scholarly journals Administration of HeberFERON in Patients with Persistent Oropharyngeal SARS-CoV-2 Wuhan/D614G Strain Viral Shedding

2021 ◽  
Vol 2 (12) ◽  
pp. 1253-1266
Author(s):  
Ivan Campa-Legra ◽  
Juan J Lence ◽  
Marel Alonso-Valdes ◽  
Marisol Diaz-Galvez ◽  
Adriana Sin-Mayor ◽  
...  
Keyword(s):  
Case Series ◽  
Viral Persistence ◽  
Control Group ◽  
Viral Shedding ◽  
Asymptomatic Patients ◽  
Group I ◽  
Case Series Study ◽  
Group Ii ◽  
Ifn Treatment ◽  
And Control

Study background: HeberFERON accelerates SARS-CoV-2 clearance in COVID-19 cases. Considering this we evaluated the employment of HeberFERON in patients with more than 14 days of viral shedding. Methods: This is a case series study of mild or moderate ill patients with laboratory-confirmed SARS-CoV-2 from one hospital in Havana, Cuba. We evaluated the effect and safety of HeberFERON in patients previously treated with Heberon Apha R that resulted with prolonged viral shedding. All patients received lopinavir-ritonavir 200/50 mg every 12 h and chloroquine 250 mg every 12 h. The primary endpoint was the time to negativization of viral RNA in patients with persistent viral shedding. The protocol was approved by the Ethics Committee of the Luis Diaz Soto Hospital. Results: The characteristics of the individuals included the age ranged from 19-87 years with a mean of 40 years, (Study and Control I groups), while in the Control group II the mean age was 43.8 years. Leukocytes, platelets, neutrophils, and eosinophils, show a significantly lower counts in the groups with viral persistence. Under IFN treatment the median viral shedding duration from diagnosis were 21 days and 19 days in Study group and Control group II, respectively. The Control group I showed a median viral shedding of 11 days (log-rank p = 0.000). Significant longer median viral negativization time (19 days) of symptomatic than asymptomatic patients (11 days, Long-rank p = 0.004), was observed. In patients under Heberon Alpha R treatment that resulted persistent for viral presence, the median time to viral negativization was 7 days for the period of administration of HeberFERON. Being symptomatic at diagnosis was significantly associated with viral persistence. The HeberFERON showed an adequate safety profile. Conclusion: HeberFERON showed a safe and rapid negativization of patients with viral persistence, achieving negativization in more than 50% of patients in 7 days.

scholarly journals Effect of Fiber Rich Product on Childhood Obesity and Lipid Profile Aged 10-12 Years

2021 ◽  
Vol 9 (3) ◽  
pp. 87-90
Author(s):  
A. Jyoth ◽  
Keyword(s):  
Exercise Group ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Diet Survey ◽  
Group Ii ◽  
And Control ◽  
Experimental Group ◽  
Positive Results ◽  
Green Peas

The effect of fiber rich product on child hood obesity studied with 60 sample which were collected randomly among 10-12 years and categorized into 2 groups i.e, experimental group and control group. Experimental group further categorized into three groups i.e, supplementation with exercise (n=15), only supplementation group (n=15), only exercise group (n=15) and control group consists of (n=15).Anthropometric, and diet survey conducted as parameters. A fiber rich product was prepared and supplemented for 2 months to the selected subjects and it consists of whole Bengal gram, whole green gram, green peas, barley and jaggery. Positive results were obtained in three experimental groups. Significant decrease observed inweight, and BMI, Total cholesterol, Triglycerides, LDL, VLDL significant increase observed in HDL in group I II and III. The results were (51.60-48.26kg, 24.7-23.1, 195.2-152.3 mg/dl, 168.2-145.0 mg/dl, 52.2-54.13 mg/dl, 109.4- 69.4mg/dl, 33.6-28.7mg/dl) in group I, In group II the results are (50.3-49.86kg, 23.7-23.4, 168.6-161.0mg/dl, 145.4-129.6mg/dl, 44.2-45.2 mg/dl, 95.3-90.0mg/dl, 29.1-28.3mg/dl).In group III the tesults aere (50.7-49.6kg, 24.5-23.9, 143.2-139.3mg/dl, 139-134.5mg/dl, 38.2-38.7mg/dl 76.8-74.1 mg/dl, 25.6-28.1mg/dl) .From the results it was clear that when compared to group II and III group I has shown better results.

