scholarly journals DISRUPTION OF CARBOHYDRATE METABOLISM IN PATIENTS WITH SEPSIS

2020 ◽  
pp. 46-50
Author(s):  
S. D. Shapoval ◽  
I. L. Savon ◽  
O. O. Maksimova ◽  
L. A. Vasilevskaja ◽  
M. M. Sofilkanich ◽  
...  
Keyword(s):  
Carbohydrate Metabolism ◽  
Type I ◽  
Case Histories ◽  
Septic Complications ◽  
Number Of Patients ◽  
Starting Point ◽  
The World ◽  
Patients With Diabetes ◽  
Hygienic Measures ◽  
Group 1

Summary. Introduction Every year, 18–20 million cases of sepsis are recorded in the world, 30 % of which result in death. Hopes that with the development of sanitary-hygienic measures the dynamics of sepsis will decrease, turned out to be illusory. The annual increase in the frequency of sepsis is 8.7 %, while it is noted that the number of patients with impaired carbohydrate metabolism increases by 8-27 %. Materials and methods. 5612 case histories of patients with purulent-septic diseases who were treated at the center for the period 2015-2019 were analyzed. Results. It was found that 213 (3.8 %) patients had diabetes mellitus (DM) type I or II (group 1), and the number of patients with complicated diabetic foot syndrome (SDS) was 43.3 % of the total number of patients (2431 patients) — 2 group. The development of sepsis in patients of the 1st group was recorded in 1.4 % of cases (46 patients), while in patients with complicated SDS — in 8.3 % (202 patients). Among the latter, in the overwhelming majority of cases, the starting point in the development of sepsis was “wet” gangrene of the lower extremities. Conclusions. In patients with diabetes, the risk of developing septic complications is significantly higher than in patients without impaired carbohydrate metabolism.

scholarly journals Prediabetes: challenges and opportunities

2021 ◽  
pp. 220-227
Author(s):  
T. B. Morgunova ◽  
I. V. Glinkina ◽  
V. V. Fadeev
Keyword(s):  
Diabetes Mellitus ◽  
Carbohydrate Metabolism ◽  
Lifestyle Modification ◽  
Risk Group ◽  
Lifestyle Changes ◽  
Moderate Intensity ◽  
Number Of Patients ◽  
Antihyperglycemic Therapy ◽  
The World ◽  
Patients With Diabetes

In the world, the number of patients with carbohydrate metabolism disorders is steadily growing. Over the past 10 years, the number of patients with diabetes mellitus in the world has more than doubled. Moreover, there is not only an increase in the number of patients with diabetes mellitus, predominantly type 2 diabetes, but also with prediabetes. The term «prediabetes» means impaired glucose tolerance and impaired fasting glycemia. To date, it is obvious that the development of prediabetes lead not only to the higher risk of diabetes mellitus in the future, but also of cardiovascular diseases. Factors that increase the risk of cardiovascular events in patients with prediabetes includeare the following: insulin resistance, accompanied by arterial hypertension and dyslipidemia, and postprandial hyperglycemia. Therefore, it is very important to timely identify patients from the risk group, diagnose and treat carbohydrate metabolism disorders already at the stage of prediabetes. Also it is very important to identify the patients from the risk group, diagnose and treat carbohydrate metabolism disorders at the stage of prediabetes. Treatment of patients with prediabetes implies, first of all, lifestyle modification (moderate hypocaloric nutrition with predominant restriction of fats and simple carbohydrates and regular physical activity of moderate intensity) in order to reduce weight. If lifestyle changes are ineffective, drug therapy may be prescribed. The article discusses the studies conducted to assess the effectiveness of lifestyle modification, as well as various options for antihyperglycemic therapy (metformin, glucagon-like peptide receptor agonists, alpha-glucosidase inhibitors, orlistat) for the treatment of patients with prediabetes. It also provides data on long-term follow-up of patients with prediabetes who received different treatment options. 

scholarly journals Peculiarities Of Treatment Of Purulent-Necrotic Complications In Patients With Diabetic Foot Syndrome

2021 ◽  
Vol 03 (06) ◽  
pp. 116-121
Author(s):  
Abdullaev R.N. ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Foot ◽  
Diabetic Foot Syndrome ◽  
Septic Complications ◽  
Complications Of Diabetes ◽  
Surgical Infection ◽  
Number Of Patients ◽  
Patients With Diabetes

