INFLUENCE OF FAT CELLS ON PATHOGENETIC LINKS OF INFLAMMATION MECHANISMS IN PATIENTS WITH PURIFIC WOUNDS THAT DO NOT HEAL FOR A LONG TIME

Summary. The purpose of the study is - study of sources of domestic and world literature on the problem of pathophysiological disorders of local homeostasis involving mast cells (МC) in purulent long-term non-healing wounds (PLTNHW). Research tasks — according to the literature, to identify the features of the course of the wound process and the possibility of regulating local homeostasis with the participation of MC in patients with PLTNHW. Conclusions. Thus, considerable progress has been made so far in understanding the molecular mechanisms of the basic phases of the normal and complicated wound process. A new step towards effective solution of the socially significant problem of surgical treatment of extensive wound defects in PLTNHW is further study of the processes of direct intercellular interaction and selection of tryptase and chymase MC as indicators of the state of the healing process and a target for pathogenetic action.

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Posterior Maxillary Prosthetic Treatment with Molar Hemisection – A case report

Indonesian Journal of Dental Medicine ◽

10.20473/ijdm.v1i1.2018.22-26 ◽

2018 ◽

Vol 1 (1) ◽

pp. 22

Author(s):

Abil Kurdi ◽

Hanoem Eka Hidayati

Keyword(s):

Case Report ◽

Healing Process ◽

Multiple Root ◽

Bridge Abutment ◽

Infected Root ◽

Alternative Treatment Option ◽

Molar Teeth ◽

Selection Of Patients ◽

Selection Of

Background: Hemisection is an alternative treatment option for maintaining tooth with multiple root that indicated for extraction. Purpose: To reported tooth with multiple root indicated by extraction to be used as a fixed-fixed bridge abutment by extracting the infected root and maintain the healthy one. Case: A 53-year-old woman with caries in upper 1st molar teeth in mesiobuccally root that can’t be maintained. Patients refuse the teeth to be extracted. Case Management: Hemisection treatment was performed on 26 mesiobuccal root, with the addition of bone graft. After the healing process, fixed-fixed bridges were made on 25, 26, 27, 28, with PFM on 25, 26, 27 and full cast crowns on 28 as the material. Discussion: Hemisection as a conservative treatment, can be an option for multiple root teeth that has been indicated for extraction but still have root that can be maintained. Conclusion: Teeth performed by hemisection treatments can be used as abutments with attention to the selection of patients to achieve long-term success.

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Archives Management and Permanent Storage of Documents

Atlanti ◽

10.33700/2670-451x.25.1.153-161(2015) ◽

2015 ◽

Vol 25 (1) ◽

pp. 153-161

Author(s):

Fikrie Berisha

Keyword(s):

Entire Area ◽

Digital Documents ◽

Digital Network ◽

Archival Documents ◽

Long Time ◽

Permanent Storage ◽

Digital Document ◽

The Moment ◽

Selection Of

Modern digital archives are modern archives which in big computer devices (servers), preserve archived original document overlooking the moment is produced. Archives in Kosovo assessment of archival documents make in two directions. First; selection of classical documents (on paper) with the value to be transformed into digital documents, and second; selection of contemporary documents produced by institutions of computer and internet era. Management of these digital documents requires procedures and professional standards for its storage and processing by the archive, in order to be ready to serve researchers and interested parties. Access to digital documents should be fast, simple procedures, providing documentation from the penetration of ‘hackers’ and people badly intention. To fulfil its mission digital document should ensure and complement the appearance of the original document. Since the user does not have the option of intervention and change in the document. Should work in protect emblem, which protects the entire area of the document in the form of molten seal, which also shows the ownership of certain archive. Safety documentation and document base by external users will be able to organize, deposit and stored at three levels: Server (1) be stored (saved) archival documents for use by the applicant; Server (2) stored data of the first and simultaneously updates added by continuous processing of new documents; and Server (3) is not accessible from outside through digital network, but stored all digital archive documentation and from here there should be no often exit. In Server 3 only entered document and stored as recent bank. From there, the document will be drawn only if it is missing or damaged document on server 1 and 2.Thus, through this categorization could be provided for long time electronic documents (digital), until to new modern inventions of modern digitalization technology that would ensure the preservation of documents for the ‘real’ long-term or permanent time.