Effect of biochemical profiles and reproductive performance during internal parasites in Goat and Sheep

2017 ◽  
Vol 2 (01) ◽  
pp. 103-109
Author(s):  
Dinesh Mahto
Keyword(s):  
Control Group ◽  
Control Groups ◽  
Treatment Groups ◽  
Group I ◽  
Internal Parasites ◽  
Mineral Mixture ◽  
Biochemical Profiles ◽  
Group Ii ◽  
Minimum Interval ◽  
And Control

Gastrointestinal parasitic infected ewes and does were kept almost parasite free for about 3 months using Albendazole alone or supplemented with mineral mixture. The Hb (g/dl) level ranged from 8.83±0.08 to 8.96±0.03 in ewes and does was 8.78±0.02 to 8.95±0.24 before treatment. The level of Hb increased significantly (P less than 0.01) in both the treatment groups after treatment on day 20.The Serum level of Ca, P, Cu and Zn in ewes and does increased significantly after treatment on day 20 in both the treatment groups as comparison to control group. Although they did not vary significantly among themselves except the level of Cu which was significantly (P less than 0.01) higher in group II than the group I in ewes and does. The level of Zn was higher in group I than group II in does. The minimum interval from treatment to onset of estrus were recorded in group II , 41 days in ewes and 43 days in does which was followed by group I 44 days in ewes and 46 days in does and control group 55 days in ewes and 52 days in does. The average required number of services per conception in does were 1.33, 1.00 and 2.00 for I, II and control groups, respectively. The corresponding values in ewes were 1.67, 1.17 and 2.17, respectively. The pregnancy rates in the three groups were 66.66, 83.33 and 33.33%, respectively in case of does. The corresponding values in ewes were 50.00, 66.66 and 33.36%, respectively.

scholarly journals A PILOT STUDY ON EFFECTIVENESS OF SELECTED INTERVENTIONS ON PAIN PERCEPTION AND PARENTAL SATISFACTION AMONG INFANTS RECEIVING IMMUNIZATIONS AT PUBLIC HEALTH CENTRE, CHENNAI.

2020 ◽  
pp. 1-3
Author(s):  
Semmalar. R ◽  
Jain Vanitha. N. S ◽  
Fabiola M. Dhanraj ◽  
Anitha Rajendra Babu ◽  
Susila Susila
Keyword(s):  
Pain Perception ◽  
Health Centre ◽  
Parental Satisfaction ◽  
Control Group ◽  
Public Health Centre ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
And Control ◽  
Experimental Group

An experimental post test only control design was used to assess the effectiveness of selected interventions on pain perception and parental satisfaction among infants receiving immunizations at Public Health Centre, Chennai. Using simple random sampling method, the total of 40 infants were allocated in four groups where each group had 10 infants. The interventions provided are oral sucrose for Experimental group I, 4 S’s technique for experimental group II, oral sucrose with 4 S’s technique for Experimental group III and routine care for Control group. The data collection tool consists of demographic profile, modified riley pain scale and parental satisfaction likert scale were used to collect data. The result of the study revealed that mean pain perception of experimental group III (3.21) was less than the experimental group I (4.08), experimental group II (3.40) and control group (4.22). There was no statistical difference between experimental group II and experimental group III at the level of 0.693 and also between experimental group I and control group at the level of 1.000 when other groups had statistically significant difference in pain perception. In mean parental satisfaction, the experimental group III (43.20) had high parental satisfaction than the experimental group I (39.80), experimental group II (41.90) and control group (38.60).Hence the pilot study concluded that 4S’s technique was the effective intervention for infant immunizations.

scholarly journals Specific humoral immunity in mink infected with the Aleutian disease virus (AMDV) and vaccinated against distemper

2021 ◽  
Vol 77 (07) ◽  
pp. 6544-2021
Author(s):  
ANDRZEJ ŻMUDA ◽  
KRZYSZTOF KOSTRO ◽  
URSZULA LISIECKA
Keyword(s):  
Humoral Response ◽  
Serum Levels ◽  
Suppressive Effect ◽  
Control Group ◽  
Reproductive Effects ◽  
Group I ◽  
Group Ii ◽  
And Control ◽  
Aleutian Disease Virus ◽  
Control Group Group

