scholarly journals An Overview of Evidence that Mercury from Dental Fillings may be an Etiological Factor in Many Health Disorders

2021 ◽  
pp. 472-485
Author(s):  
Siblerud R ◽  
Mutter J
Keyword(s):  
Health Effects ◽  
Scientific Evidence ◽  
Bipolar Disorders ◽  
Dental Amalgam ◽  
Etiological Factor ◽  
Dental Fillings ◽  
Hair Mercury ◽  
Dental Amalgams ◽  
Health Disorders ◽  
Lateral Sclerosis

Aim: The purpose of this paper is to summarize the research regarding the toxic health effects caused by mercury dental amalgams. Method: The study involved summarizing scientific articles in journals regarding health effects of dental amalgam mercury. Results: The science strongly suggests dental amalgam mercury may be an etiological factor in numerous health disorders. Mental health seems to be affected the most including such conditions as depression, anger, and irritability. Studies have also associated it with schizophrenia and bipolar disorders. The cardiovascular system also is affected including high blood pressure, heart rate, hemoglobin, hematocrit, and red blood cells. Subjects with amalgams have a decreased T lymphocyte percentage compared to a control, and the immunoglobins IgG, IgA, and IgE correlated with the number of amalgams. Myopia is reduced in amalgam bearing subjects but amalgam mercury is constricting the visual field. When comparing total health disorders of subjects with amalgams compared to those without, they suffered 45% more health disorders. Urine and hair mercury levels were significantly higher in subjects with amalgams compared to those without. The scientific evidence strongly suggests that amalgam mercury is associated with Alzheimer’s disease, multiple sclerosis, and amytrophic lateral sclerosis. Research has shown when amalgams are removed many health conditions improve. Conclusion: The evidence is overwhelming that mercury from dental amalgam is an etiological factor in many health disorders.

scholarly journals Perception of Patients with Amalgam Fillings about Toxicity of Mercury in Dental Amalgam

2012 ◽  
Vol 13 (3) ◽  
pp. 289-293 ◽  
Author(s):  
CT Bamise ◽  
Adeleke O Oginni ◽  
Michael A Adedigba ◽  
OO Olagundoye
Keyword(s):  
Formal Education ◽  
Dental Amalgam ◽  
Mercury Content ◽  
Filling Material ◽  
Human Beings ◽  
Dental Fillings ◽  
Dental Hospital ◽  
Dental Amalgams ◽  
Level Of Agreement ◽  
Amalgam Fillings

ABSTRACT Objective The objective of this study is to evaluate the awareness of patients with dental fillings about the toxicity of mercury in dental amalgam. Materials and methods Adult patients having at least one amalgam filling in their mouth were recruited in the Oral Diagnosis Department of OAUTHC, Ile-Ife Dental Hospital. Participants were recruited consecutively as they report in the clinic. Data were collected using a structured questionnaire developed based on standard questions from relevant publications. They were asked to indicate the type of filling material in their mouth, ingredients of the material, previous knowledge of mercury in dental amalgam and ailments due to mercury. They were to indicate their level of agreement with filling their cavities with dental amalgam despite prior information about its mercury content. Results There were about 446 respondents analyzed; male, 194 (43.5%); female 252 (56.5%). Six (1.4%) and 21 (4.7%) respondents were primary and secondary schools students respectively; 15(3.4%) had no formal education while about 410 (91.9%) were either undergraduate or graduate. All of them had at least one amalgam filling. 249 (55%) participants know the type of filling on their teeth; 156 (34.5%) had the knowledge of the presence of mercury in dental amalgam while 26.1% believed mercury can cause problems in human beings. About 90 (19.9%) participants claimed to have heard about adverse reactions to dental amalgams and 34 (7.5%) of them have heard about people recovering from an illness after removal of their filling. The level of agreement with filling their cavities with amalgam despite prior knowledge of its mercury content was 74% while 60% was observed for allowing just any material to be placed on their teeth. Conclusion Awareness of toxicity of mercury in dental amalgam was slightly low among the respondents studied. This may be suggested to be a reflection of nonexistent of global amalgam controversy in Nigeria. How to cite this article Bamise CT, Oginni AO, Adedigba MA, Olagundoye OO. Perception of Patients with Amalgam Fillings about Toxicity of Mercury in Dental Amalgam. J Contemp Dent Pract 2012;13(3):289-293.

scholarly journals A Comparison of Mercury Exposure from Seafood Consumption and Dental Amalgam Fillings in People with and without Amyotrophic Lateral Sclerosis (ALS): An International Online Case-Control Study

