequency of depression was higher in CHF patients with FC of III (64% vs 41%; p=0,008). Univariate regression analysis showed that in CHF patients with FC of III the depression risk was higher by 2,5 times (OR 2,50; 95% CI 1,26–4,98; p=0,009) compared to CHF patients with FC of II. Conclusion Elderly CHF patients had higher risk of geriatric syndromes such as frailty, depression, and cognitive impairment. Among CHF patients, severity of CHF clinical manifestations correlated with severity of geriatric syndromes. Funding Acknowledgement Type of funding source: None

Geriatric syndromes in elderly patients admitted to an inpatient cardiology ward

2007 ◽  
Vol 2 (6) ◽  
pp. 394-400 ◽  
Author(s):  
Kellie L. Flood ◽  
Amy Rohlfing ◽  
Cyndi V. Le ◽  
David B. Carr ◽  
Michael W. Rich
Keyword(s):  
Elderly Patients ◽  
Geriatric Syndromes

scholarly journals The Oral Anticoagulants Administration in Elderly Patients with Geriatric Syndromes: What's New?

2020 ◽  
Vol 16 (6) ◽  
pp. 984-993
Author(s):  
N. M. Vorobyeva ◽  
O. N. Tkacheva
Keyword(s):  
Atrial Fibrillation ◽  
Elderly Patients ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
The Elderly ◽  
Evidence Base ◽  
Geriatric Syndromes ◽  
Consensus Document ◽  
Venous Thromboembolic ◽  
Risk Of Falls

The administration of oral anticoagulants in elderly patients with geriatric syndromes such as senile asthenia syndrome, falls and high risk of falls, dementia, polymorbidity, polypharmacy are discussed in the article. The evidence base for the anticoagulants taking in patients with atrial fibrillation aged ≥75, ≥80, ≥85 and ≥90 years, in patients with atrial fibrillation and various geriatric syndromes, as well as in elderly patients with venous thromboembolic complications and frailty syndrome is presented. Most studies indicate significant advantages of direct oral anticoagulants (dabigatran, rivaroxaban, apixaban, and edoxaban) over the vitamin K antagonist warfarin in elderly patients with geriatric syndromes. An updated version of the FORTA consensus document, which aims to optimize the prescription of medicines for the elderly, is also presented. Apixaban has a FORTA-A safety class and is the safest oral anticoagulant in elderly patients.

scholarly journals Asthenic syndrome in elderly people: diagnostic, treatment and rehabilitation trends

2020 ◽  
pp. 40-48
Author(s):  
E.L. Davidov ◽  
◽  
N.V. Tihonova ◽  
A.V. Shulmin ◽  
V.S. Glushanko ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Elderly People ◽  
Life Quality ◽  
Geriatric Syndromes ◽  
Foreign Literature ◽  
Loss Of Autonomy ◽  
Clinical Conditions

Considering the tendency for the increasing number of elderly people, the problem of improving life quality of this category of population become more relevant. Senile asthenia (“frailty”) is one of the key clinical conditions that is currently the most common and age-associated (geriatric syndromes) one leading to loss of autonomy, increased hospitalization, as well as to disability and mortality in elderly people. The article reviews domestic and foreign literature data on issues related to the peculiarities of this condition, tactics of managing patients with SAS, as well as existing measures to prevent the development and progression of “frailty” in elderly patients.

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