The number of patients with diabetes mellitus in the Andijan region who were registered according to endocrinologists from 2000 to 2015 increased almost fourfold from 26,000 to more than 110,000 in 2016 (14). This also shows that the number of patients with various purulent-necrotic complications of diabetes mellitus also increases proportionally, in addition, there is an increase in patients with severe purulent-septic complications of these processes, with widespread, deep purulent-necrotic fasciitis [3]. Of patients in the department of surgical infection of the ASMI clinic, patients with purulent-necrotic complications of diabetes mellitus account for almost 78%, which indicates a significant increase in the number of these patients. This tendency continues and goes up every year. According to the WHO, by 2030 every 15 people will have diabetes, and by 2050 this figure will be equal to every 6 people.

scholarly journals Influence Of Different Hypoglycemic Therapy Schemes On Carbohydrate Exchange Indicators In Type 2 Diabetes Mellitus

2021 ◽  
Vol 03 (06) ◽  
pp. 13-19
Author(s):  
S.I. Ismailov ◽  
◽  
S.U. Muminova ◽  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Diabetic Nephropathy ◽  
Carbohydrate Metabolism ◽  
Impaired Renal Function ◽  
The State ◽  
Dipeptidyl Peptidase 4 ◽  
Number Of Patients ◽  
Group 1

Aim of the study: To study the effect of prescribing inhibitors of sodium glucose cotransporter type 2 (iSGLT-2) and inhibitors of dipeptidyl peptidase-4 (iDDP-4) on the parameters of carbohydrate metabolism in patients with type 2 diabetes. Materials and methods: A prospective study included 80 patients with type 2 diabetes. The average age was 52.7 ± 3.78 years; diabetes experience - 8 years; BMI-30 ± 0.17; Hb1C-9.2 ± 0.4%; fasting glycemia –10.2 mmol/; eGFR-78 ml/min; TG-2.7 ± 0.44; total cholesterol-3.4 ± 0.72; MAU 32 ± 0.125. The patients were divided into 2 groups: group 1 - 30 patients with DN with impaired renal function and 30 patients with diabetic nephropathy without renal dysfunction in the presence of metformin + iSGLT- 2; 2 group of 30 patients with impaired renal function and 30 patients with diabetic nephropathy without impaired renal function on the background of metformin + iDPP-4. Results: The study of the effect of the inclusion of drugs iSGLT-2 (group 1) and iDPP-4 (group 2) showed a positive dynamics of carbohydrate metabolism indicators in patients with type 2 diabetes. So if the initial indicators in the groups were comparable in terms of glycemic control indicators, then by the 3rd month of treatment there was a significant decrease in HbA1c in the 1st group of patients in relation to the 2nd group. The result of the correction performed within 3 months was the achievement of the state of compensation in the 1st group in 36.7%, and in the 2nd group in 28.3%, 48.3% of the patients of the 1st group were brought into the state of sub compensation and 31.7 % of patients of the 2nd group. Conclusion: On the combination of metformin and INGLT-2, a larger number of patients managed to achieve the set goals of therapy with a lower risk of overt hypoglycemia, then this combination should be considered not only more effective.

scholarly journals Mechanisms of macro-, micro- and ultramicroscopic transformation of bodies in diabetes

Morphologia ◽  
2021 ◽  
Vol 15 (3) ◽  
pp. 23-29
Author(s):  
I.I. Savka ◽  
M.N. Tsytovskyi ◽  
G.M. Dmytriv
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Clinical Aspects ◽  
Number Of Patients ◽  
The World ◽  
Patients With Diabetes

The study of structural changes of organs and tissues in the context of diabetes is one of the urgent problems of modern medicine. According to WHO, in all countries of the world the number of patients with diabetes exceeds 175 million. According to an expert estimate of the spread of this disease by 2025 will make about 300 million people. More than 1 million people with diabetes have been officially registered in Ukraine. WHO has recognized the disease as a non-communicable epidemic. The dramatic increase in the prevalence of diabetes requires a detailed study of this problem. It is established that the prevalence of diabetes increases among the population of the countries of the world depending on the region, the level of economic development of the country, gender and age. Thus, according to IDF findings, there is a tendency for the highest prevalence of diabetes among the urban (urban) able-bodied population of developing countries in persons between 40 and 59 years of age, approximately equal in both male and female. The number of patients is increasing, mainly due to patients with type 2 diabetes. Type 2 diabetes (type 2 diabetes mellitus) is a severe progressive chronic disease that is an independent risk factor for heart failure (CH) and cardiovascular complications. In the XXI century. the steady growth of type 2 diabetes and the frequency of its serious consequences is of great concern to the world medical community. It is important that at the time of diagnosis of type 2 diabetes, the prevalence of complications leading to a decline in quality of life, early disability and premature death is already high enough. Despite the presence in the fight against this disease effective drugs, modern technologies, new educational and preventive techniques, mankind loses the fight against diabetes year after year, which leads to disability due to its complications, reducing the life expectancy and quality of life of patients, loss working capacity and premature mortality. Thus, the current prevalence and incidence of diabetes and life-threatening complications suggest that there is a non-communicable diabetes epidemic in the world and in Ukraine in particular. The article represents analysis of work of numerous researchers who studied statistіcal, clinical and morphological aspects of the impact of diabetes on cardiovascular system. Main morphogenetic, morphological and clinical aspects of complications of diabetes, pathologies of microcirculation of patients with diabetes were dedicated, what makes possible to predict and detect on the early stages vascular complications in diabetes and to perform effective prevention and treatment.