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Inhibition of RANKL and Sema4d Improves Residual Ridge Resorption in Mice.

10.21203/rs.3.rs-1209410/v1 ◽

2022 ◽

Author(s):

Meri Hisamoto ◽

Shunsuke Kimura ◽

Kai Iwata ◽

Toshihiko Iwanaga ◽

Atsuro Yokoyama

Keyword(s):

Gene Expression ◽

Bone Loss ◽

Molecular Mechanisms ◽

Alveolar Bone ◽

Alveolar Bone Loss ◽

Period Gene ◽

Semaphorin 4D ◽

Long Time ◽

Extraction Model

Abstract Residual ridge resorption (RRR) is a chronic and progressive bone resorption following tooth loss. It causes deterioration of the oral environments and leads to the pathogenesis of various systemic diseases. However, the molecular mechanisms and risk factors for RRR progression are still unclear and controversial. In this study, we developed a tooth extraction model using mice for analyzing long-term morphological and gene expression changes in the alveolar bone. We further applied ovariectomy to this model to elucidate the effects of osteoporosis on RRR progression. As a result, the alveolar bone loss was biphasic and consisted of rapid loss in the early stages and subsequently slow and sustained bone loss over a long period. Gene expression analysis indicated that ovariectomy increased the expression of pro-inflammatory cytokines in the alveolar bone and prolonged the activation of osteoclasts same as histological analysis. Furthermore, the expressions of Tnfsf11 and Sema4d kept increasing for a long time in OVX mice. Administration of neutralization antibodies for receptor activator of NF-κB ligand (RANKL) effectively suppressed RRR. Similarly, inhibition of Semaphorin 4d (Sema4d) also improved alveolar bone loss. This study demonstrated that osteoporosis is a risk factor for RRR and that RANKL and Sema4d suppression are potential treatments.

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Analysis of Long-Term Measured Exterior Air Temperature in Zilina

Civil and Environmental Engineering ◽

10.2478/cee-2018-0016 ◽

2018 ◽

Vol 14 (2) ◽

pp. 124-131 ◽

Cited By ~ 1

Author(s):

Daniela Jurasova

Keyword(s):

Climate Change ◽

Temperature Measurement ◽

Air Temperature ◽

Weather Data ◽

Time Data ◽

Long Time ◽

Experimental Laboratory ◽

Weather Stations ◽

Selection Of

Abstract The climate change assumes nowadays on significance. Weather data may be available on various time scales – long-term, minutes, hours, days, periods, years. Measurements of air temperature are realized for a long time. Data in Slovakia are available from few weather stations of Slovak Hydrometeorological Institute (SHMI). For long-term and wide-ranging measurement of various parameters this can be complicated and expensive. This paper is focused on temperature measurement near the experimental laboratory. Estimation of daily, monthly and yearly mean temperatures is done in different ways. Results from experimental temperature measurement, in a way of selection of unusual extremes are presented. Shorter recording intervals describe the temperature courses in a more pertinent way.

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After the Dance is over: Some Issues and Suggestions for Follow-up Assessment in Behavior Therapy

Psychological Reports ◽

10.2466/pr0.1977.41.3f.1287 ◽

1977 ◽

Vol 41 (3_suppl) ◽

pp. 1287-1308 ◽

Cited By ~ 6

Author(s):

Eric J. Mash ◽

Leif G. Terdal

Keyword(s):

Behavior Therapy ◽

Intervention Programs ◽

Long Term Effects ◽

Long Time ◽

Time Periods ◽

Research Recommendations ◽

Selection Of

Behavioral intervention programs have thus far failed to provide sufficient follow-up information for the evaluation of long-term effects. This omission is believed to be related to an inadequate conceptualization of follow-up assessment, as well as to the methodological and practical difficulties inherent in assessing behavior over long time periods. A framework for follow-up assessment that is consistent with current behavioral efforts to program generalization is described and is contrasted with traditional views of follow-up that look for effects following the termination of treatment. Several methodological features of follow-up assessment are discussed, along with research recommendations, including the determination of length of appropriate follow-up intervals, the frequency of follow-up assessments, the need for standardization of measures both within and between studies, reactivity of follow-up assessment, the selection of follow-up measures and attrition of subjects.