The Aleutian mink disease (AD) is one of the most serious threats to modern mink breeding. In farms where AD is endemic, a significant effect on breeding and reproductive effects is caused by permanent AMDV infection. The aim of this study was investigating the influence of subclinical infection of AMDV on the functional immune status and on the state of postvaccinal immunity against mink distemper. The analyses involved 30 brown mink females aged 12 weeks and allocated into an experimental group (group I) and control group (group II), with 15 animals in each. The minks from group I originated from the farm with an endemic form of Aleutian disease. The control minks from group II originated from the AMDV-uninfected farm. The dynamics of the growth of specific antibodies was examined after vaccination of the minks from both groups against distemper. Serum levels were determined in both groups with a seroneutralisation assay (SN). Obtaining positive values in the SN test in both groups of animals confirmed the induction of a specific immune response. There were significant differences in the magnitude of the positive SN assay values between the minks from group I and group II at all days of determination. The significantly lower SN values noted in the group minks with subclinical course of AMDV reveal that Aleutian disease can cause a suppressive effect on humoral response after vaccination.

To compare the impact of sitting and supine position on behavioral distress during immunization among children (1-3 years) in selected immunization clinics

2021 ◽  
pp. 351-358
Author(s):  
Grace Kurian ◽  
Theresa Leonilda Mendonca
Keyword(s):  
Supine Position ◽  
Control Group ◽  
Sitting Position ◽  
Immunization Group ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
And Control ◽  
The Impact ◽  
Experimental Group

Background of the study: Immunizations cause distress in children due to its acute pain. Younger children are particularly in need of intervention because they report more pain and display more behavioral distress during painful procedures. One of the effective non-pharmacological interventions of acute management is comfort position given by the parent. Comfort position provided by the parent during immunizations has been demonstrated to be useful in infants, toddlers and pre-school children. Yet, this simple intervention is not used on a routine basis. Aim: The aim of the study was to compare the impact of sitting and supine position on behavioral distress during immunization among children (1-3 years) in selected immunization clinics. Objectives of the study: To determine the impact of sitting position on behavioral distress of children receiving immunization (Group I - experimental group). 1. To determine the impact of supine position on behavioral distress of children receiving immunization (Group II - control group). 2. To compare the impact of sitting and supine position on behavioral distress of children during immunization. Methods: The research design adopted for the study was post test only control group design. Immunization clinic selected based on the convenience of the investigator. Purposive sampling technique used to select the sample and the sample were assigned randomly in to Group I(experimental group) and Group II(control group).To assess the impact of position: PBRS-R was used to assess the behavioral distress of children during immunization injection. Results: The collected data was analyzed by descriptive and inferential statistics. 1. Assessment of behavioral distress scores during immunization injection showed significant difference in mean scores in Group I (16.4±2.30) and in Group II (28.45±2.59). 2. Comparison of behavioral distress scores in Group I and Group II showed that there is a significant difference (p<0.05) in behavioral distress between experimental (Group I) and control (Group II) group. 3. Item wise comparison of behavioral distress scores in Group I and Group II showed that there is no significant difference(p<0.05) in behavioral distress between experimental (Group I) and control (Group II) group. Interpretation and conclusion: Findings of the study revealed that the comfort position, i.e., sitting position was effective in reducing behavioral distress during immunisation. Hence, paediatric nurses ought to promote the use of comfort position to reduce behavioral distress associated with painful procedure.

scholarly journals Application of P4 rapid test and exogenous source of progesterone in prevention of early embryonic death in dairy cows

2021 ◽  
pp. 24-27
Author(s):  
G. Bonev
Keyword(s):  
Pregnancy Rate ◽  
Rapid Test ◽  
Control Group ◽  
Group I ◽  
Group Ii ◽  
And Control ◽  
Intravaginal Device ◽  
Exogenous Source ◽  
Group 1 ◽  
Embryonic Death