2018 ◽  
Vol 15 (12) ◽  
pp. 2874 ◽  
Author(s):  
Jane Parkin Kullmann ◽  
Roger Pamphlett
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Toxic Metal ◽  
Selenium Deficiency ◽  
Dental Amalgam ◽  
Mercury Exposure ◽  
Seafood Consumption ◽  
Online Questionnaire ◽  
Metal Interactions ◽  
Dental Fillings ◽  
Lateral Sclerosis

Exposures to toxic metals such as mercury have been suggested to be risk factors for amyotrophic lateral sclerosis (ALS). Human intake of mercury commonly occurs via consumption of seafood or from mercury-containing amalgam dental restorations (‘mercury fillings’). We therefore compared mercury exposures from these sources in 401 ALS and 452 non-ALS respondents, using an internationally-available online questionnaire that asked respondents how often they ate seafood and what their favourite types of seafoods were. Respondents were also asked to record numbers of current or former mercury fillings. ALS and non-ALS respondents did not differ in their frequency of seafood consumption or in monthly mercury intake from favourite seafoods. Both groups had similar numbers of current, as well as former, mercury fillings. In conclusion, this study found no evidence that mercury exposure from eating seafood, or from mercury dental fillings, was associated with the risk of developing ALS. Therefore, if mercury does play a role in the pathogenesis of ALS, other sources of exposure to mercury in the environment or workplace need to be considered. Alternatively, a susceptibility to mercury toxicity in ALS, such as genetic or epigenetic variations, multiple toxic metal interactions, or selenium deficiency, may be present.

scholarly journals The Hazardous Effects of Dental Amalgam Fillings in Human Body: A Systematic Review

2021 ◽  
pp. 45-54
Author(s):  
Laila Mohammed Alanazi ◽  
Zahra Helal Alqallaf ◽  
Waad Mohammad Alghamdi ◽  
Ahmed Mufadhi Alanazi ◽  
Salihah Muslih Alqarni ◽  
...  
Keyword(s):  
Human Body ◽  
Lupus Erythematosus ◽  
High Strength ◽  
Dental Amalgam ◽  
Tooth Color ◽  
Dental Fillings ◽  
Dental Amalgams ◽  
Materials Used ◽  
Dental Amalgam Fillings ◽  
Amalgam Fillings

The Dental amalgam used in the dental fillings is basically an alloy of mercury (Hg). The amalgam is one of the most commonly used and versatile restorative material. Since more than 150 years this alloy of mercury, that is amalgam is used for it been economical, easy to use, durable, high strength and bacterio-static characteristics. Due to environmental pollution, detrimental health its use is decreasing in recent times. Also its not so appealing like the other materials used that resemble the tooth color. The tooth coloured restorative materials are recommended by both the doctor and the patient. Many researchers suggested that over the period of time the mercury from the filling might leach into the mouth. Thus in this study a detailed review of all the literature available online is done to understand the hazardous effects of dental amalgam fillings in the human body. The systematic literature search using Scopus, PubMed, EMBASE and Web of Science electronic databases was done using PRISMA. The experiments conducted in Sheep and monkey suggested the penetration of amalgam into the jaw bone of the patient with dental restorations. Constant exposure of mercury at lower levels can also lead to multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. Most commonly reported renal dysfunction due to the dental amalgams are Tubular and Glomerular damage of the kidneys.

Risk of Mercury exposure during childhood: a review of Sri Lankan situation

2020 ◽  
Vol 35 (3) ◽  
pp. 229-232
Author(s):  
Himan K. A. Galappaththi ◽  
Inoka Suraweera
Keyword(s):  
Sri Lanka ◽  
Health Effects ◽  
Fish Consumption ◽  
Public Awareness ◽  
Mercury Level ◽  
Fluorescent Light ◽  
Aquatic Life ◽  
Hair Mercury ◽  
Coastal Belt ◽  
High Mercury

AbstractSri Lanka had ratified the Minamata convention in the year 2017 and is planning to phase out Mercury by 2020. Mercury thermometers and compact fluorescent light bulbs are abundant at hospitals, households and schools. Limitations in safe disposal and containment mechanisms have enhanced the unregulated e-waste collection and extraction. Sri Lanka has plentiful lagoons, fishing bays, and inland irrigation systems. Fish consumption is high, especially around the coastal belt. Mercury can bioaccumulate in humans by the consumption of fish from contaminated sources. Children are at risk of exposure in their living environments and via food. A multicountry study done across three oceans on Mercury threat to women & children revealed, lagoon pollution from industrial Mercury emissions in Sri Lanka, possessing high Mercury among local females who consume fish from that lagoon. The mean hair Mercury level in coastal areas with high fish consumption exceeded the reference dose even among children. Aquatic life and crop studies revealed a mixed picture of Mercury levels which some are lower and some are higher than the permissible levels. Studies on environmental Mercury levels and correlations with health effects among children will help to fill the data gap. Public awareness of the health effects of Mercury and mechanisms of Mercury disposal should be established.