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Synchronized flutter of two slender flags

Journal of Fluid Mechanics ◽

10.1017/jfm.2016.451 ◽

2016 ◽

Vol 801 ◽

pp. 652-669 ◽

Cited By ~ 5

Author(s):

Jérôme Mougel ◽

Olivier Doaré ◽

Sébastien Michelin

Keyword(s):

Large Amplitude ◽

Axial Flow ◽

Coupled Dynamics ◽

Hydrodynamic Coupling ◽

Close Proximity ◽

Long Time ◽

Dynamical Properties ◽

Body Theory ◽

Selection Of

The interactions and synchronization of two parallel and slender flags in a uniform axial flow are studied in the present paper by generalizing Lighthill’s elongated body theory (EBT) and Lighthill’s large-amplitude elongated body theory (LAEBT) to account for the hydrodynamic coupling between flags. The proposed method consists of two successive steps, namely the reconstruction of the flow created by a flapping flag within the LAEBT framework and the computation of the fluid force generated by this non-uniform flow on the second flag. In the limit of slender flags in close proximity, we show that the effect of the wakes has little influence on the long-time coupled dynamics and can be neglected in the modelling. This provides a simplified framework extending LAEBT to the coupled dynamics of two flags. Using this simplified model, both linear and large-amplitude results are reported to explore the selection of the flapping regime as well as the dynamical properties of two side-by-side slender flags. Hydrodynamic coupling of the two flags is observed to destabilize the flags for most parameters, and to induce a long-term synchronization of the flags, either in-phase or out-of-phase.

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Developmental, molecular and genetic studies on grapevine response to temperature open breeding strategies for adaptation to warming

OENO One ◽

10.20870/oeno-one.2017.51.2.1587 ◽

2017 ◽

Vol 51 (2) ◽

pp. 155-165 ◽

Cited By ~ 16

Author(s):

Laurent Torregrosa ◽

Antoine Bigard ◽

Agnes Doligez ◽

David Lecourieux ◽

Markus Rienth ◽

...

Keyword(s):

Molecular Mechanisms ◽

Berry Development ◽

Wine Production ◽

Genetic Studies ◽

Genomic Analyses ◽

Entire Plant ◽

Response To Temperature ◽

The Impact ◽

Selection Of

Aim: In the long term, genetic improvement is one of the major strategies to support sustainable wine production in a changing climate. Over the past 5 years, we have developed an interdisciplinary research program that aimed to: i) characterize the impact of temperature increase sensed by the entire plant or individual bunches on the development and functioning of the plant, ii) identify the physiological and molecular mechanisms regulating the response of vegetative and reproductive development to heat stress and iii) develop tools to map quantitative trait loci (QTLs) of plant and berry development in duly controlled, stable, and contrasting environmental conditions.Methods and results: Performing high-throughput genomic analyses combined with the use of innovative experimental designs (fruiting cuttings, microvines, single berry sampling) was critical to decipher the ecophysiological and molecular mechanisms involved in the vine response to high temperature.Conclusion: Warming promotes vegetative growth and hampers plant carbon balance, disturbing flower set and young berry development. High temperatures modify primary and secondary fruit metabolisms, desynchronizing sugar and organic acid metabolisms and delaying sugar and polyphenol accumulation during ripening. The study of day and night transcriptomic and proteomic signatures associated with heat highlighted key players of the response to temperature in the fruit. Significance and impact of the study: Capitalizing on this knowledge, a new program is being proposed for the selection of cultivars limiting the accumulation of sugars in the berry while maintaining other qualitative compounds.

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MODERN APPROACHES TO COMPREHENSIVE SURGICAL TREATMENT OF PURULENT LONG-HEALING WOUNDS

Kharkiv Surgical School ◽

10.37699/2308-7005.5-6.2020.11 ◽

2020 ◽

pp. 61-66

Author(s):

K. A. Goltsev ◽

I. A. Krivoruchko ◽

A. N. Goltsev ◽

A. V. Sivozhelezov ◽

N. A. Sykal ◽

...