Abstract. The objectives of this study were: 1) to determine the percent of cows with low P4 at Day 7-8 post-AI; 2) to treat the animal with low progesterone for 14 days with a P4-releasing intravaginal device (PRID DELTA); 3) to analyze the influence of P4 exogenous supplementation on pregnancy rate in treated and non-treated cows and 4) to create a protocol using “P4 Rapid” test allowing increased pregnancy rate under farm conditions. For this purpose, the current study has been conducted on 155 repeat breeding Holstein cows (<3 artificially inseminated – AI) with prolonged estrus cycle (<26 days). At day 7 and 8 post-AI, the milk progesterone levels were measured (P4 Rapid test). The cows with low P4 (n=104 or 67%) were divided into two groups each n=52. In Group I the progesterone devices were inserted for two weeks and control Group II without progesterone devices. At days 40 and 50 post artificial insemination (AI) all animals (n=104) were submitted to ultrasound pregnancy detection. Pregnancy was registered in 27 animals (51.9%) for Group 1, and in 16 cows (30.7%) for Group II. P4 Rapid is a quick, easy and practically applicable test to measure milk progesterone levels in dairy farms. The method is highly accurate and detects animals with low or high P4 at Day 7-8 after insemination. It also allows identification of conditions such as ovarian cysts, ovarian hypofunction and distinguishing of cycling and non-cycling cows. The combination of P4 measurement by P4 Rapid test and treatment with exogenous P4 to increase circulating concentrations in the first few days after conception can prevent embryo death and improve reproductive efficiency in dairy cattle.

α-Defensin Levels in Whole Saliva of Totally Edentulous Subjects

2008 ◽  
Vol 21 (4) ◽  
pp. 845-849 ◽  
Author(s):  
C. Fanali ◽  
R. Inzitari ◽  
T. Cabras ◽  
E. Pisano ◽  
M. Castagnola ◽  
...  
Keyword(s):  
High Performance ◽  
Control Group ◽  
Liquid Chromatography Mass Spectrometry ◽  
Control Groups ◽  
Group I ◽  
Whole Saliva ◽  
Group Ii ◽  
Edentulous Patients ◽  
Gingival Mucosa ◽  
And Control

Salivary levels of α-defensins 1–4 and histatins 1, 3 and 5 were determined in 11 totally edentulous patients, 11 younger healthy adults with normal gingival mucosa (Control group I) and 8 subjects, age-matched with edentulous patients, having a minimum of 25 teeth (Control group II). Whole saliva was treated with trifluoroacetic acid and the acidic soluble fraction analyzed by High Performance Liquid Chromatography-Mass Spectrometry. The area of the extracted ion current peaks was used for peptide quantification. Levels of α-defensinsl-4, but not of histatins, were significantly lower in totally edentulous patients with respect to both Control group I and Control group II. The two control groups did not show significant differences. The reduced level of oral α-defensins, which are mainly of crevicular origin, is most likely due to the absence of the gingival sulcus in the edentulous subjects. The near absence of α-defensins might be in part responsible for the higher vulnerability of the oral cavity to oral pathogen infections observed in totally edentulous patients.

scholarly journals EFFICACY OF BLADDER TRAINING PROCEDURE IN PATIENTS UNDERGOING TURP

2018 ◽  
Vol 25 (1) ◽  
Author(s):  
Nicolaus Kresno Harimurti ◽  
Zulfikar Ali ◽  
Trisula Utomo
Keyword(s):  
Urinary Retention ◽  
Training Group ◽  
Control Group ◽  
Training Procedure ◽  
Bladder Training ◽  
Group I ◽  
Significant Difference ◽  
History Of ◽  
Group Ii ◽  
And Control

Objective: Catheter management is conducted to the patients undergoing transurethral resection of the prostate (TURP). There were many arguments between clinical practitioners about bladder training procedure after TURP procedure. This study aims to determine whether there is a relationship between bladder training action and success of spontaneous micturition in post TURP procedure in patients with urinary retention caused by prostate enlargement. Material & methods: Randomized clinical trial was conducted at Kardinah General Hospital, Tegal from October 2015 to February 2016. 44 study participants who underwent TURP were randomly allocated into two groups. In Group I, patient’s Folley catheter was clamped prior to its removal (bladder training group); and in Group II was not clamped (control group). Results: Mean age of patients was 64.48 ± 8.1 years old. There were 23 patients (52.3%) have had history of recurrent urinary retention and 21 patients (47.7%) have had not (p=0.560). There were 4 patients (17.4%) in Group I and 1 patient (4.7%) in Group II who required re-catheterization and discharge with catheter. There was no statistically significant difference in spontaneous micturition rate between bladder training group and control group (p=0.187).  Conclusion: The result of the current study identified that bladder training to patients undergoing TURP procedure had no significant impact in spontaneous micturition.