EXAMINATION OF DIETARY METHYLMERCURY EXPOSURE IN THE CASA PIA STUDY OF THE HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN

2001 ◽  
Vol 64 (7) ◽  
pp. 521-530 ◽  
Author(s):  
Carina C. Evens ◽  
Michael D. Martin ◽  
James S. Woods ◽  
Henrique Luis Soares ◽  
Mario Bernardo ◽  
...  
Keyword(s):  
Health Effects ◽  
Methylmercury Exposure ◽  
Dental Amalgams

Lithium Clinics in Berlin and Dresden: a 50-Year Experience

2018 ◽  
Vol 51 (05) ◽  
pp. 166-171 ◽  
Author(s):  
Werner Felber ◽  
Michael Bauer ◽  
Ute Lewitzka ◽  
Bruno Müller-Oerlinghausen
Keyword(s):  
Side Effects ◽  
Lithium Treatment ◽  
Scientific Evidence ◽  
Bipolar Disorders ◽  
Lithium Therapy ◽  
Psychopharmacological Treatment ◽  
Academic Settings ◽  
History Of ◽  
The 1960S

AbstractAlthough lithium’s serendipitous discovery as a medication for depression dates back more than 200 years, the first scientific evidence that it prevents mania and depression arose only in the 1960s. However, at that time there was a lack of knowledge about how to administer and monitor lithium therapy safely and properly. The lithium clinics in Dresden and Berlin were remarkably similar in their beginnings in the late 1960s regarding patient numbers and scientific expertise without being aware of one another due to the Iron Curtain separating Germany into a western and eastern part until 1990. In what were initially lithium-care programs run independently from one another, the lithium clinics embedded in academic settings in Dresden and Berlin represent a milestone in the history of psychopharmacological treatment of affective disorders in Germany and trailblazers for today’s lithium therapy. Nowadays, lithium’s clinical applications are unquestioned, such as its use in strategies to prevent mood episodes and suicide, and to treat depression. The extensively documented knowledge of lithium treatment is the fruit of more than 50 years of observing disease courses and of studying side effects and influencing factors of lithium prophylaxis. Its safe and proper administration—in determining the correct indication, baseline and follow-up examinations, recommended dosages, monitoring, or the management of side effects—is well established. Subsequently, both national and international guidelines continue recommending lithium as the gold standard in treating patients with unipolar and bipolar disorders.

Preface

PEDIATRICS ◽  
1984 ◽  
Vol 74 (4) ◽  
pp. 585-585
Author(s):  
WILLIAM H. FOEGE
Keyword(s):  
Health Effects ◽  
Infant Feeding ◽  
Infant Health ◽  
Task Force ◽  
Scientific Evidence ◽  
Health Department ◽  
The United States ◽  
Positive Health ◽  
Department Of Health ◽  
Infant Feeding Decisions

In November 1981, Dr Edward N. Brandt, Assistant Secretary of Health, Department of Health and Human Services, commissioned the Task Force to examine the scientific evidence regarding infant feeding and infant health in both the United States and developing countries. In addition, the report was to include recent information on trends, infant-feeding practices, and factors associated with infant-feeding decisions. The purpose of the Task Force was to determine those areas that were reasonably well studied and well proven and also to indicate where important deficiencies in knowledge existed. Because of the enormous volume of scientific literature dealing with infant feeding, the Task Force elected to concentrate on the most recent studies. In addition, studies of health effects were reviewed if they primarily addressed clinical outcomes in infants or children as end points. This approach necessarily excluded many of the laboratory studies that provide the theoretical framework under which breast-feeding would be expected to have important positive health effects relative to other forms of infant feeding. The Task Force also realized that because of the nature of clinical and epidemiologic research in this area, few of their conclusions could be based on the gold standard of causal research, namely, the randomized clinical trial. Nevertheless, to avoid arriving at conclusions and to say merely that more research was needed, would not live up to responsibility the Task Force was given. Accordingly, the authors of this report have tried to indicate which observational studies were of sufficient quality and consistency that reasonably firm conclusions could be reached, while indicating methodologic difficulties as they were found.

scholarly journals Radon Exposure and Neurodegenerative Disease

2020 ◽  
Vol 17 (20) ◽  
pp. 7439
Author(s):  
Silvia Gómez-Anca ◽  
Juan Miguel Barros-Dios
Keyword(s):  
Neurodegenerative Diseases ◽  
Scientific Evidence ◽  
Subsequent Development ◽  
Brain Anatomy ◽  
Inclusion Criteria ◽  
Motor Neuron Diseases ◽  
Radon Exposure ◽  
Bibliographic Search ◽  
The Brain ◽  
Lateral Sclerosis