scholarly journals PROTEOLYTIC SYSTEM CONDITION AS IN THE CASE OF NEUTROPHIL ELASTASE IN PATIENTS WITH TROPHIC ULCERS ON THE BACKGROUND OF DIABETES MELLITUS

2020 ◽  
Vol 8 (4) ◽  
pp. 346-350
Author(s):  
A.S. Nikolaienko
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
International Diabetes Federation ◽  
Poor Quality ◽  
Proteolytic System ◽  
Financial Costs ◽  
Number Of Patients ◽  
The World ◽  
Patients With Diabetes

According to the WHO and the International Diabetes Federation (IDF), the number of patients with diabetes in the world reached 463 million people in 2019. A typical manifestation of complications of diabetes mellitus is the development of trophic ulcers of the lower extremities, which leads to poor quality of life, disability, and high financial costs for treatment.

scholarly journals Sequential management of tibial fractures using a temporary unicortical external fixator

SICOT-J ◽  
2018 ◽  
Vol 4 ◽  
pp. 39
Author(s):  
Anne-Pauline Russo ◽  
Alexandre Caubere ◽  
Ammar Ghabi ◽  
Antoine Grosset ◽  
Philippe Mangin ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Damage Control ◽  
Significant Loss ◽  
Tibial Fractures ◽  
External Fixators ◽  
Type I ◽  
Septic Complications ◽  
Damage Control Orthopedics ◽  
Number Of Patients ◽  
Im Nailing

Introduction: The development of damage control orthopedics (DCO) procedures has led to the development of temporary unicortical external fixators (TUEFs) intended to limit deep infectious complications and facilitate early conversion to internal fixation. Methods: A retrospective study was conducted in two French military trauma centers, including on patients being treated for tibial fractures with a TUEF (UNYCO® − Orthofix®) followed by an early conversion to intramedullary nailing. Results: Eleven patients with an average age of 41 were included between September 2015 and June 2017. A total of 12 TUEFs were implanted for one closed fracture and 11 open fractures, including one type I, eight types II, and two Gustilo types IIIB. The indication of DCO was related to hemodynamic instability in three cases, to the severity of soft tissue lesions in eight cases, and to the context of treatment in one case. The conversion to IM nailing was made after an average of 7.6 days. No significant loss of reduction was observed until internal osteosynthesis, which was performed with “fixator in place” in ten cases. The coverage of Gustilo type III injuries was performed by free flap transfers at the same time as IM nailing. All the patients were reviewed with an average follow-up of 16.5 months. Bone union was achieved in all cases. Two IM nailing dynamizations were carried out, but no bone grafting was required. Two cases of pandiaphysitis were observed and treated without functional complications. Discussion: Despite a limited number of patients, this study demonstrates the reliability of the TUEF to maintain the reduction of tibial fractures and facilitate early conversion to IM nailing. Unicortical fixation does not prevent septic complications related to the severity of soft tissue injuries.

Dreams Give Birth to Reality”. Engraving Austroseraphicum Coelum as an Attempt to Create a New Reality by the Spanish Habsburgs Dynastic Propaganda / Sny rodzą rzeczywistość…”. Grafika Austroseraphicum Coelum jako próba kreowania nowej rzeczywistości za pomocą propagandy dynastycznej Habsburgów hiszpańskich

2014 ◽  
Vol 39 (1) ◽  
Author(s):  
Jan Kurowiak
Keyword(s):  
Seventeenth Century ◽  
The Netherlands ◽  
General Condition ◽  
Symbolic System ◽  
Political Situation ◽  
Mission Of God ◽  
Starting Point ◽  
The World ◽  
The Church