scholarly journals Microleakage Assessment of Resin Infiltration Combined Restoration in Artificial Decalcified-Cavitated Lesion

2020 ◽  
Vol 47 (3) ◽  
pp. 257-265
Author(s):  
Eunjeong Jang ◽  
Soyoung Park ◽  
Jonghyun Shin ◽  
Shin Kim ◽  
Taesung Jeong
Keyword(s):  
Glass Ionomer Cement ◽  
Control Group ◽  
Resin Infiltration ◽  
Group I ◽  
Resin Modified Glass Ionomer ◽  
Group Ii ◽  
And Control ◽  
Caries Lesions ◽  
Experimental Group

This study was performed to evaluate the restoration combined with resin infiltration (RI) of early cavitated smooth surface caries lesion in terms of microleakage. Flowable resin and resin-modified glass ionomer cement (RMGIC) were compared.Sound 20 extracted 3rd molars were divided into 2 groups randomly. Artificial decalcified lesion was induced. Cavities were prepared on the mesial and distal surfaces, and randomly set as experimental and control group. RI was applied to the experimental group before cavity restoration. The control group was restored without RI. In group I and II, flowable resin and RMGIC was used for restoration respectively. After thermocycling and silver nitrate immersion, microleakage was assessed by μ-CT.Depth of microleakage was lower in experimental group than control group only in group II (p = 0.05). Microleakage depth was lower in group II than group I in both experimental and control groups (p = 0.05).RI pretreatment before restoration of early cavitated caries lesions might reduce the microleakage and help long-term maintenance of restoration. In this study, RMGIC was less polymerization shrinkage. Restoration with RMGIC after RI pretreatment reduced the microleakage of the restoration compared to the flowable resin.

scholarly journals A comparative study on impact of dry versus moist heat application on feasibility of peripheral intravenous cannulation among the patients of a selected hospital at Mangalore

2017 ◽  
Vol 07 (03) ◽  
pp. 021-024
Author(s):  
Jisha K. ◽  
Latha S. ◽  
Gincy Joseph
Keyword(s):  
Hot Water ◽  
Control Group ◽  
Moist Heat ◽  
Dry Heat ◽  
Group I ◽  
Heat Application ◽  
Group Ii ◽  
And Control ◽  
The Impact ◽  
Experimental Group

AbstractThe present study was conducted to assess the impact of dry v/s moist heat application on feasibility of peripheral intravenous cannulation. The study design adopted was true experimental - post test only with control group design. Using randomized block sampling 60 patients were selected and equally allocated into 3 groups-dry heat (group I), moist heat (group II) and control group each with 20 samples. The baseline clinical data were collected from the patients by interview method. Dry heat with a hot water bag at temperature of 120-140 degree Fahrenheit was applied to the peripheral cannulation site in experimental group I and moist 0 heat was applied to group II by wrapping a moist towel (110-1150 F) over the site for seven minutes. Numerical Pain scale was used to measure the level of pain experienced during peripheral intravenous cannulation. Data obtained in these areas were analysed by descriptive and inferential statistics. A significant difference was found between experimental group and control group. The Mann Whitney U test scores for Impact of dry heat and moist heat on feasibility showed that the p value for the components of feasibility like (time taken for cannulation and pain score) is < 0.05, and both dry heat and moist heat is effective in improving the feasibility of IV cannulation. Comparison of dry heat and moist heat by Kruskal Wallis test revealed that dry heat is more effective than moist heat(least time for cannulation (Median =1) and least pain (Median==1).No significant association was found between the level of pain and selected variables. This study proved that dry heat application reduces the time for cannulation and level of pain experienced by the clients during intravenous cannulation.

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