Background: To carry out a systematic review of scientific literature about the association between radon exposure and neurodegenerative diseases. Methods: We performed a bibliographic search in the following databases: Pub med (Medline), Cochrane, BioMed Central and Web of Science. We collected the data by following a predetermined search strategy in which several terms werecombined. After an initial search, 77 articles were obtained.10 of which fulfilled the inclusion criteria. Five of these 10 studies were related to multiple sclerosis (MS), 2 were about motor neuron diseases (MND), in particular amyotrophic lateral sclerosis (ALS) and 3 were related to both Alzheimer’s disease (AD) and Parkinson’s disease (PD). Results: The majority of the included articles, suggested a possible association between radon exposure and a subsequent development of neurodegenerative diseases. Some of the studies that obtained statistically significant resultsrevealed a possible association between radon exposure and an increase in MS prevalence. Furthermore, it was also suggested that radon exposure increases MND and AD mortality. Regarding AD and PD, it was observed that certainde cay products of radon-222 (222Rn), specifically polonium-210 (210Po) and bismuth-210 (210Bi), present a characteristic distributionpattern within the brain anatomy. However, the study with the highest scientific evidence included in this review, which investigated a possible association between the concentration of residential radon gas and the MS incidence, revealed no significant results. Conclusions: It cannot be concluded, although it is observed, that there is a possible causal association between radon exposure and neurodegenerative diseases. Most of the available studies are ecological so, studies of higher statistical evidence are needed to establish a causal relationship. Further research is needed on this topic.

The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders

2020 ◽  
Vol 55 (1) ◽  
pp. 7-117 ◽  
Author(s):  
Gin S Malhi ◽  
Erica Bell ◽  
Darryl Bassett ◽  
Philip Boyce ◽  
Richard Bryant ◽  
...  
Keyword(s):  
Clinical Practice ◽  
New Zealand ◽  
Mood Disorders ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Primary Care Physicians ◽  
Scientific Evidence ◽  
Bipolar Disorders ◽  
Relevant Information ◽  
Zealand College

Objectives: To provide advice and guidance regarding the management of mood disorders, derived from scientific evidence and supplemented by expert clinical consensus to formulate s that maximise clinical utility. Methods: Articles and information sourced from search engines including PubMed, EMBASE, MEDLINE, PsycINFO and Google Scholar were supplemented by literature known to the mood disorders committee (e.g. books, book chapters and government reports) and from published depression and bipolar disorder guidelines. Relevant information was appraised and discussed in detail by members of the mood disorders committee, with a view to formulating and developing consensus-based recommendations and clinical guidance. The guidelines were subjected to rigorous consultation and external review involving: expert and clinical advisors, key stakeholders, professional bodies and specialist groups with interest in mood disorders. Results: The Royal Australian and New Zealand College of Psychiatrists mood disorders clinical practice guidelines 2020 (MDcpg2020) provide up-to-date guidance regarding the management of mood disorders that is informed by evidence and clinical experience. The guideline is intended for clinical use by psychiatrists, psychologists, primary care physicians and others with an interest in mental health care. Conclusion: The MDcpg2020 builds on the previous 2015 guidelines and maintains its joint focus on both depressive and bipolar disorders. It provides up-to-date recommendations and guidance within an evidence-based framework, supplemented by expert clinical consensus. Mood disorders committee: Gin S Malhi (Chair), Erica Bell, Darryl Bassett, Philip Boyce, Richard Bryant, Philip Hazell, Malcolm Hopwood, Bill Lyndon, Roger Mulder, Richard Porter, Ajeet B Singh and Greg Murray.

Neurological disorders other than dementia

2015 ◽  
Author(s):  
Raymond Voltz ◽  
Stefan Lorenzl ◽  
Georg Nübling
Keyword(s):  
Palliative Care ◽  
Neurological Disorders ◽  
Controlled Trial ◽  
Scientific Evidence ◽  
Care Needs ◽  
Specific Symptom ◽  
Positive Effects ◽  
Care Approach ◽  
Palliative Care Needs ◽  
Lateral Sclerosis

The significance of a palliative care approach for patients with neurological disorders other than dementia is increasingly recognized. Whereas the care for these patients, for example, those with amyotrophic lateral sclerosis (ALS) or motor neuron disease, had been incorporated in the initial concept by Dame Cicely Saunders, recent scientific evidence supports this position. The need for palliative care in these patients is underpinned by their frequent wish for hastening death. This chapter describes palliative care approaches for a number of neurological disorders other than dementia. For ALS, palliative care management including specific issues such as respiratory insufficiency or malnutrition are fairly well established. Also, in parkinsonian syndromes, a lot of palliative care needs can be recognized and managed effectively. For patients with multiple sclerosis, the first randomized controlled trial showed clearly positive effects on symptoms as well as usage of health-care resources. The chapter also summarizes the drug use for specific symptom management, accounting for alternative application routes.

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