Keyword(s):

Surgical Treatment ◽

World Literature ◽

Pathological Changes ◽

Significant Progress ◽

Present Stage ◽

New Approaches ◽

Modern Methods ◽

Healing Wounds ◽

Made In

Summary. The purpose of the study is — analysis of the sources of domestic and world literature with the study of modern approaches to the complex surgical treatment of purulent long-term non-healing wounds (PLTNHW). Research tasks — according to the literature, to determine the possibilities of surgical treatment at the present stage in patients with PLTNHW. Conclusions. Thus, to date, significant progress has been made in the surgical treatment of PLTNHW. Numerous diagnostic and therapeutic methods can significantly improve the results of surgical treatment of PLTNHW, but they are not without some disadvantages. In this regard, the development and implementation of new approaches and modern methods for diagnosing pathological changes and the effect on the wound process using modern developments and technologies is relevant.

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A Study on Molecular Mechanisms of Adiposis Induced by Long-Term Treatment of High-Fat and High-Sucrose in C57BL/6J Mice

Physiological Research ◽

10.33549/physiolres.933830 ◽

2019 ◽

pp. 75-87 ◽

Cited By ~ 1

Author(s):

Xiaodan Li ◽

Peipei Tu ◽

Muhammad Umar ◽

Qiqi Liu ◽

Wenya Luo ◽

...

Keyword(s):

Dna Methyltransferase ◽

Molecular Mechanisms ◽

Methylation Pattern ◽

Term Treatment ◽

High Fat ◽

Long Term Treatment ◽

Long Time ◽

Promoter Dna ◽

High Sucrose

Adiposis is reputed as a twin disease of type 2 diabetes and greatly harmful to human health. In order to understand the molecular mechanisms of adiposis, the changes of physiological, pathological, epigenetic and correlative gene expression were investigated during the adiposis development of C57BL/6J mice induced by long time (9 months) high-fat and high-sucrose diet (HFSD) sustainably. The results showed that mRNA transcription level of the Leptin, Glut4 and Glut2 genes have been obviously changed, which exhibit a negative correlation with methylation on their promoter DNA. The results also revealed that HFSD induced higher level of DNA methyltransferase 1 (DNMT1) in fat tissue might play important role in regulating the changes of methylation pattern on Glut4 and Leptin genes, and which might be one of the molecular mechanisms for the adiposis development.

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Developmental, molecular and genetic studies on grapevine response to temperature open breeding strategies for adaptation to warming

OENO One ◽

10.20870/oeno-one.2016.0.0.1587 ◽

2017 ◽

Vol 51 (2) ◽

pp. 155 ◽

Cited By ~ 4

Author(s):

Laurent Torregrosa ◽

Antoine Bigard ◽

Agnes Doligez ◽

David Lecourieux ◽

Markus Rienth ◽

...

Keyword(s):

Molecular Mechanisms ◽

Berry Development ◽

Wine Production ◽

Genetic Studies ◽

Genomic Analyses ◽

Entire Plant ◽

Response To Temperature ◽

The Impact ◽

Selection Of

Aim: In the long term, genetic improvement is one of the major strategies to support sustainable wine production in a changing climate. Over the past 5 years, we have developed an interdisciplinary research program that aimed to: i) characterize the impact of temperature increase sensed by the entire plant or individual bunches on the development and functioning of the plant, ii) identify the physiological and molecular mechanisms regulating the response of vegetative and reproductive development to heat stress and iii) develop tools to map quantitative trait loci (QTLs) of plant and berry development in duly controlled, stable, and contrasting environmental conditions.Methods and results: Performing high-throughput genomic analyses combined with the use of innovative experimental designs (fruiting cuttings, microvines, single berry sampling) was critical to decipher the ecophysiological and molecular mechanisms involved in the vine response to high temperature.Conclusion: Warming promotes vegetative growth and hampers plant carbon balance, disturbing flower set and young berry development. High temperatures modify primary and secondary fruit metabolisms, desynchronizing sugar and organic acid metabolisms and delaying sugar and polyphenol accumulation during ripening. The study of day and night transcriptomic and proteomic signatures associated with heat highlighted key players of the response to temperature in the fruit. Significance and impact of the study: Capitalizing on this knowledge, a new program is being proposed for the selection of cultivars limiting the accumulation of sugars in the berry while maintaining other qualitative compounds.

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