AbstractAs a work of propaganda, graphics Austroseraphicum Coelum Paulus Pontius should create a new reality, make appearances. The main impression while seeing the graphics is the admiration for the power of Habsburgs, which interacts with the power of the Mother of God. She, in turn, refers the viewer to God, as well as Franciscans placed on the graphic, they become a symbol of the Church. This is a starting point for further interpretation of the drawing. By the presence of certain characters, allegories, symbols, we can see references to a particular political situation in the Netherlands - the war with the northern provinces of Spain. The message of the graphic is: the Spanish Habsburgs, commissioned by the mission of God, they are able to fight all of the enemies, especially Protestants, with the help of Immaculate and the Franciscans. The main aim of the graphic is to convince the viewer that this will happen and to create in his mind a vision of the new reality. But Spain was in the seventeenth century nothing but a shadow of former itself (in the time of Philip IV the general condition of Spain get worse). That was the reason why they wanted to hold the belief that the empire continues unwavering. The form of this work (graphics), also allowed to export them around the world, and the ambiguity of the symbolic system, its contents relate to different contexts, and as a result, the Habsburgs, not only Spanish, they could promote their strength everywhere. Therefore it was used very well as a single work of propaganda, as well as a part of a broader campaign

COGNITIVE DEFICIENCY AT ISCHEMIC OM STROKE

2020 ◽  
Vol 1 (1) ◽  
pp. 55-57
Author(s):  
Dildora Khaydarova ◽  
◽  
Hilola Davronova ◽  
Asliddin Akbarov ◽  
Keyword(s):  
Social Problems ◽  
Cerebrovascular Diseases ◽  
Cerebral Stroke ◽  
Number Of Patients ◽  
High Prevalence ◽  
The World ◽  
Cognitive Deficiency ◽  
Complications And Mortality

Cerebrovascular diseases remain one of the most pressing medical and social problems in many countries of the world, due to their high prevalence, severity of complications and mortality. In Uzbekistan, the number of patients with cerebral stroke is quite large -about 40-45 thousandcases of cerebral stroke are registered annually

EVALUATION OF THE EFECTS OF EMBEDDING THERAPY AND ELECTRONIC ACUPUNCTURE COMBINED WITH “DOC HOAT TANG KY SINH” REMEDY IN THE TREATMENT OF LOW BACK PAIN BY OSTEOARTHRITIS

2016 ◽  
pp. 33-38
Author(s):  
Thi Ngoc Dung Thai ◽  
Thi Tan Nguyen
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Effective Treatment ◽  
Key Words ◽  
Low Back ◽  
Good Level ◽  
Embedding Therapy ◽  
The World ◽  
Group 2 ◽  
Group 1

Background: Low back pain by osteoarthristis is one of the most common diseases in the world as well as in Vietnam, estimated 70-85% people in the world have low back pain sometime in their lives. Obiectives: To evaluate the effects of embedding therapy and electronic acupuncture combined with “Doc hoat tang ky sinh” remedy in the treatment of low back pain by spondylosis. Materials and methods: 72 patients diagnosed of low back pain by spondylosis, were examined and treated at Phu Yen Traditional Medicine Hospital, divided equally into 2 groups (group 1 and group 2). Results: In group 1: Effective treatment at good and fair good level accounted for 41.7% and 41.7%. In group 2: Good level occupied 33.3% and fair good level occupied 55.6%. Conclusion: The ratios of good and fair good in 2 groups were equal (p >0.05) Key words: Low back pain, spondylosis, embedding therapy, electronic acupuncture

The Paradox of “A High Standard of Public Honesty”

2017 ◽  
Author(s):  
James Kennedy ◽  
Ronald Kroeze
Keyword(s):  
The Netherlands ◽  
Early Modern ◽  
Side Effect ◽  
High Standard ◽  
Dutch Republic ◽  
Liberal Politics ◽  
Patronage Politics ◽  
Starting Point ◽  
The World ◽  
Late Nineteenth

This chapter takes as its starting point the contemporary idea that the Netherlands is one of the least corrupt countries in the world; an idea that it dates back to the late-nineteenth and early-twentieth centuries. In this chapter, the authors explain how corruption was controlled in the Netherlands against the background of the rise and fall of the Dutch Republic, modern statebuilding and liberal politics. However, the Dutch case also presents some complexities: first, the decrease in some forms of corruption was due not to early democratization or bureaucratization, but was rather a side-effect of elite patronage-politics; second, although some early modern forms of corruption disappeared around this period, new forms have emerged in more recent times.

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